Dihydrochelerythrine - Compound Card

Dihydrochelerythrine

Select a section from the left sidebar

Dihydrochelerythrine

Structure
Zoomed Structure
  • Family: Plantae - Rutaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Benzophenanthridine Alkaloid
Canonical Smiles COc1c(OC)ccc2c1CN(C)c1c2ccc2c1cc1OCOc1c2
InChI InChI=1S/C21H19NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-9H,10-11H2,1-3H3
InChIKey ALZAZMCIBRHMFF-UHFFFAOYSA-N
Formula C21H19NO4
HBA 5
HBD 0
MW 349.39
Rotatable Bonds 2
TPSA 40.16
LogP 4.2
Number Rings 5
Number Aromatic Rings 3
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 349.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Zanthoxylum gilletii Rutaceae Plantae 1291627

Showing of synonyms

  • Nyaboke HO, Moraa M, et al. (2018). Cytotoxicity of lupeol from the stem bark of Zanthoxylum gilletii against multi-factorial drug resistant cancer cell lines. Investigational Medicinal Chemistry and Pharmacology,2018,1(1),10.. [View] [PubMed]
Pubchem: 485077
Chebi: 140672
Nmrshiftdb2: 60021235
CPRiL: 146095
Structure

SMILES: O1COc(c12)cc3c(c2)c4c(cc3)c5c(CN4)cccc5

Level: 0

Mol. Weight: 349.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.25
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.550
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-2.33

