Methylhexadecanoate - Compound Card

Methylhexadecanoate

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Methylhexadecanoate

Structure
Zoomed Structure
  • Family: Asteraceae-Compositae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Sesquiterpene
Canonical Smiles CCC(CCCCCCCCCCCCC(=O)OCc1cccnc1)C
InChI InChI=1S/C23H39NO2/c1-3-21(2)15-12-10-8-6-4-5-7-9-11-13-17-23(25)26-20-22-16-14-18-24-19-22/h14,16,18-19,21H,3-13,15,17,20H2,1-2H3
InChIKey DETPTYSSZNSZLH-UHFFFAOYSA-N
Formula C23H39NO2
HBA 3
HBD 0
MW 361.57
Rotatable Bonds 16
TPSA 39.19
LogP 6.85
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 26
Formal Charge 0
Fraction CSP3 0.74
Exact Mass 361.3
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Acanthospermum hispidum Asteraceae-Compositae Plantae 182999

Showing of synonyms

  • Mihigo SO, Masesane IB, et al. (2015). Preliminary GC-MS Profiling and Anti-bacterial activity Investigation of Tridax procumbensLinn. (Asteraceae). International Journal of Chemistry and Aquatic Sciences, 2015, 1(1), 55-64. [View]
Pubchem: 564319

No compound-protein relationship available.

Structure

SMILES: c1ccncc1

Level: 0

Mol. Weight: 79.1 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.17
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.86
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.83

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.65
Plasma Protein Binding
50.87
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.35
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.83
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.84
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
5.79
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.68
Rat (Acute)
1.92
Rat (Chronic Oral)
2.08
Fathead Minnow
4.21
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
390.37
Hydration Free Energy
-4.4
Log(D) at pH=7.4
5.98
Log(P)
7.68
Log S
-4.57
Log(Vapor Pressure)
-7.1
Melting Point
21.89
pKa Acid
11.24
pKa Basic
4.53
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peridinin-chlorophyll a protein, high-salt form O76183 O76183_AMPCA Amphidinium carterae 3 0.9588
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 3 0.9222
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8813
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8640
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.8452
Class B acid phosphatase Q540U1 APHA_SALTM Salmonella typhimurium 2 0.8386
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.8250
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8146
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.8098
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7995
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7960
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7950
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7946
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7943
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7941
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7927
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7925
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7924
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7917
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7915
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7914
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7908
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7898
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7896
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7895
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7891
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7876
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7863
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7860
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7840
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7839
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7835
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7825
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7822
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.7819
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7814
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.7812
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7806
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.7801
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7799
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7798
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7793
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7791
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 2 0.7777
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7772
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 2 0.7772
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7769
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7761
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7756
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7753
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7751
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7750
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7747
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7746
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7745
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7740
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7734
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7732
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7731
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.7726
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7717
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7713
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7713
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.7699
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7695
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7694
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7689
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7678
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7677
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7667
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7657
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7655
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7650
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7648
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7645
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 2 0.7638
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7631
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7630
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 2 0.7629
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7627
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7622
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.7613
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.7612
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7612
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7588
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7584
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7583
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7571
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7563
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7547
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7541
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7537
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7535
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7527
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7526
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7526
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7525
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7524
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7524
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7524
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7518
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.7517
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7515
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7515
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7514
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7514
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7510
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7509
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7508
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.7502
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.7501
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7500
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7496
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7494
Lethal factor P15917 LEF_BACAN Bacillus anthracis 2 0.7493
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7492
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7488
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7486
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7485
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7482
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7480
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.7479
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7477
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7473
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7473
Nucleoside diphosphate kinase Q5UQL3 NDK_MIMIV Acanthamoeba polyphaga mimivirus 2 0.7468
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7467
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 2 0.7466
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7457
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 2 0.7452
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7451
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7451
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7449
Cyclic AMP receptor protein Q5SID7 CRP_THET8 Thermus thermophilus 2 0.7446
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7442
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7441
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7440
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7438
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7434
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7430
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7419
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.7414
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7413
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7413
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7413
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7412
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 2 0.7412
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7406
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 2 0.7404
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7394
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7377
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7376
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7360
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7359
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7357
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7356
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7355
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.7352
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7351
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7343
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 2 0.7339
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7337
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7334
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7332
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7331
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7331
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 2 0.7329
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.7327
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7327
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7322
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.7322
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7319
Phenylpyruvate C(3)-methyltransferase Q643C8 MPPJ_STRHY Streptomyces hygroscopicus 2 0.7315
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7311
F420-dependent methylenetetrahydromethanopterin dehydrogenase P94951 MTD_METKA Methanopyrus kandleri 2 0.7310
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7308
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7308
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7308
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7308
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.7306
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7304
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7302
Cyclin-dependent kinase 8 P49336 CDK8_HUMAN Homo sapiens 2 0.7301
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7299
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.7299
cAMP-dependent protein kinase type II-beta regulatory subunit P12369 KAP3_RAT Rattus norvegicus 2 0.7299
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7296
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7296
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7295
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.7294
