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Myrianthiphylin

Family: Plantae - Cecropiaceae
Kingdom: Plantae
Class: Lignan

Canonical Smiles	O=C(/C=C/c1ccc(cc1)O)OCC(C(Cc1ccc(c(c1)O)O)COC(=O)/C=C/c1ccc(cc1)O)Cc1ccc(c(c1)O)O
InChI	InChI=1S/C36H34O10/c37-29-9-1-23(2-10-29)7-15-35(43)45-21-27(17-25-5-13-31(39)33(41)19-25)28(18-26-6-14-32(40)34(42)20-26)22-46-36(44)16-8-24-3-11-30(38)12-4-24/h1-16,19-20,27-28,37-42H,17-18,21-22H2/b15-7+,16-8+
InChIKey	CZVOUMFRPVSUSI-BGPOSVGRSA-N
Formula	C₃₆H₃₄O₁₀
HBA	10
HBD	6
MW	626.66
Rotatable Bonds	13
TPSA	173.98
LogP	5.45
Number Rings	4
Number Aromatic Rings	4
Heavy Atom Count	46
Formal Charge	0
Fraction CSP3	0.17
Exact Mass	626.22
Number of Lipinski Rule Violations	3

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Myrianthus arboreus	Cecropiaceae	Plantae	1781621

Showing of synonyms

Ngounou FN, Lontsi D, et al. (1990). Myrianthiphyllin, The First Lignan Cinnamate from Myrianthus arboreus.. Planta medica,1990, 56(2), 227-229. [View] [PubMed]

No compound-protein relationship available.

SMILES: c1ccccc1C=CC(=O)OCC(Cc2ccccc2)C(Cc3ccccc3)COC(=O)C=Cc4ccccc4

Level: 3

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1C=CC(=O)OCC(Cc2ccccc2)CCOC(=O)C=Cc3ccccc3

Level: 3

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1C=CC(=O)OCC(Cc2ccccc2)CCc3ccccc3

Level: 2

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1C=CC(=O)OCCCCOC(=O)C=Cc2ccccc2

Level: 1

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1C=CC(=O)OCCCCc2ccccc2

Level: 1

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1C=CC(=O)OCCCc2ccccc2

Level: 1

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1CCCCc2ccccc2

Level: 1

Mol. Weight: 626.66 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 626.66 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -6.23
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.88
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Substrate
Skin Permeability: 33.77

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 1.18
Plasma Protein Binding: 68.04
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Non-Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Inhibitor

Excretion

Clearance: 9.69
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: -0.31
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.3
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.96
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -64177.19
Rat (Acute): 1.94
Rat (Chronic Oral): 3.61
Fathead Minnow: 102.23
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 1092.94
Hydration Free Energy: -2.92
Log(D) at pH=7.4: 4.05
Log(P): 5.69
Log S: -5.71
Log(Vapor Pressure): -101.7
Melting Point: 241.54
pKa Acid: 7.64
pKa Basic: 8.59

