Abyssinone I - Compound Card

Abyssinone I

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Abyssinone I

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles Oc1ccc2c(c1)O[C@@H](CC2=O)c1ccc2c(c1)C=CC(O2)(C)C
InChI InChI=1S/C20H18O4/c1-20(2)8-7-13-9-12(3-6-17(13)24-20)18-11-16(22)15-5-4-14(21)10-19(15)23-18/h3-10,18,21H,11H2,1-2H3/t18-/m0/s1
InChIKey MITHUEHYZARDCT-SFHVURJKSA-N
Formula C20H18O4
HBA 4
HBD 1
MW 322.36
Rotatable Bonds 1
TPSA 55.76
LogP 4.28
Number Rings 4
Number Aromatic Rings 2
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.25
Exact Mass 322.12
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Erythrina abyssinica Leguminosae/Fabaceae Plantae 1237573

Showing of synonyms

  • Taniguchi M, Kubo I. (1993). Ethnobotanical drug discovery based on medicine men's trials in the African savanna: screening of east African plants for antimicrobial activity II.. Journal of Natural Products,1993,56(9),1539-1546. [View] [PubMed]
Pubchem: 442152
Kegg Ligand: C09318
Chebi: 2367
Nmrshiftdb2: 60072959
Metabolights: MTBLC2367

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c(c3)ccc(c34)OCC=C4

Level: 1

Mol. Weight: 322.36 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 322.36 g/mol

Structure

SMILES: C1=CCOc(c12)cccc2

Level: 0

Mol. Weight: 322.36 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-4.73
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.590
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.15

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.320
Plasma Protein Binding
79.63
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.990
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.220
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.470
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
5.800
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Toxic
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
1.780
Rat (Acute)
2.310
Rat (Chronic Oral)
2.120
Fathead Minnow
4.590
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
432.670
Hydration Free Energy
-8.570
Log(D) at pH=7.4
3.500
Log(P)
4.26
Log S
-5.65
Log(Vapor Pressure)
-7.85
Melting Point
185.77
pKa Acid
8.41
pKa Basic
5.23
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9827
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9827
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9638
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.9638
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9407
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9407
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9377
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9377
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9297
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9297
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9279
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9279
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9129
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9129
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9040
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9040
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9037
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9037
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9010
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.9010
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8995
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.8995
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8915
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8915
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8844
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8844
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8839
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 3 0.8839
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8817
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8817
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8793
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8793
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8788
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8788
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8785
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8785
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8751
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8751
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8741
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8741
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8730
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8730
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8705
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8705
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8637
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8637
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8624
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8624
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8591
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8591
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8391
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8391
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8344
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8344
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8313
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8313
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8311
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8311
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8309
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8309
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 4 0.8283
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 4 0.8283
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8252
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8252
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8240
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8240
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8196
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8196
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.8193
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.8193
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8168
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8168
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8166
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8166
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8155
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8155
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8139
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8139
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8130
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.8130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8127
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8127
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8113
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8113
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8084
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8084
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8067
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8067
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.8052
Cytochrome P450 2C19 P33261 CP2CJ_HUMAN Homo sapiens 3 0.8052
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8036
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8036
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8012
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8012
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8003
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8003
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7990
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7990
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.7979
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.7979
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7970
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7970
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7936
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7936
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7933
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7933
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7899
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7899
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7869
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7869
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7859
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7859
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7851
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7851
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7843
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7843
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7780
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7780
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7746
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7746
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7743
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7743
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7716
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7716
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7697
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7697
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7672
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7672
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7671
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7671
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7664
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7664
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7655
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7655
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7647
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7647
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7644
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7644
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7628
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7628
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7625
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7625
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7618
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7618
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7618
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7618
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7611
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7611
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7611
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7611
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7611
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7611
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7610
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7610
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7600
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.7600
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7571
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7571
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7556
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7556
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7553
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7553
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7548
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7548
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7535
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7535
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7534
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.7534
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7517
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7517
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7515
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7515
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7513
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7513
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7480
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7480
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7475
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7475
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7471
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7471
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7457
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7457
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7443
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7443
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7440
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7440
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7434
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 3 0.7434
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7428
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7428
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7425
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7425
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7408
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7408
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7404
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7404
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7394
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7394
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7391
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7391
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7385
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7385
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7382
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7382
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7378
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7365
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7365
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7355
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7355
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7346
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7346
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7335
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7335
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7327
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7327
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7325
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7325
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7323
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7323
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7321
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 2 0.7321
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7317
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7317
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7292
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7292
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7279
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7279
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7275
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7275
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7271
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7271
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7271
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7271
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7260
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7260
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7251
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7251
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7240
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7240
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7239
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7239
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7237
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7237
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7233
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7233
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.7213
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.7213
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7211
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7211
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7202
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7202
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7193
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7193
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7187
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7187
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7186
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7186
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7170
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7170
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7167
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7167
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7164
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7164
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7161
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7161
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7160
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7160
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7158
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7158
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7155
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7155
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7149
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7149
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7149
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7149
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7140
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7140
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7139
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7139
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7135
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7135
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7134
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7134
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7120
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7120
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7112
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7112
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7111
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7111
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7109
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7109
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7100
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7100
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7098
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 3 0.7098
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7094
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7094
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7086
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7086
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7084
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7084
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7084
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7084
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7083
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7083
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7079
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7079
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7075
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7075
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7070
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7070
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7070
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 4 0.7070
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7059
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7059
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7058
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7058
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7050
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7050
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7049
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7049
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 4 0.7048
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 4 0.7048
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7046
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7046
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7038
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7038
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7036
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7036
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7029
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7029
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7022
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7022
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7022
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7022
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7007
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7007
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7005
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7005
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7002
Formate--tetrahydrofolate ligase P21164 FTHS_MOOTH Moorella thermoacetica 2 0.7002
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7000
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7000

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