5,6-dihydronitidine - Compound Card

5,6-dihydronitidine

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5,6-dihydronitidine

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Furoquinoline Alkaloid
Canonical Smiles COc1cc2c(cc1OC)CN(c1c2ccc2c1cc1c(c2)OCO1)C
InChI InChI=1S/C21H19NO4/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22/h4-9H,10-11H2,1-3H3
InChIKey MTVOSXTZNVKGIF-UHFFFAOYSA-N
Formula C21H19NO4
HBA 5
HBD 0
MW 349.39
Rotatable Bonds 2
TPSA 40.16
LogP 4.2
Number Rings 5
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 349.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Toddalia asiatica Rutaceae Plantae 2839963

Showing of synonyms

  • Gakunju DM, Mberu EK, et al. (1995). Potent antimalarial activity of the alkaloid nitidine, isolated from a Kenyan herbal remedy. Antimicrobial Agents and Chemotherapy,1995,39(12),2606-2609. [View] [PubMed]
Pubchem: 99641
Nmrshiftdb2: 60062125
CPRiL: 296506
Structure

SMILES: O1COc(c12)cc3c(c2)c4c(cc3)c5c(CN4)cccc5

Level: 0

Mol. Weight: 349.39 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp)
-5.24
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.540
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-2.38

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.440
Plasma Protein Binding
72.94
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
13.250
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.240
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.410
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
7.100
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-4.920
Rat (Acute)
2.680
Rat (Chronic Oral)
1.450
Fathead Minnow
5.540
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
498.020
Hydration Free Energy
-6.140
Log(D) at pH=7.4
3.360
Log(P)
4.48
Log S
-4.98
Log(Vapor Pressure)
-8.57
Melting Point
169.08
pKa Acid
11.37
pKa Basic
5.25
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9866
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9866
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9759
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9759
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9717
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9717
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9715
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9715
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9606
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9606
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9471
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9471
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9450
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9450
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9417
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9417
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9390
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9390
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9368
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9368
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9360
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9360
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9322
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9322
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9276
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9276
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9269
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9269
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9249
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9249
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9223
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9223
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9163
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9163
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9153
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9153
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9128
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9128
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9121
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9121
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9102
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9102
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9101
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9101
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9096
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9096
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9057
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9057
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9043
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9043
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9035
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9035
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8992
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8992
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8918
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8918
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8896
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8896
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8769
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8769
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8746
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8746
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8704
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8704
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8702
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8702
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8689
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8689
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8578
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8578
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8512
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8512
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8510
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8510
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8501
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8501
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8494
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8494
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8430
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8430
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8428
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8428
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8382
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8382
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8372
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8372
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8351
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8351
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8342
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8342
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8334
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8334
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8275
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8275
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8261
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8261
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8252
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8252
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8140
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8140
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8109
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8109
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8097
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8097
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8095
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8095
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8082
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8082
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8059
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8059
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8057
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8057
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8041
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8041
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8034
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8034
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.8017
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.8017
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8009
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8009
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7935
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7935
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7934
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7934
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7924
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7924
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7907
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7907
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7878
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7878
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7873
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7873
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7866
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7866
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7836
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.7836
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7832
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7832
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7829
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7829
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7821
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7821
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7816
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7816
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7813
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7813
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7813
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7813
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7809
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7809
Avidin P02701 AVID_CHICK Gallus gallus 4 0.7799
Avidin P02701 AVID_CHICK Gallus gallus 4 0.7799
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7762
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7762
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7746
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7746
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7722
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7722
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7710
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7710
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7704
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7704
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7703
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7703
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7656
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7656
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7651
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7651
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7647
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7647
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7639
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7639
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7636
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7636
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7629
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7629
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7618
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7618
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7605
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7605
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7605
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7605
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7602
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7602
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7599
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7599
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7594
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7594
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7593
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7593
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7592
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7592
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7590
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7590
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7577
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7577
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7576
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7576
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7557
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7557
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7549
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7549
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7545
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7545
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7537
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7537
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7534
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7534
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7523
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7523
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7518
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7518
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7518
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7518
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7512
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7512
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7510
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7510
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7499
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7499
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7495
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7495
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7492
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7492
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7482
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.7482
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7457
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7457
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7455
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7455
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 3 0.7445
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 3 0.7445
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7443
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7443
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7443
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7443
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7435
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7435
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7428
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 4 0.7428
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7410
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7410
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7401
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7401
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7376
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7376
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7370
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7370
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7370
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7370
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7367
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7367
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7365
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7365
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7360
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7360
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7348
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7348
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7342
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7342
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7339
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7339
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7325
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7325
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7312
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7312
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7312
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7312
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7306
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7306
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7305
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7305
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7304
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7304
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7292
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7292
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7288
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7288
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7288
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7288
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7286
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7286
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7285
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7285
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7284
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7284
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7283
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7283
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7278
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7278
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7278
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7278
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7271
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7271
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7271
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7271
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7267
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7267
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7263
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7263
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7261
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7261
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7258
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7258
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7249
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7249
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7243
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7243
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7242
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7242
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7239
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7239
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7237
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7237
Toll-like receptor 8 Q9NR97 TLR8_HUMAN Homo sapiens 3 0.7231
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7231
Toll-like receptor 8 Q9NR97 TLR8_HUMAN Homo sapiens 3 0.7231
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7231
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7228
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7228
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7222
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7222
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7219
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7219
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7211
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7211
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7211
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7211
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7206
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7206
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7206
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7206
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7196
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7196
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7196
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7196
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7194
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7194
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7194
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7194
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7192
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7192
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7185
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7185
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7184
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7184
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7183
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7183
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7183
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7183
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7181
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7181
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7177
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7177
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7175
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7175
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7170
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7170
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7167
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7167
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7158
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7158
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7156
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7156
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7152
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7152
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7151
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7151
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7146
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7146
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7133
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7133
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7132
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7132
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7128
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7128
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7124
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7124
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7123
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7123
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7122
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7122
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7121
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7121
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7120
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7120
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7114
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7114
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7113
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7113
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7112
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7112
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7111
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7111
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7111
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7111
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7103
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7103
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7103
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7103
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7101
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7100
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7100
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7098
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7098
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7096
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7096
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7095
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7095
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7090
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7090
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7090
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7090
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7085
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7085
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7085
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7085
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7084
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7084
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7080
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7080
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7078
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7078
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7075
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7075
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7072
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7072
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7069
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7069
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7063
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7063
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7059
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7059
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7057
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7057
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7055
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7055
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7054
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7054
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7049
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7049
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7042
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7042
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7038
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7038
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7030
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7030
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7030
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7030
HAP protein Q8IM15 Q8IM15_PLAF7 Plasmodium falciparum 3 0.7024
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7024
HAP protein Q8IM15 Q8IM15_PLAF7 Plasmodium falciparum 3 0.7024
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7024
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7023
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7023
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7020
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7020
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7018
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7018
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 2 0.7018
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 2 0.7018
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7014
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7014
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7005
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7005
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7003
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7003
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7002
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7002
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7002
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7002
Serine/threonine-protein kinase receptor R3 P37023 ACVL1_HUMAN Homo sapiens 3 0.7001
Serine/threonine-protein kinase receptor R3 P37023 ACVL1_HUMAN Homo sapiens 3 0.7001

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