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7287
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7286
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7283
Pyridoxal kinase O00764 PDXK_HUMAN Homo sapiens 2 0.7279
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7276
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7274
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7272
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.7269
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.7268
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7266
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7266
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 2 0.7266
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 2 0.7262
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7262
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7259
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7258
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.7255
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7253
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7252
Alanine racemase Q180W0 Q180W0_CLOD6 Clostridioides difficile 2 0.7250
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7249
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7247
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.7245
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7244
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7241
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7241
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7238
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7238
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7237
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7235
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7233
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7231
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.7230
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7229
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7229
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7227
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7223
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7222
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7222
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7222
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7221
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7220
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7219
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 2 0.7218
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7217
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7214
VioE domain-containing protein Q7NSZ5 Q7NSZ5_CHRVO Chromobacterium violaceum 2 0.7213
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7208
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7207
L-lactate dehydrogenase (cytochrome) P00175 CYB2_YEAST Saccharomyces cerevisiae 2 0.7207
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7207
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7206
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7204
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.7204
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7202
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7201
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7196
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7194
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7193
Metallophosphoesterase A3DJ38 A3DJ38_HUNT2 Clostridium thermocellum 2 0.7187
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7185
Matrix metalloproteinase-20 O60882 MMP20_HUMAN Homo sapiens 2 0.7182
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 2 0.7181
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7177
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7177
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.7176
thiamine diphosphokinase Q82ZE3 Q82ZE3_ENTFA Enterococcus faecalis 2 0.7172
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7170
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7165
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7163
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic O96693 DXR_PLAFX Plasmodium falciparum 2 0.7163
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 2 0.7162
Aminopeptidase N P15145 AMPN_PIG Sus scrofa 2 0.7158
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7158
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7155
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 2 0.7154
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 2 0.7154
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7154
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7149
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 2 0.7148
Adenylate cyclase 2 A0A2U2H3Y1 A0A384LKY8_YERPE Yersinia pestis 2 0.7148
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7147
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7145
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 2 0.7140
Carbonic anhydrase Q39588 Q39588_CHLRE Chlamydomonas reinhardtii 2 0.7124
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7122
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7122
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7108
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7106
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7102
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7101
Proline iminopeptidase O32449 PIP_SERMA Serratia marcescens 2 0.7100
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7098
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7096
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7096
Phospholipase A2 P00593 PA21B_BOVIN Bos taurus 2 0.7094
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.7091
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7090
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7089
Three-prime repair exonuclease 1 Q91XB0 TREX1_MOUSE Mus musculus 2 0.7084
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 2 0.7081
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.7075
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7068
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7061
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.7051
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7045
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7045
Thiazole tautomerase P25053 TENI_BACSU Bacillus subtilis 2 0.7041
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7040
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7038
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7037
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.7035
Unconventional myosin-Va Q02440 MYO5A_CHICK Gallus gallus 2 0.7030
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7029
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 2 0.7022
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7022
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 2 0.7019
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7018
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7015
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7011
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 2 0.7006
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 2 0.7004
Inosine-5'-monophosphate dehydrogenase P50097 IMDH_TRIFO Tritrichomonas foetus 2 0.7004
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 2 0.7001
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.6997
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6997
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 2 0.6982
Polymerase basic protein 2 P31345 PB2_I75A3 Influenza A virus 2 0.6976
1-deoxy-D-xylulose 5-phosphate reductoisomerase P45568 DXR_ECOLI Escherichia coli 2 0.6968
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6964
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.6963
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.6960
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.6955
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.6954
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.6948
Penicillin G acylase P06875 PAC_ECOLX Escherichia coli 2 0.6939
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.6937
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.6933
Acidic mammalian chitinase Q9BZP6 CHIA_HUMAN Homo sapiens 2 0.6932
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.6931
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 2 0.6931
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 2 0.6925
D-cysteine desulfhydrase Q8ZNT7 DCYD_SALTY Salmonella typhimurium 2 0.6924
5-methylthioadenosine/S-adenosylhomocysteine deaminase Q7NZ90 Q7NZ90_CHRVO Chromobacterium violaceum 2 0.6923
Carbonic anhydrase 1 P00915 CAH1_HUMAN Homo sapiens 2 0.6920
Bis(5'-adenosyl)-triphosphatase P49789 FHIT_HUMAN Homo sapiens 2 0.6919
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6919
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.6916
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.6907
Snake venom metalloproteinase atrolysin-D P15167 VM1AD_CROAT Crotalus atrox 2 0.6905
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 2 0.6904
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 2 0.6900
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.6894
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.6891
S-methyl-5'-thioadenosine phosphorylase I0B503 I0B503_SCHMA Schistosoma mansoni 2 0.6886
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.6885
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.6870
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 2 0.6853
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 2 0.6848
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.6835
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.6819
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.6815
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.6810
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.6806
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.6802
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.6801
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 2 0.6794
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.6784
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.6779
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 2 0.6775
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 2 0.6774
mRNA cleavage and polyadenylation factor CLP1 Q08685 CLP1_YEAST Saccharomyces cerevisiae 2 0.6764
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.6764
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.6762
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.6760
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.6746
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.6743
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.6739
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.6725
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6709
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.6697
Gibberellin receptor GID1 Q6L545 GID1_ORYSJ Oryza sativa subsp. japonica 2 0.6685
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.6677
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.6677
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 2 0.6658
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.6657
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.6654
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.6651
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.6647
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 2 0.6643
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.6643
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.6643
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6636
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6631
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.6628
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.6628
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.6627
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 2 0.6624
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.6622
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.6619
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.6617
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.6616
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.6613
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.6603
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.6603
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6599
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.6579
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.6578
Nucleoside diphosphate kinase A5J299 A5J299_PENVA Penaeus vannamei 2 0.6568
Pyrrolysine--tRNA ligase Q8PWY1 PYLS_METMA Methanosarcina mazei 2 0.6564
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.6561
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.6561
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6557
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6556
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.6552
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6550
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6549
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.6544
