7-O-methylaromadendrin - Compound Card

7-O-methylaromadendrin

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7-O-methylaromadendrin

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc2O[C@H](c3ccc(cc3)O)[C@H](C(=O)c2c(c1)O)O
InChI InChI=1S/C16H14O6/c1-21-10-6-11(18)13-12(7-10)22-16(15(20)14(13)19)8-2-4-9(17)5-3-8/h2-7,15-18,20H,1H3/t15-,16+/m0/s1
InChIKey LZLGHWHSUZVUFZ-JKSUJKDBSA-N
Formula C16H14O6
HBA 6
HBD 3
MW 302.28
Rotatable Bonds 2
TPSA 96.22
LogP 1.78
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 302.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Vepris uguenensis Rutaceae Plantae 2695421
2 Vepris uguenensis Rutaceae Plantae 2695421

Showing of synonyms

  • Kiplimo JJ, Shahidul Islam M, et al. (2012). Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity. Phytochemistry,2012,83(2012),136-143. [View] [PubMed]
  • Kiplimo JJ, Koorbanally NA. (2012). The phytochemistry and biological activity of secondary metabolites from Kenyan Vernonia and Vepris species. PhD Thesis, University of Kwazulu-Natal, South Africa,2012. [View] [PubMed]
CPRiL: 264013
Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 302.28 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 302.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 302.28 g/mol

Antioxidant

Absorption

Caco-2 (logPapp)
-4.66
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.830
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.52

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.080
Plasma Protein Binding
75.66
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.590
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.010
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.230
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.750
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.500
Rat (Acute)
2.160
Rat (Chronic Oral)
2.760
Fathead Minnow
4.070
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
419.100
Hydration Free Energy
-10.750
Log(D) at pH=7.4
2.310
Log(P)
1.92
Log S
-4.09
Log(Vapor Pressure)
-7.72
Melting Point
191.81
pKa Acid
6.61
pKa Basic
2.88
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9839
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9839
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9482
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9482
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9406
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9406
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9385
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9385
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9367
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9367
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9344
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9344
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9189
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9189
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9131
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9131
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9101
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9101
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9059
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9059
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9037
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9037
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9036
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9036
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9020
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9020
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9009
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9009
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9001
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9001
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.8956
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.8956
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8936
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8936
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8923
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8923
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8897
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8897
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8875
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8875
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8851
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8851
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8826
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8826
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8805
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8805
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8789
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8789
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8781
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8781
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8771
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8771
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8755
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8755
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8736
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8736
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8691
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8691
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8630
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8630
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8627
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8627
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8626
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8626
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8594
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8594
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8556
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8556
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8530
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8530
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8526
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8526
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8470
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8470
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8465
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8465
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8441
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8441
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8427
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8427
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8426
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8426
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8412
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8412
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8399
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8399
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8392
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.8392
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8383
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8383
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8374
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8374
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8346
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8346
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8342
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8342
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8312
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8312
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8280
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8280
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8263
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8263
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8262
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8262
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8166
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8166
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8102
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8102
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8080
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8080
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8074
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8074
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8044
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8044
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7992
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7992
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7983
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7983
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7966
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7966
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7965
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7965
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7958
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7958
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.7947
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.7947
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7860
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7860
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7860
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7860
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7811
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.7811
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7785
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7785
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7780
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7780
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7759
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7759
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7753
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7753
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7726
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7726
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7694
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7694
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7690
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7690
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7679
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7679
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7672
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7672
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7666
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7666
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7662
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7662
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.7662
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7662
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7655
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7655
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7630
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7630
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7619
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7619
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7614
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7614
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7609
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7609
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7580
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7580
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7548
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7548
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7526
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7526
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7512
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.7512
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7486
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7486
Ascorbate-specific PTS system EIIC component P39301 ULAA_ECOLI Escherichia coli 3 0.7483
Ascorbate-specific PTS system EIIC component P39301 ULAA_ECOLI Escherichia coli 3 0.7483
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7477
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7477
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7473
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7473
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7466
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7466
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7436
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7436
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7427
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7427
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7427
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7427
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7418
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7418
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7410
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7410
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7410
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7410
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7407
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7407
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7407
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7407
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7399
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7399
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7388
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7388
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7379
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.7379
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7375
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7375
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7375
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7375
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7364
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7364
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7360
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7360
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7339
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7339
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7337
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7337
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7332
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7332
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7314
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7314
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7303
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7303
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7295
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7295
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7279
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7279
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7260
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7260
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7244
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7244
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7239
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7239
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7237
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7237
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7237
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7237
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7235
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7235
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7234
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7234
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7219
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7219
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7213
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7213
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7212
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7212
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7210
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7210
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7190
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7190
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7171
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7171
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7167
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7167
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7162
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7162
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7155
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7155
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7151
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7151
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7128
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7128
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7122
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7122
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7120
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7120
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7118
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7118
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7107
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7107
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7105
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7105
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7103
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7103
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7096
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 3 0.7096
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7090
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7090
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7089
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7089
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7070
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7070
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7055
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7055
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7036
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7036
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7023
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7023
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7020
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7020
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7019
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7019
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7017
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7017
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7016
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7016
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7014
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7014
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7009
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7009
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7008
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7008
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7003
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7003
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7000
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7000

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