5-hydroxypyridine-3-carboxamide - Compound Card

5-hydroxypyridine-3-carboxamide

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5-hydroxypyridine-3-carboxamide

Structure
Zoomed Structure
  • Family: Plantae - Apocynaceae
  • Kingdom: Plantae
  • Class: Alkaloid
Canonical Smiles NC(=O)c1cc(O)cnc1
InChI InChI=1S/C6H6N2O2/c7-6(10)4-1-5(9)3-8-2-4/h1-3,9H,(H2,7,10)
InChIKey UIJCDEKRKCCYIF-UHFFFAOYSA-N
Formula C6H6N2O2
HBA 3
HBD 2
MW 138.13
Rotatable Bonds 1
TPSA 76.21
LogP -0.11
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 10
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 138.04
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Funtumia elastica Apocynaceae Plantae 69379

Showing of synonyms

  • Ma'mag LK, Zintchem AAA, et al. (2021). Antiplasmodial and antileishmanial inhibitory activity of triterpenes and steroidal alkaloid from the leaves of Funtumia elastica (Preuss) Stapf (Apocynaceae).. Fitoterapia,2021, 151, 104869. [View] [PubMed]
Pubchem: 354313

No compound-protein relationship available.

Structure

SMILES: c1ccncc1

Level: 0

Mol. Weight: 138.13 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.68
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.020
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.86

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.280
Plasma Protein Binding
15.14
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.160
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
-0.070
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
1.860
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
3.800
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.780
Rat (Acute)
1.420
Rat (Chronic Oral)
2.020
Fathead Minnow
3.190
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
317.800
Hydration Free Energy
-16.290
Log(D) at pH=7.4
-0.720
Log(P)
-0.84
Log S
-0.89
Log(Vapor Pressure)
-5.97
Melting Point
219.56
pKa Acid
7.67
pKa Basic
3.95
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.9593
Regucalcin Q64374 RGN_MOUSE Mus musculus 3 0.9507
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9441
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9440
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9361
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.9345
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.9318
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.9296
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.9292
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9269
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.9267
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 3 0.9233
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.9223
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9217
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.9191
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9170
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.9167
Laminarinase Q9WXN1 Q9WXN1_THEMA Thermotoga maritima 3 0.9152
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9150
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9136
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.9132
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.9100
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.9049
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9048
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.9041
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9034
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.9005
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.8993
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8955
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8952
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8931
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8928
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8919
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.8917
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8898
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8893
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8885
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8884
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8860
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8851
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.8849
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 3 0.8833
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8809
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8777
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8771
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8769
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8750
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8730
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8712
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8702
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8693
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 3 0.8662
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8661
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8650
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8597
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8597
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8577
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.8568
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 3 0.8541
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8502
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.8473
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8427
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8414
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.8406
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8405
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8391
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8376
Repressor protein Q7X0D9 Q7X0D9_ACIAD Acinetobacter baylyi 3 0.8346
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 3 0.8312
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 3 0.8301
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8267
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 2 0.8263
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8241
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.8237
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8210
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.8193
Aldos-2-ulose dehydratase P84193 AUD_PHACH Phanerodontia chrysosporium 3 0.8146
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8141
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.8116
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8038
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.8036
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8023
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.8010
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7927
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7878
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7818
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7802
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 3 0.7791
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7787
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7781
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7765
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7748
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7743
Beta-glucosidase 1A Q25BW5 BGL1A_PHACH Phanerodontia chrysosporium 3 0.7712
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7710
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7700
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7679
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7643
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7641
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7636
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7633
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7629
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7591
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7584
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7573
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7572
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7544
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7535
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7534
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7524
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7520
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7519
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 2 0.7507
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7501
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7492
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7486
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7486
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7483
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 3 0.7477
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7469
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7461
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7445
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7436
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7432
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 3 0.7430
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7430
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7429
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 3 0.7424
Aminotransferase homolog Q9S5Y7 Q9S5Y7_CAMJU Campylobacter jejuni 3 0.7422
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 3 0.7420
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7414
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7411
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7407
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7386
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7371
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7367
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.7362
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 3 0.7354
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7353
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7344
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7335
Chromosomal replication initiator protein DnaA P46798 DNAA_THEMA Thermotoga maritima 3 0.7331
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 3 0.7328
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7326
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7326
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7322
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7313
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7308
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7305
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7304
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7273
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7271
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7269
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7269
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7268
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7266
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7265
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7251
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 3 0.7245
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7245
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 3 0.7238
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7232
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7232
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7230
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7214
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7209
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7205
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7200
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7195
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7194
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7193
ATP-dependent Clp protease ATP-binding subunit ClpX O25926 CLPX_HELPY Helicobacter pylori 3 0.7185
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 3 0.7180
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 3 0.7180
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7177
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7175
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7169
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7167
Mitogen-activated protein kinase kinase kinase 7 O43318 M3K7_HUMAN Homo sapiens 3 0.7165
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.7164
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 3 0.7160
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 3 0.7159
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 3 0.7158
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7156
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7155
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7154
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7147
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7146
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7146
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7145
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7142
Purine nucleoside phosphorylase DeoD-type B1JL34 DEOD_YERPY Yersinia pseudotuberculosis serotype O:3 2 0.7141
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7139
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7134
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7134
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7129
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.7127
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 3 0.7126
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 3 0.7118
eIF-2-alpha kinase GCN2 P15442 GCN2_YEAST Saccharomyces cerevisiae 3 0.7112
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7111
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 3 0.7110
Polyamine oxidase FMS1 P50264 FMS1_YEAST Saccharomyces cerevisiae 2 0.7109
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7105
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7105
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7104
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7104
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7103
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7098
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7095
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7091
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 3 0.7089
Eukaryotic translation initiation factor 2 subunit alpha P20459 IF2A_YEAST Saccharomyces cerevisiae 3 0.7089
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7089
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7087
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 3 0.7087
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7085
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7084
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 3 0.7082
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7082
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 3 0.7081
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7078
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 3 0.7078
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7077
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 3 0.7075
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 3 0.7074
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7068
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7065
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7063
Serine/threonine-protein kinase RIO1 Q9BRS2 RIOK1_HUMAN Homo sapiens 3 0.7063
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 3 0.7063
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7062
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7062
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 3 0.7059
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Q8U0R7 PURP_PYRFU Pyrococcus furiosus 3 0.7055
ATP-dependent protease ATPase subunit HslU P43773 HSLU_HAEIN Haemophilus influenzae 3 0.7054
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7049
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7049
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.7046
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 3 0.7044
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7043
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7043
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7043
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 3 0.7040
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7026
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 3 0.7023
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7012
Receptor-interacting serine/threonine-protein kinase 1 Q13546 RIPK1_HUMAN Homo sapiens 3 0.7010
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7010
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7007
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7006
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 3 0.7005

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