7-hydroxy-5,8-dimethoxyflavone - Compound Card

7-hydroxy-5,8-dimethoxyflavone

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7-hydroxy-5,8-dimethoxyflavone

Structure
Zoomed Structure
  • Family: Polygonaceae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(O)cc(c2c1oc(cc2=O)c1ccccc1)OC
InChI InChI=1S/C17H14O5/c1-20-14-9-12(19)16(21-2)17-15(14)11(18)8-13(22-17)10-6-4-3-5-7-10/h3-9,19H,1-2H3
InChIKey NZOUUYOSKJFMKB-UHFFFAOYSA-N
Formula C17H14O5
HBA 5
HBD 1
MW 298.29
Rotatable Bonds 3
TPSA 68.9
LogP 3.18
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.12
Exact Mass 298.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Polygonum senegalense Polygonaceae Plantae 471708

Showing of synonyms

  • Midiwo JO, Gikonyo NK, et al. (1992). Flavonoids of Polygonum senegalense (Meisn) Part II: More surface and internal tissue flavonoid aglycones.. Bulletin of the Chemical Society of Ethiopia,1992,6(2),119-122. [View] [PubMed]
Pubchem: 14825644
Nmrshiftdb2: 70006238

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 222.24 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 146.14 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.6
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.340
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.53

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.460
Plasma Protein Binding
84.59
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.520
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.800
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.110
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.890
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.540
Rat (Acute)
2.340
Rat (Chronic Oral)
2.150
Fathead Minnow
5.050
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
413.080
Hydration Free Energy
-9.560
Log(D) at pH=7.4
3.020
Log(P)
3.04
Log S
-5.08
Log(Vapor Pressure)
-7.17
Melting Point
176.52
pKa Acid
8.29
pKa Basic
1.69
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9835
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9835
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9800
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9800
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9759
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9759
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9629
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9629
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9628
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9628
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9529
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9529
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9468
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9468
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9434
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9434
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9427
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9427
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9417
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9417
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9411
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9411
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9377
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9377
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9298
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9298
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9293
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9293
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9262
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9262
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9231
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9231
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.9197
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.9197
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9185
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9185
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9182
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.9182
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9163
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9163
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9130
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9076
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.9076
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9068
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9068
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9052
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9052
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9040
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9040
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9031
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9031
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9016
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9016
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9011
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.9011
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9010
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9010
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.9008
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.9008
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9004
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9004
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9002
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9002
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8983
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8983
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8914
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8914
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8876
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8876
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8826
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8826
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8824
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8824
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8801
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8801
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8794
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8794
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8758
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8758
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8693
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8693
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8681
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8681
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8680
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8680
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8679
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8679
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8668
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8668
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8661
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8661
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8652
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8652
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8648
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8648
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8639
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8639
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8569
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8569
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8531
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8531
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8519
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8519
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8503
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8503
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8501
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8501
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8482
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8482
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8477
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8477
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8447
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8447
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8440
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8440
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8437
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8437
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8428
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8428
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8410
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8410
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8389
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8389
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8364
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8364
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8361
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8361
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8338
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8338
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8337
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8337
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8336
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8336
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8279
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8279
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8256
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8256
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8252
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8252
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8252
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8252
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8200
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8200
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8174
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8174
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8162
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8162
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8142
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8142
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8132
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8132
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8130
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8130
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8128
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8128
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8096
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8096
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8093
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8093
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8061
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8061
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.8047
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.8047
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8007
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8003
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8003
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7999
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7999
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7972
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7972
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7969
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7969
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7967
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7967
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7966
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7966
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7961
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7961
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7947
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7947
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7927
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 3 0.7927
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7925
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7925
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7924
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7924
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7909
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7909
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7884
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7884
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7878
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7878
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7859
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7859
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7811
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7811
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7810
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7810
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7810
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7810
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7801
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7801
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7796
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7796
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7790
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7790
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7786
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7786
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7765
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7765
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7761
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7761
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7734
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7734
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7723
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7723
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7705
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7705
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7691
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7691
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7678
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7678
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7659
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7659
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7659
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7659
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7656
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7656
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7655
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7655
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7649
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7649
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7643
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7643
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7629
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7629
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7629
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7629
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7629
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7629
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7617
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7617
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7614
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7614
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7606
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7606
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7600
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7600
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7597
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7597
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7575
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7575
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7572
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7572
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7558
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7558
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7553
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7553
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7551
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7551
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7534
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7534
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7531
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7531
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7523
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7523
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7520
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7520
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7517
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7517
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7496
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7496
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7484
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7484
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7478
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7478
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7467
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7467
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7462
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7462
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7461
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7461
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7452
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7452
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7444
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7444
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7444
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7444
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7436
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7436
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7434
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7434
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7430
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7430
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7425
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7425
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7420
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7420
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7407
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7407
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7406
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7406
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7404
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7404
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7402
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7402
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7394
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7394
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7390
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7390
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7378
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7378
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7365
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7365
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7358
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7358
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7349
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 3 0.7349
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7348
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7348
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.7337
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 4 0.7337
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7336
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7336
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7335
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7335
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7334
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7334
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7334
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7334
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7332
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7332
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7332
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.7332
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7324
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7324
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7322
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7322
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7315
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7315
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7312
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7312
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7306
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7306
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7306
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7306
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7305
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7305
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7301
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7301
Transcriptional regulator Q8NMG3 Q8NMG3_CORGL Corynebacterium glutamicum 3 0.7294
Transcriptional regulator Q8NMG3 Q8NMG3_CORGL Corynebacterium glutamicum 3 0.7294
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7292
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7292
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7277
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7277
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7268
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7268
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7260
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7260
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7257
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7257
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7252
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7252
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7250
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.7250
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7249
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7249
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7223
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7223
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7219
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7219
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7212
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7212
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7211
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7211
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7209
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7209
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7207
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7207
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7194
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7194
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 4 0.7191
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 4 0.7191
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7187
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7187
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7182
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7182
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7177
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7177
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7174
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.7174
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7166
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7166
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7165
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7165
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7156
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7156
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7155
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7155
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7152
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7152
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7140
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7140
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7133
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7133
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7128
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7128
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7124
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7124
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7118
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 3 0.7118
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7116
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7116
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7112
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7112
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7112
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7112
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7108
Histone-lysine N-methyltransferase 2C Q8NEZ4 KMT2C_HUMAN Homo sapiens 3 0.7108
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7106
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7106
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7101
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7101
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7100
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7100
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7093
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7093
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7092
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7092
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7084
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7084
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7083
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 3 0.7083
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7077
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7077
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7074
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7074
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7063
Histone-lysine N-methyltransferase EHMT2 Q96KQ7 EHMT2_HUMAN Homo sapiens 3 0.7063
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7062
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7062
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7052
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7052
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7048
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7048
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7045
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7045
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7042
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7042
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7040
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7040
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7037
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7037
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7035
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7035
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7027
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7027
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7021
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7021
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7021
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7021
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7018
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7018
Histone-lysine N-methyltransferase 2A Q03164 KMT2A_HUMAN Homo sapiens 3 0.7018
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7018
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7015
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7015
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7014
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7014

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