2-hydroxy-3,4,6-trimethoxychalcone - Compound Card

2-hydroxy-3,4,6-trimethoxychalcone

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2-hydroxy-3,4,6-trimethoxychalcone

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1cc(OC)c(c(c1/C=C/C(=O)c1ccccc1)O)OC
InChI InChI=1S/C18H18O5/c1-21-15-11-16(22-2)18(23-3)17(20)13(15)9-10-14(19)12-7-5-4-6-8-12/h4-11,20H,1-3H3/b10-9+
InChIKey MNAQIJCVPFKJAU-MDZDMXLPSA-N
Formula C18H18O5
HBA 5
HBD 1
MW 314.34
Rotatable Bonds 6
TPSA 64.99
LogP 3.31
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 314.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Uvaria dependens Annonaceae Plantae 1144412

Showing of synonyms

  • Nkunya MH, Waibel R, et al. (1993). Three flavonoids from the stem bark of the antimalarial Uvaria dependens.. Phytochemistry,1993,34(3),853-856. [View] [PubMed]
Pubchem: 42607663
Nmrshiftdb2: 70024737

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 208.26 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.4
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.470
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.38

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.150
Plasma Protein Binding
58.42
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.020
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.740
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.140
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.300
Micronucleos
Safe
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.920
Rat (Acute)
2.180
Rat (Chronic Oral)
2.610
Fathead Minnow
5.090
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
383.940
Hydration Free Energy
-8.530
Log(D) at pH=7.4
3.010
Log(P)
2.6
Log S
-5.36
Log(Vapor Pressure)
-6.35
Melting Point
117.59
pKa Acid
7.32
pKa Basic
0.62
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9772
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9772
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9758
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9758
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9687
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9687
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9621
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9621
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9522
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9522
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9489
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9489
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9453
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9453
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9433
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9433
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9401
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.9401
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9400
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9400
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9356
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.9356
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9351
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.9351
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9345
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9345
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9283
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9283
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9279
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9279
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9223
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9223
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9184
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9184
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9183
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.9183
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.9162
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.9162
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9160
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.9160
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9098
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9098
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.9094
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 3 0.9094
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9065
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9065
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8950
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8950
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8938
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8938
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8917
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8917
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8886
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8886
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8852
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.8852
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8795
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8795
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8788
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8788
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8779
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8779
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8775
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8775
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8739
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 3 0.8739
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8723
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8723
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8670
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8670
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8645
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8645
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8618
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8618
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8569
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.8569
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8524
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8524
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8513
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8513
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8498
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.8498
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8482
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8482
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8478
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8478
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8470
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8470
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8435
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.8435
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8383
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8383
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.8380
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 4 0.8380
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8360
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8360
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.8331
cytokinin dehydrogenase E3T1W8 E3T1W8_MAIZE Zea mays 3 0.8331
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8297
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8297
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8269
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8269
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8264
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8264
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8222
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8222
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8186
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8186
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8183
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8183
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8176
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8176
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8170
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 3 0.8170
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8081
Isoflavone-7-O-methyltransferase 8 O24529 7OMT8_MEDSA Medicago sativa 4 0.8081
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8072
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8072
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8061
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8061
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8047
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8047
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8003
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8003
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7970
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7970
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7964
Isoliquiritigenin 2'-O-methyltransferase P93324 CHOMT_MEDSA Medicago sativa 3 0.7964
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7946
D-mycarose 3-C-methyltransferase Q194Q4 Q194Q4_STRAA Streptomyces argillaceus 4 0.7946
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7938
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7938
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7938
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 4 0.7938
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7937
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7937
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7903
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7903
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7897
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7897
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7893
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7893
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7888
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7888
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7882
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7882
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7872
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7872
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7871
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7871
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7852
Seminal ribonuclease P00669 RNS_BOVIN Bos taurus 3 0.7852
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7851
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7851
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7844
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7844
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7841
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7841
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7828
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7828
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7823
Subunit alpha of sarocosine oxidase Q50LF0 Q50LF0_9CORY Corynebacterium sp. U-96 3 0.7823
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7815
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7815
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7800
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 4 0.7800
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7793
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7793
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7778
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7778
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7764
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7764
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7756
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7756
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7755
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7755
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7726
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7726
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7724
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7724
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7719
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7719
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7711
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.7711
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7709
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7709
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7705
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7705
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7699
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7699
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7693
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.7693
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7668
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7668
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7654
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7654
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7649
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7649
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7617
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7617
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7591
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7591
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7587
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7587
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7573
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7573
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7572
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7572
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7568
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7568
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7564
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7564
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7562
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7562
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7556
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7556
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7544
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7544
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7541
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7541
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7530
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7530
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7527
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7527
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7527
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7527
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7509
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7509
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7504
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7504
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7501
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7501
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7489
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7489
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7487
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7487
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7478
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7478
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7474
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7474
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7461
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7461
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7458
Ephrin type-A receptor 3 P29320 EPHA3_HUMAN Homo sapiens 3 0.7458
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7444
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7444
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7438
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7438
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7430
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7430
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7428
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7428
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7426
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7426
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7416
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7416
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7414
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7414
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7409
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7409
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7406
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7406
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7405
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7405
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7404
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7404
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7403
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7403
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7398
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7398
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7389
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7389
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7378
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7378
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7375
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7375
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7363
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7363
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7362
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7362
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7357
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7357
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7352
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7352
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7344
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7344
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7344
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7344
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7342
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7342
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7338
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7338
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7337
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7337
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7330
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7330
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7307
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7307
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7305
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7305
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7303
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7303
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7295
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7295
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7290
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7290
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7289
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7289
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7289
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7289
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7287
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7287
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7281
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7281
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7281
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7281
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7272
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7272
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7271
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7271
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7266
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7266
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7257
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7257
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7257
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7257
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7254
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7254
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7251
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7251
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7250
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7250
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7248
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7248
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7247
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7247
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7241
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7241
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7239
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7239
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7236
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 3 0.7236
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7235
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7235
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7230
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7230
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7223
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7223
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7218
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7218
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7213
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7213
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7211
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7211
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7199
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7199
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7190
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7190
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7188
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7188
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7186
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7186
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7185
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7185
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7180
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7180
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7180
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7180
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7163
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7163
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7161
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7161
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7153
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7153
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7150
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7150
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7150
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7150
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7149
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7149
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7147
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7147
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7147
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7147
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7144
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7144
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7142
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7142
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7141
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7141
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7139
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7139
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7137
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 3 0.7137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7136
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7136
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7135
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7135
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 2 0.7134
Calmodulin-like domain protein kinase isoenzyme gamma, related F0V9W9 F0V9W9_NEOCL Neospora caninum 2 0.7134
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7128
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7128
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 3 0.7128
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7128
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7127
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7127
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7111
Nucleoside phosphorylase, putative Q57VZ2 Q57VZ2_TRYB2 Trypanosoma brucei brucei 3 0.7111
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7104
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7104
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7103
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7103
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7103
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7103
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7098
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7098
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7086
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7086
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7085
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7085
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7077
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7077
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7076
Interleukin-1 receptor-associated kinase 4 Q9NWZ3 IRAK4_HUMAN Homo sapiens 3 0.7076
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7071
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7071
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7071
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7071
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7070
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7070
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7061
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7061
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7061
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 2 0.7061
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7045
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7045
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7043
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7043
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7043
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7043
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7041
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7041
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7037
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7037
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7037
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7037
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7030
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7030
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7025
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7025
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7024
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7024
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7024
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7024
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7020
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7020
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7018
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7018
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7015
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7015
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7013
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7013
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7012
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7012
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7005
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7005

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