7, 4′-dihydroxy-5-methoxy-flavanone - Compound Card

7, 4′-dihydroxy-5-methoxy-flavanone

Select a section from the left sidebar

7, 4′-dihydroxy-5-methoxy-flavanone

Structure
Zoomed Structure
  • Family: Plantae - Compositae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles COc1cc(O)cc2c1C(=O)CC(O2)c1ccc(cc1)O
InChI InChI=1S/C16H14O5/c1-20-14-6-11(18)7-15-16(14)12(19)8-13(21-15)9-2-4-10(17)5-3-9/h2-7,13,17-18H,8H2,1H3
InChIKey CWZLMWSCLBFCBY-UHFFFAOYSA-N
Formula C16H14O5
HBA 5
HBD 2
MW 286.28
Rotatable Bonds 2
TPSA 75.99
LogP 2.81
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 21
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 286.08
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Helichrysum foetidum Compositae Plantae 261783

Showing of synonyms

  • Malolo FA, Bissoue Nouga A, et al. (2015). Protease-inhibiting, molecular modeling and antimicrobial activities of extracts and constituents from Helichrysum foetidum and Helichrysum mechowianum (compositae).. Chemistry Central journal,2015, 9, 32. [View] [PubMed]
Pubchem: 188424
Chebi: 178313
Nmrshiftdb2: 70015562

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 286.28 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 286.28 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.28 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.56
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.640
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.94

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.160
Plasma Protein Binding
53.72
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.320
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.140
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.800
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.190
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.390
Rat (Acute)
1.820
Rat (Chronic Oral)
2.410
Fathead Minnow
4.440
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
409.430
Hydration Free Energy
-9.560
Log(D) at pH=7.4
2.190
Log(P)
2.14
Log S
-4.85
Log(Vapor Pressure)
-7.42
Melting Point
199.82
pKa Acid
8.12
pKa Basic
4.58
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9801
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9737
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9634
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.9561
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9536
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.9529
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9516
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9484
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9482
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9476
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9404
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9401
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9388
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9359
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9359
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9335
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9311
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9311
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9289
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.9260
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9257
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.9239
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9228
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9184
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.9173
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9163
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9135
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9100
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.9073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.9066
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9059
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9031
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9004
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8995
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8986
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8929
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8908
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.8895
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8887
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8854
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.8850
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8832
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.8830
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8820
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8809
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8764
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8763
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8735
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8699
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8668
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.8644
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8596
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8578
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 3 0.8575
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 6 0.8567
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8548
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.8546
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8506
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8470
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8463
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8459
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8457
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 4 0.8447
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.8437
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8413
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.8412
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8409
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8400
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8395
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 4 0.8358
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8345
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.8312
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.8312
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8300
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8287
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8247
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8211
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8183
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8177
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8135
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8128
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8121
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8103
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.8103
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8097
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8085
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8083
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.8078
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8068
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8068
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8067
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.8059
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8058
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8033
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8033
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 3 0.7972
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7936
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7903
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7885
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7870
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7857
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7855
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7853
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7837
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7802
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7787
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7755
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7714
Pyruvate kinase PKM P14618 KPYM_HUMAN Homo sapiens 3 0.7712
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7709
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7696
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7693
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7653
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7642
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7634
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7632
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7613
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7611
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7605
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7594
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7591
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7586
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7584
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7577
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7574
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7568
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7564
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7560
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7541
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7537
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7532
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7530
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7526
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 2 0.7513
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7511
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 4 0.7501
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7498
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7489
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7488
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7478
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7471
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7469
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7467
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7456
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7453
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7446
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.7443
Nucleoside 2-deoxyribosyltransferase Q8RLY5 Q8RLY5_LACHE Lactobacillus helveticus 3 0.7429
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7401
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7394
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7393
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7390
C-1-tetrahydrofolate synthase, cytoplasmic P11586 C1TC_HUMAN Homo sapiens 3 0.7385
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7384
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7381
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7380
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7376
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7358
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7348
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7334
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7323
Rac-like GTP-binding protein ARAC7 O82480 RAC7_ARATH Arabidopsis thaliana 3 0.7319
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7312
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7310
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7305
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7304
Phenolphthiocerol/phthiocerol polyketide synthase subunit C P96202 PPSC_MYCTU Mycobacterium tuberculosis 3 0.7300
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7289
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7287
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7276
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7270
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7268
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7263
Isoflavone 4'-O-methyltransferase Q29U70 I4OMT_MEDTR Medicago truncatula 3 0.7261
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7254
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7254
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7250
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q8ZMF7 ISPF_SALTY Salmonella typhimurium 3 0.7248
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7246
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7243
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7243
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7242
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.7235
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7231
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7214
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7207
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7201
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7198
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7188
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7185
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7184
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7180
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.7177
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7175
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7171
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7168
Formylmethanofuran--tetrahydromethanopterin formyltransferase Q49610 FTR_METKA Methanopyrus kandleri 3 0.7167
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.7166
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7166
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7156
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7154
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7153
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7150
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7144
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7139
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7127
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7123
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7111
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7109
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 3 0.7109
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7097
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7084
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7082
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7081
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7079
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7078
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7068
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7049
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7046
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7039
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7038
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7035
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7020
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7018
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7018
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7017
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7013
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7011
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7005
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7004
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7002
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 3 0.7001

Download SDF