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.6543
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6540
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.6537
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6535
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.6534
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6531
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 2 0.6530
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6527
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6525
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6524
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6523
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6523
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6522
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6520
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6516
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.6516
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6511
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6507
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6506
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.6505
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6503
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.6503
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 2 0.6502
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.6496
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6492
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.6492
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6491
Avidin P02701 AVID_CHICK Gallus gallus 2 0.6491
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6490
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6489
L-seryl-tRNA(Sec) kinase Q58933 PSTK_METJA Methanocaldococcus jannaschii 2 0.6489
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 2 0.6487
5-aminolevulinate synthase P18079 HEM1_RHOCB Rhodobacter capsulatus 2 0.6487
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 2 0.6483
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.6480
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6480
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6479
Androgen receptor O97775 ANDR_PANTR Pan troglodytes 2 0.6478
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6473
Androgen receptor P19091 ANDR_MOUSE Mus musculus 2 0.6473
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.6473
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6472
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6470
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6468
Nucleoside diphosphate kinase O58429 NDK_PYRHO Pyrococcus horikoshii 2 0.6467
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.6465
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.6465
Mitomycin biosynthesis 6-O-methyltransferase Q9X5T6 MMCR_STRLA Streptomyces lavendulae 2 0.6465
Nucleoside diphosphate kinase Q2SWE7 NDK_BURTA Burkholderia thailandensis 2 0.6464
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6460
Phenolphthiocerol/phthiocerol polyketide synthase subunit C P96202 PPSC_MYCTU Mycobacterium tuberculosis 2 0.6460
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6459
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6456
Gibberellin receptor GID1A Q9MAA7 GID1A_ARATH Arabidopsis thaliana 2 0.6456
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 2 0.6453
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 2 0.6450
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6449
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.6447
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6446
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.6441
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6441
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.6441
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6439
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.6439
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 3 0.6437
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.6436
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.6436
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6435
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.6433
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6419
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.6414
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 2 0.6414
Uncharacterized ACR, COG1565 superfamily Q2T1U7 Q2T1U7_BURTA Burkholderia thailandensis 2 0.6412
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.6409
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.6408
Cytochrome b6 P83791 CYB6_MASLA Mastigocladus laminosus 2 0.6401
Malate synthase G P9WK17 MASZ_MYCTU Mycobacterium tuberculosis 2 0.6390
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 2 0.6370
Transcriptional activator protein LasR P25084 LASR_PSEAE Pseudomonas aeruginosa 2 0.6368
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.6365
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.6363
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.6362
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.6357
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.6353
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.6349
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6345
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 2 0.6343
3-hydroxy-3-methylglutaryl-coenzyme A reductase P13702 MVAA_PSEMV Pseudomonas mevalonii 2 0.6343
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 2 0.6339
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.6332
Pyridoxal kinase, putative C4LVZ4 C4LVZ4_ENTHI Entamoeba histolytica 2 0.6330
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.6326
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.6325
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.6316
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.6312
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.6309
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.6307
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 2 0.6302
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 2 0.6293
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6293
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.6292
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 2 0.6287
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.6285
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6285
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.6283
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.6276
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.6273
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.6273
Uridine phosphorylase Q5SID9 Q5SID9_THET8 Thermus thermophilus 2 0.6269
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6260
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 2 0.6259
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.6259
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.6256
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6252
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6240
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 2 0.6235
Genome polyprotein P03303 POLG_HRV14 Human rhinovirus 14 2 0.6231
Matrilysin P09237 MMP7_HUMAN Homo sapiens 2 0.6230
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.6226
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.6223
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 2 0.6222
Glucocorticoid receptor P04150 GCR_HUMAN Homo sapiens 2 0.6215
Cartilage oligomeric matrix protein P35444 COMP_RAT Rattus norvegicus 2 0.6202
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.6202
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.6191
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6191
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.6188
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.6185
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.6183
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6173
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 2 0.6170
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.6162
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 2 0.6148
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 2 0.6143
Carboxypeptidase A1 P00730 CBPA1_BOVIN Bos taurus 2 0.6143
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6139
Tyrosine 3-monooxygenase P04177 TY3H_RAT Rattus norvegicus 2 0.6131
Aminotransferase homolog Q9S5Y7 Q9S5Y7_CAMJU Campylobacter jejuni 2 0.6126
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.6122
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6120
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.6117
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.6117
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.6115
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.6113
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 2 0.6107
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.6103
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 2 0.6098
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.6096
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 2 0.6090
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.6087
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 2 0.6087
cGMP-dependent protein kinase 1 P00516 KGP1_BOVIN Bos taurus 2 0.6085
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 2 0.6081
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6080
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.6079
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.6078
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 2 0.6076
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6076
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 2 0.6067
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 2 0.6067
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 2 0.6067
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 2 0.6065
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6064
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.6063
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.6062
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.6062
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.6060
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 O88703 HCN2_MOUSE Mus musculus 2 0.6060
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.6059
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 2 0.6054
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.6053
Actin, alpha skeletal muscle P68135 ACTS_RABIT Oryctolagus cuniculus 2 0.6053
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.6050
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6049
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.6049
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 2 0.6047
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.6046
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.6045
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 2 0.6045
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.6045
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 2 0.6041
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.6040
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 2 0.6040
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 2 0.6039
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 2 0.6037
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.6033
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6033
Integrin alpha-IIb P08514 ITA2B_HUMAN Homo sapiens 2 0.6032
Insulin-degrading enzyme P14735 IDE_HUMAN Homo sapiens 2 0.6032
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.6029
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.6027
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.6024
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.6023
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.6022
Beta-2-microglobulin P61769 B2MG_HUMAN Homo sapiens 2 0.6021
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 2 0.6021
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.6018
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.6018
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 2 0.6017
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.6017
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.6017
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 2 0.6015
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.6014
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.6014
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.6013
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 2 0.6012
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.6011
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.6011
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.6011
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.6011
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.6010
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.6009
Gibberellin receptor GID1 Q6L545 GID1_ORYSJ Oryza sativa subsp. japonica 2 0.6008
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.6008
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.6007
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.6007
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.6004
