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Confluentic acid

Family: Plantae - Burseraceae
Kingdom: Plantae
Class: Phenolic
- Subclass: Phenolic Acid

Canonical Smiles	CCCCCC(=O)Cc1cc(OC)cc(c1C(=O)Oc1cc(CCCCC)c(c(c1)OC)C(=O)O)O
InChI	InChI=1S/C28H36O8/c1-5-7-9-11-18-14-22(17-24(35-4)26(18)27(31)32)36-28(33)25-19(13-20(29)12-10-8-6-2)15-21(34-3)16-23(25)30/h14-17,30H,5-13H2,1-4H3,(H,31,32)
InChIKey	UANVCGQMNRTKGM-UHFFFAOYSA-N
Formula	C₂₈H₃₆O₈
HBA	7
HBD	2
MW	500.59
Rotatable Bonds	15
TPSA	119.36
LogP	5.75
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	36
Formal Charge	0
Fraction CSP3	0.46
Exact Mass	500.24
Number of Lipinski Rule Violations	2

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Dacryodes edulis	Burseraceae	Plantae	246365

Showing of synonyms

Dongmo KJJ, Tali MBT, et al. (2023). In vitro antiplasmodial activity and toxicological profile of extracts, fractions and chemical constituents of leaves and stem bark from Dacryodes edulis (Burseraceae).. BMC complementary medicine and therapies,2023, 23(1), 211. [View] [PubMed]

Pubchem: 99614

Cas: 6009-12-7

Gnps: CCMSLIB00005719947

Zinc: ZINC000005410063

Chebi: 144140

Nmrshiftdb2: 60028117

Comptox: DTXSID70208834

CPRiL: 387646

SMILES: c1ccccc1C(=O)Oc2ccccc2

Level: 1

Mol. Weight: 500.59 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 500.59 g/mol

Anti-plasmodial

Absorption

Caco-2 (logPapp): -5.01
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.06
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -4.02

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.68
Plasma Protein Binding: 62.51
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Inhibitor

Excretion

Clearance: 4.27
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.02
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Safe
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.04
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.69
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: -297.66
Rat (Acute): 2.2
Rat (Chronic Oral): 3.12
Fathead Minnow: 4.75
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 497.72
Hydration Free Energy: -3.02
Log(D) at pH=7.4: 2.78
Log(P): 6.35
Log S: -5.79
Log(Vapor Pressure): -10.1
Melting Point: 118.25
pKa Acid: 7.05
pKa Basic: 4.51

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9520
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9462
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9395
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9348
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9335
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.9252
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9245
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9219
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.9164
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9105
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9039
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	4	0.8982
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	3	0.8966
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8963
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8960
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8952
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	3	0.8876
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8839
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8829
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8807
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8759
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8740
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8727
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8720
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8720
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8715
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8701
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.8692
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8604
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8578
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8557
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8545
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8519
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8519
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8519
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.8517
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8505
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8471
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8443
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8432
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.8426
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8421
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8387
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8357
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8262
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8257
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8256
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8237
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.8231
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.8195
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.8183
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.8181
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.8167
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8158
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8150
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8100
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	Q81LL4	MTNN_BACAN	Bacillus anthracis	3	0.8062
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8026
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8017
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7988
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7981
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7961
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7960
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.7959
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7945
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7939
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.7929
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7895
Nucleoside diphosphate kinase	P15266	NDK_MYXXA	Myxococcus xanthus	3	0.7882
thiamine diphosphokinase	Q82ZE3	Q82ZE3_ENTFA	Enterococcus faecalis	3	0.7828
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7825
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7820
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7791
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7762
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.7732
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7680
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7657
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7655
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7644
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7640
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7636
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7633
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7629
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7603
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7595
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7588
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7586
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7580
Fatty acid-binding protein 10-A, liver basic	Q9I8L5	FA10A_DANRE	Danio rerio	2	0.7579
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7571
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7557
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7553
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7511
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7465
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7462
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7450
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7449
4-hydroxyphenylacetate 3-monooxygenase, reductase component	Q5SJP7	HPAC_THET8	Thermus thermophilus	3	0.7443
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7437
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7436
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7428
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7421
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	3	0.7412
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7399
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	2	0.7396
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7395
Aspartokinase 1, chloroplastic	Q9LYU8	AK1_ARATH	Arabidopsis thaliana	3	0.7382
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7379
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	3	0.7376
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7376
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7364
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7359
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.7358
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	P49354	FNTA_HUMAN	Homo sapiens	3	0.7356
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7355
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7349
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7336
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7335
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7329
Cellular retinoic acid-binding protein 2	P29373	RABP2_HUMAN	Homo sapiens	3	0.7326
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7317
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7314
RNA-directed RNA polymerase	P11124	RDRP_BPPH6	Pseudomonas phage phi6	3	0.7309
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7307
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.7304
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	4	0.7297
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7286
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7279
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7271
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7260
Lysozyme C II	P11941	LYSC2_ONCMY	Oncorhynchus mykiss	3	0.7259
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7258
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7253
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7253
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7251
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7250
Fatty acid-binding protein 2, liver	P81400	FABP2_AMBME	Ambystoma mexicanum	3	0.7248
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7247
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7244
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7234
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7234
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7232
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	2	0.7230
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7226
Uridine phosphorylase	P0A1F6	UDP_SALTY	Salmonella typhimurium	3	0.7219
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7215
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.7215
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7214
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7213
L-lactate dehydrogenase (cytochrome)	P00175	CYB2_YEAST	Saccharomyces cerevisiae	3	0.7204
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7200
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7185
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7181
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	2	0.7173
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7170
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7166
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7162
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7162
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7158
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	Q8N5Z0	AADAT_HUMAN	Homo sapiens	2	0.7151
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7148
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7147
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7147
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7144
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.7143
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7141
Vitamin D-binding protein	P02774	VTDB_HUMAN	Homo sapiens	2	0.7140
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7136
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7128
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7124
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7113
[LysW]-aminoadipate kinase	O50147	LYSZ_THET2	Thermus thermophilus	3	0.7112
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7107
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7100
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7097
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7096
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	2	0.7094
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7093
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7089
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7089
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7087
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7083
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7078
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7077
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7074
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	2	0.7074
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7071
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7067
Beta-hexosaminidase	Q9KU37	NAGZ_VIBCH	Vibrio cholerae serotype O1	3	0.7065
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7049
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7045
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	2	0.7033
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7030
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	3	0.7021
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7017
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7006
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7006
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7002

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