(+)-piperitol-3,3-dimethylallyl ether - Compound Card

(+)-piperitol-3,3-dimethylallyl ether

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(+)-piperitol-3,3-dimethylallyl ether

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Lignan
Canonical Smiles COc1ccc(cc1OCC=C(C)C)[C@H]1OC[C@H]2[C@@H]1CO[C@@H]2c1ccc2c(c1)OCO2
InChI InChI=1S/C25H28O6/c1-15(2)8-9-27-22-10-16(4-6-20(22)26-3)24-18-12-29-25(19(18)13-28-24)17-5-7-21-23(11-17)31-14-30-21/h4-8,10-11,18-19,24-25H,9,12-14H2,1-3H3/t18-,19-,24+,25+/m0/s1
InChIKey VPSRGTGHZKLTBU-QKFIJCJASA-N
Formula C25H28O6
HBA 6
HBD 0
MW 424.49
Rotatable Bonds 6
TPSA 55.38
LogP 4.84
Number Rings 5
Number Aromatic Rings 2
Heavy Atom Count 31
Formal Charge 0
Fraction CSP3 0.44
Exact Mass 424.19
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Zanthoxylum usambarense Rutaceae Plantae 2562172
2 Zanthoxylum usambarense Rutaceae Plantae 2562172

Showing of synonyms

  • He W, Van Puyvelde L, et al. (2002). Chemical constituents and biological activities of Zanthoxylum usambarense. Phytotherapy Research,2002,16(1),66-70. [View] [PubMed]
  • He W, De Kimpe N. (2000). Study of biological active principles from Kenyan medicinal plants. PhD Thesis, University of Ghent, Belgium, 2000-2001. [View]
Pubchem: 162928617

No compound-protein relationship available.

Structure

SMILES: O1COc(c12)ccc(c2)C3OCC(C34)C(OC4)c5ccccc5

Level: 2

Mol. Weight: 424.49 g/mol

Structure

SMILES: O1COc(c12)ccc(c2)C3OCC(C34)COC4

Level: 1

Mol. Weight: 424.49 g/mol

Structure

SMILES: C1OCC(C12)COC2c3ccccc3

Level: 1

Mol. Weight: 424.49 g/mol

Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 424.49 g/mol

Structure

SMILES: C1OCC(C12)COC2

Level: 0

Mol. Weight: 424.49 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 424.49 g/mol

Antifungal
Insecticidal

Absorption

Caco-2 (logPapp)
-5.08
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.560
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.41

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.410
Plasma Protein Binding
89.8
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.550
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.180
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.410
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
7.400
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-128.800
Rat (Acute)
2.030
Rat (Chronic Oral)
1.660
Fathead Minnow
5.000
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
477.840
Hydration Free Energy
-2.820
Log(D) at pH=7.4
3.720
Log(P)
5.07
Log S
-5.71
Log(Vapor Pressure)
-8.17
Melting Point
102.11
pKa Acid
10.31
pKa Basic
4.6
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9261
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9261
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9170
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.9170
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9061
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9061
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9004
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9004
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8944
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8944
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8937
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8937
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8893
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8893
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8790
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8790
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 5 0.8784
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 5 0.8784
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8703
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8703
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8667
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8667
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8666
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8666
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8608
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8608
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8584
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8584
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8540
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.8540
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8480
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8480
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8273
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8273
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8201
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8201
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8108
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8108
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8088
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8088
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8081
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8081
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8002
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8002
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7965
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7965
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7894
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.7894
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7873
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7873
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7870
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7870
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7855
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7855
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7796
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7796
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7796
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7796
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7744
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7744
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7702
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7702
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7700
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7700
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7696
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7696
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7689
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7689
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7654
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7654
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7649
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7649
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7602
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7602
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7592
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.7592
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7587
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7587
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7586
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7586
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7583
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7583
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7575
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7575
Beta-lactamase Q79MP6 Q79MP6_PSEAI Pseudomonas aeruginosa 2 0.7575
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7575
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.7570
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.7570
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7540
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 4 0.7540
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7533
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7533
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7501
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7501
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7496
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7496
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7494
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7494
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7492
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7492
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7482
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7482
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7473
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7473
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7462
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7462
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7462
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 3 0.7462
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7447
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7447
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7437
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7437
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7430
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7430
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7427
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7427
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7410
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 3 0.7410
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7396
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 4 0.7396
Genome polyprotein Q99AU2 Q99AU2_9HEPC Hepatitis C virus subtype 1b 3 0.7395
Genome polyprotein Q99AU2 Q99AU2_9HEPC Hepatitis C virus subtype 1b 3 0.7395
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7388
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7388
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 4 0.7373
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 4 0.7373
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7363
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7363
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7361
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7361
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7358
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7358
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7341
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7341
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7337
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7337
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7332
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7332
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7318
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7318
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7318
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7318
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7314
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7314
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7307
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7307
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7300
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7300
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7297
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7297
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7293
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7293
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7291
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7291
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7272
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7272
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7266
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7266
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7245
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7245
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7244
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7244
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7228
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.7228
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7213
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7213
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7211
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7211
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7206
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7206
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7204
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7204
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7197
Nickel-binding periplasmic protein P33590 NIKA_ECOLI Escherichia coli 2 0.7197
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7194
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7194
Tryptase alpha/beta-1 Q15661 TRYB1_HUMAN Homo sapiens 3 0.7194
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7194
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7193
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7193
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7193
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7193
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7184
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7184
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7183
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7183
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7182
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7182
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7176
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7176
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7167
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7167
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7162
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7162
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7155
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7155
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7150
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7150
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7142
Polymerase acidic protein P03433 PA_I34A1 Influenza A virus 2 0.7142
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7134
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7134
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7121
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7121
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7115
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7115
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7113
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7113
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7111
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7111
Protein-tyrosine kinase 2-beta Q14289 FAK2_HUMAN Homo sapiens 3 0.7108
Protein-tyrosine kinase 2-beta Q14289 FAK2_HUMAN Homo sapiens 3 0.7108
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7095
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7095
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7081
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7081
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7077
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7077
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7076
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7076
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7067
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7067
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7065
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7065
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7059
Orotidine 5'-phosphate decarboxylase O26232 PYRF_METTH Methanothermobacter thermautotrophicus 3 0.7059
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7054
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7054
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7045
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7045
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7040
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7040
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7037
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7037
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7036
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7036
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7024
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 4 0.7024
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7023
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7023
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7018
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7018
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7016
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7016
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7005
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7005

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