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.6004
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.6003
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.6002
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.6002
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.6002
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 2 0.6001
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.5999
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.5995
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5994
Macrophage metalloelastase P39900 MMP12_HUMAN Homo sapiens 2 0.5993
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.5990
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5990
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 2 0.5989
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 2 0.5989
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.5988
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.5988
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.5985
Galactoside O-acetyltransferase P07464 THGA_ECOLI Escherichia coli 2 0.5985
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.5983
Adenosine monophosphate-protein transferase Q8ZVF7 Q8ZVF7_PYRAE Pyrobaculum aerophilum 2 0.5979
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.5978
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 2 0.5978
cAMP-activated global transcriptional regulator Vfr P55222 VFR_PSEAE Pseudomonas aeruginosa 2 0.5977
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.5976
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 2 0.5976
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.5975
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5974
Cathepsin S P25774 CATS_HUMAN Homo sapiens 2 0.5973
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5972
Acetolactate synthase catalytic subunit, mitochondrial P07342 ILVB_YEAST Saccharomyces cerevisiae 2 0.5971
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 2 0.5969
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.5969
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 2 0.5968
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.5966
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.5965
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.5964
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.5964
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.5963
Genome polyprotein Q6YMS4 POLG_DEN3S Dengue virus type 3 2 0.5963
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.5962
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5962
Cell division control protein 42 homolog P60953 CDC42_HUMAN Homo sapiens 2 0.5962
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 2 0.5960
Purine nucleoside phosphorylase DeoD-type 1 Q9KPM0 DEOD1_VIBCH Vibrio cholerae serotype O1 2 0.5960
Carnitine O-palmitoyltransferase 2, mitochondrial P18886 CPT2_RAT Rattus norvegicus 2 0.5958
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.5956
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.5956
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.5955
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 2 0.5955
Protease O38896 O38896_9HIV1 Human immunodeficiency virus 1 2 0.5954
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 O88704 HCN1_MOUSE Mus musculus 2 0.5954
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 2 0.5953
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.5952
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.5952
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.5952
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.5951
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.5951
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.5950
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.5947
Nicotinamide riboside kinase 1 Q9NWW6 NRK1_HUMAN Homo sapiens 2 0.5946
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.5944
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.5942
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.5942
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5941
4-hydroxyphenylacetate 3-monooxygenase, reductase component Q5SJP7 HPAC_THET8 Thermus thermophilus 2 0.5940
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.5939
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5937
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 2 0.5937
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.5936
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 2 0.5935
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 2 0.5932
Bifunctional protein GlmU P43889 GLMU_HAEIN Haemophilus influenzae 2 0.5931
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Q9UL51 HCN2_HUMAN Homo sapiens 2 0.5931
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.5930
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 2 0.5930
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.5929
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.5928
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 2 0.5928
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5928
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5927
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5927
Chromosomal replication initiator protein DnaA P46798 DNAA_THEMA Thermotoga maritima 2 0.5926
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.5926
MutT/nudix family protein O33199 O33199_MYCTO Mycobacterium tuberculosis 2 0.5921
Nicotinamide phosphoribosyltransferase Q80Z29 NAMPT_RAT Rattus norvegicus 2 0.5918
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.5918
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5918
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.5917
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 2 0.5915
Beta-galactoside alpha-2,6-sialyltransferase 1 P15907 SIAT1_HUMAN Homo sapiens 2 0.5912
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.5908
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 2 0.5908
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5907
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 2 0.5906
ALK tyrosine kinase receptor Q9UM73 ALK_HUMAN Homo sapiens 2 0.5903
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.5902
Threonine--tRNA ligase P0A8M3 SYT_ECOLI Escherichia coli 2 0.5901
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5901
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.5900
Purine phosphoribosyltransferase (GpT-1) Q97W95 Q97W95_SACS2 Saccharolobus solfataricus 2 0.5900
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.5899
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 2 0.5899
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.5897
Benzoylformate decarboxylase P20906 MDLC_PSEPU Pseudomonas putida 2 0.5897
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.5896
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5896
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5895
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5895
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.5893
Decaprenylphosphoryl-beta-D-ribose oxidase I6X8C4 I6X8C4_MYCTU Mycobacterium tuberculosis 2 0.5893
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.5892
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 2 0.5891
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.5891
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 2 0.5888
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.5887
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5886
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.5886
Heat shock cognate 71 kDa protein P11142 HSP7C_HUMAN Homo sapiens 2 0.5884
Methyltransferase type 12 Q88JU2 Q88JU2_PSEPK Pseudomonas putida 2 0.5884
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5883
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.5883
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5882
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 2 0.5881
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic Q1XH05 HGL1B_WHEAT Triticum aestivum 2 0.5881
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.5880
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 2 0.5879
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5878
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.5878
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.5878
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 2 0.5877
Oxygenase Q194P4 Q194P4_STRAA Streptomyces argillaceus 2 0.5876
Cystathionine gamma-synthase P56069 METB_HELPY Helicobacter pylori 2 0.5872
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 2 0.5872
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 2 0.5871
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.5870
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 2 0.5870
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.5870
Cyclic nucleotide-gated potassium channel mll3241 Q98GN8 CNGK1_RHILO Mesorhizobium japonicum) 2 0.5870
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.5869
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 2 0.5869
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.5868
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5867
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5866
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.5865
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.5865
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5864
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 2 0.5863
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.5862
Type II methyltransferase M.HhaI P05102 MTH1_HAEPH Haemophilus parahaemolyticus 2 0.5860
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.5860
Serine protease 1 P00760 TRY1_BOVIN Bos taurus 3 0.5858
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 2 0.5858
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.5858
Adenine DNA glycosylase P83847 MUTY_GEOSE Geobacillus stearothermophilus 2 0.5858
Tannase B3Y018 B3Y018_LACPN Lactiplantibacillus plantarum 2 0.5856
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.5856
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.5855
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5855
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 2 0.5854
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.5854
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 2 0.5852
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 2 0.5852
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5850
Xylose isomerase P12070 XYLA_ARTS7 Arthrobacter sp 2 0.5850
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.5848
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 2 0.5847
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 2 0.5847
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.5846
Ascorbate-specific PTS system EIIC component P39301 ULAA_ECOLI Escherichia coli 2 0.5845
Nucleoside diphosphate kinase, cytosolic P22887 NDKC_DICDI Dictyostelium discoideum 2 0.5844
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.5844
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5843
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 2 0.5839
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5839
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.5838
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.5834
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5834
Putative cysteine ligase BshC P55342 BSHC_BACSU Bacillus subtilis 2 0.5833
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.5833
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.5833
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5832
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.5830
Dipeptidyl peptidase 4 P14740 DPP4_RAT Rattus norvegicus 2 0.5830
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.5829
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5828
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5828
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 3 0.5827
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5825
Cytochrome P450 2C9 P11712 CP2C9_HUMAN Homo sapiens 2 0.5825
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 2 0.5825
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.5824
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.5824
Endoglycoceramidase II O33853 O33853_RHOSO Rhodococcus sp 2 0.5822
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 2 0.5820
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 2 0.5818
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5818
23S rRNA (guanine(745)-N(1))-methyltransferase P36999 RLMA_ECOLI Escherichia coli 2 0.5815
Catabolite activator protein C3SQJ7 C3SQJ7_ECOLX Escherichia coli 2 0.5813
Vanillyl-alcohol oxidase P56216 VAOX_PENSI Penicillium simplicissimum 2 0.5812
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5812
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.5811
Cytosolic heat shock protein 90 Q7XJ80 Q7XJ80_HORVU Hordeum vulgare 2 0.5810
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.5810
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 2 0.5809
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 2 0.5806
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5806
Lactaldehyde dehydrogenase P25553 ALDA_ECOLI Escherichia coli 2 0.5803
