Hexadecanoic acid, ethyl ester - Compound Card

Hexadecanoic acid, ethyl ester

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Hexadecanoic acid, ethyl ester

Structure
Zoomed Structure
  • Family: Plantae - Acanthaceae
  • Kingdom: Plantae
  • Class: Lipid
    • Subclass: Fatty Acid Ester
Canonical Smiles CCCCCCCCCCCCCCCC(=O)OCC
InChI InChI=1S/C18H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20-4-2/h3-17H2,1-2H3
InChIKey XIRNKXNNONJFQO-UHFFFAOYSA-N
Formula C18H36O2
HBA 2
HBD 0
MW 284.48
Rotatable Bonds 15
TPSA 26.3
LogP 6.03
Number Rings 0
Number Aromatic Rings 0
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.94
Exact Mass 284.27
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Acanthospermum hispidum Asteraceae Plantae 182999
2 Eremomastax speciosa Acanthaceae Plantae 37794

Showing of synonyms

  • Eve MO, Alfred TN, et al. (2020). Chemical constituents of Erememostax speciosa (HOCHST.) cufod leaves and its cytotoxic potential on NIH-3T3 cells. Bulletin of the Chemical Society of Ethiopia,2020,34(3),634-640. [View]
  • Mihigo SO, Masesane IB, et al. (2015). Preliminary GC-MS Profiling and Anti-bacterial activity Investigation of Tridax procumbensLinn. (Asteraceae). International Journal of Chemistry and Aquatic Sciences, 2015, 1(1), 55-64. [View]
Pubchem: 12366
Chebi: 84932
Nmrshiftdb2: 10008972
Metabolights: MTBLC84932
CPRiL: 74269

No scaffolds available.

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.85
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-3.62
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.19

