Tecleanthine - Compound Card

Tecleanthine

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Tecleanthine

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles COc1c2OCOc2cc2c1c(=O)c1c(n2C)c(OC)ccc1
InChI InChI=1S/C17H15NO5/c1-18-10-7-12-16(23-8-22-12)17(21-3)13(10)15(19)9-5-4-6-11(20-2)14(9)18/h4-7H,8H2,1-3H3
InChIKey QYWWGVQKWKTLMU-UHFFFAOYSA-N
Formula C17H15NO5
HBA 6
HBD 0
MW 313.31
Rotatable Bonds 2
TPSA 58.92
LogP 2.44
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 313.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Teclea trichocarpa Rutaceae Plantae 2695420

Showing of synonyms

  • Muriithi MW, Abraham WR, et al. (2002). Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine. Journal of Natural Products,2002,65(7),956-959. [View] [PubMed]
Pubchem: 628642
Nmrshiftdb2: 70014492

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)cc3c(c2)c(=O)c4c([nH]3)cccc4

Level: 0

Mol. Weight: 313.31 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-4.63
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.100
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.96

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.440
Plasma Protein Binding
72.01
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.470
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.280
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.520
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.420
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.170
Rat (Acute)
2.230
Rat (Chronic Oral)
1.590
Fathead Minnow
5.110
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
441.850
Hydration Free Energy
-9.770
Log(D) at pH=7.4
1.390
Log(P)
2.42
Log S
-3.68
Log(Vapor Pressure)
-7.28
Melting Point
180.03
pKa Acid
6.21
pKa Basic
2.54
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9677
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9677
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9371
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9371
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9269
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9269
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9247
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9247
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9210
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9210
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9170
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9170
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9054
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9054
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8800
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8800
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8643
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8643
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8635
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8635
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8503
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8503
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8396
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8396
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8356
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8356
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8344
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8344
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8338
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8338
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8269
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8269
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8255
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 3 0.8255
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8232
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.8232
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8220
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8220
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8201
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8201
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8199
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8199
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8197
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8197
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8115
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.8115
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8057
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8057
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7984
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7984
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7938
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7938
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7934
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7934
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7911
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7911
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7901
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7901
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7878
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 3 0.7878
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7875
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7875
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7858
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7858
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7853
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7853
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7734
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7734
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7734
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7734
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7669
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7669
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7662
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7662
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7650
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7650
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7645
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7645
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7645
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7645
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7643
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7643
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7616
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7616
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7613
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7613
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7597
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7597
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7577
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7577
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7575
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7575
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7555
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7555
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7548
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7548
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7547
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7547
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7541
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7541
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7540
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7540
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7515
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7515
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7411
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7411
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7394
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7394
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7374
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7374
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7343
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7343
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7301
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7301
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7300
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7300
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7292
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7292
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7288
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7288
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7260
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7260
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7256
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7256
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7255
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7255
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7243
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7243
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7242
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7242
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7226
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7226
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7219
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7219
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7216
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7216
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7215
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7215
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7190
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7190
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7171
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7171
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7169
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7169
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7158
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7158
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7147
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7147
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7137
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7137
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7136
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7136
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7128
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7128
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7120
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7120
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7115
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7115
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7113
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7113
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7111
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7111
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7104
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7104
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7098
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7098
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7094
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7094
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7083
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7083
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7077
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7077
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7067
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7067
Deoxyribodipyrimidine photo-lyase Q8PYK9 Q8PYK9_METMA Methanosarcina mazei 4 0.7065
Deoxyribodipyrimidine photo-lyase Q8PYK9 Q8PYK9_METMA Methanosarcina mazei 4 0.7065
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7057
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7057
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7056
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7056
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7046
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7046
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7032
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7032
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 2 0.7026
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 2 0.7026
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7019
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7019
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7011
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7011

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