N-acetylhexosamine 1-kinase E8MF12 NAHK_BIFL2 Bifidobacterium longum subsp. longum 2 0.5803
Bifunctional purine biosynthesis protein ATIC P31335 PUR9_CHICK Gallus gallus 2 0.5802
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5801
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.5799
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.5796
CMP/hydroxymethyl CMP hydrolase B4Y381 B4Y381_9ACTN Streptomyces rimofaciens 2 0.5796
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5796
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5795
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 2 0.5794
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 2 0.5794
Beta-elicitin cinnamomin P15569 ELIB_PHYCI Phytophthora cinnamomi 2 0.5792
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5792
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.5792
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 2 0.5791
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.5791
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 2 0.5790
DNA (cytosine-5)-methyltransferase 1 Q9AXT8 H32_ARATH Zea mays 2 0.5789
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.5789
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.5788
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5785
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.5785
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 2 0.5785
LD-carboxypeptidase A0A6L8PVW7 A0A1Q4LWC0_BACAN Bacillus anthracis 2 0.5783
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 2 0.5783
Insulin-like growth factor 1 receptor P08069 IGF1R_HUMAN Homo sapiens 2 0.5782
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.5782
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.5780
1-aminocyclopropane-1-carboxylate deaminase Q7M523 1A1D_CYBSA Cyberlindnera saturnus 2 0.5779
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5779
Ras-related protein Rap-1b P61224 RAP1B_HUMAN Homo sapiens 2 0.5779
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5777
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 2 0.5776
Shikimate dehydrogenase (NADP(+)) O67049 AROE_AQUAE Aquifex aeolicus 2 0.5773
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5772
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 2 0.5772
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 2 0.5772
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5771
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.5770
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 2 0.5769
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 2 0.5769
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.5768
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.5766
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5766
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.5764
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.5764
Egl nine homolog 1 Q9GZT9 EGLN1_HUMAN Homo sapiens 2 0.5764
ATP-dependent Clp protease ATP-binding subunit ClpX O25926 CLPX_HELPY Helicobacter pylori 2 0.5763
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 2 0.5762
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5762
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 2 0.5761
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.5760
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 2 0.5759
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.5759
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.5758
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.5757
Egl nine homolog 1 Q9GZT9 EGLN1_HUMAN Homo sapiens 2 0.5757
DNA-binding transcriptional dual regulator CRP P0ACJ8 CRP_ECOLI Escherichia coli 2 0.5757
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5756
Glucocorticoid receptor P04150 GCR_HUMAN Homo sapiens 2 0.5752
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.5751
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5751
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 2 0.5749
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 2 0.5748
Genome polyprotein Q8QL64 Q8QL64_9FLAV Modoc virus 2 0.5748
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.5746
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 2 0.5745
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.5744
PTS system glucose-specific EIIA component P69783 PTGA_ECOLI Escherichia coli 2 0.5742
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.5742
Aminopeptidase A2V759 A2V759_9BACL Aneurinibacillus sp. AM-1 2 0.5741
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 2 0.5741
Cysteine synthase 1 P47998 CYSK1_ARATH Arabidopsis thaliana 2 0.5740
Copper-transporting ATPase 1 Q04656 ATP7A_HUMAN Homo sapiens 2 0.5738
16S rRNA (adenine(1408)-N(1))-methyltransferase A8C927 NPMA_ECOLX Escherichia coli 2 0.5738
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.5737
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.5735
Type II methyltransferase M1.MboII P23192 MTM2_MORBO Moraxella bovis 2 0.5732
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.5732
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.5732
Mevalonate kinase P17256 KIME_RAT Rattus norvegicus 2 0.5731
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5731
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 2 0.5731
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.5731
Mismatch repair endonuclease PMS2 P54278 PMS2_HUMAN Homo sapiens 2 0.5730
Alpha-aminoadipic semialdehyde dehydrogenase P49419 AL7A1_HUMAN Homo sapiens 2 0.5730
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.5730
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.5729
GMP reductase 2 Q9P2T1 GMPR2_HUMAN Homo sapiens 2 0.5728
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.5727
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5727
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.5724
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.5724
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5722
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5722
HD domain protein Q836G9 Q836G9_ENTFA Enterococcus faecalis 2 0.5722
YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein Q5SHN1 Q5SHN1_THET8 Thermus thermophilus 2 0.5721
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 2 0.5720
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.5720
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5719
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.5719
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.5718
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 2 0.5717
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.5717
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 2 0.5714
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.5713
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 2 0.5713
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.5713
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 2 0.5712
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.5711
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 2 0.5710
Annexin A5 P08758 ANXA5_HUMAN Homo sapiens 2 0.5710
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.5709
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.5707
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5706
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 2 0.5705
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.5704
eIF-2-alpha kinase GCN2 P15442 GCN2_YEAST Saccharomyces cerevisiae 2 0.5703
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.5702
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 2 0.5702
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.5702
Cyclic nucleotide-binding domain-containing protein E0RR11 E0RR11_SPITD Spirochaeta thermophila 2 0.5702
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 2 0.5700
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5700
Malate dehydrogenase P10584 MDH_THETH Thermus thermophilus 2 0.5699
Adenosine kinase Q9TVW2 ADK_TOXGO Toxoplasma gondii 2 0.5699
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 2 0.5699
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 2 0.5698
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 2 0.5698
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 2 0.5697
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 2 0.5697
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 2 0.5695
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5694
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.5694
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.5694
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5693
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5693
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5692
Tyrosine-protein kinase ABL1 P00519 ABL1_HUMAN Homo sapiens 2 0.5692
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.5691
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.5691
Chaperone protein ClpB Q9RA63 CLPB_THET8 Thermus thermophilus 2 0.5690
Purine nucleoside phosphorylase P50389 PNPH_SACS2 Saccharolobus solfataricus 2 0.5690
Transcriptional activator protein LasR P25084 LASR_PSEAE Pseudomonas aeruginosa 2 0.5684
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.5683
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 2 0.5683
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.5682
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 2 0.5682
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.5681
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.5680
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5679
5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Q8U0R7 PURP_PYRFU Pyrococcus furiosus 2 0.5678
5'-methylthioadenosine nucleosidase / s-adenosylhomocysteine nucleosidase Q8YBL1 Q8YBL1_BRUME Brucella melitensis biotype 1 2 0.5677
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 2 0.5676
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.5676
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5676
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 2 0.5675
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.5675
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 2 0.5675
Avidin P02701 AVID_CHICK Gallus gallus 2 0.5674
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5674
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial P11310 ACADM_HUMAN Homo sapiens 2 0.5673
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 2 0.5673
DNA double-strand break repair protein Mre11 Q9X1X0 Q9X1X0_THEMA Thermotoga maritima MSB8 2 0.5672
ATP-dependent 6-phosphofructokinase isozyme 2 P06999 PFKB_ECOLI Escherichia coli 2 0.5672
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.5670
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 2 0.5668
M17 leucyl aminopeptidase Q8IL11 Q8IL11_PLAF7 Plasmodium falciparum 2 0.5668
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5667
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.5666
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 2 0.5665
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 2 0.5665
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 2 0.5664
Hydroxyethylthiazole kinase Q830K4 THIM_ENTFA Enterococcus faecalis 2 0.5664
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 2 0.5664
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5663
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 2 0.5662
Ribosomal RNA small subunit methyltransferase Nep1 Q57977 NEP1_METJA Methanocaldococcus jannaschii 2 0.5661
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 2 0.5660
Caffeoyl-CoA O-methyltransferase Q40313 CAMT_MEDSA Medicago sativa 2 0.5658
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 2 0.5658
Acetylornithine/succinyldiaminopimelate aminotransferase P40732 ARGD_SALTY Salmonella typhimurium 2 0.5658
Metallo-beta-lactamase type 2 C7C422 BLAN1_KLEPN Klebsiella pneumoniae 2 0.5657
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5657
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.5656
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5655
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.5654
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 2 0.5654
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.5654
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.5653
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.5653
S-methyl-5'-thioadenosine phosphorylase Q97W94 MTAP_SACS2 Saccharolobus solfataricus 2 0.5653
Purine nucleoside phosphorylase DeoD-type P0ABP9 DEOD_ECO57 Escherichia coli O157:H7 2 0.5652
L-methionine gamma-lyase P13254 MEGL_PSEPU Pseudomonas putida 2 0.5651
Mitochondrial dynamics protein MIEF1 Q9NQG6 MID51_HUMAN Homo sapiens 1 0.5651
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5650
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.5650
Glucosidase II subunit alpha Q9STC1 Q9STC1_GRALE Gracilariopsis lemaneiformis 2 0.5650
Mitogen-activated protein kinase kinase kinase 7 O43318 M3K7_HUMAN Homo sapiens 2 0.5649
Nucleoside diphosphate kinase, cytosolic P22887 NDKC_DICDI Dictyostelium discoideum 2 0.5648
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 2 0.5648
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5648
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5648
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5647
