Montrifoline - Compound Card

Montrifoline

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Montrifoline

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Furoquinoline Alkaloid
Canonical Smiles COc1cc2nc3occc3c(c2cc1OC[C@H](C(O)(C)C)O)OC
InChI InChI=1S/C18H21NO6/c1-18(2,21)15(20)9-25-14-7-11-12(8-13(14)22-3)19-17-10(5-6-24-17)16(11)23-4/h5-8,15,20-21H,9H2,1-4H3/t15-/m1/s1
InChIKey CODUJIFHJTUEBU-OAHLLOKOSA-N
Formula C18H21NO6
HBA 7
HBD 2
MW 347.37
Rotatable Bonds 6
TPSA 94.18
LogP 2.51
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.39
Exact Mass 347.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Teclea nobilis Rutaceae Plantae 1220089

Showing of synonyms

  • Lacroix D, Prado S, et al. (2012). Absolute configuration of 2′(R)-acetylmontrifoline and 2'(R)-montrifoline, furoquinolines from the fruits of Teclea nobilis. Phytochemistry Letters,2012,5(1),22-25. [View] [PubMed]
Pubchem: 162911907
Nmrshiftdb2: 60072346

No compound-protein relationship available.

Structure

SMILES: c1coc(c12)nc3c(c2)cccc3

Level: 0

Mol. Weight: 347.37 g/mol

Anti-leishmanial
Anti-plasmodial
Antitrypanosomal

Absorption

Caco-2 (logPapp)
-4.61
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.710
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.160
Plasma Protein Binding
78.27
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.980
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.920
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.130
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.100
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-0.710
Rat (Acute)
2.430
Rat (Chronic Oral)
2.570
Fathead Minnow
4.520
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
432.520
Hydration Free Energy
-11.960
Log(D) at pH=7.4
2.500
Log(P)
1.47
Log S
-3.04
Log(Vapor Pressure)
-7.55
Melting Point
154.56
pKa Acid
8.61
pKa Basic
5.91
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9456
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9456
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9232
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9232
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9229
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9229
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9204
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9204
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8999
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8999
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8939
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8939
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8932
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8932
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8901
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8901
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8888
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8888
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8796
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8796
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8783
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8783
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8759
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8759
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8744
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8744
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.8738
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.8738
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8596
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8596
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8448
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8448
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 3 0.8409
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 3 0.8409
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8376
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8376
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 3 0.8226
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 3 0.8226
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8175
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8175
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8168
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8168
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8139
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8139
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8128
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.8128
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8095
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8095
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8027
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8027
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7986
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7986
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7981
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7981
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7937
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7937
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7866
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7866
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7837
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7837
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7832
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7832
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7829
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7829
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7810
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7810
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7804
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7804
Aclacinomycin 10-hydroxylase RdmB Q54527 RDMB_STREF Streptomyces purpurascens 3 0.7803
Aclacinomycin 10-hydroxylase RdmB Q54527 RDMB_STREF Streptomyces purpurascens 3 0.7803
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7789
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7789
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7787
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7787
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7759
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7759
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7733
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7733
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7721
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7721
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7684
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7684
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7666
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7666
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7665
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 2 0.7665
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7634
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7634
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7624
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7624
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7618
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7618
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7615
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7615
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7612
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7612
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7610
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7610
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7605
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7605
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7597
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7597
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7591
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7591
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7586
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7586
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7575
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7575
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7547
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7547
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7544
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7544
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7522
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7522
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7519
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7519
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7512
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7512
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7502
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.7502
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7496
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7496
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7493
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7493
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7490
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7490
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7485
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7485
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7477
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7477
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7458
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7458
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7450
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7450
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7447
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7447
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7444
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7444
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7443
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7443
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7443
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7443
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7438
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7438
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7434
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.7434
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7431
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7431
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7430
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7430
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7416
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7416
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7415
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7415
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7404
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 3 0.7404
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7403
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7403
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7400
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7400
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7394
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7394
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7374
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7374
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7370
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7370
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7355
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7355
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7348
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7348
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7345
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7345
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7336
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7336
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7320
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7320
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7318
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 3 0.7318
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7299
Cytochrome P450 2D6 P10635 CP2D6_HUMAN Homo sapiens 3 0.7299
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7291
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7291
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7274
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7274
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7270
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7270
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7268
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7268
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7266
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.7266
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7262
Rifampin ADP-ribosyl transferase A0QRS5 A0QRS5_MYCS2 Mycolicibacterium smegmatis155) 3 0.7262
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7258
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7258
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7257
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7257
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7253
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7253
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7252
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7252
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7240
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7240
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7232
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7232
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7219
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7219
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.7202
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 3 0.7202
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7198
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7198
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7192
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.7192
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7191
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7191
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7176
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7176
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7170
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7170
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7166
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7166
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7163
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7163
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7156
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7156
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7149
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7149
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7148
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7148
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7135
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7135
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7134
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7134
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7128
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7128
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7118
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7118
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7117
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7117
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7109
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7109
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7100
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7100
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7096
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7096
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7095
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7095
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7079
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7079
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7066
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7066
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7061
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7061
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7059
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7059
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7058
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7058
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7055
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7055
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7052
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7052
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7039
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7039
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7038
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7038
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7035
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7035
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7030
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7030
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7027
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7027
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7026
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7026
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7024
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7024
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7019
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7019
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7018
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7018

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