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Tetrahydroprotoberberine

Family: Plantae - Annonaceae
Kingdom: Plantae
Class: Alkaloid
- Subclass: Berberine Alkaloid

Canonical Smiles	c1ccc2c(c1)CC1N(C2)CCc2c1cccc2
InChI	InChI=1S/C17H17N/c1-2-7-15-12-18-10-9-13-5-3-4-8-16(13)17(18)11-14(15)6-1/h1-8,17H,9-12H2
InChIKey	BRLDZKPJJNASGG-UHFFFAOYSA-N
Formula	C₁₇H₁₇N
HBA	1
HBD	0
MW	235.33
Rotatable Bonds	0
TPSA	3.24
LogP	3.34
Number Rings	4
Number Aromatic Rings	2
Heavy Atom Count	18
Formal Charge	0
Fraction CSP3	0.29
Exact Mass	235.14
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Anonidium mannii	Annonaceae	Plantae	2109291

Showing of synonyms

Mefegue FA, Michel T, et al. (2021). Anti-breast cancer potential of Anonidium mannii (Oliv.) Engl. & Diels barks ethanolic extract: UPLC-ESI-QTOF-MS detection of anticancer alkaloids. Journal of ethnopharmacology,2021, 276, 114131. [View] [PubMed]

Pubchem: 101707

Cas: 483-49-8

Chebi: 35611

Metabolights: MTBLC35611

CPRiL: 107637

SMILES: c1cccc(c12)CCN3C2Cc4c(C3)cccc4

Level: 0

Mol. Weight: 235.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.52
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.3
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: -2.92

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 0.97
Plasma Protein Binding: 34.71
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 4.78
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Toxic
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 2.28
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.45
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.68
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 2.17
Rat (Acute): 3.18
Rat (Chronic Oral): 1.51
Fathead Minnow: 4.42
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 332.87
Hydration Free Energy: -5.48
Log(D) at pH=7.4: 3.22
Log(P): 3.67
Log S: -2.89
Log(Vapor Pressure): -5.89
Melting Point: 99.44
pKa Acid: 13.79
pKa Basic: 8.09

