Alternarienonic acid - Compound Card

Alternarienonic acid

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Alternarienonic acid

Structure
Zoomed Structure
  • Family: Pleosporaceae
  • Kingdom: Fungi
  • Class: Amide
Canonical Smiles CC(=O)NCC1CCN(CC1)C(=O)c1ccc(cn1)Br
InChI InChI=1S/C14H18BrN3O2/c1-10(19)16-8-11-4-6-18(7-5-11)14(20)13-3-2-12(15)9-17-13/h2-3,9,11H,4-8H2,1H3,(H,16,19)
InChIKey QASFNTGFEJZBGE-UHFFFAOYSA-N
Formula C14H18BrN3O2
HBA 3
HBD 1
MW 340.22
Rotatable Bonds 3
TPSA 62.3
LogP 1.83
Number Rings 2
Number Aromatic Rings 1
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.5
Exact Mass 339.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Alternaria species Pleosporaceae Fungi 5598

Showing of synonyms

  • Aly AH, Edrada-Ebel R, et al. (2008). Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products,2008,71(6),972-980. [View] [PubMed]
Pubchem: 103640363

No compound-protein relationship available.

Structure

SMILES: n1ccccc1C(=O)N2CCCCC2

Level: 1

Mol. Weight: 190.25 g/mol

Structure

SMILES: C1CCNCC1

Level: 0

Mol. Weight: 85.15 g/mol

Structure

SMILES: c1ccncc1

Level: 0

Mol. Weight: 79.1 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.81
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.64
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.97

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.41
Plasma Protein Binding
42.05
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.54
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.35
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.45
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.73
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.07
Rat (Acute)
2.66
Rat (Chronic Oral)
1.59
Fathead Minnow
3.73
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
382.01
Hydration Free Energy
-12.16
Log(D) at pH=7.4
1.12
Log(P)
0.79
Log S
-1.93
Log(Vapor Pressure)
-7.88
Melting Point
158.24
pKa Acid
7.89
pKa Basic
3.19
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9721
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9721
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9581
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9581
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9567
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.9567
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.9518
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.9518
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.9431
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.9431
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9403
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9403
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9368
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.9368
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.9340
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.9340
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9326
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9326
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9272
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.9272
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9242
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9242
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9216
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9216
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.9184
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.9184
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.9179
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.9179
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9157
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9157
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9155
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9155
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9108
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.9108
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9085
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9085
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.9080
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 3 0.9080
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9030
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.9030
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8961
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8961
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8948
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8948
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8917
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.8917
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8826
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8826
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8799
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8799
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8758
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8758
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8740
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8740
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8680
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8680
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8529
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8529
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8484
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.8484
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8303
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8303
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 3 0.8268
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 3 0.8268
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.8232
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.8232
Acetyl-CoA carboxylase 2 O00763 ACACB_HUMAN Homo sapiens 4 0.8153
Acetyl-CoA carboxylase 2 O00763 ACACB_HUMAN Homo sapiens 4 0.8153
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8121
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8121
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8112
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8112
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8106
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8106
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.8078
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.8078
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7964
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7964
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7939
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7939
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7840
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7840
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7796
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7796
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7783
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7783
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7732
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7732
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7728
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7728
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7698
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7698
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7692
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7692
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7688
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7688
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7684
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7684
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7675
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7675
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7667
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7667
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 3 0.7649
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 3 0.7649
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7648
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 3 0.7648
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7641
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7641
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.7626
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.7626
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7623
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7623
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7623
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7623
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7621
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7621
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7616
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7616
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7609
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7609
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7590
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7590
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7583
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 2 0.7583
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7563
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7563
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7561
Raucaffricine-O-beta-D-glucosidase Q9SPP9 RG1_RAUSE Rauvolfia serpentina 3 0.7561
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7544
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7544
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7523
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7523
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7522
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7522
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7512
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7512
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7510
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7510
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7501
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7501
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7498
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7498
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7494
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7494
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7484
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7484
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7471
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7471
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7469
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7469
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7463
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7463
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7450
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7450
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7441
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7441
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7434
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7434
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7428
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7428
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7427
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7427
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7419
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7419
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7418
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7418
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7417
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7417
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7412
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7412
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7406
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7406
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7395
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7395
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7388
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7388
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7387
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7387
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7382
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7382
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 2 0.7380
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 2 0.7380
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7373
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7373
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7367
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7367
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7365
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7365
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 2 0.7358
NTPase P4 Q94M05 Q94M05_9VIRU Pseudomonas phage phi12 2 0.7358
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7355
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7355
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7349
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7349
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7346
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7346
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7342
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7342
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7340
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7340
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7335
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7335
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7328
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7328
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7327
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7327
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7322
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7322
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7316
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7316
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7314
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7314
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7306
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7306
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7304
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7304
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7303
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.7303
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7292
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7292
Cytidine deaminase P19079 CDD_BACSU Bacillus subtilis 3 0.7291
Cytidine deaminase P19079 CDD_BACSU Bacillus subtilis 3 0.7291
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7274
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7274
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7260
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7260
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7258
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7258
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7257
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7257
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7253
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7253
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7252
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7252
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7250
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7250
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7249
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7249
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7247
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7247
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7247
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7247
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7245
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7245
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7245
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7245
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7243
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7243
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7227
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7227
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 4 0.7221
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 4 0.7221
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7210
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7210
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7209
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7209
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7208
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7208
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7204
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7204
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7202
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7202
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7201
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7201
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7200
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7200
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7198
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7198
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7197
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7197
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7195
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7195
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7193
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7193
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7190
Nucleoside diphosphate kinase P15266 NDK_MYXXA Myxococcus xanthus 2 0.7190
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7189
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7189
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7186
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7186
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7183
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7183
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7183
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7183
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7183
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7183
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7178
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7178
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7176
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7176
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7169
Fructose-1,6-bisphosphatase 1 P09467 F16P1_HUMAN Homo sapiens 2 0.7169
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7165
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7165
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7164
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7164
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7163
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7163
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7163
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7163
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7159
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7159
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7157
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7157
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7153
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7153
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7151
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7151
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7142
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7142
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7140
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7140
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7138
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7138
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7137
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 2 0.7137
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 2 0.7137
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7137
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7129
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7129
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7129
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7129
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7123
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7123
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7114
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7114
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7113
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7113
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7111
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7111
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7105
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7105
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7101
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7101
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7100
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7100
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7100
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7100
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 2 0.7097
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 2 0.7097
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7090
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7090
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7090
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7090
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7084
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7084
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7079
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7079
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7074
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7074
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7072
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7072
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7071
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7071
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7068
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.7068
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7060
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7060
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7058
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7058
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7056
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7056
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7053
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7053
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7051
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7051
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 2 0.7050
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 2 0.7050
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7046
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7046
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7046
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7046
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7041
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7041
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7029
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7029
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7019
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7019
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7017
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7017
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 2 0.7016
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 2 0.7016
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7009
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7009
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7007
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7007
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7004
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7004

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