2'-hydroxy-3',4',6'-trimethoxychalcone - Compound Card

2'-hydroxy-3',4',6'-trimethoxychalcone

Select a section from the left sidebar

2'-hydroxy-3',4',6'-trimethoxychalcone

Structure
Zoomed Structure
  • Family: Plantae - Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Chalcone
Canonical Smiles COc1cc(OC)c(c(c1C(=O)/C=C/c1ccccc1)O)OC
InChI InChI=1S/C18H18O5/c1-21-14-11-15(22-2)18(23-3)17(20)16(14)13(19)10-9-12-7-5-4-6-8-12/h4-11,20H,1-3H3/b10-9+
InChIKey OCGIXADHTXAPKN-MDZDMXLPSA-N
Formula C18H18O5
HBA 5
HBD 1
MW 314.34
Rotatable Bonds 6
TPSA 64.99
LogP 3.31
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 314.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Uvaria scheffleri Annonaceae Plantae 2588162

Showing of synonyms

  • Nkunya MH, Achenbach H, et al. (1990). Schefflerin and isoschefflerin: prenylated chalcones and other constituents of Uvaria scheffleri.. Phytochemistry,1990,29(4),1261-1264. [View] [PubMed]
Pubchem: 5354780
Nmrshiftdb2: 70068851

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 314.34 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 314.34 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.48
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.450
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.41

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.160
Plasma Protein Binding
59.1
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.030
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.040
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.430
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.320
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.920
Rat (Acute)
2.100
Rat (Chronic Oral)
2.790
Fathead Minnow
5.000
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
394.270
Hydration Free Energy
-9.610
Log(D) at pH=7.4
2.920
Log(P)
3.06
Log S
-5.48
Log(Vapor Pressure)
-6.43
Melting Point
111.99
pKa Acid
7.63
pKa Basic
1.72
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9609
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9609
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9594
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9594
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9582
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9582
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9459
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9459
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9425
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9425
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9420
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9420
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9409
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9409
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9390
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9390
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9355
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9355
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9317
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9317
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9259
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9259
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9256
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9256
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9190
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9190
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9174
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9174
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9161
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9161
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9144
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9144
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9091
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.9091
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8989
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8989
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8974
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8974
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8962
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8962
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8940
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8940
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8937
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8937
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8923
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8923
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8890
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8890
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8818
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8818
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8802
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8802
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8795
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8795
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8786
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8786
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8759
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.8759
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8716
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8716
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8699
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8699
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8693
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8693
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8682
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8682
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8606
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8606
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8562
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8562
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8492
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8492
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8449
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.8449
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8446
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8446
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8433
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8433
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8412
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.8412
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8370
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8370
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8322
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.8322
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8300
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.8300
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8268
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8268
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8266
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.8266
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8265
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8265
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8261
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8261
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8246
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8246
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8237
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8237
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8232
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8232
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8149
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8149
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8134
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8134
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8128
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8128
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8115
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8115
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8063
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.8063
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8046
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8046
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8002
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8002
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7985
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7985
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7970
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7970
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7967
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.7967
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7963
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7963
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7945
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7945
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7891
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7891
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7882
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 3 0.7882
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7880
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7880
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7874
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7874
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7874
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7874
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7843
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7843
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7832
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7832
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7804
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7804
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7801
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7801
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7770
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7770
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7762
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7762
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7754
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7754
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7738
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7738
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7734
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7734
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7731
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7731
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7728
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7728
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7726
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7726
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7720
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 3 0.7720
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7704
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7704
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7682
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 4 0.7682
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7678
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 3 0.7678
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7659
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7659
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7644
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7644
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7634
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7634
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7634
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7634
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7624
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7624
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7622
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7622
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7605
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7605
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7603
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7603
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7602
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7602
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7594
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7594
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7582
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7582
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7572
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7572
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7561
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7561
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7559
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7559
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7548
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7548
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7546
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7546
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7544
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7544
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7542
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7542
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7536
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7536
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7526
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7526
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7525
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7525
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7514
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7514
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7508
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7508
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7506
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7506
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7505
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7505
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7497
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.7497
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7493
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7493
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7492
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7492
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7485
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7485
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7478
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7478
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7477
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7477
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7474
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7474
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7469
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7469
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7462
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7462
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7448
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7448
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7447
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7447
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7439
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7439
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7424
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7424
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7423
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7423
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7416
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7416
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7414
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7414
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7413
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7413
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7408
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7408
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7407
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7407
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7405
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7405
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7405
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7405
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7388
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7388
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7386
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7386
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7374
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7374
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7356
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7356
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7348
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7348
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7342
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7342
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7342
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7342
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7339
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7339
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7338
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7338
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7335
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7335
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 2 0.7335
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 2 0.7335
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7334
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 3 0.7334
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7331
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7331
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7324
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7324
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7316
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7316
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7313
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7313
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7310
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7310
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7310
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7310
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7307
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7307
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7307
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7307
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7302
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7302
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7301
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7301
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7297
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7297
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7293
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7293
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7291
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7291
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7289
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7289
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7287
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7287
Serine endoprotease DegS P0AEE3 DEGS_ECOLI Escherichia coli 4 0.7287
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7287
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7286
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7286
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7286
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 4 0.7286
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7274
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7274
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7272
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7272
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7268
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7268
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7267
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7267
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.7264
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 4 0.7264
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7260
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7260
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7255
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7255
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7248
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7248
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7243
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7243
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7238
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 4 0.7238
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7237
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7237
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7228
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7228
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7223
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7223
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7219
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7219
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7218
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7218
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7216
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7216
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7213
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7213
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7202
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7202
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7201
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7201
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7201
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7201
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7196
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7196
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7194
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7194
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7193
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7193
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7189
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7189
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7184
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7184
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7184
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7184
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7183
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7183
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7172
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7172
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7171
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7171
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7171
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7171
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7160
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7160
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7159
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7159
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7152
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7152
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7136
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7136
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7134
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7134
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7123
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7123
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7120
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7120
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7117
Purine nucleoside phosphorylase 2 P45563 XAPA_ECOLI Escherichia coli 3 0.7117
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7115
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7115
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7115
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7115
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7113
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 3 0.7113
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7108
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 3 0.7108
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7104
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7104
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7103
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7103
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7099
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7099
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7099
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7099
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7095
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7095
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7092
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.7092
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7089
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7089
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7088
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7088
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7084
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7084
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7076
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7076
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7068
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7068
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7067
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7067
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7063
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 3 0.7063
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7059
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.7059
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7051
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7051
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7050
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7050
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7049
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7049
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 2 0.7047
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 2 0.7047
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7044
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7044
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7044
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7044
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7041
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 3 0.7041
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7039
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7039
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7038
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7038
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7032
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7032
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7031
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7031
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7026
Botulinum neurotoxin type B P10844 BXB_CLOBO Clostridium botulinum 3 0.7026
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7023
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7023
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7021
Type II methyltransferase M.RsrI P14751 MTR1_RHOSH Cereibacter sphaeroides 3 0.7021
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7015
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7015
Uridine phosphorylase 2 O95045 UPP2_HUMAN Homo sapiens 4 0.7015
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7015
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7014
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7014
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7013
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7013
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7006
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7006
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7004
Replicase polyprotein 1ab P0C6X7 R1AB_CVHSA Human SARS coronavirus 3 0.7004
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7003
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7003
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7000
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7000

Download SDF