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.9531
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.9461
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.9422
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9381
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.9354
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9350
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9320
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.9302
Inorganic pyrophosphatase	Q3JUV5	Q3JUV5_BURP1	Burkholderia pseudomallei	3	0.9258
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.9156
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9149
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.9134
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8999
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8982
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8909
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.8895
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	3	0.8838
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8836
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8828
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.8822
Aldehyde dehydrogenase, dimeric NADP-preferring	P30838	AL3A1_HUMAN	Homo sapiens	3	0.8808
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	3	0.8752
Glycylpeptide N-tetradecanoyltransferase	Q4Q5S8	Q4Q5S8_LEIMA	Leishmania major	3	0.8716
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	3	0.8678
Renin	P00797	RENI_HUMAN	Homo sapiens	3	0.8647
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8612
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8589
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8538
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8510
Poly [ADP-ribose] polymerase tankyrase-1	O95271	TNKS1_HUMAN	Homo sapiens	3	0.8485
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8476
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8451
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8384
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	3	0.8180
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.8137
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.8071
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8061
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.8021
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8011
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.8002
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7999
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7997
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7987
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7987
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	2	0.7963
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7956
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7949
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7893
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	2	0.7890
Histidine kinase 4	Q9C5U0	AHK4_ARATH	Arabidopsis thaliana	3	0.7886
E3 ubiquitin-protein ligase XIAP	P98170	XIAP_HUMAN	Homo sapiens	3	0.7882
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7873
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7871
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7846
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7830
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7819
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7818
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	2	0.7813
Mandelate racemase	P11444	MANR_PSEPU	Pseudomonas putida	3	0.7802
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7800
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7796
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7794
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7790
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7790
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.7786
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7778
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	2	0.7776
Tyrosine-protein kinase HCK	P08631	HCK_HUMAN	Homo sapiens	2	0.7775
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7772
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7771
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7769
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7764
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7761
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7760
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7756
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	2	0.7756
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	2	0.7756
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7751
Mitogen-activated protein kinase 1	P63086	MK01_RAT	Rattus norvegicus	3	0.7743
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	2	0.7733
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7732
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	2	0.7732
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7730
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7724
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	2	0.7724
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	2	0.7719
Cytochrome P450 130	P9WPN5	CP130_MYCTU	Mycobacterium tuberculosis	2	0.7715
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7714
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7707
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7706
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7705
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	2	0.7691
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7688
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7684
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7682
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7682
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	3	0.7680
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7680
Peroxisome proliferator-activated receptor alpha	Q07869	PPARA_HUMAN	Homo sapiens	2	0.7678
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7677
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7671
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7669
Beta-ketoacyl-[acyl-carrier-protein] synthase III	Q820T1	FABH_ENTFA	Enterococcus faecalis	2	0.7665
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7662
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	2	0.7661
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7655
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7644
Pyruvate kinase PKM	P14618	KPYM_HUMAN	Homo sapiens	2	0.7644
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7642
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7634
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7633
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	2	0.7632
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7631
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7631
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	2	0.7631
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7629
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7629
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7629
Orf1a polyprotein	Q692E5	Q692E5_CVHSA	SARS coronavirus TJF	2	0.7627
Tyrosine-protein kinase JAK3	P52333	JAK3_HUMAN	Homo sapiens	2	0.7627
Hepatocyte growth factor receptor	P08581	MET_HUMAN	Homo sapiens	2	0.7621
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	2	0.7614
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7611
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7610
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7610
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7606
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7603
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7602
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	2	0.7599
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7597
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	2	0.7594
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7590
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	2	0.7587
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7586
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	2	0.7575
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	2	0.7573
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	2	0.7567
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7559
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7556
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	2	0.7553
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7552
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	2	0.7551
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	2	0.7543
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7540
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7540
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7539
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7537
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7536
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7534
Histamine N-methyltransferase	P50135	HNMT_HUMAN	Homo sapiens	2	0.7525
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7520
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7519
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7519
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7511
Cytochrome P450 2C9	P11712	CP2C9_HUMAN	Homo sapiens	2	0.7508
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7507
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7502
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7500
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	2	0.7500
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	2	0.7497
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7490
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7488
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	2	0.7486
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7485
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7482
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7481
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7473
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	2	0.7470
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7469
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7468
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7464
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7463
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7457
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7456
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7455
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7449
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7448
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7442
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	2	0.7439
Purine nucleoside phosphorylase	Q9BMI9	Q9BMI9_SCHMA	Schistosoma mansoni	2	0.7427
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7426
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	2	0.7426
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7425
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7423
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7420
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7417
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7414
Thiamin pyrophosphokinase 1	Q9R0M5	TPK1_MOUSE	Mus musculus	3	0.7412
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7411
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7404
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7402
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7401
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	3	0.7396
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7396
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7396
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7387
Pentalenic acid synthase	Q825I8	CYP28_STRAW	Streptomyces avermitilis	2	0.7384
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	2	0.7383
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7381
Squalene synthase	P37268	FDFT_HUMAN	Homo sapiens	2	0.7376
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7376
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7374
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7372
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7369
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7368
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	2	0.7362
Phospholipase A2, membrane associated	P14555	PA2GA_HUMAN	Homo sapiens	2	0.7359
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7359
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7356
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7352
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	2	0.7347
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7345
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7341
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7333
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	2	0.7332
Stimulator of interferon genes protein	Q3TBT3	STING_MOUSE	Mus musculus	2	0.7330
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	2	0.7328
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7327
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7317
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	2	0.7315
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7313
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7308
Ketimine reductase mu-crystallin	O54983	CRYM_MOUSE	Mus musculus	2	0.7307
Troponin C, slow skeletal and cardiac muscles	P09860	TNNC1_CHICK	Gallus gallus	2	0.7300
Peroxisome proliferator-activated receptor delta	Q03181	PPARD_HUMAN	Homo sapiens	2	0.7297
72 kDa type IV collagenase	P08253	MMP2_HUMAN	Homo sapiens	3	0.7296
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7295
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7293
Uncharacterized protein	C7YVL8	C7YVL8_NECH7	Nectria haematococca	3	0.7292
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	2	0.7290
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	2	0.7288
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7282
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	3	0.7280
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7277
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7274
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	2	0.7269
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7264
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7260
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	2	0.7258
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7255
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7254
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7251
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7247
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7243
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	2	0.7234
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7232
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	P60472	UPPS_ECOLI	Escherichia coli	2	0.7232
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7221
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7217
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	2	0.7214
Toluene-4-monooxygenase system, hydroxylase component subunit alpha	Q00456	TMOA_PSEME	Pseudomonas mendocina	2	0.7207
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	2	0.7193
(RS)-norcoclaurine 6-O-methyltransferase	Q5C9L7	6OMT_THLFG	Thalictrum flavum subsp. glaucum	3	0.7189
Class B acid phosphatase	P0AE22	APHA_ECOLI	Escherichia coli	2	0.7180
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7177
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	2	0.7176
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7173
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7171
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	2	0.7171
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7169
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	2	0.7165
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7160
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7154
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	2	0.7153
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7152
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	2	0.7151
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7147
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7146
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	2	0.7142
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	2	0.7132
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7111
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7111
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7104
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	2	0.7101
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	3	0.7099
Cytokinin dehydrogenase 1	Q9T0N8	CKX1_MAIZE	Zea mays	2	0.7082
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7075
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7065
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	2	0.7064
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	2	0.7059
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7054
Troponin C, slow skeletal and cardiac muscles	P63316	TNNC1_HUMAN	Homo sapiens	2	0.7053
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7043
Tryptophan synthase alpha chain	P00929	TRPA_SALTY	Salmonella typhimurium	2	0.7040
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	3	0.7029
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7028
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7026
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	2	0.7020
Biphenyl-2,3-diol 1,2-dioxygenase	P47228	BPHC_PARXL	Paraburkholderia xenovorans	2	0.7015
Cytochrome P450 2D6	P10635	CP2D6_HUMAN	Homo sapiens	2	0.7011
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	2	0.7008
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7007

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