Elgonene I - Compound Card

Elgonene I

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Elgonene I

Structure
Zoomed Structure
  • Family: Fungi - Hymenochaetaceae
  • Kingdom: Fungi
  • Class: Terpenoid
    • Subclass: Sesquiterpene
Canonical Smiles OC[C@]1(C)CCCC(=C)[C@H]1CCc1cocc1
InChI InChI=1S/C15H22O2/c1-12-4-3-8-15(2,11-16)14(12)6-5-13-7-9-17-10-13/h7,9-10,14,16H,1,3-6,8,11H2,2H3/t14-,15+/m1/s1
InChIKey MSYNVXUZUQKMIG-CABCVRRESA-N
Formula C15H22O2
HBA 2
HBD 1
MW 234.34
Rotatable Bonds 4
TPSA 33.37
LogP 3.57
Number Rings 2
Number Aromatic Rings 1
Heavy Atom Count 17
Formal Charge 0
Fraction CSP3 0.6
Exact Mass 234.16
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Sanghuangporus sp. Hymenochaetaceae Fungi 2267874

Showing of synonyms

  • Cheng T, Chepkirui C, et al. (2019). Sesquiterpenes from an Eastern African medicinal mushroom belonging to the genus Sanghuangporus.. Journal of Natural Products,2019,82(5),1283-1291.. [View] [PubMed]
Pubchem: 155564513

No compound-protein relationship available.

Structure

SMILES: C1CCCC(C1=C)CCc2ccoc2

Level: 1

Mol. Weight: 234.34 g/mol

Structure

SMILES: C=C1CCCCC1

Level: 0

Mol. Weight: 234.34 g/mol

Structure

SMILES: c1ccoc1

Level: 0

Mol. Weight: 234.34 g/mol

Antimicrobial

Absorption

Caco-2 (logPapp)
-4.83
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.19
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.27

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.77
Plasma Protein Binding
62.14
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.93
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.1
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Safe
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.53
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
5.04
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.85
Rat (Acute)
2.59
Rat (Chronic Oral)
2.07
Fathead Minnow
3.92
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
308.01
Hydration Free Energy
-6.5
Log(D) at pH=7.4
2.95
Log(P)
3.81
Log S
-3.37
Log(Vapor Pressure)
-4.99
Melting Point
49.29
pKa Acid
10.98
pKa Basic
7.23
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9717
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.9717
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.9521
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.9521
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9266
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.9266
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9258
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9258
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9205
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9205
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.9160
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 3 0.9160
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9066
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9066
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9032
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9032
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8963
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8963
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8924
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8924
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8832
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8832
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8679
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8679
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8629
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8629
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8615
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8615
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8595
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.8595
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8528
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8528
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8317
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8317
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8226
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8226
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8120
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8120
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.8104
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 3 0.8104
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8097
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8097
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.8081
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.8081
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8069
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.8069
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8030
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8030
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8029
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8029
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8021
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8021
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7998
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7998
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7994
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7994
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7991
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7991
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7986
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7986
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7962
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7962
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7926
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7926
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7923
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7923
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7877
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7877
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7840
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7840
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7839
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7839
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7836
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7836
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7825
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.7825
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7816
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7816
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7798
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7798
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7793
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7793
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7783
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7783
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7774
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7774
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7739
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7739
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7738
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7738
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 2 0.7722
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7722
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7722
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 2 0.7722
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7689
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7689
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7640
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7640
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7634
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7634
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7627
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 3 0.7627
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7620
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7620
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7602
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7602
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7591
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7591
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7591
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7591
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7581
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7581
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7566
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 3 0.7566
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7556
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7556
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7555
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7555
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7554
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7554
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7547
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7547
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7520
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7520
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7509
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7509
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 3 0.7502
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 3 0.7502
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7494
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7494
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7487
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7487
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7483
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7483
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7476
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7476
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7476
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7476
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7422
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7422
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7418
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7418
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7414
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7414
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 3 0.7407
Peroxisome proliferator-activated receptor alpha Q07869 PPARA_HUMAN Homo sapiens 3 0.7407
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7385
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7385
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7382
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7382
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7377
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7377
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7364
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 2 0.7364
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7351
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7351
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7341
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7341
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7341
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7341
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7339
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7339
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7332
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7332
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7327
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7327
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7325
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7325
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7322
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7322
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7320
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7320
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7317
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7317
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7317
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7317
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7317
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7317
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7316
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7316
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7314
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7314
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7312
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7312
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7301
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7301
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7296
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7296
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7288
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7288
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7286
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7286
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7279
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7279
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7268
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7268
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7250
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7250
Epothilone C/D epoxidase Q9KIZ4 C167_SORCE Sorangium cellulosum 2 0.7246
Epothilone C/D epoxidase Q9KIZ4 C167_SORCE Sorangium cellulosum 2 0.7246
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7234
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7234
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7234
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7234
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7231
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7231
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7225
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7225
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7206
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7206
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7203
Histone deacetylase 7 Q8WUI4 HDAC7_HUMAN Homo sapiens 3 0.7203
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7188
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7188
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7181
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7181
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7175
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.7175
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7175
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7175
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7171
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7171
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7165
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7165
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7162
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.7162
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7157
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7157
Carbonic anhydrase 4 Q64444 CAH4_MOUSE Mus musculus 2 0.7157
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7157
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7153
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7153
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7140
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7140
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7126
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7126
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7115
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.7115
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7114
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7114
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7113
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7113
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7103
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7103
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7102
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7102
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7090
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7090
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7074
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.7074
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7072
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7072
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7071
Amino-acid acetyltransferase Q5FAK7 Q5FAK7_NEIG1 Neisseria gonorrhoeae 2 0.7071
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7067
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7067
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7065
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7065
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7061
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7061
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7056
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7056
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7056
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.7056
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7053
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7053
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7052
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7052
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7047
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7047
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7044
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7044
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7036
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7036
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7035
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7035
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7028
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7028
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7026
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7026
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7024
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7024
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7023
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7023
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7005
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7005
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7001
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7001

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