8,9-dimethoxy-5H-phenanthridin-6-one - Compound Card

8,9-dimethoxy-5H-phenanthridin-6-one

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8,9-dimethoxy-5H-phenanthridin-6-one

Structure
Zoomed Structure
  • Family: Annonaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Phenanthridine Alkaloid
Canonical Smiles COc1cc2c(cc1OC)c(=O)[nH]c1c2cccc1
InChI InChI=1S/C15H13NO3/c1-18-13-7-10-9-5-3-4-6-12(9)16-15(17)11(10)8-14(13)19-2/h3-8H,1-2H3,(H,16,17)
InChIKey JSZDJKBYMGGQAL-UHFFFAOYSA-N
Formula C15H13NO3
HBA 3
HBD 1
MW 255.27
Rotatable Bonds 2
TPSA 51.32
LogP 2.7
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 255.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Anonidium mannii Annonaceae Plantae 2109291
2 Oxyanthus unilocularis Annonaceae Plantae 1768086

Showing of synonyms

  • Kayo MT, Simo MK, et al. (2021). Antifungal potential of extracts, fractions and compounds from Uvaria comperei (Annonaceae) and Oxyanthus unilocularis (Rubiaceae).. Natural product research,2021, 35(24), 5732-5736. [View] [PubMed]
  • Ngangoue MO, Ndifor AR, et al. (2024). Isolation and antibacterial activity of anomanol B and other secondary metabolites from the stem bark of Anonidium mannii (Annonaceae). Natural product research,2024, 38(11), 1813-1822. [View] [PubMed]
Pubchem: 12703535

No compound-protein relationship available.

Structure

SMILES: c1cccc(c1c23)[nH]c(=O)c2cccc3

Level: 0

Mol. Weight: 195.22 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.57
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.230
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.82

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.420
Plasma Protein Binding
62.25
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.160
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.640
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.150
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.340
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.820
Rat (Acute)
2.250
Rat (Chronic Oral)
2.060
Fathead Minnow
4.690
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
406.490
Hydration Free Energy
-10.790
Log(D) at pH=7.4
2.100
Log(P)
2.05
Log S
-5.26
Log(Vapor Pressure)
-6.67
Melting Point
256.02
pKa Acid
7.63
pKa Basic
5.29
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.9806
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.9757
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.9691
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9680
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9497
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 4 0.9480
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.9468
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9397
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9375
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.9191
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 3 0.9175
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 4 0.9145
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.9140
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.9086
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9063
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9060
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9043
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9026
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.9022
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 3 0.8998
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8980
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8958
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8945
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.8942
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8937
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8909
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8904
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8900
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8885
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8873
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.8843
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8837
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8833
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8820
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8792
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8782
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8769
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8721
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8705
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8686
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8661
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 3 0.8646
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8639
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8618
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.8606
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8601
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 3 0.8545
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8515
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8487
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8477
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8474
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8430
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8421
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8400
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8388
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8371
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8369
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 4 0.8327
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8327
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8326
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8319
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8309
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8306
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8284
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.8216
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.8209
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8199
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8183
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.8142
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8114
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8112
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8110
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8099
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8069
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8030
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8019
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8015
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8011
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8007
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7997
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7981
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.7973
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7965
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.7960
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7957
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7950
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 3 0.7945
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7938
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 4 0.7934
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 4 0.7930
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7898
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7846
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7846
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7846
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7838
Nitric oxide synthase, inducible P35228 NOS2_HUMAN Homo sapiens 3 0.7829
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7810
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 3 0.7746
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.7736
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.7730
Putative secreted protein C9Z6T8 C9Z6T8_STRSW Streptomyces scabiei 4 0.7693
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7681
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7680
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7678
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7674
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7672
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7656
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7654
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7651
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7643
Renin P00797 RENI_HUMAN Homo sapiens 3 0.7642
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7628
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7626
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7625
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7617
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7614
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7602
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7575
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7572
HLA class I histocompatibility antigen, B alpha chain P01889 HLAB_HUMAN Homo sapiens 3 0.7561
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 3 0.7533
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7521
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7518
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7508
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7499
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7484
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7481
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7481
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7480
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7479
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7476
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7470
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7465
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7463
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7456
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7454
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7449
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7444
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7433
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7426
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7423
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7413
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7408
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7406
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7399
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7398
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7393
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7393
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7390
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7383
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7380
Cytochrome P450 2C5 P00179 CP2C5_RABIT Oryctolagus cuniculus 3 0.7379
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7376
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7376
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7375
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7361
Glutamate receptor ionotropic, NMDA 1 P35439 NMDZ1_RAT Rattus norvegicus 4 0.7341
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.7340
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7331
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 2 0.7329
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7322
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7314
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7312
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7304
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7301
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7299
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7296
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7294
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7281
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7266
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7263
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7263
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7262
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7261
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7257
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7254
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 3 0.7237
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7231
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7228
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7212
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 3 0.7208
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 2 0.7203
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7200
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7194
Pyruvate dehydrogenase [ubiquinone] P07003 POXB_ECOLI Escherichia coli 3 0.7192
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7186
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7183
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.7181
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7170
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7165
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7161
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7161
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 2 0.7151
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7141
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7141
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7132
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7113
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7103
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7100
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7099
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.7083
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7080
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7076
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7075
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7072
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7070
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7067
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7063
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7062
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7056
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7036
Serine/threonine-protein kinase receptor R3 P37023 ACVL1_HUMAN Homo sapiens 3 0.7035
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7035
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7035
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7023
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7017
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7015
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7011
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7010
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7009
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7009
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7008
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.7005
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7003
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7003
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.7001
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7001

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