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9840
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9563
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.9516
Insulin-degrading enzyme	P14735	IDE_HUMAN	Homo sapiens	3	0.9424
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	3	0.9384
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.9286
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.9284
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.9079
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9012
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8998
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8928
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	3	0.8879
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8870
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8853
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8760
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	3	0.8753
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8669
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8603
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	3	0.8595
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	4	0.8587
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8575
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8567
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.8556
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8542
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	4	0.8533
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8466
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.8451
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.8450
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.8449
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	4	0.8447
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8401
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8400
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8371
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	3	0.8343
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8339
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.8326
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8298
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.8286
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8222
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8206
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.8169
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8158
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8129
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.8120
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8114
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	Q4WP27	Q4WP27_ASPFU	Aspergillus fumigatus	3	0.8079
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.8077
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8067
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8057
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8036
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.8012
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7990
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.7971
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.7957
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7940
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7939
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.7919
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7918
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.7914
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7910
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7909
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	4	0.7902
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	3	0.7889
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7845
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.7813
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.7808
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7808
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7803
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7803
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7800
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7799
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.7761
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7748
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7747
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7723
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7723
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7704
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7697
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7689
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7685
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7683
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7681
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7651
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7649
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.7644
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7642
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7640
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.7631
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7629
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7608
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7604
Threonine--tRNA ligase	P0A8M3	SYT_ECOLI	Escherichia coli	4	0.7587
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7584
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7579
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	3	0.7562
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7534
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7531
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7530
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7525
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	4	0.7524
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7516
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7514
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	3	0.7513
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7490
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7486
Beta-glucuronidase	P05804	BGLR_ECOLI	Escherichia coli	3	0.7477
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7475
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	4	0.7458
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7450
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.7437
Polymerase basic protein 2	Q2LG68	Q2LG68_9INFA	Influenza A virus)	4	0.7424
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7424
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7421
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7419
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	4	0.7418
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7415
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7415
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7415
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7405
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.7402
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	4	0.7395
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7386
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7381
Formate--tetrahydrofolate ligase	Q2RM91	FTHS_MOOTA	Moorella thermoacetica	2	0.7376
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.7356
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7347
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7341
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7334
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7320
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7320
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	5	0.7315
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7309
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.7306
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7300
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7294
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7294
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7290
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7288
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7279
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7277
Virulence sensor histidine kinase PhoQ	P0DM80	PHOQ_SALTY	Salmonella typhimurium	3	0.7267
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7264
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	4	0.7259
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7250
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7249
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7248
Basic phospholipase A2 homolog piratoxin-1	P58399	PA2H1_BOTPI	Bothrops pirajai	4	0.7243
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7239
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7224
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7213
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7212
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7202
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	4	0.7197
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7194
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7189
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7186
Methylmalonyl-CoA decarboxylase	P52045	SCPB_ECOLI	Escherichia coli	3	0.7168
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7164
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7162
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7158
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	3	0.7158
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7157
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.7154
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7151
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7146
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7141
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7138
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7136
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7136
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7134
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7134
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	Q9CCZ4	Y2640_MYCLE	Mycobacterium leprae	3	0.7129
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7126
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7119
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7112
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7103
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7095
Ethylene receptor 1	P49333	ETR1_ARATH	Arabidopsis thaliana	3	0.7086
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	4	0.7082
UTP-monosaccharide-1-phosphate uridylyltransferase	D3G6S4	D3G6S4_LEIMA	Leishmania major	3	0.7080
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	3	0.7068
Small heat shock protein StHsp14.0	Q970D9	Q970D9_SULTO	Sulfurisphaera tokodaii	3	0.7068
Anthranilate phosphoribosyltransferase	P00500	TRPD_ACIAD	Acinetobacter baylyi	2	0.7064
Fructose-1,6-bisphosphatase 1	P09467	F16P1_HUMAN	Homo sapiens	2	0.7060
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7058
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7056
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7055
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7051
histidine kinase	O32393	O32393_ARTPT	Arthrospira platensis	3	0.7050
Adenosine receptor A2a	P29274	AA2AR_HUMAN	Homo sapiens	4	0.7048
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7028
Eukaryotic translation initiation factor 4E-1	P29557	IF4E1_WHEAT	Triticum aestivum	4	0.7026
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7021
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7019
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.7011
Formate--tetrahydrofolate ligase	P21164	FTHS_MOOTH	Moorella thermoacetica	2	0.7009
Chromosome partitioning protein ParA	B0ZE06	B0ZE06_ECOLX	Escherichia coli	3	0.7007
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7006
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7004
Genome polyprotein	C0LMU0	C0LMU0_9FLAV	dengue virus type 3	3	0.7001
adenine phosphoribosyltransferase	Q967M2	Q967M2_GIAIN	Giardia intestinalis	2	0.7001

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