5-[(1E)-2-(4-hy- droxyphenyl)ethenyl]-4-methoxyphenyl}-2-methyl-1-propanone - Compound Card

5-[(1E)-2-(4-hy- droxyphenyl)ethenyl]-4-methoxyphenyl}-2-methyl-1-propanone

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5-[(1E)-2-(4-hy- droxyphenyl)ethenyl]-4-methoxyphenyl}-2-methyl-1-propanone

Structure
Zoomed Structure
  • Family: Plantae - Dipterocarpaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Terpenoid Phenolic
Canonical Smiles COc1cc(/C=C/c2ccc(cc2)O)c(c(c1)O)C(=O)C(C)C
InChI InChI=1S/C19H20O4/c1-12(2)19(22)18-14(10-16(23-3)11-17(18)21)7-4-13-5-8-15(20)9-6-13/h4-12,20-21H,1-3H3/b7-4+
InChIKey OYEVQRMCFUDHGA-QPJJXVBHSA-N
Formula C19H20O4
HBA 4
HBD 2
MW 312.37
Rotatable Bonds 5
TPSA 66.76
LogP 4.12
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 23
Formal Charge 0
Fraction CSP3 0.21
Exact Mass 312.14
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Monotes kerstingii Dipterocarpaceae Plantae 2029430

Showing of synonyms

  • Fotso GW, Mogue Kamdem L, et al. (2019). Antimicrobial secondary metabolites from the stem barks and leaves of Monotes kerstingii Gilg (Dipterocarpaceae).. Fitoterapia,2019, 137, 104239. [View] [PubMed]
Pubchem: 10710242
Nmrshiftdb2: 70081164

No compound-protein relationship available.

Structure

SMILES: c1ccccc1C=Cc2ccccc2

Level: 1

Mol. Weight: 312.37 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 312.37 g/mol

Antibacterial

Absorption

Caco-2 (logPapp)
-4.51
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.600
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.89

