2-(p-hydroxy-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol - Compound Card

2-(p-hydroxy-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol

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2-(p-hydroxy-3-(3-methylbut-2-en-1-yl)benzyl)benzofuran-6-ol

Structure
Zoomed Structure
  • Family: Moraceae
  • Kingdom: Plantae
  • Class: Phenolic
    • Subclass: Benzylbenzofuran Derivative
Canonical Smiles CC(=CCc1cc(ccc1O)Cc1cc2c(o1)cc(cc2)O)C
InChI InChI=1S/C20H20O3/c1-13(2)3-5-15-9-14(4-8-19(15)22)10-18-11-16-6-7-17(21)12-20(16)23-18/h3-4,6-9,11-12,21-22H,5,10H2,1-2H3
InChIKey KZZAZUNOEPLVNP-UHFFFAOYSA-N
Formula C20H20O3
HBA 3
HBD 2
MW 308.38
Rotatable Bonds 4
TPSA 53.6
LogP 4.94
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.2
Exact Mass 308.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Dorstenia kameruniana Moraceae Plantae 984812

Showing of synonyms

  • Adem FA, Kuete V, et al. (2018). Cytotoxic benzylbenzofuran derivatives from Dorstenia kameruniana.. Fitoterapia,2018,128,26-30.. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: c1ccccc1Cc(c2)oc(c23)cccc3

Level: 1

Mol. Weight: 208.26 g/mol

Structure

SMILES: c1coc(c12)cccc2

Level: 0

Mol. Weight: 118.13 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 78.11 g/mol

Cytotoxic

Absorption

Caco-2 (logPapp)
-4.88
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.7
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.8