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.5646
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 2 0.5645
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 2 0.5644
7alpha-hydroxysteroid dehydrogenase P0AET8 HDHA_ECOLI Escherichia coli 3 0.5643
Fatty acid-binding protein, intestinal P02693 FABPI_RAT Rattus norvegicus 3 0.5643
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5642
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5641
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.5640
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 2 0.5639
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase P47229 BPHD_PARXL Paraburkholderia xenovorans 2 0.5639
Cytosol aminopeptidase O86436 AMPA_PSEPU Pseudomonas putida 2 0.5638
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 2 0.5636
Retinal dehydrogenase 2 O94788 AL1A2_HUMAN Homo sapiens 2 0.5636
Abscisic acid receptor PYL10 Q8H1R0 PYL10_ARATH Arabidopsis thaliana 2 0.5635
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5635
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.5635
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5635
Rho-associated protein kinase 1 Q13464 ROCK1_HUMAN Homo sapiens 2 0.5634
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.5633
Transcriptional activator protein LasR P25084 LASR_PSEAE Pseudomonas aeruginosa 2 0.5632
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5632
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.5632
Ethylene receptor 1 P49333 ETR1_ARATH Arabidopsis thaliana 2 0.5631
Serine/threonine-protein kinase RIO1 Q9BRS2 RIOK1_HUMAN Homo sapiens 2 0.5628
Phosphomethylpyrimidine synthase, chloroplastic O82392 THIC_ARATH Arabidopsis thaliana 2 0.5628
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.5627
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5626
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5624
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5624
Lipoprotein E P26093 HEL_HAEIN Haemophilus influenzae 2 0.5623
[LysW]-aminoadipate kinase O50147 LYSZ_THET2 Thermus thermophilus 2 0.5622
Type 4 fimbrial biogenesis protein PilM G3XD28 G3XD28_PSEAE Pseudomonas aeruginosa 2 0.5622
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5622
Plasmid partition protein A P07620 PARA_ECOLX Escherichia coli 2 0.5622
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5622
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 2 0.5621
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5620
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 2 0.5620
Biphenyl dioxygenase ferredoxin reductase subunit E7FJB9 E7FJB9_9BURK Acidovorax sp. KKS102 2 0.5620
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5619
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5618
ATP-dependent protease ATPase subunit HslU P43773 HSLU_HAEIN Haemophilus influenzae 2 0.5618
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 2 0.5618
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 2 0.5618
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5617
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.5616
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 2 0.5615
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.5615
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.5615
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.5614
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5614
UDP-N-acetylbacillosamine N-acetyltransferase Q0P9D1 PGLD_CAMJE Campylobacter jejuni subsp. jejuni serotype O:2 2 0.5614
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.5613
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 2 0.5612
Orf1a polyprotein Q692E5 Q692E5_CVHSA SARS coronavirus TJF 2 0.5612
(R)-S-adenosyl-L-methionine hydrolase O58212 O58212_PYRHO Pyrococcus horikoshii OT3 2 0.5611
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 2 0.5607
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.5607
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 2 0.5606
SRSF protein kinase 1 Q96SB4 SRPK1_HUMAN Homo sapiens 2 0.5605
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.5605
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 2 0.5604
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 2 0.5604
Ferredoxin--NADP reductase, chloroplastic P00455 FENR_SPIOL Spinacia oleracea 2 0.5604
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.5604
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.5603
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 2 0.5602
Glycogen synthase P0A6U8 GLGA_ECOLI Escherichia coli 2 0.5602
Cysteine synthase P45040 CYSK_HAEIN Haemophilus influenzae 2 0.5601
Eukaryotic translation initiation factor 2 subunit alpha P20459 IF2A_YEAST Saccharomyces cerevisiae 2 0.5601
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.5599
ADP-dependent (S)-NAD(P)H-hydrate dehydratase P94368 NNRD_BACSU Bacillus subtilis 2 0.5599
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5599
Serine/threonine-protein kinase PLK Q4KMI8 Q4KMI8_DANRE Danio rerio 2 0.5596
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.5595
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 2 0.5595
Heat shock protein 83 P12861 HSP83_TRYBB Trypanosoma brucei brucei 2 0.5595
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 2 0.5595
Indole-3-glycerol phosphate synthase P9WFX7 TRPC_MYCTU Mycobacterium tuberculosis 1 0.5594
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.5593
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 2 0.5591
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.5589
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5589
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.5588
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 2 0.5588
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 2 0.5587
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.5587
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5587
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.5584
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5583
Methionine aminopeptidase 2 P9WK19 MAP12_MYCTU Mycobacterium tuberculosis 2 0.5581
Precorrin-3 methylase O68097 O68097_RHOCA Rhodobacter capsulatus 2 0.5580
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.5580
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 2 0.5579
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 2 0.5579
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5579
EhpF Q8GPH0 Q8GPH0_ENTAG Enterobacter agglomerans 2 0.5575
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.5574
Bile acid receptor Q96RI1 NR1H4_HUMAN Homo sapiens 2 0.5570
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.5570
Argininosuccinate synthase P59846 ASSY_THET8 Thermus thermophilus 2 0.5570
Spermidine synthase P19623 SPEE_HUMAN Homo sapiens 2 0.5570
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.5569
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5568
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.5567
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 2 0.5567
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.5566
Avidin P02701 AVID_CHICK Gallus gallus 2 0.5566
Probable enoyl-CoA hydratase EchA8 P9WNN9 ECHA8_MYCTU Mycobacterium tuberculosis 2 0.5565
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 2 0.5565
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5565
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.5562
Orotidine 5'-phosphate decarboxylase Q5L0U0 PYRF_GEOKA Geobacillus kaustophilus 2 0.5561
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5560
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.5560
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 2 0.5560
Sodium/potassium-transporting ATPase subunit alpha Q4H132 Q4H132_SQUAC Squalus acanthias 2 0.5558
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5556
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.5555
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.5555
Genome polyprotein P12823 POLG_DEN2P Dengue virus type 2 2 0.5555
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5555
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.5554
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5554
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 2 0.5553
Nucleoside diphosphate kinase Q381H3 Q381H3_TRYB2 Trypanosoma brucei brucei 2 0.5553
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5553
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5552
Aminopeptidase N P04825 AMPN_ECOLI Escherichia coli 2 0.5550
Guanylate kinase P15454 KGUA_YEAST Saccharomyces cerevisiae 2 0.5550
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 2 0.5549
2-keto-3-deoxy-gluconate kinase Q96XN9 Q96XN9_SULTO Sulfolobus tokodaii 2 0.5549
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 2 0.5549
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 2 0.5546
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.5546
Ribosomal RNA large subunit methyltransferase H P0C1V0 RLMH_STAAU Staphylococcus aureus 2 0.5544
DNA (cytosine-5)-methyltransferase 3A O88508 DNM3A_MOUSE Mus musculus 2 0.5543
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.5543
Alcaligin biosynthesis protein Q7W557 Q7W557_BORPA Bordetella parapertussis 2 0.5543
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 2 0.5542
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 2 0.5540
GTP 3',8-cyclase P69848 MOAA_STAA8 Staphylococcus aureus 2 0.5539
Anti-sigma F factor O32727 SP2AB_GEOSE Geobacillus stearothermophilus 2 0.5539
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 2 0.5538
Nucleoprotein P13699 NCAP_LASSJ Lassa virus 2 0.5538
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5538
Carboxyethyl-arginine beta-lactam-synthase P0DJQ7 BLS_STRCL Streptomyces clavuligerus 2 0.5536
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.5535
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5534
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.5533
Thyroid hormone receptor alpha P04625 THA_CHICK Gallus gallus 2 0.5532
Genome polyprotein P29991 POLG_DEN27 Dengue virus type 2 2 0.5531
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 2 0.5530
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.5529
Psp operon transcriptional activator P37344 PSPF_ECOLI Escherichia coli 2 0.5527
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5526
Gibberellin receptor GID1A Q9MAA7 GID1A_ARATH Arabidopsis thaliana 2 0.5526
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.5526
Serine/threonine-protein kinase CtkA Q9ZKJ5 CTKA_HELPJ Helicobacter pylori 2 0.5526
Pyruvate:ferredoxin oxidoreductase P94692 PFOR_DESAF Desulfocurvibacter africanus 2 0.5526
ATP-dependent protease subunit HslV P0A7B8 HSLV_ECOLI Escherichia coli 2 0.5526
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 2 0.5525
ADP-dependent (S)-NAD(P)H-hydrate dehydratase P94368 NNRD_BACSU Bacillus subtilis 2 0.5523
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5522
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.5522
Mitogen-activated protein kinase kinase kinase 21 Q5TCX8 M3K21_HUMAN Homo sapiens 2 0.5521
Methyltransferase D0VX01 D0VX01_WSLV Wesselsbron virus 2 0.5519
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 2 0.5518
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5517
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.5516
Pyruvate:ferredoxin oxidoreductase P94692 PFOR_DESAF Desulfocurvibacter africanus 2 0.5516
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 2 0.5513
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.5513
Cytosine-specific methyltransferase Q8EVR5 Q8EVR5_MYCPE Mycoplasma penetrans 2 0.5511
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.5511
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.5508
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.5506
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.5506
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.5505
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 2 0.5502
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 2 0.5501
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.5501
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5501
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.5500
Glutamate dehydrogenase 1, mitochondrial P00366 DHE3_BOVIN Bos taurus 2 0.5500
Tryptophan synthase beta chain 1 Q8U093 TRPB1_PYRFU Pyrococcus furiosus 2 0.5500
Ribosomal protein S6 kinase alpha-1 Q15418 KS6A1_HUMAN Homo sapiens 2 0.5498
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5498
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5498
Thiamine-monophosphate kinase O67883 THIL_AQUAE Aquifex aeolicus 2 0.5496
E3 ubiquitin-protein ligase RNF31 Q96EP0 RNF31_HUMAN Homo sapiens 2 0.5496
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5494
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 2 0.5493
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.5490
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 2 0.5489
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 2 0.5489
Serine/threonine-protein kinase CtkA Q9ZKJ5 CTKA_HELPJ Helicobacter pylori 2 0.5489
Vitamin B12 import system permease protein BtuC P06609 BTUC_ECOLI Escherichia coli 2 0.5489
Gene 2 protein Q716H3 Q716H3_BPSFV Shigella phage Sf6 2 0.5488
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 2 0.5485