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.170
Plasma Protein Binding
53.9
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
6.090
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.150
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.840
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.670
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
4.220
Rat (Acute)
1.940
Rat (Chronic Oral)
2.870
Fathead Minnow
4.930
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
402.630
Hydration Free Energy
-8.320
Log(D) at pH=7.4
3.980
Log(P)
5.15
Log S
-5.9
Log(Vapor Pressure)
-6.73
Melting Point
123.9
pKa Acid
8.2
pKa Basic
6.22
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9846
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 3 0.9602
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9579
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9573
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9562
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9520
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9471
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9445
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9413
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.9373
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9347
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.9308
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9304
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.9303
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.9273
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.9250
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9246
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9242
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9207
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.9202
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 3 0.9195
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9189
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.9181
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9176
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9QYJ6 PDE10_RAT Rattus norvegicus 3 0.9062
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9058
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 4 0.9010
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9007
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8998
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8971
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8965
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8953
Major pollen allergen Bet v 1-A P15494 BEV1A_BETPN Betula pendula 3 0.8949
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 5 0.8939
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8923
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8908
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8886
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8884
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.8884
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8825
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 4 0.8778
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8754
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 4 0.8744
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8720
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8684
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8655
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8647
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8638
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 3 0.8636
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8631
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8617
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.8600
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8599
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8591
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8587
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8556
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8550
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8547
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8537
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8532
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8522
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8493
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8492
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 4 0.8486
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8479
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 5 0.8474
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8450
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8439
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8433
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8432
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8432
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8430
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.8428
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8418
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.8413
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8380
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8370
Valacyclovir hydrolase Q86WA6 BPHL_HUMAN Homo sapiens 3 0.8367
Cytokinin dehydrogenase 1 Q9T0N8 CKX1_MAIZE Zea mays 3 0.8357
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8339
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8331
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8279
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8261
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.8237
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.8233
Major strawberry allergen Fra a 1-3 D0E0C7 FRA13_FRAAN Fragaria ananassa 4 0.8229
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8207
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8204
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8198
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8169
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8164
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8161
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8158
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.8146
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.8132
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.8121
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8067
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8058
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8047
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8034
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.8028
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.8022
Dihydrofolate reductase P00378 DYR_CHICK Gallus gallus 3 0.7993
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7972
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7960
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7936
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7924
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7919
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7917
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7910
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7895
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7890
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7883
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7870
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7869
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7867
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7853
Dihydrofolate reductase P22906 DYR_CANAX Candida albicans 3 0.7842
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7840
GTPase KRas P01116 RASK_HUMAN Homo sapiens 3 0.7838
Matrilysin P09237 MMP7_HUMAN Homo sapiens 3 0.7813
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7796
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7785
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7781
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7748
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 4 0.7729
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7703
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7701
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7696
Nitric oxide synthase 1 P29476 NOS1_RAT Rattus norvegicus 3 0.7663
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7660
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7660
Methylmalonyl-CoA decarboxylase P52045 SCPB_ECOLI Escherichia coli 3 0.7653
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.7651
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7647
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7643
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7639
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7617
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7612
Hepatocyte growth factor receptor P08581 MET_HUMAN Homo sapiens 4 0.7611
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7610
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7608
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7597
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7584
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 3 0.7574
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7566
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7557
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7555
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7548
Myosin heavy chain, striated muscle P24733 MYS_ARGIR Argopecten irradians 3 0.7546
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7540
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.7535
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7533
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7521
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7521
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7515
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7509
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 3 0.7508
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7506
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7500
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7500
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7493
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7491
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7489
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7468
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7464
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7455
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7450
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7450
Probable bifunctional SAT/APS kinase O67174 SATC_AQUAE Aquifex aeolicus 3 0.7447
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7445
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7440
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7438
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7436
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 4 0.7436
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7433
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 4 0.7431
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.7429
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7428
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7424
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7410
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7409
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7409
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7408
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7398
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7392
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7383
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7383
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7373
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7371
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7366
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7362
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7360
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7360
Ephrin type-A receptor 2 P29317 EPHA2_HUMAN Homo sapiens 3 0.7351
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7331
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7326
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7324
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7324
Glutamate receptor 3 P19492 GRIA3_RAT Rattus norvegicus 3 0.7323
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7322
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7322
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7322
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7320
Isoleucine--tRNA ligase P56690 SYI_THET8 Thermus thermophilus 3 0.7317
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7313
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7311
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7306
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7305
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7301
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7299
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7293
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7286
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha P49354 FNTA_HUMAN Homo sapiens 3 0.7285
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7285
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7283
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7277
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7263
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7262
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7261
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7260
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 3 0.7259
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 2 0.7253
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7249
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7242
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7240
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 2 0.7228
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7225
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7218
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7215
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7208
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7207
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7199
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7198
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7197
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7194
Rac-like GTP-binding protein ARAC7 O82480 RAC7_ARATH Arabidopsis thaliana 3 0.7192
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7190
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7187
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7179
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7179
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7178
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 4 0.7177
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7177
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7172
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7164
Aldehyde dehydrogenase, mitochondrial P05091 ALDH2_HUMAN Homo sapiens 4 0.7162
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7155
12-oxophytodienoate reductase 1 Q9XG54 OPR1_SOLLC Solanum lycopersicum 2 0.7149
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7146
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7139
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7139
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7137
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7136
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7136
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7134
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7128
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7126
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial Q6NVY1 HIBCH_HUMAN Homo sapiens 3 0.7124
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7123
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7122
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7120
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7120
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7117
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7116
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7113
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 2 0.7112
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7112
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7106
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 2 0.7104
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7098
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7095
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7092
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7088
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7087
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 2 0.7084
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7084
Petrobactin biosynthesis protein AsbB Q81RQ8 Q81RQ8_BACAN Bacillus anthracis 3 0.7083
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7083
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 2 0.7081
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7076
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7076
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7072
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7072
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7062
Pili retraction protein PilT Q5SHF6 Q5SHF6_THET8 Thermus thermophilus 4 0.7060
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7055
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7049
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7045
Protocatechuate 3,4-dioxygenase beta chain P00437 PCXB_PSEPU Pseudomonas putida 2 0.7042
Acyl-CoA:acyl-CoA alkyltransferase Q8PDX2 OLEA_XANCP Xanthomonas campestris pv. campestris 3 0.7040
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7036
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7036
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7034
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7025
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7023
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7016
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7015
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7002
Alpha/beta hydrolase fold A5VAT9 A5VAT9_SPHWW Sphingomonas wittichii 2 0.7002

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