Flindersiamine - Compound Card

Flindersiamine

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Flindersiamine

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Furoquinoline Alkaloid
Canonical Smiles COc1c2OCOc2cc2c1nc1occc1c2OC
InChI InChI=1S/C14H11NO5/c1-16-11-7-3-4-18-14(7)15-10-8(11)5-9-12(13(10)17-2)20-6-19-9/h3-5H,6H2,1-2H3
InChIKey IMJCEVWDXKCHOI-UHFFFAOYSA-N
Formula C14H11NO5
HBA 6
HBD 0
MW 273.24
Rotatable Bonds 2
TPSA 62.95
LogP 2.73
Number Rings 4
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 273.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Vepris uguenensis Rutaceae Plantae 2695421
2 Vepris uguenensis Rutaceae Plantae 2695421
3 Vepris uguenensis Rutaceae Plantae 2695421
4 Teclea simplicifolia Rutaceae Plantae 482953
5 Araliopsis soyauxii Rutaceae Plantae 1317904

Showing of synonyms

  • Cheplogoi PK, Mulholland DA, et al. (2008). An azole, an amide and a limonoid from Vepris uguenensis (Rutaceae). Phytochemistry,2008,69(6),1384-1388. [View] [PubMed]
  • Nganou BK, Mbaveng AT, et al. (2019). Furoquinolines and dihydrooxazole alkaloids with cytotoxic activity from the stem bark of Araliopsis soyauxii.. Fitoterapia,2019, 133, 193-199. [View] [PubMed]
  • Njeru DN, Derese S, et al. (2015). Phytochemical investigation of the stem bark and the leaves of Teclea simplicifolia for analgesic activity. M.Sc. Thesis-1, University of Nairobi, Kenya,2015. [View] [PubMed]
  • Kiplimo JJ, Shahidul Islam M, et al. (2012). Ring A-seco limonoids and flavonoids from the Kenyan Vepris uguenensis Engl. and their antioxidant activity. Phytochemistry,2012,83(2012),136-143. [View] [PubMed]
  • Kiplimo JJ, Koorbanally NA. (2012). The phytochemistry and biological activity of secondary metabolites from Kenyan Vernonia and Vepris species. PhD Thesis, University of Kwazulu-Natal, South Africa,2012. [View] [PubMed]
Pubchem: 68221
Kegg Ligand: C10678
Chebi: 5093
Nmrshiftdb2: 60023033

No compound-protein relationship available.

Structure

SMILES: c1coc(c12)nc3c(c2)cc4c(c3)OCO4

Level: 0

Mol. Weight: 273.24 g/mol

Antimalarial

Absorption

Caco-2 (logPapp)
-4.59
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.390
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.92

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.170
Plasma Protein Binding
87.07
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
12.940
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.690
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.170
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.160
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.430
Rat (Acute)
2.730
Rat (Chronic Oral)
2.190
Fathead Minnow
4.960
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Toxic

General Properties

Boiling Point
406.510
Hydration Free Energy
-9.470
Log(D) at pH=7.4
2.560
Log(P)
2.83
Log S
-4.0
Log(Vapor Pressure)
-6.57
Melting Point
158.85
pKa Acid
8.51
pKa Basic
4.07
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9704
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9704
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9671
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9671
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9517
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9517
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9411
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9411
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9368
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9368
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9316
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9316
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.9238
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.9238
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9233
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9233
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9211
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9211
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9194
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9194
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9103
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9103
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.9075
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.9075
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9026
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9026
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.9007
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.9007
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8886
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8886
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8885
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8885
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8871
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8871
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8869
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8869
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8847
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8847
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8800
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8800
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8714
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8714
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8688
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8688
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8636
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8636
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8635
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8635
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8607
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8607
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8592
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8592
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8558
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8558
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8460
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 4 0.8460
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8454
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8454
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8425
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8425
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8355
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8355
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8330
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8330
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8298
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8298
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8261
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8261
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8245
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8245
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8221
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8221
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8163
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8163
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8108
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8108
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8035
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8035
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8017
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8017
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8014
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8014
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8006
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8006
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7974
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7974
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7959
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.7959
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7954
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7954
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7904
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7904
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7901
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7901
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7895
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7895
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7868
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7868
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7851
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7851
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7835
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7835
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7794
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7794
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7782
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7782
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7765
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7765
Cyclin-dependent kinase 2 homolog Q07785 CDC2H_PLAFK Plasmodium falciparum 4 0.7742
Cyclin-dependent kinase 2 homolog Q07785 CDC2H_PLAFK Plasmodium falciparum 4 0.7742
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7740
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7740
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7733
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7733
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7707
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7707
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7695
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7695
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7683
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7683
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7683
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7683
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7676
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7676
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7662
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7662
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7660
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7660
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7646
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7646
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7643
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7643
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7636
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7636
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7620
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7620
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7616
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7616
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7599
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7599
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7596
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7596
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7595
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7595
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7578
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7578
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7559
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7559
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 4 0.7554
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 4 0.7554
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7549
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7549
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7547
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7547
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7535
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7535
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7520
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7520
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7510
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7510
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7503
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7503
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7500
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7500
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7490
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7490
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7489
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7489
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7478
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7478
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7454
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7454
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 4 0.7454
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 4 0.7454
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7428
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7428
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7416
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7416
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7411
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7411
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7388
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7388
Serine/threonine-protein kinase PAK 4 O96013 PAK4_HUMAN Homo sapiens 4 0.7387
Serine/threonine-protein kinase PAK 4 O96013 PAK4_HUMAN Homo sapiens 4 0.7387
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7383
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7383
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7368
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7368
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7352
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7352
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7339
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7339
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7336
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7336
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7335
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7335
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7328
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7328
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7322
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7322
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7321
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7321
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7318
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7312
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7312
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7311
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7311
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7302
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7302
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7298
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7298
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7292
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7292
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7290
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7290
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7274
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7274
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7261
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7261
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7257
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7257
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7247
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7247
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7243
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7243
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7238
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7238
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7232
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7232
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7222
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7222
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7219
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7219
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7182
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7182
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7181
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7181
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7170
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7170
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7169
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7169
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7166
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7166
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7145
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7145
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7143
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7143
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7131
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7131
Deoxyribodipyrimidine photo-lyase Q8PYK9 Q8PYK9_METMA Methanosarcina mazei 4 0.7129
Deoxyribodipyrimidine photo-lyase Q8PYK9 Q8PYK9_METMA Methanosarcina mazei 4 0.7129
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7110
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7110
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.7110
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7110
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7107
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7107
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7100
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7100
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7092
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7092
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7090
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7090
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7089
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7089
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7079
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7079
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7064
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7064
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7060
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7060
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7059
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7059
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7053
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7053
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7050
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7050
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7047
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7047
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7045
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7045
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7044
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7044
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7040
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7040
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7040
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7040
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7038
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7038
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7037
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7037
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7028
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7028
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7019
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7019
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7015
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7015
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7012
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7011
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7011
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7010
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7010

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