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.5484
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5484
Retinoic acid receptor RXR-alpha P28700 RXRA_MOUSE Mus musculus 2 0.5483
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 2 0.5483
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5480
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 2 0.5480
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 2 0.5475
3-hydroxy-3-methylglutaryl-coenzyme A reductase P04035 HMDH_HUMAN Homo sapiens 2 0.5475
Release factor glutamine methyltransferase Q9WYV8 PRMC_THEMA Thermotoga maritima 2 0.5474
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 2 0.5473
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5473
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 2 0.5471
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5471
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.5470
Epoxide hydrolase LasB B6ZK72 LSD19_STRLS Streptomyces lasalocidi 3 0.5467
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 2 0.5467
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5466
Gag-Pol polyprotein P0C6F2 POL_HV1LW Human immunodeficiency virus type 1 group M subtype B 2 0.5465
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 2 0.5464
5'-methylthioadenosine nucleosidase Q9T0I8 MTN1_ARATH Arabidopsis thaliana 2 0.5464
Avd protein A7YYL1 A7YYL1_XENTR Xenopus tropicalis 2 0.5463
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 2 0.5462
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5462
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5461
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.5461
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 2 0.5460
Signaling protein P83820 P83820_THETH Thermus thermophilus 2 0.5458
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5456
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5456
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5456
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5455
tRNA (cytidine-2'-O-)-methyltransferase TrmJ Q4JB16 TRMJ_SULAC Sulfolobus acidocaldarius 2 0.5454
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 2 0.5453
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5453
Methionine--tRNA ligase P00959 SYM_ECOLI Escherichia coli 3 0.5451
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.5450
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5448
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5446
Putative snRNP Sm-like protein Q8ZYG5 Q8ZYG5_PYRAE Pyrobaculum aerophilum 1 0.5446
Avidin P02701 AVID_CHICK Gallus gallus 2 0.5444
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.5444
7-alpha-hydroxysteroid deydrogenase G9FRD7 G9FRD7_9CLOT Clostridium sardiniense 2 0.5443
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5441
histidine kinase Q9WZV7 Q9WZV7_THEMA Thermotoga maritima 2 0.5440
tRNA (cytidine(34)-2'-O)-methyltransferase P44868 TRML_HAEIN Haemophilus influenzae 2 0.5440
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 2 0.5440
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5438
Trimethylamine monooxygenase Q83XK4 Q83XK4_9GAMM Methylophaga aminisulfidivorans 2 0.5438
Transitional endoplasmic reticulum ATPase P55072 TERA_HUMAN Homo sapiens 2 0.5436
DNA ligase P43813 DNLJ_HAEIN Haemophilus influenzae 2 0.5432
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5431
Mannosylglycerate synthase D0MI02 D0MI02_RHOM4 Rhodothermus marinus 2 0.5430
Genome polyprotein A9LIE0 A9LIE0_9FLAV dengue virus type 3 2 0.5427
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 2 0.5426
Genome polyprotein Q2YHF0 POLG_DEN4T Dengue virus type 4 2 0.5426
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5425
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 2 0.5425
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 2 0.5423
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5422
Type IV pilus retractation ATPase PilT P24559 PILT_PSEAE Pseudomonas aeruginosa 2 0.5422
Cobalamin synthesis related protein Q6NIF5 Q6NIF5_CORDI Corynebacterium diphtheriae 2 0.5422
Avidin P02701 AVID_CHICK Gallus gallus 2 0.5421
dTDP-fucosamine acetyltransferase Q8FBQ3 WECD_ECOL6 Escherichia coli O6:H1 2 0.5421
Putative aminoglycoside phosphotransferase P9WI99 Y3168_MYCTU Mycobacterium tuberculosis 2 0.5420
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5419
Glucosamine 6-phosphate N-acetyltransferase Q17427 GNA1_CAEEL Caenorhabditis elegans 2 0.5418
Heat shock 70 kDa protein 1A P0DMV8 HS71A_HUMAN Homo sapiens 2 0.5417
Lactose operon repressor P03023 LACI_ECOLI Escherichia coli 2 0.5416
3-dehydroquinate dehydratase Q48255 AROQ_HELPY Helicobacter pylori 2 0.5414
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.5413
RNA 2'-O ribose methyltransferase Q5SLL8 Q5SLL8_THET8 Thermus thermophilus 2 0.5413
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 2 0.5412
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 3 0.5410
Pantothenate kinase P9WPA7 COAA_MYCTU Mycobacterium tuberculosis 1 0.5410
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5408
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5407
Receptor-interacting serine/threonine-protein kinase 1 Q13546 RIPK1_HUMAN Homo sapiens 2 0.5407
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.5402
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 2 0.5401
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.5401
Uncharacterized PhzA/B-like protein PA3332 Q9HYR3 Y3332_PSEAE Pseudomonas aeruginosa 2 0.5399
Plasmid segregation protein ParM P11904 PARM_ECOLX Escherichia coli 2 0.5399
Activated CDC42 kinase 1 Q07912 ACK1_HUMAN Homo sapiens 2 0.5398
Heat shock cognate 71 kDa protein P19120 HSP7C_BOVIN Bos taurus 2 0.5396
Transitional endoplasmic reticulum ATPase Q01853 TERA_MOUSE Mus musculus 2 0.5394
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 2 0.5392
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.5391
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 2 0.5389
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.5387
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 2 0.5387
Thymidylate synthase Q4JQW2 TYSY_VZVO Varicella-zoster virus 2 0.5387
Retinol-binding protein 4 P02753 RET4_HUMAN Homo sapiens 2 0.5386
tRNA (guanine-N(1)-)-methyltransferase Q2GIL5 TRMD_ANAPZ Anaplasma phagocytophilum 2 0.5386
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 2 0.5384
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 2 0.5383
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.5382
Actin-related protein 4 P80428 ARP4_YEAST Saccharomyces cerevisiae 2 0.5374
rRNA methylase Q8DSS3 Q8DSS3_STRMU Streptococcus mutans serotype c 1 0.5372
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 2 0.5370
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 2 0.5368
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5366
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.5365
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 2 0.5364
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 2 0.5362
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5359
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.5357
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.5357
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 2 0.5356
Virulence sensor histidine kinase PhoQ P0DM80 PHOQ_SALTY Salmonella typhimurium 2 0.5355
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5354
L-glutamine synthetase Q1QZR8 Q1QZR8_CHRSD Chromohalobacter salexigens 2 0.5348
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 2 0.5347
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 2 0.5346
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5338
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5337
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 2 0.5335
Gastrotropin P10289 FABP6_PIG Sus scrofa 2 0.5333
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.5332
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5331
Chaperonin Q877G8 Q877G8_METMI Methanococcus maripaludis 2 0.5331
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.5330
Type 4 fimbrial biogenesis protein PilM G3XD28 G3XD28_PSEAE Pseudomonas aeruginosa 2 0.5330
Nitrogen regulatory protein P-II P70731 P70731_AZOBR Azospirillum brasilense 2 0.5329
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 2 0.5327
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.5327
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5325
Extracellular fatty acid-binding protein P21760 EXFAB_CHICK Gallus gallus 2 0.5323
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 2 0.5320
Purine nucleoside phosphorylase Q8I3X4 Q8I3X4_PLAF7 Plasmodium falciparum 2 0.5319
Aspartate-semialdehyde dehydrogenase Q51344 DHAS_PSEAE Pseudomonas aeruginosa 2 0.5319
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.5319
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 2 0.5317
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 1 0.5316
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.5315
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.5314
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 2 0.5313
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.5313
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 2 0.5312
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 2 0.5305
Isochorismate pyruvate lyase Q51507 PCHB_PSEAE Pseudomonas aeruginosa 1 0.5304
Cytochrome b-c1 complex subunit 1, mitochondrial P31800 QCR1_BOVIN Bos taurus 2 0.5302
Glycolate oxidase P05414 GOX_SPIOL Spinacia oleracea 3 0.5301
Purine nucleoside phosphorylase P50389 PNPH_SACS2 Saccharolobus solfataricus 2 0.5301
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 1 0.5299
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5295
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5295
Uncharacterized protein Q46E79 Q46E79_METBF Methanosarcina barkeri 2 0.5294
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5284
5-hydroxytryptamine receptor 2B P41595 5HT2B_HUMAN Homo sapiens 2 0.5284
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5275
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Q16836 HCDH_HUMAN Homo sapiens 2 0.5270
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.5269
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 2 0.5269
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 1 0.5266
6-phosphogluconate dehydrogenase, decarboxylating P96789 6PGD_LACLM Lactococcus lactis subsp. cremoris 2 0.5264
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.5263
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 1 0.5263
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5259
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 2 0.5256
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.5255
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.5252
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5250
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.5247
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 2 0.5246
Bifunctional dihydrofolate reductase-thymidylate synthase Q27793 DRTS_TRYCR Trypanosoma cruzi 1 0.5246
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.5244
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5238
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 2 0.5237
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 2 0.5232
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5231
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.5224
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5223
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5222
Dihydroorotate dehydrogenase (quinone), mitochondrial Q63707 PYRD_RAT Rattus norvegicus 2 0.5220
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 2 0.5216
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.5216
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.5216
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.5213
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5212
CRP-like cAMP-activated global transcriptional regulator P9WMH3 CRPL_MYCTU Mycobacterium tuberculosis 2 0.5212
1-deoxy-D-xylulose 5-phosphate reductoisomerase Q9X5F2 DXR_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.5212
3',5'-cyclic-AMP phosphodiesterase 4B Q07343 PDE4B_HUMAN Homo sapiens 2 0.5212
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5211
Geranyl diphosphate synthase large subunit Q9SBR3 Q9SBR3_MENPI Mentha piperita 2 0.5207
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.5203
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 1 0.5199
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 2 0.5196
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 3 0.5195
Elongation factor Tu 1 P0CE47 EFTU1_ECOLI Escherichia coli 2 0.5195
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 2 0.5195
Peptide deformylase 1B, chloroplastic/mitochondrial Q9FUZ2 DEF1B_ARATH Arabidopsis thaliana 2 0.5195
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.5191
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 2 0.5185
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 2 0.5185
Alpha-tocopherol transfer protein Q8BWP5 TTPA_MOUSE Mus musculus 3 0.5183
Aclacinomycin methylesterase RdmC Q54528 RDMC_STREF Streptomyces purpurascens 3 0.5183
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 1 0.5183
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 2 0.5179
