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Alternariol 5-O-methyl ether-4'-O-sulfate

Family: Fungi - Pleosporaceae
Kingdom: Fungi
Class: Coumarin

Canonical Smiles	COc1cc(O)c2c(c1)c1c(C)cc(cc1oc2=O)OS(=O)=O
InChI	InChI=1S/C15H12O7S/c1-7-3-9(22-23(18)19)6-12-13(7)10-4-8(20-2)5-11(16)14(10)15(17)21-12/h3-6,16,23H,1-2H3
InChIKey	JPSFJHVXHURIEG-UHFFFAOYSA-N
Formula	C₁₅H₁₂O₇S
HBA	7
HBD	2
MW	336.32
Rotatable Bonds	3
TPSA	103.04
LogP	1.87
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	23
Formal Charge	0
Fraction CSP3	0.13
Exact Mass	336.03
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Alternaria species	Pleosporaceae	Fungi	5598

Showing of synonyms

Aly AH, Edrada-Ebel R, et al. (2008). Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products,2008,71(6),972-980. [View] [PubMed]

Pubchem: 24899918

Cas: 1030376-87-4

Zinc: ZINC000040975050

Nmrshiftdb2: 80005814

Chembl: CHEMBL499173

No compound-protein relationship available.

SMILES: c1cccc(c1c23)oc(=O)c2cccc3

Level: 0

Mol. Weight: 336.32 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp): -4.8
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.710
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.52

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.440
Plasma Protein Binding: 73.36
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.950
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.480
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.250
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.900
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.420
Rat (Acute): 2.540
Rat (Chronic Oral): 2.430
Fathead Minnow: 4.770
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 454.500
Hydration Free Energy: -8.200
Log(D) at pH=7.4: 1.890
Log(P): 2.09
Log S: -3.96
Log(Vapor Pressure): -7.35
Melting Point: 175.85
pKa Acid: 8.01
pKa Basic: 2.19

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.9323
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.9323
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9188
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.9188
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8912
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8912
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8911
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8911
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8903
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8903
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8884
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8884
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8827
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.8827
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8807
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8807
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8714
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.8714
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	3	0.8710
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	3	0.8710
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8676
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8676
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.8665
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	4	0.8665
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8664
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8664
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.8643
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.8643
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	4	0.8642
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A	Q13946	PDE7A_HUMAN	Homo sapiens	4	0.8642
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8640
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.8640
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8615
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8615
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8606
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8606
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8586
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8586
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8580
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.8580
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	3	0.8563
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	3	0.8563
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8561
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8561
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8547
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.8547
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8522
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8522
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	4	0.8520
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	4	0.8520
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8481
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8481
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8456
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8456
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8446
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.8446
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8424
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8424
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8413
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8413
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	4	0.8375
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B	Q13370	PDE3B_HUMAN	Homo sapiens	4	0.8375
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8351
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8351
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8338
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8338
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8327
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8327
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8256
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8256
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8174
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8174
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8163
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8163
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.8136
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	4	0.8136
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8132
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8132
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8128
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8128
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8094
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8094
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8084
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8084
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8047
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8047
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8027
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.8027
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8007
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8007
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8007
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8007
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7998
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.7998
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7993
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7993
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7969
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7969
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7960
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7960
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7923
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7923
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7917
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7917
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7899
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7899
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	4	0.7875
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	4	0.7875
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7874
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7874
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7869
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7869
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7777
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.7777
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7705
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7705
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7681
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7681
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7677
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7677
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7668
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7668
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7651
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7651
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7637
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7637
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7625
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7625
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.7621
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	3	0.7621
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7589
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7589
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7586
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.7586
NADPH--cytochrome P450 reductase	P00388	NCPR_RAT	Rattus norvegicus	4	0.7549
NADPH--cytochrome P450 reductase	P00388	NCPR_RAT	Rattus norvegicus	4	0.7549
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7541
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7541
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7490
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7490
NADPH--cytochrome P450 reductase	P00388	NCPR_RAT	Rattus norvegicus	4	0.7485
NADPH--cytochrome P450 reductase	P00388	NCPR_RAT	Rattus norvegicus	4	0.7485
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7477
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7477
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7469
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7469
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7467
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	3	0.7467
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.7464
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.7464
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7454
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7454
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7450
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7450
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7435
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7435
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.7423
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.7423
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7423
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	4	0.7423
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7416
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7416
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7402
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7402
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7389
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7389
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7382
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7382
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7381
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7381
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7340
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7340
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7332
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7332
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7313
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7313
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7309
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.7309
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7300
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.7300
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7289
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7289
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7285
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7285
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7284
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7284
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7284
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7284
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7280
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7280
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7265
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7265
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7258
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7258
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.7254
Bromodomain testis-specific protein	Q58F21	BRDT_HUMAN	Homo sapiens	3	0.7254
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7251
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7251
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7224
Orotidine 5'-phosphate decarboxylase	Q5L0U0	PYRF_GEOKA	Geobacillus kaustophilus	3	0.7224
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7214
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7214
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7207
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7207
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7206
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7206
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7203
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7203
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7201
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	4	0.7201
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7198
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7198
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7194
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7194
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7185
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7185
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7172
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7172
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7170
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7170
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7157
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7157
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7155
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7155
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7152
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7152
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7145
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7145
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7144
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7144
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7140
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.7140
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	3	0.7140
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7140
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.7122
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	3	0.7122
Phosphoenolpyruvate carboxykinase [GTP]	P9WIH3	PCKG_MYCTU	Mycobacterium tuberculosis	3	0.7122
Phosphoenolpyruvate carboxykinase [GTP]	P9WIH3	PCKG_MYCTU	Mycobacterium tuberculosis	3	0.7122
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7114
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7114
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7106
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7106
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7087
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7087
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	4	0.7086
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	4	0.7086
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7077
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7077
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7077
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7077
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7071
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7071
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7063
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7063
Exotoxin A	P11439	TOXA_PSEAE	Pseudomonas aeruginosa	3	0.7062
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7062
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7062
Exotoxin A	P11439	TOXA_PSEAE	Pseudomonas aeruginosa	3	0.7062
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7044
Phosphoenolpyruvate carboxykinase [GTP]	A5TYT6	PCKG_MYCTA	Mycobacterium tuberculosis	3	0.7044
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7043
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7043
Type IV pilus retractation ATPase PilT	P24559	PILT_PSEAE	Pseudomonas aeruginosa	3	0.7034
Type IV pilus retractation ATPase PilT	P24559	PILT_PSEAE	Pseudomonas aeruginosa	3	0.7034
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7032
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7032
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7021
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7021
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7016
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	3	0.7016
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7006
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	3	0.7006
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7002
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	3	0.7002

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