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Neotenone

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Isoflavonoid

Canonical Smiles	COc1cc2OCOc2cc1C1COc2c(C1=O)cc1c(c2)occ1
InChI	InChI=1S/C19H14O6/c1-21-15-7-18-17(24-9-25-18)5-11(15)13-8-23-16-6-14-10(2-3-22-14)4-12(16)19(13)20/h2-7,13H,8-9H2,1H3
InChIKey	JZNIBAUSQWDFGE-UHFFFAOYSA-N
Formula	C₁₉H₁₄O₆
HBA	6
HBD	0
MW	338.32
Rotatable Bonds	2
TPSA	67.13
LogP	3.53
Number Rings	5
Number Aromatic Rings	3
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.21
Exact Mass	338.08
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Neorautanenia mitis	Leguminosae/Fabaceae	Plantae	167620

Showing of synonyms

Joseph CC, Ndoile MM, et al. (2004). Larvicidal and mosquitocidal extracts, a coumarin, isoflavonoids and pterocarpans from Neorautanenia mitis.. Transactions of the Royal Society of Tropical Medicine and Hygiene,2004,98(8),451-455. [View] [PubMed]

Pubchem: 73603

Cas: 10091-02-8

Nmrshiftdb2: 70119696

Chembl: CHEMBL1988403

No compound-protein relationship available.

SMILES: c1coc(c12)cc3c(c2)C(=O)C(CO3)c(c4)ccc(c45)OCO5

Level: 1

Mol. Weight: 338.32 g/mol

SMILES: c1coc(c12)cc3c(c2)C(=O)CCO3

Level: 0

Mol. Weight: 338.32 g/mol

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 338.32 g/mol

Larvicidal

Mosquitocidal

Absorption

Caco-2 (logPapp): -4.87
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.710
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.87

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.510
Plasma Protein Binding: 74.35
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.030
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.630
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.490
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.940
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -2.520
Rat (Acute): 2.510
Rat (Chronic Oral): 1.910
Fathead Minnow: 5.250
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Toxic

General Properties

Boiling Point: 453.490
Hydration Free Energy: -7.280
Log(D) at pH=7.4: 2.860
Log(P): 3.48
Log S: -5.37
Log(Vapor Pressure): -9.13
Melting Point: 164.5
pKa Acid: 8.01
pKa Basic: 2.82

