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3beta-acetyl-11alpha,28-dihydroxy-16-oxo-12-oleanene
- Family: Plantae - Myrsinaceae
- Kingdom: Plantae
-
Class: Terpenoid
- Subclass: Triterpenoid
Canonical Smiles | OC[C@@]12CCC(C[C@H]2[C@@]2([C@](CC1=O)(C)[C@]1(C)CC[C@@H]3[C@](C1[C@@H](C2)O)(C)CC[C@@H](C3(C)C)OC(=O)C)C)(C)C |
---|---|
InChI | InChI=1S/C33H54O5/c1-20(35)38-25-11-12-29(6)22(28(25,4)5)10-13-30(7)26(29)21(36)16-31(8)23-17-27(2,3)14-15-33(23,19-34)24(37)18-32(30,31)9/h21-23,25-26,34,36H,10-19H2,1-9H3/t21-,22+,23+,25+,26?,29+,30-,31-,32+,33-/m1/s1 |
InChIKey | SDTWVLAVAFZUJC-AQKOSRGESA-N |
Formula | C33H54O5 |
HBA | 5 |
HBD | 2 |
MW | 530.79 |
Rotatable Bonds | 2 |
TPSA | 83.83 |
LogP | 6.33 |
Number Rings | 5 |
Number Aromatic Rings | 0 |
Heavy Atom Count | 38 |
Formal Charge | 0 |
Fraction CSP3 | 0.94 |
Exact Mass | 530.4 |
Number of Lipinski Rule Violations | 2 |
# | Species | Family | Kingdom | NCBI Taxonomy ID |
---|---|---|---|---|
1 | Embelia schimperi | Myrsinaceae | Plantae | 2595069 |
Showing of synonyms
3beta-acetyl-11alpha,28-dihydroxy-16-oxo-12-oleanene
No compound-protein relationship available.
SMILES: C1CCCC(C12)C3C(CC2=O)C4C(CC3)C5C(CC4)CCCC5
Level: 0
Mol. Weight: 530.79 g/mol
No bioactivities available.
Absorption
- Caco-2 (logPapp)
- -4.85
- Human Oral Bioavailability 20%
- Bioavailable
- Human Intestinal Absorption
- Absorbed
- Madin-Darby Canine Kidney
- -4.78
- Human Oral Bioavailability 50%
- Bioavailable
- P-Glycoprotein Inhibitor
- Non-Inhibitor
- P-Glycoprotein Substrate
- Non-Substrate
- Skin Permeability
- -1.91
Distribution
- Blood-Brain Barrier (CNS)
- -
- Blood-Brain Barrier
- Penetrable
- Fraction Unbound (Human)
- 1.49
- Plasma Protein Binding
- 91.99
- Steady State Volume of Distribution
- -
Metabolism
- Breast Cancer Resistance Protein
- Non-Inhibitor
- CYP 1A2 Inhibitor
- Non-Inhibitor
- CYP 1A2 Substrate
- Substrate
- CYP 2C19 Inhibitor
- Non-Inhibitor
- CYP 2C19 Substrate
- Substrate
- CYP 2C9 Inhibitor
- Non-Inhibitor
- CYP 2C9 Substrate
- Non-Substrate
- CYP 2D6 Inhibitor
- Non-Inhibitor
- CYP 2D6 Substrate
- Non-Substrate
- CYP 3A4 Inhibitor
- Non-Inhibitor
- CYP 3A4 Substrate
- Substrate
- OATP1B1
- Non-Inhibitor
- OATP1B3
- Non-Inhibitor
Excretion
- Clearance
- 6.36
- Organic Cation Transporter 2
- Non-Inhibitor
- Half-Life of Drug
- -
Toxicity
- AMES Mutagenesis
- Safe
- Avian
- Safe
- Bee
- Toxic
- Bioconcentration Factor
- -1.22
- Biodegradation
- Safe
- Carcinogenesis
- Safe
- Crustacean
- Safe
- Liver Injury I (DILI)
- Toxic
- Eye Corrosion
- Safe
- Eye Irritation
- Safe
- Maximum Tolerated Dose
- 0.92
- Liver Injury II
- Toxic
- hERG Blockers
- Safe
- Daphnia Maga
- 6.56
- Micronucleos
- Safe
- NR-AhR
- Safe
- NR-AR
- Toxic
- NR-AR-LBD
- Safe
- NR-Aromatase
- Safe
- NR-ER
- Safe
- NR-ER-LBD
- Safe
- NR-GR
- Toxic
- NR-PPAR-gamma
- Safe
- NR-TR
- Safe
- T. Pyriformis
- -599.49
- Rat (Acute)
- 2.33
- Rat (Chronic Oral)
- 2.04
- Fathead Minnow
- 3.78
- Respiratory Disease
- Toxic
- Skin Sensitisation
- Safe
- SR-ARE
- Safe
- SR-ATAD5
- Safe
- SR-HSE
- Safe
- SR-MMP
- Safe
- SR-p53
- Safe
General Properties
- Boiling Point
- 487.87
- Hydration Free Energy
- -2.99
- Log(D) at pH=7.4
- 5.89
- Log(P)
- 5.7
- Log S
- -6.26
- Log(Vapor Pressure)
- -9.04
- Melting Point
- 264.84
- pKa Acid
- 8.93
- pKa Basic
- 6.44
No predicted protein targets found for this compound.