Butyraxanthone D - Compound Card

Butyraxanthone D

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Butyraxanthone D

Structure
Zoomed Structure
  • Family: Plantae - Clusiaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1c(O)cc2c(c1C/C=C(/CCCC(O)(C)C)\C)c(=O)c1c(o2)cc(cc1O)O
InChI InChI=1S/C24H28O7/c1-13(6-5-9-24(2,3)29)7-8-15-20-19(12-17(27)23(15)30-4)31-18-11-14(25)10-16(26)21(18)22(20)28/h7,10-12,25-27,29H,5-6,8-9H2,1-4H3/b13-7+
InChIKey VQIHPPHJAYRDMW-NTUHNPAUSA-N
Formula C24H28O7
HBA 7
HBD 4
MW 428.48
Rotatable Bonds 7
TPSA 120.36
LogP 4.5
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 31
Formal Charge 0
Fraction CSP3 0.38
Exact Mass 428.18
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Pentadesma butyracea Clusiaceae Plantae 198785

Showing of synonyms

  • Zelefack F, Guilet D, et al. (2009). Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea.. Journal of natural products,2009, 72(5), 954-957. [View] [PubMed]
Pubchem: 25073519
Nmrshiftdb2: 70021999

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 428.48 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-5.76
Human Oral Bioavailability 20%
Non-Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.980
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.74

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.180
Plasma Protein Binding
53.4
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.830
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.960
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.680
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.290
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-20.180
Rat (Acute)
2.260
Rat (Chronic Oral)
3.330
Fathead Minnow
5.590
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
505.490
Hydration Free Energy
-6.640
Log(D) at pH=7.4
2.360
Log(P)
4.59
Log S
-4.85
Log(Vapor Pressure)
-9.25
Melting Point
218.09
pKa Acid
8.51
pKa Basic
7.25
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9221
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9200
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9194
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9181
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.9160
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.9143
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9140
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8897
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.8896
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8843
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.8819
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.8811
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8795
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8774
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8769
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8691
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8685
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8644
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8622
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8586
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8552
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8543
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.8535
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8534
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 3 0.8531
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8521
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8480
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8474
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8474
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8455
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.8446
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8426
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8426
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8407
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8397
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8389
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 4 0.8388
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8384
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8379
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8377
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8364
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8357
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.8347
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8339
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8311
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 4 0.8297
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 3 0.8297
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8272
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8269
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8232
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8232
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8226
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8217
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8192
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8182
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8178
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.8176
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8176
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8167
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8153
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8148
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8130
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8129
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8124
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8093
Beta sliding clamp P0A988 DPO3B_ECOLI Escherichia coli 3 0.8086
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8077
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 4 0.8070
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 3 0.8040
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8008
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8005
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7977
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7953
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 4 0.7943
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7927
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7919
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7913
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7888
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 4 0.7871
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7858
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.7855
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7845
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7836
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7824
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7816
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7806
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7802
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7796
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7789
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7776
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7775
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7764
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7761
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7746
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.7736
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 4 0.7726
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7708
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7706
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 4 0.7703
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7687
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7675
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7671
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7664
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7663
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7652
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7646
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7645
Endolysin P00720 ENLYS_BPT4 Enterobacteria phage T4 3 0.7644
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7644
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7630
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7605
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7585
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7585
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7546
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7544
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7526
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7523
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7508
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7506
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7499
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7498
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7485
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7480
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.7467
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7463
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7462
Purine nucleoside phosphorylase DeoD-type Q5EEL8 DEOD_BACCE Bacillus cereus 3 0.7461
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7456
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7449
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7446
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7443
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7442
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7442
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7441
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.7437
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7414
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7413
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7404
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7386
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7379
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7375
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7371
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7370
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7369
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7369
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 4 0.7368
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7364
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7359
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7357
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7349
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7338
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 4 0.7321
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.7321
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 3 0.7320
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7313
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7305
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7299
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7285
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7272
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7271
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.7270
NAD(P)H dehydrogenase (quinone) Q9I509 NQOR_PSEAE Pseudomonas aeruginosa 5 0.7267
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7266
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7258
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7257
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7257
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7255
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7250
Diguanylate phosphodiesterase A6T8V8 A6T8V8_KLEP7 Klebsiella pneumoniae subsp. pneumoniae 4 0.7249
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7240
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7236
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7235
Transthyretin Q9PTT3 Q9PTT3_SPAAU Sparus aurata 3 0.7224
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7222
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7218
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7213
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7210
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7207
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 3 0.7198
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7191
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7187
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7186
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7182
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7174
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7166
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7164
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7155
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7149
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 4 0.7147
Dihydrofolate reductase Q81R22 Q81R22_BACAN Bacillus anthracis 4 0.7132
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7129
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7126
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7124
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7122
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7120
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7114
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7113
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7099
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7090
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7086
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7083
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7082
Cell division protein FtsZ P9WN95 FTSZ_MYCTU Mycobacterium tuberculosis 4 0.7080
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7075
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 3 0.7073
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7067
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7066
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7064
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7062
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7056
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7054
Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit P54322 PYRDB_LACLM Lactococcus lactis subsp. cremoris 5 0.7039
Transcriptional regulator URE2 P23202 URE2_YEAST Saccharomyces cerevisiae 3 0.7038
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 4 0.7037
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7025
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7023
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7017
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7017
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7004
NAD(P)H dehydrogenase (quinone) P0A8G6 NQOR_ECOLI Escherichia coli 5 0.7003
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7003
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7002
Cytochrome P450 I6YD01 I6YD01_MYCTU Mycobacterium tuberculosis 4 0.7000
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7000

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