Arginine kinase O15992 KARG_ANTJA Anthopleura japonica 1 0.5178
Adenosine 5'-monophosphoramidase HINT1 P80912 HINT1_RABIT Oryctolagus cuniculus 1 0.5177
D-alanine aminotransferase P19938 DAAA_BACYM Bacillus sp 1 0.5176
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 2 0.5175
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5174
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.5173
AGAP001556-PA Q7PXT9 Q7PXT9_ANOGA Anopheles gambiae 2 0.5173
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5167
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 2 0.5167
tRNA-specific 2-thiouridylase MnmA Q97T38 MNMA_STRPN Streptococcus pneumoniae serotype 4 2 0.5163
cAMP-dependent protein kinase regulatory subunit P07278 KAPR_YEAST Saccharomyces cerevisiae 2 0.5161
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 2 0.5160
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5158
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 2 0.5158
Avidin P02701 AVID_CHICK Gallus gallus 1 0.5156
Stimulator of interferon genes protein Q86WV6 STING_HUMAN Homo sapiens 2 0.5155
Apoptosis regulator Bcl-2 P10415 BCL2_HUMAN Homo sapiens 2 0.5155
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic P49235 HGGL1_MAIZE Zea mays 1 0.5154
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 P28907 CD38_HUMAN Homo sapiens 2 0.5153
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5152
Nucleoside diphosphate kinase Q5SLV5 NDK_THET8 Thermus thermophilus 1 0.5149
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 2 0.5148
Cyclic GMP-AMP synthase Q9KVG7 DNCV_VIBCH Vibrio cholerae serotype O1 2 0.5145
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 2 0.5145
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5144
Collagenase 3 P45452 MMP13_HUMAN Homo sapiens 2 0.5143
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 2 0.5143
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 2 0.5142
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 1 0.5141
Uridine phosphorylase P12758 UDP_ECOLI Escherichia coli 2 0.5140
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5138
Acetylglutamate kinase, chloroplastic Q9SCL7 NAGK_ARATH Arabidopsis thaliana 2 0.5138
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.5137
p-hydroxybenzoate hydroxylase P00438 PHHY_PSEFL Pseudomonas fluorescens 2 0.5136
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 1 0.5134
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.5133
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 2 0.5133
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 2 0.5130
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5129
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.5129
Carbonic anhydrase 13 Q8N1Q1 CAH13_HUMAN Homo sapiens 2 0.5129
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 1 0.5125
Peptidoglycan recognition protein 1 Q9GK12 PGRP1_CAMDR Camelus dromedarius 2 0.5124
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5123
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 2 0.5122
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5121
Uncharacterized protein MJ0489 Q57913 Y489_METJA Methanocaldococcus jannaschii 2 0.5120
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.5119
Neprilysin P08473 NEP_HUMAN Homo sapiens 2 0.5116
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5114
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5111
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 2 0.5111
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5110
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 2 0.5107
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5107
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5107
Adenosine 5'-monophosphoramidase HINT1 P49773 HINT1_HUMAN Homo sapiens 1 0.5107
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 2 0.5106
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.5105
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.5105
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.5103
Putative repressor SimReg2 Q9AMH9 Q9AMH9_STRAT Streptomyces antibioticus 2 0.5102
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 2 0.5101
CinA-like protein Q5SHB0 Q5SHB0_THET8 Thermus thermophilus 2 0.5098
Cytochrome P450 2C8 P10632 CP2C8_HUMAN Homo sapiens 2 0.5098
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5098
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.5097
Feruloyl esterase A O42807 FAEA_ASPNG Aspergillus niger 1 0.5097
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5095
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 2 0.5094
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 2 0.5094
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.5094
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.5093
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5091
Phytohormone-binding protein G7J032 PHBP_MEDTR Medicago truncatula 3 0.5090
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5090
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.5090
Poly [ADP-ribose] polymerase tankyrase-1 O95271 TNKS1_HUMAN Homo sapiens 3 0.5087
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 2 0.5087
Glycoside Hydrolase Family 13 Q65MI2 Q65MI2_BACLD Bacillus licheniformis 1 0.5087
Methyltransferase O26771 O26771_METTH Methanothermobacter thermautotrophicus 2 0.5084
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.5083
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.5083
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.5082
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 2 0.5082
Beta-glucosidase 12 B8AVF0 BGL12_ORYSI Oryza sativa subsp. indica 1 0.5082
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.5081
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase Q9WY79 MURE_THEMA Thermotoga maritima 2 0.5081
Strictosidine-O-beta-D-glucosidase Q8GU20 SG1_RAUSE Rauvolfia serpentina 2 0.5078
Cyclic GMP-AMP synthase Q8C6L5 CGAS_MOUSE Mus musculus 2 0.5078
GMP reductase 1 P36959 GMPR1_HUMAN Homo sapiens 2 0.5075
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 2 0.5075
Purine nucleoside phosphorylase P55859 PNPH_BOVIN Bos taurus 1 0.5075
Matrilysin P09237 MMP7_HUMAN Homo sapiens 2 0.5074
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.5073
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 2 0.5073
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5072
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 2 0.5071
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 2 0.5071
Gag-Pol polyprotein P04587 POL_HV1B5 Human immunodeficiency virus type 1 group M subtype B 2 0.5068
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.5067
Amidophosphoribosyltransferase P00497 PUR1_BACSU Bacillus subtilis 2 0.5066
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 1 0.5066
Beta-glucuronidase P05804 BGLR_ECOLI Escherichia coli 2 0.5065
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 2 0.5064
Purine nucleoside phosphorylase Q9BMI9 Q9BMI9_SCHMA Schistosoma mansoni 2 0.5063
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) Q91XE4 ACY3_MOUSE Mus musculus 1 0.5063
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 2 0.5062
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.5062
Integrin beta-1-binding protein 1 O14713 ITBP1_HUMAN Homo sapiens 2 0.5060
Nicotinamide riboside transporter PnuC D2ZZC1 PNUC_NEIMU Neisseria mucosa 2 0.5059
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.5057
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5055
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.5055
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5053
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.5051
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 2 0.5050
Inosine-5'-monophosphate dehydrogenase Q756Z6 Q756Z6_ASHGO Ashbya gossypii 2 0.5049
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5048
Endoplasmic reticulum chaperone BiP P11021 BIP_HUMAN Homo sapiens 2 0.5047
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 1 0.5047
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.5045
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 2 0.5045
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.5043
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.5040
DNA adenine methylase P0AEE8 DMA_ECOLI Escherichia coli 2 0.5040
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 2 0.5039
S-methyl-5'-thioadenosine phosphorylase Q13126 MTAP_HUMAN Homo sapiens 2 0.5039
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 1 0.5039
Orf1ab polyprotein Q6T1E9 Q6T1E9_CVHSA SARS coronavirus CUHK-L2 2 0.5038
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 2 0.5037
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 2 0.5037
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.5035
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 2 0.5035
CRP-like cAMP-activated global transcriptional regulator P9WMH3 CRPL_MYCTU Mycobacterium tuberculosis 2 0.5035
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 2 0.5035
Uridine phosphorylase Q9KT71 Q9KT71_VIBCH Vibrio cholerae serotype O1 2 0.5034
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.5033
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.5032
Serine/threonine-protein kinase/endoribonuclease IRE1 Q9EQY0 ERN1_MOUSE Mus musculus 2 0.5031
Pol protein Q000H7 Q000H7_9HIV1 Human immunodeficiency virus 1 2 0.5030
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5030
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.5029
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 2 0.5029
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 2 0.5029
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.5028
Mitogen-activated protein kinase 1 P63086 MK01_RAT Rattus norvegicus 2 0.5027
Aklanonic acid methyl ester cyclase AcmA O52646 DNRD_STRGJ Streptomyces galilaeus 2 0.5026
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.5025
mRNA-capping enzyme subunit alpha P78587 MCE1_CANAX Candida albicans 2 0.5024
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 2 0.5023
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 Q10588 BST1_HUMAN Homo sapiens 2 0.5023
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 1 0.5023
3',5'-cyclic-AMP phosphodiesterase 4A P27815 PDE4A_HUMAN Homo sapiens 2 0.5022
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.5022
Nicotinamide phosphoribosyltransferase P43490 NAMPT_HUMAN Homo sapiens 2 0.5020
Actin-related protein 3 P61157 ARP3_BOVIN Bos taurus 2 0.5020
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 2 0.5019
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.5019
Protein translocase subunit SecA P10408 SECA_ECOLI Escherichia coli 2 0.5018
diphosphomevalonate decarboxylase Q9FD73 Q9FD73_STAEP Staphylococcus epidermidis 1 0.5018
Protein adenylyltransferase and cysteine protease IbpA Q06277 IBPA_HISS2 Histophilus somni 1 0.5018
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.5017
N-glycosylase/DNA lyase O15527 OGG1_HUMAN Homo sapiens 2 0.5017
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5017
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5016
Lactoperoxidase A5JUY8 PERL_BUBBU Bubalus bubalis 2 0.5016
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.5015
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5015
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.5014
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 2 0.5014
Hexokinase-4 P35557 HXK4_HUMAN Homo sapiens 2 0.5013
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5013
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.5012
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.5011
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.5011
Microcin C7 self-immunity protein MccF Q47511 MCCF_ECOLX Escherichia coli 2 0.5011
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 2 0.5010
Disintegrin and metalloproteinase domain-containing protein 17 P78536 ADA17_HUMAN Homo sapiens 2 0.5010
Serine hydroxymethyltransferase Q7SIB6 Q7SIB6_GEOSE Geobacillus stearothermophilus 2 0.5010
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5009
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 2 0.5008
Phosphoribosyl isomerase A P16250 HIS4_STRCO Streptomyces coelicolor / M145) 2 0.5008
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 2 0.5007
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.5007
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.5007
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5006
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.5005
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8RQP5 ISPF_THET8 Thermus thermophilus 2 0.5005
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 1 0.5005
Nicotinamide riboside kinase 1 Q9NWW6 NRK1_HUMAN Homo sapiens 2 0.5004
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 2 0.5003
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.5003
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.5003
Vitamin D3 receptor A Q9PTN2 VDRA_DANRE Danio rerio 2 0.5002
Bifunctional purine biosynthesis protein PurH P9WHM7 PUR9_MYCTU Mycobacterium tuberculosis 2 0.5002
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 2 0.5001
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 2 0.5001
Estrogen receptor beta Q62986 ESR2_RAT Rattus norvegicus 2 0.5000

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