7-prenyloxy-4'-methoxykaempferol - Compound Card

7-prenyloxy-4'-methoxykaempferol

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7-prenyloxy-4'-methoxykaempferol

Structure
Zoomed Structure
  • Family: Plantae - Dipterocarpaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1ccc(cc1)c1oc2cc(OCC=C(C)C)cc(c2c(=O)c1O)O
InChI InChI=1S/C21H20O6/c1-12(2)8-9-26-15-10-16(22)18-17(11-15)27-21(20(24)19(18)23)13-4-6-14(25-3)7-5-13/h4-8,10-11,22,24H,9H2,1-3H3
InChIKey AUORCQISJDNDKJ-UHFFFAOYSA-N
Formula C21H20O6
HBA 6
HBD 2
MW 368.39
Rotatable Bonds 5
TPSA 89.13
LogP 4.22
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 27
Formal Charge 0
Fraction CSP3 0.19
Exact Mass 368.13
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Monotes kerstingii Dipterocarpaceae Plantae 2029430

Showing of synonyms

  • Fotso GW, Mogue Kamdem L, et al. (2019). Antimicrobial secondary metabolites from the stem barks and leaves of Monotes kerstingii Gilg (Dipterocarpaceae).. Fitoterapia,2019, 137, 104239. [View] [PubMed]
Pubchem: 102132811

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 368.39 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 368.39 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 368.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.53
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.790
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-0.9

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.520
Plasma Protein Binding
91.17
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
4.120
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.880
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.300
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.080
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-1.470
Rat (Acute)
2.300
Rat (Chronic Oral)
2.450
Fathead Minnow
5.130
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
463.770
Hydration Free Energy
-9.060
Log(D) at pH=7.4
3.260
Log(P)
4.29
Log S
-6.0
Log(Vapor Pressure)
-8.2
Melting Point
169.83
pKa Acid
7.54
pKa Basic
4.31
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9779
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9686
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9562
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 5 0.9329
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9313
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9250
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.9166
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.9107
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9088
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 5 0.9079
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.9026
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.9016
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9006
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8971
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8944
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.8931
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8909
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8905
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8901
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.8872
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8852
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8844
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8836
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8827
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8826
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8824
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8818
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.8761
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8756
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8746
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8721
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8702
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8690
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.8643
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.8636
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8620
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8614
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8613
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8603
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8568
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8564
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8543
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8528
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8506
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.8506
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8504
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8477
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8474
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8407
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8399
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8387
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.8382
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8356
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8353
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 5 0.8345
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8337
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8313
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8270
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8227
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8209
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.8205
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8179
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8175
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8161
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8154
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8150
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8149
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8138
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8105
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 5 0.8087
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8078
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 5 0.8071
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8070
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 4 0.8067
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8067
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 4 0.8054
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8027
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8010
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.8006
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7996
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7932
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7928
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 4 0.7927
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7896
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7874
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7872
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7867
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7853
Cyclin-dependent kinase 5 Q00535 CDK5_HUMAN Homo sapiens 4 0.7838
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7838
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7831
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7817
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7814
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 4 0.7805
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7786
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7769
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7748
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.7730
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7712
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.7705
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7705
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7696
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7689
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7683
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7675
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7666
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7663
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7654
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7652
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7650
Histone deacetylase 4 P56524 HDAC4_HUMAN Homo sapiens 2 0.7650
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7647
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7646
Terminal oxygenase component of carbazole Q84II6 Q84II6_JANS3 Janthinobacterium sp 3 0.7644
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7642
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7640
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7635
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 4 0.7634
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7628
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7626
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7623
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7622
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7619
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7612
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7604
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7601
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7592
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7592
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.7588
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7584
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7582
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7577
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7559
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7556
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7552
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7548
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 4 0.7515
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7507
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 4 0.7504
Putative secreted protein C9Z6T8 C9Z6T8_STRSW Streptomyces scabiei 4 0.7485
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7468
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7468
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7468
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7466
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.7463
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7457
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7450
Glycosyltransferase A4F1R4 A4F1R4_CLITE Clitoria ternatea 5 0.7449
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7435
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7433
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7421
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7420
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7416
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7403
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7399
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7399
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7398
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7396
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7388
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7382
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7368
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7356
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7353
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7351
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7350
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7343
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.7337
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7337
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 3 0.7328
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7325
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7321
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7321
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 4 0.7320
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7317
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7307
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7304
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7303
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7299
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7292
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7290
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7284
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7280
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7278
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7268
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7256
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7252
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7247
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 3 0.7240
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7235
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7229
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7221
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7221
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7213
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7208
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 3 0.7200
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7196
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7193
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7189
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7187
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7187
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7182
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7177
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7175
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7173
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7171
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7147
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7146
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.7145
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7144
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7142
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7141
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7138
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7138
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7135
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7125
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7117
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 2 0.7117
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7116
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7115
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7115
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 4 0.7108
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7107
Nucleoprotein P33469 NCAP_CVHOC Human coronavirus OC43 3 0.7107
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7103
Interleukin-2 P60568 IL2_HUMAN Homo sapiens 2 0.7103
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7088
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7088
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7078
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7076
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7056
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7054
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7051
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7043
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7041
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7040
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7035
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7035
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7021
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7019
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7016
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7004
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7002
Neutrophil collagenase P22894 MMP8_HUMAN Homo sapiens 2 0.7002
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7002

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