3,5,7-trihydroxy-8-methoxyflavone - Compound Card

3,5,7-trihydroxy-8-methoxyflavone

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3,5,7-trihydroxy-8-methoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Compositae
  • Kingdom: Plantae
  • Class: Flavonoid
Canonical Smiles COc1c(O)cc(c2c1oc(c1ccccc1)c(c2=O)O)O
InChI InChI=1S/C16H12O6/c1-21-15-10(18)7-9(17)11-12(19)13(20)14(22-16(11)15)8-5-3-2-4-6-8/h2-7,17-18,20H,1H3
InChIKey NAENHANDGVDMPA-UHFFFAOYSA-N
Formula C16H12O6
HBA 6
HBD 3
MW 300.27
Rotatable Bonds 2
TPSA 100.13
LogP 2.59
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.06
Exact Mass 300.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Helichrysum mechowianum Compositae Plantae 3030040

Showing of synonyms

  • Malolo FA, Bissoue Nouga A, et al. (2015). Protease-inhibiting, molecular modeling and antimicrobial activities of extracts and constituents from Helichrysum foetidum and Helichrysum mechowianum (compositae).. Chemistry Central journal,2015, 9, 32. [View] [PubMed]
Pubchem: 5378234
Nmrshiftdb2: 60022985

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 300.27 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 300.27 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 300.27 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.98
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.830
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.71

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.270
Plasma Protein Binding
97.13
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.410
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.190
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.170
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.560
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.410
Rat (Acute)
2.490
Rat (Chronic Oral)
3.000
Fathead Minnow
4.440
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
428.430
Hydration Free Energy
-8.680
Log(D) at pH=7.4
2.090
Log(P)
2.4
Log S
-4.55
Log(Vapor Pressure)
-7.2
Melting Point
209.26
pKa Acid
9.45
pKa Basic
1.56
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9743
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9406
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.9312
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9286
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9191
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.9132
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9033
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9028
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.8979
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8958
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.8889
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.8873
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8866
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 4 0.8860
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8799
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8776
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8776
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8768
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8748
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8736
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8730
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8711
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8696
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8693
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8683
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.8661
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8635
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8624
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8606
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8601
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 5 0.8586
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 4 0.8580
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8563
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8544
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8544
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8509
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8506
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8500
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8495
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8481
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8478
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8456
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8450
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.8448
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 4 0.8441
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8430
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8387
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8368
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8364
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8356
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8353
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8339
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8337
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8329
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8327
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8307
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.8278
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8261
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8249
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8244
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8232
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 3 0.8230
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 5 0.8217
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8198
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8174
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8143
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8139
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8130
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8121
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.8073
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8072
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8068
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8064
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8052
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8045
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8040
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8039
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8036
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8021
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.8020
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8020
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8014
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.8014
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7989
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7974
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7969
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7954
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7952
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7945
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7922
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.7919
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7912
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7910
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7901
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7863
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.7847
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7841
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7809
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7803
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.7795
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7789
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7747
Putative secreted protein C9Z6T8 C9Z6T8_STRSW Streptomyces scabiei 4 0.7733
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7710
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7707
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7701
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.7701
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7701
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7691
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7691
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7667
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7637
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7617
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7617
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7616
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7599
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7594
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7588
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7587
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7586
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7585
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7584
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7573
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7568
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7545
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7543
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7540
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7537
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7537
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7513
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7510
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7506
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7490
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7485
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.7484
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7477
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7476
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7473
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7467
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7467
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7466
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7458
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7438
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7436
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7436
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7432
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7417
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7413
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 4 0.7409
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7397
Cystathionine gamma-synthase P56069 METB_HELPY Helicobacter pylori 3 0.7382
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7379
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7377
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7377
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7371
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7360
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7342
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7328
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7327
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7325
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7324
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 4 0.7323
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7316
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7314
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7307
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7301
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7298
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7288
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7286
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7285
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7285
Quercetin 2,3-dioxygenase Q7SIC2 QDOI_ASPJA Aspergillus japonicus 4 0.7277
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7272
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7269
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7245
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7241
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7240
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7240
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7238
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7233
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7233
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7233
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7219
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7217
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7215
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7208
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7205
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7200
Dihydrofolate reductase P9WNX1 DYR_MYCTU Mycobacterium tuberculosis 4 0.7196
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.7188
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7186
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7185
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7179
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7175
Plasma membrane ATPase Q42932 Q42932_NICPL Nicotiana plumbaginifolia 2 0.7175
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7161
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7157
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7155
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7137
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7131
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7128
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7123
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7112
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7110
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 4 0.7105
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.7104
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.7099
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7098
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7098
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7093
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7081
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7075
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7072
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7070
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7064
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7045
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7044
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7042
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 4 0.7032
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7030
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7028
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 4 0.7020
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7017
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7017
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7013
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7013
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7012
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7011
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7011
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7010
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7007
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7006
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7006

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