Uguenenprenol - Compound Card

Uguenenprenol

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Uguenenprenol

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: C-7 Prenylated Flavonoid
Canonical Smiles OC/C(=C/COc1cc2O[C@H](c3ccc(cc3)O)[C@H](C(=O)c2c(c1)O)O)/C
InChI InChI=1S/C20H20O7/c1-11(10-21)6-7-26-14-8-15(23)17-16(9-14)27-20(19(25)18(17)24)12-2-4-13(22)5-3-12/h2-6,8-9,19-23,25H,7,10H2,1H3/b11-6+/t19-,20+/m0/s1
InChIKey MSWOYPGTQZJKQY-CHUTXNTCSA-N
Formula C20H20O7
HBA 7
HBD 4
MW 372.37
Rotatable Bonds 5
TPSA 116.45
LogP 2.09
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 372.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Vepris uguenensis Rutaceae Plantae 2695421

Showing of synonyms

  • Kiplimo JJ, Shahidul Islam M, et al. (2012). Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity. Phytochemistry,2012,83(2012),136-143. [View] [PubMed]
Pubchem: 71501757

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 372.37 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 372.37 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 372.37 g/mol

Antioxidant

Absorption

Caco-2 (logPapp)
-5.55
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.900
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.31

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.030
Plasma Protein Binding
76.06
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
11.480
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.270
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.050
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.360
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Toxic
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-3.440
Rat (Acute)
2.150
Rat (Chronic Oral)
2.880
Fathead Minnow
4.680
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
476.180
Hydration Free Energy
-9.660
Log(D) at pH=7.4
2.370
Log(P)
1.88
Log S
-4.5
Log(Vapor Pressure)
-9.12
Melting Point
181.19
pKa Acid
6.48
pKa Basic
4.19
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9501
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9501
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9367
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9367
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9359
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9359
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9229
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9229
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9219
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9219
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9202
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9202
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9168
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9168
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9101
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9101
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9076
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9076
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9075
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9075
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9056
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9056
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9047
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9047
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9038
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9038
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8944
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8944
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8943
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8943
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8913
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8913
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8875
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8875
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8834
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8834
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8747
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8747
Maltose/maltodextrin-binding periplasmic protein P0AEX9 MALE_ECOLI Escherichia coli 3 0.8739
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8739
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8739
Maltose/maltodextrin-binding periplasmic protein P0AEX9 MALE_ECOLI Escherichia coli 3 0.8739
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8726
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8726
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8662
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8662
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8661
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8661
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8639
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8639
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8578
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8578
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8568
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.8568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8528
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8528
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8464
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8464
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8352
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8352
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8342
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8342
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8324
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8324
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8306
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8306
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8290
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8290
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8263
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8263
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8252
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.8252
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8228
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8228
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8213
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8213
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8194
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8194
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8183
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8183
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8169
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8169
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8156
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8156
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8135
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8135
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8130
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8130
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8089
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8089
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8078
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8078
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7987
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7987
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7985
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7985
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7945
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7945
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.7939
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.7939
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7917
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7917
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7876
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7876
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7870
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7870
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7777
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7777
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7773
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7773
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7755
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7755
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7752
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7752
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 4 0.7742
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 4 0.7742
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7735
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7735
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7706
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7706
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7696
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7696
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7686
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7686
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7678
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7678
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7658
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7658
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7656
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7656
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7650
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.7650
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7642
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7642
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7640
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7640
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7627
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7627
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7619
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7619
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7561
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.7561
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7538
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7538
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7532
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7532
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7477
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7477
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7474
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7474
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7472
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7472
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7469
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7469
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7462
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7462
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7460
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7460
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7432
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7432
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7417
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7417
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7416
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7416
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7402
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7402
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7398
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7398
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7397
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7397
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7396
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7396
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7378
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7378
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7371
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7371
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7369
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7369
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7362
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7362
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7322
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7322
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7297
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7297
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7288
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7288
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7281
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7281
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7255
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7255
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.7254
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.7254
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7237
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 3 0.7237
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7212
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7212
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7206
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7206
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7195
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7195
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7193
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7193
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7189
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7189
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7181
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7181
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7177
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 3 0.7177
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7172
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7172
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7162
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7162
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7158
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7158
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7140
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7140
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7123
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7123
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7119
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7119
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7117
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7117
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7114
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7114
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7112
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7112
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7099
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7099
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7096
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7096
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7092
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7092
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7092
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7092
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7091
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7091
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7078
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.7078
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7065
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7065
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7064
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7064
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7059
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7059
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7059
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7059
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7057
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7057
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7052
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7052
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7048
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7048
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7035
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7035
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7029
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7029
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7019
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7019
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7008
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7008
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7008
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7008
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7001
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7001

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