4,5,6,7-tetramethoxyfuro[2,3-b]quinoline - Compound Card

4,5,6,7-tetramethoxyfuro[2,3-b]quinoline

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4,5,6,7-tetramethoxyfuro[2,3-b]quinoline

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles COc1cc2nc3occc3c(c2c(c1OC)OC)OC
InChI InChI=1S/C15H15NO5/c1-17-10-7-9-11(14(20-4)13(10)19-3)12(18-2)8-5-6-21-15(8)16-9/h5-7H,1-4H3
InChIKey WYJBIVKHXACTCU-UHFFFAOYSA-N
Formula C15H15NO5
HBA 6
HBD 0
MW 289.29
Rotatable Bonds 4
TPSA 62.95
LogP 3.02
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.27
Exact Mass 289.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Teclea simplicifolia Rutaceae Plantae 482953

Showing of synonyms

  • Njeru DN, Derese S, et al. (2015). Phytochemical investigation of the stem bark and the leaves of Teclea simplicifolia for analgesic activity. M.Sc. Thesis-1, University of Nairobi, Kenya,2015. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1coc(c12)nc3c(c2)cccc3

Level: 0

Mol. Weight: 289.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.51
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.390
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.22

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.130
Plasma Protein Binding
78.25
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
10.370
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.180
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.030
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.550
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.870
Rat (Acute)
2.840
Rat (Chronic Oral)
2.560
Fathead Minnow
4.990
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
397.330
Hydration Free Energy
-9.520
Log(D) at pH=7.4
2.560
Log(P)
2.09
Log S
-3.14
Log(Vapor Pressure)
-5.91
Melting Point
136.2
pKa Acid
8.33
pKa Basic
5.01
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9601
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9601
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9592
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9592
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9588
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9588
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9572
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9572
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9462
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9462
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9413
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9413
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9350
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9350
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9286
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9286
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9187
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9187
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8996
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8996
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8967
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8967
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8943
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8943
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8850
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8850
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8801
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8801
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8790
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8790
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8744
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.8744
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8730
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8730
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8708
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8708
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8693
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8693
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8689
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8689
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8640
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8640
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8639
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8639
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8623
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8623
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8616
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8616
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8584
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8584
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8562
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8562
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8561
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8561
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8509
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8509
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8500
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8500
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8487
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8487
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8473
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8473
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8294
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 3 0.8294
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8160
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8160
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8107
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.8107
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8094
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8094
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8073
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8073
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8064
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8064
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8046
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8046
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8042
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8042
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8024
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8024
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8016
Renin P00797 RENI_HUMAN Homo sapiens 3 0.8016
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7974
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7974
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7928
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7928
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7910
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7910
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7893
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7893
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7881
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7881
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7877
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7877
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7840
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7840
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7826
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7826
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7800
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7800
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7787
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7787
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7752
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7752
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7732
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7732
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7726
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7726
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7716
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7716
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7706
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7706
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7705
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7705
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7688
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7688
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7657
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7657
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7636
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7636
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7634
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7634
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7632
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7632
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7626
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7626
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7609
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 3 0.7609
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7605
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7605
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7582
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7582
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7581
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7581
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7575
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7575
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7560
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7560
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7559
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7559
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7558
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7558
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7556
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7556
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7538
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7538
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7533
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7533
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7520
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7520
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7501
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7501
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7494
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7494
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7489
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7489
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7482
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7482
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7480
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7480
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7471
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7471
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7464
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7464
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7452
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 2 0.7452
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7450
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7450
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7448
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7448
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7436
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7436
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7428
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7428
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7426
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7426
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7419
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7419
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7412
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7412
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7409
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7409
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7408
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7408
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 4 0.7404
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 4 0.7404
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7403
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7403
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7398
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7398
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7397
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7397
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7388
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7388
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7386
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7386
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7384
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7384
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7383
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7383
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7360
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7360
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7357
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7357
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7347
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7347
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7347
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7347
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7345
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7345
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7334
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7334
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7312
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7312
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7309
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7309
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7307
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7307
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7301
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7301
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7299
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7299
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7280
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.7280
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7275
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7275
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7274
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7274
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7272
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7272
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7265
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7265
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7264
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.7264
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7262
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7262
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7249
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7249
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7248
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7248
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7245
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7245
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7241
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7241
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7240
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7240
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7236
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7236
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7227
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7227
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7219
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7219
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7215
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7215
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7207
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7207
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7197
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7197
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7194
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7194
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7187
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7187
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7186
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7186
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7182
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7182
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 2 0.7179
Prostaglandin reductase 3 Q8N4Q0 PTGR3_HUMAN Homo sapiens 2 0.7179
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7172
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7172
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7170
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7170
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7160
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7160
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7159
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7159
Fatty acid-binding protein, adipocyte P04117 FABP4_MOUSE Mus musculus 2 0.7145
Fatty acid-binding protein, adipocyte P04117 FABP4_MOUSE Mus musculus 2 0.7145
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7140
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7140
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7135
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7135
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7130
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7130
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7123
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7123
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7107
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7107
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7099
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7099
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7093
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7093
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7091
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7091
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7085
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7085
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7077
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7077
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7071
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7071
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7066
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7066
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7065
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7065
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7057
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7057
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7055
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7055
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7055
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7055
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7051
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7051
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7051
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7051
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7044
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7044
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7043
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7043
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7035
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7035
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7033
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7033
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7031
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7031
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.7026
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.7026
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7021
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7021
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7019
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7019
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7018
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7018
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7007
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.7007
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7002
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7002

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