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
0.91
Plasma Protein Binding
67.82
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.61
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
2.04
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.95
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.89
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.74
Rat (Acute)
1.68
Rat (Chronic Oral)
2.37
Fathead Minnow
5.06
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
430.97
Hydration Free Energy
-10.45
Log(D) at pH=7.4
4.33
Log(P)
5.15
Log S
-5.09
Log(Vapor Pressure)
-9.07
Melting Point
169.38
pKa Acid
9.72
pKa Basic
7.4
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9543
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9543
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9535
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9535
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9519
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9519
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9488
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9488
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9391
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9391
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9381
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9381
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.9287
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.9287
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9272
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9272
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9232
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9232
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9225
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9225
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9203
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9203
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9146
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9146
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.9090
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.9090
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.9075
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.9075
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9065
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9065
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9061
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.9061
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9057
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.9057
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9023
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9023
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8992
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8992
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8992
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.8992
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8910
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8910
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8853
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8853
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8841
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8841
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8825
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8825
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8805
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 3 0.8805
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.8793
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 3 0.8793
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8789
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.8789
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8765
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8765
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8748
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8748
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8730
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8730
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8700
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8700
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8683
Serine/threonine-protein kinase PLK2 Q9NYY3 PLK2_HUMAN Homo sapiens 3 0.8683
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8683
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.8683
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8674
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8674
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8671
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8671
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8656
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8656
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 4 0.8638
Phosphatidylinositol 3-kinase catalytic subunit type 3 Q8NEB9 PK3C3_HUMAN Homo sapiens 4 0.8638
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8624
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8624
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8620
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.8620
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8615
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8615
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8612
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8612
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8580
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8580
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8549
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8549
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8549
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8549
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8547
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8547
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8540
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8540
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8538
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8538
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8527
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.8527
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8506
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8506
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8495
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8495
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8492
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8492
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8448
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8448
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8445
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8445
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8444
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8444
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8438
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.8438
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8422
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8422
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8417
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.8417
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8416
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8416
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8393
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 4 0.8393
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8392
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8392
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8366
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 3 0.8366
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8362
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8362
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8277
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8277
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8275
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8275
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8272
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8272
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8267
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8267
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8261
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.8261
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8257
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8257
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8251
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8251
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8243
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8243
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8243
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8243
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8240
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8240
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8235
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8235
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8232
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8232
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8229
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8229
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.8218
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 4 0.8218
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8196
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8196
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8196
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8196
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8169
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8169
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8169
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8169
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8168
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8168
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8167
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8167
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8151
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8151
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8131
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8131
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8123
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8123
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8121
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.8121
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8103
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8103
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8102
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8102
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8099
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8099
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8078
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8078
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8071
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8071
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8071
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8071
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8060
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8060
Androgen receptor P19091 ANDR_MOUSE Mus musculus 4 0.8056
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8056
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8056
Androgen receptor P19091 ANDR_MOUSE Mus musculus 4 0.8056
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8053
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8053
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8036
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8036
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8031
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8031
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.8031
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8031
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8028
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8028
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8014
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.8014
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8011
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.8011
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8009
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8009
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8007
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.8007
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7995
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7995
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7991
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7991
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7985
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7985
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7977
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7977
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7974
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7974
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7956
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7956
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7950
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7950
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7950
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7950
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7949
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7949
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7945
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7945
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7942
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7942
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7938
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7938
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7937
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7937
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.7933
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.7933
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7920
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7920
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7908
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7908
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7902
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7902
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7896
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7896
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7895
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.7895
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7891
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7891
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7888
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7888
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7886
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7886
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7884
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7884
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7879
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7879
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7875
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7875
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7869
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7869
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7867
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 4 0.7867
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7866
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7866
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7852
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7852
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7850
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7850
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7847
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7847
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7836
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.7836
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7832
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.7832
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7827
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7827
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7821
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7821
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7815
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7815
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7808
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7808
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7803
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7803
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7795
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7795
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7780
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7780
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7766
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7766
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7765
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7765
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7753
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7753
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7750
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7750
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7744
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7744
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7736
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7736
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7727
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7727
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7725
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7725
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7723
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7723
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7708
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7708
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7700
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7700
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7696
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7696
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7692
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7692
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7691
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7691
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7686
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7686
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7685
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.7685
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7684
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7684
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7683
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7683
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7683
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7683
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7681
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7681
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7681
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7681
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7679
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.7679
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7678
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7678
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7671
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7671
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7669
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7669
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7658
Histamine N-methyltransferase P50135 HNMT_HUMAN Homo sapiens 4 0.7658
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7656
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7656
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7644
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7644
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7640
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 3 0.7640
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7635
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7635
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7629
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.7629
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7629
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7629
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7625
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7625
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7614
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7614
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7611
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7611
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7608
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 4 0.7608
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7602
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7602
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7601
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7601
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7592
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7592
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7579
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7579
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7578
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7578
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7574
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7574
Sulfotransferase 1E1 P49891 ST1E1_MOUSE Mus musculus 4 0.7563
Sulfotransferase 1E1 P49891 ST1E1_MOUSE Mus musculus 4 0.7563
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7560
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7560
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7555
