2-hydroxypterocarpin - Compound Card

2-hydroxypterocarpin

Select a section from the left sidebar

2-hydroxypterocarpin

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Pterocarpan
Canonical Smiles COc1cc2OC[C@@H]3[C@H](c2cc1O)Oc1c3cc2c(c1)OCO2
InChI InChI=1S/C17H14O6/c1-19-14-4-12-9(2-11(14)18)17-10(6-20-12)8-3-15-16(22-7-21-15)5-13(8)23-17/h2-5,10,17-18H,6-7H2,1H3/t10-,17-/m0/s1
InChIKey GDUBLLYLIZLLNX-BTDLBPIBSA-N
Formula C17H14O6
HBA 6
HBD 1
MW 314.29
Rotatable Bonds 1
TPSA 66.38
LogP 2.74
Number Rings 5
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.29
Exact Mass 314.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Neorautanenia mitis Leguminosae/Fabaceae Plantae 167620

Showing of synonyms

  • Sakurai Y, Sakurai N, et al. (2006). Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis.. Journal of Natural Products,2006,69(3),397-399. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: O1COc(c2)c1cc(c23)OC4C3COc5c4cccc5

Level: 0

Mol. Weight: 314.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.81
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.460
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.99

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.260
Plasma Protein Binding
83.08
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
13.150
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.600
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.090
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.120
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.440
Rat (Acute)
2.050
Rat (Chronic Oral)
1.710
Fathead Minnow
4.650
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
417.870
Hydration Free Energy
-7.620
Log(D) at pH=7.4
2.930
Log(P)
2.57
Log S
-4.75
Log(Vapor Pressure)
-8.37
Melting Point
194.7
pKa Acid
9.35
pKa Basic
2.21
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9452
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9452
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9352
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9352
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9271
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.9271
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9258
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9258
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9169
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9169
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.9130
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.9130
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9056
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9056
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9048
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9048
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9012
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.9012
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8967
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8967
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8952
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.8952
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8923
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8923
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8868
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8868
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8859
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8859
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8841
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8841
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8831
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8831
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8787
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8787
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8785
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8785
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8733
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8733
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8697
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8697
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8688
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8688
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8681
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8681
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8681
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8681
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8638
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8638
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8624
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8624
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8564
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8564
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8563
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8563
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8554
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8554
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8549
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8549
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8526
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8526
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8488
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8488
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8481
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.8481
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8478
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8478
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8465
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8465
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8454
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8454
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8453
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8453
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8436
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8436
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8389
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8389
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8364
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8364
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8327
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8327
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8296
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8296
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8257
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8257
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.8255
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 4 0.8255
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8243
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8243
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8194
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8194
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8125
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8125
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8113
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8113
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8112
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8112
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8098
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.8098
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8078
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8078
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8024
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8024
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 4 0.8010
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 4 0.8010
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8002
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.8002
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7986
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7986
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7972
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7972
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7972
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7972
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7964
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7964
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7932
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7932
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7916
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7916
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7853
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7853
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7848
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.7848
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7819
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7819
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7808
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7808
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7805
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7805
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7767
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7767
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7697
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7697
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7672
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7672
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7651
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7651
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7646
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7646
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7638
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7638
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7630
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7630
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7630
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7630
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7605
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7605
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7601
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7601
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7593
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7593
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7591
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7591
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7576
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7576
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7559
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7559
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7544
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7544
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7482
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7482
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7476
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7476
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7469
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7469
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7466
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7466
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7454
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7454
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7452
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7452
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7440
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7440
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7431
O-GlcNAcase NagJ Q0TR53 OGA_CLOP1 Clostridium perfringens 3 0.7431
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7428
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7428
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7403
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7403
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7392
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 3 0.7392
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7375
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7375
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7374
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7374
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7373
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7373
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7365
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7365
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7357
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7357
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7352
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7352
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7348
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7348
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7345
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7345
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7344
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7344
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7338
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7338
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7324
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7324
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7319
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7319
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7316
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7316
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7299
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7299
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7295
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7295
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7283
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.7283
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7273
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7273
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7268
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7268
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7263
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7263
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7261
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7261
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7259
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7259
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7249
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7249
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7249
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7249
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7241
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7241
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7234
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7234
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7233
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7233
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7226
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7226
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7221
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7221
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7209
Macrophage colony-stimulating factor 1 receptor P07333 CSF1R_HUMAN Homo sapiens 3 0.7209
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7199
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7199
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7195
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7195
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7193
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7193
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7180
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7180
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7180
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7180
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7179
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7179
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7177
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7177
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7174
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7174
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7170
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.7170
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7162
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7162
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7154
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7154
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7152
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7152
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7151
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7151
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7148
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7148
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7146
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7146
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7139
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7139
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7133
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7133
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7131
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7131
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7122
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7122
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7110
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7110
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7109
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7109
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7107
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7107
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7100
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7100
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7092
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7092
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7089
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7089
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7086
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7086
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7086
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7086
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7084
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7084
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7079
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7079
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7070
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7070
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7070
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7070
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7068
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7068
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7051
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7051
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7046
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7046
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7040
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7040
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7036
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7036
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7032
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7032
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 3 0.7031
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 3 0.7031
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7025
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 4 0.7025
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7023
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7023
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7021
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7021
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7008
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7008
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7005
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7005
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7005
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7005
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7004
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7004

Download SDF