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.460
Plasma Protein Binding
74.89
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
13.250
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
2.150
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.410
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.890
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-5.250
Rat (Acute)
2.720
Rat (Chronic Oral)
1.470
Fathead Minnow
5.570
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
498.070
Hydration Free Energy
-6.030
Log(D) at pH=7.4
3.160
Log(P)
4.43
Log S
-4.87
Log(Vapor Pressure)
-8.64
Melting Point
166.72
pKa Acid
11.28
pKa Basic
5.45
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9836
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9836
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9719
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9719
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9710
Multidrug-efflux transporter 1 regulator P39075 BMRR_BACSU Bacillus subtilis 3 0.9710
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9636
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9636
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9599
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.9599
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9581
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9581
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9578
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9578
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9529
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9529
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9527
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9527
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9447
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9447
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9381
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9381
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9352
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9352
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9341
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 3 0.9341
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9328
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9328
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9281
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.9281
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9268
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9268
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9249
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.9249
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.9227
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 3 0.9227
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9198
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9198
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9191
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 3 0.9191
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9187
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9187
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9185
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9185
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9134
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9134
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9118
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9118
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9048
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.9048
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9033
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9033
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9032
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9032
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8982
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8982
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8927
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8927
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8917
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8917
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8869
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8869
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8840
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8840
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8804
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8804
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8787
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8787
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8768
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 4 0.8768
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8766
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8766
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8763
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8763
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8698
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8698
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8667
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8667
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8659
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8659
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8642
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8642
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8629
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8629
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8592
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.8592
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8582
Cytochrome P450 2B4 P00178 CP2B4_RABIT Oryctolagus cuniculus 3 0.8582
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8570
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8570
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8558
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8558
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8468
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8468
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8465
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8465
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8460
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.8460
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8456
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8456
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8447
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.8447
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8442
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8442
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8440
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8440
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8406
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8406
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8399
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8399
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8399
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.8399
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8326
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8326
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8317
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8317
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8309
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8309
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8257
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.8257
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8158
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8158
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8128
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8128
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8079
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8079
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8057
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8057
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8057
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 4 0.8057
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8039
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8039
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8039
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8039
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8013
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8013
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7976
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7976
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7967
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7967
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7963
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7963
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7938
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7938
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7918
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7918
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7879
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7879
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7875
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7875
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7865
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7865
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7858
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7858
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7837
Aldo-keto reductase family 1 member A1 P50578 AK1A1_PIG Sus scrofa 3 0.7837
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7828
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7828
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7808
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7808
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7798
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7798
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7774
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7774
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7771
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7771
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7767
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7767
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7750
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.7750
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7744
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7744
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7734
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 4 0.7734
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7730
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7730
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7723
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7723
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7714
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7714
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7711
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7711
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7697
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7697
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7694
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7694
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7675
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7675
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7646
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.7646
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7646
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 4 0.7646
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7633
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7633
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7618
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7618
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7613
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7613
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 3 0.7612
(RS)-norcoclaurine 6-O-methyltransferase Q5C9L7 6OMT_THLFG Thalictrum flavum subsp. glaucum 3 0.7612
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7609
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7609
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7602
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7602
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7600
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7600
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7596
Bromodomain protein, putative Q8I240 Q8I240_PLAF7 Plasmodium falciparum 4 0.7596
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7591
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7591
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7588
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7588
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7586
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7586
Renin P00797 RENI_HUMAN Homo sapiens 2 0.7586
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7586
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7567
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7567
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7567
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7567
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7566
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7566
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7566
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7566
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7566
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7566
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7560
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7560
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7555
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7555
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7538
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.7538
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7530
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7530
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7530
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7530
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7516
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7516
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7508
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7508
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7500
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7500
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7490
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7490
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7484
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7484
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7482
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7482
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7469
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7469
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7463
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7463
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7462
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7462
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7460
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7460
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7453
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7453
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7453
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7453
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7450
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.7450
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 2 0.7434
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 2 0.7434
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7433
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.7433
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7426
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7426
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7426
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7426
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7419
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7419
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7413
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7413
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7404
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7404
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7400
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7400
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7398
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7398
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7386
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7386
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7382
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7382
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 2 0.7382
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7382
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7380
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 3 0.7380
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7375
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7375
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7372
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7372
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7369
Farnesyl pyrophosphate synthase P14324 FPPS_HUMAN Homo sapiens 2 0.7369
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7368
Carbonic anhydrase 4 P22748 CAH4_HUMAN Homo sapiens 3 0.7368
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7360
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7360
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7359
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7359
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7355
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7355
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7354
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7354
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7348
Beta-adrenergic receptor kinase 1 P25098 ARBK1_HUMAN Homo sapiens 3 0.7348
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7337
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7337
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7334
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7334
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7332
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7332
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7331
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7331
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7329
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 2 0.7329
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7328
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7328
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7320
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7320
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7318
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7318
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7307
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7307
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7306
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7306
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7304
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 2 0.7304
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7304
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7304
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7287
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7287
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7284
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7284
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7283
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7283
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7279
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7279
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7269
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7269
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7267
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7267
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7261
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7261
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7258
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.7258
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7257
Reticuline oxidase P30986 RETO_ESCCA Eschscholzia californica 4 0.7257
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7247
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7247
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.7244
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.7244
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7239
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7239
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7237
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7237
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7235
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7235
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7234
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7234
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7229
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.7229
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7225
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7225
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7224
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7224
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7220
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7220
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7220
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7220
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7218
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7218
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7216
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7216
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7213
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7213
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7211
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7211
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7206
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7206
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7202
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7202
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7200
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7200
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7199
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7199
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7199
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7199
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7196
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7196
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7194
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7194
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7184
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7184
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7180
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7180
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7179
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.7179
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7175
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7175
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7167
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7167
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7162
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7162
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7156
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7156
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7155
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7155
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7146
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7146
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7145
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7145
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7143
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7143
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7138
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.7138
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7133
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7133
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7125
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7125
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7123
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7123
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7114
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7114
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7112
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7112
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7111
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.7111
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7110
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7110
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.7109
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.7109
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7108
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 3 0.7108
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7103
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7103
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7101
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7101
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7096
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7096
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7091
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7091
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7088
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7088
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7087
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7087
Toll-like receptor 8 Q9NR97 TLR8_HUMAN Homo sapiens 3 0.7080
Toll-like receptor 8 Q9NR97 TLR8_HUMAN Homo sapiens 3 0.7080
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7076
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7076
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7075
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7075
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7071
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7071
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7066
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7066
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7064
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7064
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7064
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7064
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7061
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7061
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7056
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7056
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7047
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7047
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7046
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7046
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7045
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7045
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7042
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7042
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7039
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7039
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7039
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7039
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7038
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7038
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7037
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7037
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7035
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7035
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7035
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7035
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7033
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.7033
HAP protein Q8IM15 Q8IM15_PLAF7 Plasmodium falciparum 3 0.7030
HAP protein Q8IM15 Q8IM15_PLAF7 Plasmodium falciparum 3 0.7030
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7023
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7023
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7018
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7018
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7017
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7017
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7015
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7015
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.7009
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.7009
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7005
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7005
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7003
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7003

Download SDF