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7555
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7555
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7555
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7554
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7554
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7550
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7550
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7540
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7540
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7538
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7538
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7535
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7535
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7532
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7532
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7530
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7530
Integrin alpha-IIb P08514 ITA2B_HUMAN Homo sapiens 3 0.7526
Integrin alpha-IIb P08514 ITA2B_HUMAN Homo sapiens 3 0.7526
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7522
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7522
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7522
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7522
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7516
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7516
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7515
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7515
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7514
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7514
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7505
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7505
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7494
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7494
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7491
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7491
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7482
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7482
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7478
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7478
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7475
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7475
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7473
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7473
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7473
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7473
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7471
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7471
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7471
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7471
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7470
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7470
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7470
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7470
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7468
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7468
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7467
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7467
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7465
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7465
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7462
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7462
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7460
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7460
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7454
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7454
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7452
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7452
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7451
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7451
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7448
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7448
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7439
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7439
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7431
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7431
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7429
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7429
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7428
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7428
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7426
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7426
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7425
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7425
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7424
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7424
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7424
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7424
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7424
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7424
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7423
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7423
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7421
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7421
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7420
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7420
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7408
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7408
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7407
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7407
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7407
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7407
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7396
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7396
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7393
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7393
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7392
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7392
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7389
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7389
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7389
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7389
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7382
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7382
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7379
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7379
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7374
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7374
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7373
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7373
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7371
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7371
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7369
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7369
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7367
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7367
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7365
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7365
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7355
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7355
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7351
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7351
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7350
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7350
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7344
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7344
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7344
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7344
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7343
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.7343
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7342
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7342
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7336
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7336
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7327
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7327
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7323
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7323
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7314
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7314
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7310
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7310
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7308
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7308
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7307
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7307
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7302
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7302
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7300
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7300
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7298
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7298
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7297
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.7297
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7292
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7292
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7291
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7291
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7291
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7291
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7285
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7285
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7284
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7284
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7283
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7283
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7282
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7282
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7278
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7278
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7277
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7277
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7273
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7273
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7270
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 3 0.7270
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7269
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7269
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7261
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7261
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7260
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7260
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7260
Thymidylate synthase P07607 TYSY_MOUSE Mus musculus 3 0.7260
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7255
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7255
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7252
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7252
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7251
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7251
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7248
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7248
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7246
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7246
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7246
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7246
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7243
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7243
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7243
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 3 0.7243
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7243
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7243
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7240
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7240
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7239
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7239
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7239
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7239
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7237
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7237
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7234
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7234
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7233
Putative N-acetyl glucosaminyl transferase Q6U8B0 Q6U8B0_RAOTE Raoultella terrigena 3 0.7233
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7227
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7227
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7225
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7225
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7224
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7224
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7223
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7223
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7222
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7222
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7217
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7217
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7216
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7216
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7215
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7215
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7214
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7214
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7203
Cytidylate kinase Q5SL35 KCY_THET8 Thermus thermophilus 3 0.7203
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7195
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7195
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7193
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7193
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7192
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7192
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7186
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7186
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7182
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7182
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7177
Ribosome-inactivating protein alpha-trichosanthin P09989 RIPT_TRIKI Trichosanthes kirilowii 3 0.7177
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7174
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7174
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7168
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7168
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7166
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7166
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7161
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7161
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7154
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7154
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7142
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7142
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7140
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 3 0.7140
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7135
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7135
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7135
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7135
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7132
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 3 0.7132
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7125
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7125
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7125
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7125
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7124
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 4 0.7124
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7121
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7121
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7121
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7121
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7115
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7115
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7115
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7115
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7115
Archaeal actin homolog Q9HKL4 ACTH_THEAC Thermoplasma acidophilum 2 0.7115
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7113
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7113
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7112
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7112
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7112
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7112
Toll-like receptor 8 Q9NR97 TLR8_HUMAN Homo sapiens 3 0.7108
Toll-like receptor 8 Q9NR97 TLR8_HUMAN Homo sapiens 3 0.7108
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7102
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7102
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7101
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7101
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7099
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7099
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 4 0.7097
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7097
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 4 0.7097
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7097
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7095
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7095
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7093
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7093
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7093
RAC-alpha serine/threonine-protein kinase P31749 AKT1_HUMAN Homo sapiens 3 0.7093
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7092
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7092
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7088
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7088
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7086
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 3 0.7086
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7082
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7082
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7081
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7081
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7080
Botulinum neurotoxin type A P0DPI0 BXA1_CLOBO Clostridium botulinum 2 0.7080
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7076
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7076
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7074
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7074
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7074
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.7074
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7069
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7069
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7068
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7068
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7067
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.7067
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7064
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7064
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7060
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7060
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7060
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7060
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7058
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7058
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7057
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7057
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7055
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7055
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7052
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7052
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7047
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7047
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7045
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7045
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.7045
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7045
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7044
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7044
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7039
Dihydrofolate reductase P0ABQ4 DYR_ECOLI Escherichia coli 3 0.7039
Glycylpeptide N-tetradecanoyltransferase A5K1A2 A5K1A2_PLAVS Plasmodium vivax 3 0.7035
Glycylpeptide N-tetradecanoyltransferase A5K1A2 A5K1A2_PLAVS Plasmodium vivax 3 0.7035
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7034
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7034
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7032
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7032
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7032
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7032
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7029
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7029
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7026
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7026
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7024
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7024
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7019
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7019
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7014
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7014
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7010
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7010
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7008
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7008

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