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.52
Plasma Protein Binding
32.6
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.75
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.8
Biodegradation
Toxic
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Toxic
Eye Irritation
Toxic
Maximum Tolerated Dose
2.3
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
4.78
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
6.65
Rat (Acute)
1.46
Rat (Chronic Oral)
2.28
Fathead Minnow
4.02
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
324.72
Hydration Free Energy
-0.76
Log(D) at pH=7.4
5.6
Log(P)
7.7
Log S
-6.42
Log(Vapor Pressure)
-4.32
Melting Point
21.75
pKa Acid
11.27
pKa Basic
5.76
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peridinin-chlorophyll a protein, high-salt form O76183 O76183_AMPCA Amphidinium carterae 3 0.9568
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8780
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.8361
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7832
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7740
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7633
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7614
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7596
Sodium/potassium-transporting ATPase subunit alpha Q4H132 Q4H132_SQUAC Squalus acanthias 2 0.7585
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7545
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7531
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7530
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7511
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7506
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7503
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7494
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7486
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7478
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7436
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7358
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7357
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 2 0.7325
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7325
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7302
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7291
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 2 0.7288
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7285
Carnitine O-acetyltransferase P47934 CACP_MOUSE Mus musculus 2 0.7285
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7275
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7241
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7218
thiamine diphosphokinase Q82ZE3 Q82ZE3_ENTFA Enterococcus faecalis 2 0.7178
Pyrrolysine--tRNA ligase Q8PWY1 PYLS_METMA Methanosarcina mazei 2 0.7124
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7116
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7105
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.7097
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7063
Branched-chain-amino-acid aminotransferase, mitochondrial O15382 BCAT2_HUMAN Homo sapiens 2 0.7055
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7037
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.6948
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.6928
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.6902
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.6886
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 2 0.6873
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.6822
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.6813
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.6753
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.6696
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.6574
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.6523
4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase P9WNH5 HSAD_MYCTU Mycobacterium tuberculosis 2 0.6516
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.6515
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.6439
Phospholipase A2 P00593 PA21B_BOVIN Bos taurus 2 0.6396
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 2 0.6365
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 2 0.6334
Gibberellin receptor GID1 Q6L545 GID1_ORYSJ Oryza sativa subsp. japonica 2 0.6259
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.6197
Ferrichrome outer membrane transporter/phage receptor P06971 FHUA_ECOLI Escherichia coli 2 0.6190
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.6150
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.6150
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.6140
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 2 0.6118
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.6109
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.6081
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.6081
Ferric enterobactin-binding periplasmic protein FepB P0AEL6 FEPB_ECOLI Escherichia coli 2 0.6075
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.6073
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.6066
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.6064
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.6059
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.6058
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.6057
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 2 0.6044
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.6040
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.6040
Polyamine oxidase 1 O64411 PAO1_MAIZE Zea mays 2 0.6039
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.6038
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.6038
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.6035
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.6033
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 2 0.6029
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.6029
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.6029
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.6027
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.6026
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.6024
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.6020
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.6020
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.6019
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.6013
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.6012
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.6007
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.6007
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.6005
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.6002
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.6000
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.5995
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.5990
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.5989
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.5989
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.5988
Farnesyl pyrophosphate synthase, putative A5K4U6 A5K4U6_PLAVS Plasmodium vivax 2 0.5985
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5982
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5981
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.5979
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.5977
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 2 0.5974
Angiotensin-converting enzyme Q10714 ACE_DROME Drosophila melanogaster 2 0.5974
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 2 0.5974
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 2 0.5973
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5971
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.5964
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.5964
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 2 0.5964
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.5958
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 2 0.5957
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5956
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.5950
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.5948
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 2 0.5945
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 2 0.5943
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.5940
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5931
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.5927
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.5926
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.5918
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5914
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.5912
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.5911
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5911
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5910
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5909
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5902
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5900
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.5896
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 2 0.5891
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.5888
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.5885
Bile acid receptor Q62735 NR1H4_RAT Rattus norvegicus 3 0.5883
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.5883
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.5882
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5878
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 2 0.5874
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5873
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.5870
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.5868
Adenylate cyclase type 5 P30803 ADCY5_CANLF Canis lupus familiaris 2 0.5865
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5859
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.5858
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.5854
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.5852
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.5849
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5846
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5845
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.5836
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5831
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5822
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5819
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.5818
Rhodopsin P02699 OPSD_BOVIN Bos taurus 2 0.5817
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.5813
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.5805
Lactaldehyde dehydrogenase P25553 ALDA_ECOLI Escherichia coli 2 0.5802
Beta-elicitin cinnamomin P15569 ELIB_PHYCI Phytophthora cinnamomi 2 0.5801
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5791
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.5787
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5785
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.5770
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 2 0.5759
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5759
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.5756
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.5756
Diaminopropionate ammonia-lyase P66899 DPAL_ECOLI Escherichia coli 2 0.5752
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5747
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5731
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5724
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5713
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.5712
Avidin P02701 AVID_CHICK Gallus gallus 2 0.5698
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 2 0.5697
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5695
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5674
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5671
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.5656
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.5656
Avd protein A7YYL1 A7YYL1_XENTR Xenopus tropicalis 2 0.5642
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5638
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.5636
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.5633
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5633
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.5630
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 2 0.5622
Glucosidase II subunit alpha Q9STC1 Q9STC1_GRALE Gracilariopsis lemaneiformis 2 0.5617
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.5616
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 2 0.5607
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.5603
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5602
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.5590
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.5588
Avidin P02701 AVID_CHICK Gallus gallus 2 0.5577
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.5566
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.5555
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.5554
Vitamin D3 receptor P11473 VDR_HUMAN Homo sapiens 2 0.5552
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 2 0.5550
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.5504
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 2 0.5503
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.5494
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 2 0.5493
Retinoic acid receptor RXR-alpha P28700 RXRA_MOUSE Mus musculus 2 0.5492
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 3 0.5484
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5472
Cartilage oligomeric matrix protein P35444 COMP_RAT Rattus norvegicus 2 0.5462
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5461
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 2 0.5458
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.5432
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5423
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.5416
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 2 0.5413
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.5409
Japanin M1MR49 M1MR49_RHIAP Rhipicephalus appendiculatus 2 0.5407
Aminotransferase C7E5X4 C7E5X4_9GAMM Psychrobacter sp. B6 2 0.5402
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.5398
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 2 0.5393
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 2 0.5389
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 1 0.5376
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.5371
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 2 0.5367
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 2 0.5322
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.5315
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.5306
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5285
Retinoic acid receptor RXR Q8T5C6 RXR_BIOGL Biomphalaria glabrata 2 0.5282
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 2 0.5272
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.5260
Cholesterol side-chain cleavage enzyme, mitochondrial P00189 CP11A_BOVIN Bos taurus 2 0.5251
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 2 0.5231
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.5228
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.5217
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.5205
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5194
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) Q91XE4 ACY3_MOUSE Mus musculus 1 0.5184
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.5182
Scytalone dehydratase P56221 SCYD_MAGO7 Pyricularia oryzae 2 0.5163
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.5161
Mycinamicin VI 2''-O-methyltransferase Q83WF2 MYCE_MICGR Micromonospora griseorubida 3 0.5157
Methionine gamma-lyase Q86D28 Q86D28_ENTHI Entamoeba histolytica 3 0.5152
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.5146
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.5146
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.5141
Phosphotriesterase Q5KZU5 Q5KZU5_GEOKA Geobacillus kaustophilus 1 0.5140
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 2 0.5139
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.5139
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5138
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 2 0.5135
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 2 0.5133
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.5125
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 2 0.5123
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.5122
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.5122
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.5111
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5104
Vitamin D3 receptor P11473 VDR_HUMAN Homo sapiens 3 0.5099
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.5095
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 2 0.5094
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.5090
diphosphomevalonate decarboxylase Q9FD73 Q9FD73_STAEP Staphylococcus epidermidis 1 0.5083
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 2 0.5079
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.5076
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.5075
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5071
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.5064
Plasma membrane ATPase 3 Q08436 PMA3_NICPL Nicotiana plumbaginifolia 2 0.5062
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.5061
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.5059
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.5048
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.5043
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.5036
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.5036
Cholesterol oxidase P22637 CHOD_BREST Brevibacterium sterolicum 2 0.5036
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 2 0.5033
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.5027
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.5026
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 2 0.5023
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 2 0.5017
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.5016
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5014
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 2 0.5014
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.5013
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 2 0.5003

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