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9509
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9509
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9423
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9423
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9399
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9399
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.9368
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.9368
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.9352
Beta-2-microglobulin	P61769	B2MG_HUMAN	Homo sapiens	3	0.9352
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9339
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9339
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9260
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9260
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9140
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9140
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9034
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.9034
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9025
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9025
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9024
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9024
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8980
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8980
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8971
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8971
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8941
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8941
Enoyl-[acyl-carrier-protein] reductase [NADH]	Q5NGQ3	Q5NGQ3_FRATT	Francisella tularensis subsp. tularensis	3	0.8938
Enoyl-[acyl-carrier-protein] reductase [NADH]	Q5NGQ3	Q5NGQ3_FRATT	Francisella tularensis subsp. tularensis	3	0.8938
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8926
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8926
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8868
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8868
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.8862
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	3	0.8862
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.8784
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.8784
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8754
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8754
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.8706
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.8706
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8702
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8702
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.8701
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.8701
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8688
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.8688
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8679
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8679
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8668
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8668
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8651
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8651
Aldehyde dehydrogenase, dimeric NADP-preferring	P30838	AL3A1_HUMAN	Homo sapiens	3	0.8644
Aldehyde dehydrogenase, dimeric NADP-preferring	P30838	AL3A1_HUMAN	Homo sapiens	3	0.8644
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8629
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8629
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8620
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8620
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8575
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8575
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8549
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8549
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8545
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8545
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.8529
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	4	0.8529
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8470
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.8470
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8463
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8463
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8459
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8459
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8452
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.8452
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.8430
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.8430
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8373
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8373
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8312
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8312
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.8296
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.8296
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.8283
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.8283
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8271
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.8271
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8262
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8262
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.8262
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8262
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8249
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8249
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8239
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8239
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8219
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8219
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.8185
AGAP001556-PA	Q7PXT9	Q7PXT9_ANOGA	Anopheles gambiae	3	0.8185
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8178
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8178
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8173
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8173
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8170
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8170
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8137
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8137
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8078
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8078
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8059
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.8059
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8046
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8046
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.8046
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8046
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8031
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8031
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7961
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7961
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7944
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7944
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.7923
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.7923
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7909
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	3	0.7909
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.7885
E3 ubiquitin-protein ligase Mdm2	P56273	MDM2_XENLA	Xenopus laevis	3	0.7885
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7874
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7874
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7846
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7846
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.7845
Prostaglandin E synthase 2	Q9N0A4	PGES2_MACFA	Macaca fascicularis	3	0.7845
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7840
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7840
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7840
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7840
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7838
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7838
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7777
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.7777
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7766
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7766
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7763
Orf1ab polyprotein	Q6T1E9	Q6T1E9_CVHSA	SARS coronavirus CUHK-L2	3	0.7763
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7756
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.7756
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	4	0.7739
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	4	0.7739
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7728
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7728
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7723
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7723
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	5	0.7716
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	5	0.7716
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7710
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7710
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7707
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7707
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7692
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7692
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7674
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7674
Enoyl-acyl carrier reductase	C6KSZ2	C6KSZ2_PLAF7	Plasmodium falciparum	4	0.7656
Enoyl-acyl carrier reductase	C6KSZ2	C6KSZ2_PLAF7	Plasmodium falciparum	4	0.7656
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7635
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7635
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7621
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7621
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7619
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7619
Enoyl-acyl carrier protein reductase	Q6TEI5	Q6TEI5_PLABE	Plasmodium berghei	4	0.7615
Enoyl-acyl carrier protein reductase	Q6TEI5	Q6TEI5_PLABE	Plasmodium berghei	4	0.7615
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7607
Nitroreductase domain-containing protein	Q8DW21	Q8DW21_STRMU	Streptococcus mutans serotype c	3	0.7607
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7596
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7596
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7593
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7593
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7585
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7585
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7585
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7585
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7584
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7584
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7578
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7578
Mu-type opioid receptor	P42866	OPRM_MOUSE	Mus musculus	3	0.7577
Mu-type opioid receptor	P42866	OPRM_MOUSE	Mus musculus	3	0.7577
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7565
Oxygen-insensitive NAD(P)H nitroreductase	P38489	NFSB_ECOLI	Escherichia coli	3	0.7565
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7540
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7540
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7532
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7532
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7529
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7529
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7529
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7529
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7517
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7517
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.7512
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.7512
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7509
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7509
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7502
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7502
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7491
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7491
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7489
Calmodulin	P62157	CALM_BOVIN	Bos taurus	3	0.7489
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7473
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7473
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7469
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7469
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.7466
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	3	0.7466
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7458
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7458
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7450
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7450
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7430
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7430
Kelch-like ECH-associated protein 1	Q14145	KEAP1_HUMAN	Homo sapiens	3	0.7417
Kelch-like ECH-associated protein 1	Q14145	KEAP1_HUMAN	Homo sapiens	3	0.7417
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7410
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7410
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7388
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7388
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7381
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7381
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7371
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7371
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7366
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7366
Sulfotransferase 1E1	P49888	ST1E1_HUMAN	Homo sapiens	3	0.7361
Sulfotransferase 1E1	P49888	ST1E1_HUMAN	Homo sapiens	3	0.7361
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7347
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.7347
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7339
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	4	0.7339
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7338
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7338
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7330
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7330
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7330
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7330
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7313
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7313
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7304
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7304
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7285
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7285
Cytochrome b-c1 complex subunit 1, mitochondrial	P31800	QCR1_BOVIN	Bos taurus	3	0.7285
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7285
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7277
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7277
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7276
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7276
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7266
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7266
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7265
Scytalone dehydratase	P56221	SCYD_MAGO7	Pyricularia oryzae	3	0.7265
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	2	0.7252
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	2	0.7252
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7250
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7250
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7245
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7245
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q9R1E6	ENPP2_MOUSE	Mus musculus	3	0.7229
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Q9R1E6	ENPP2_MOUSE	Mus musculus	3	0.7229
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7227
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7227
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7219
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7219
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7213
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7213
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7211
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7211
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7208
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7208
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7203
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7203
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7203
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7203
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7191
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7191
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7179
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	3	0.7179
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7174
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7174
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7170
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7170
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.7163
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.7163
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7162
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7162
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7162
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7162
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7157
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7157
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7153
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7153
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7140
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7140
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7140
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7140
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7138
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7138
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7136
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7136
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7120
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7120
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	3	0.7107
Sterol 14-alpha demethylase	Q7Z1V1	CP51_TRYCC	Trypanosoma cruzi	3	0.7107
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7099
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7099
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7090
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7090
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7086
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.7086
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7080
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7080
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7079
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7079
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7076
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7076
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7076
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7076
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7064
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7064
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7056
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	3	0.7056
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7047
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7047
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7038
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.7038
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7036
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7036
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7036
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7036
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7030
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7030
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7028
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7028
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7026
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7026
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7019
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7019
Isoliquiritigenin 2'-O-methyltransferase	P93324	CHOMT_MEDSA	Medicago sativa	3	0.7018
Isoliquiritigenin 2'-O-methyltransferase	P93324	CHOMT_MEDSA	Medicago sativa	3	0.7018
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7018
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7018
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7014
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7014
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7008
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7008

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