1,4-dihydroxyisoquinoline - Compound Card

1,4-dihydroxyisoquinoline

Select a section from the left sidebar

1,4-dihydroxyisoquinoline

Structure
Zoomed Structure
  • Family: Plantae - Euphorbiaceae
  • Kingdom: Plantae
  • Class: Alkaloid
    • Subclass: Isoquinoline Alkaloid
Canonical Smiles O=c1[nH]cc(c2c1cccc2)O
InChI InChI=1S/C9H7NO2/c11-8-5-10-9(12)7-4-2-1-3-6(7)8/h1-5,11H,(H,10,12)
InChIKey KOJRWXLHYKLCFJ-UHFFFAOYSA-N
Formula C9H7NO2
HBA 2
HBD 2
MW 161.16
Rotatable Bonds 0
TPSA 53.09
LogP 1.23
Number Rings 2
Number Aromatic Rings 2
Heavy Atom Count 12
Formal Charge 0
Fraction CSP3 0.0
Exact Mass 161.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Discoglypremna caloneura Euphorbiaceae Plantae 316671

Showing of synonyms

  • Toukam PD, Kom CW, et al. (2022). A new isoquinoline and ceramide from the stem barks of Discoglypremna caloneura (Pax) Prain (Euphorbiaceae) with antiproteinase and cytotoxic activities.. Natural product research,2022, 36(6), 1543-1551. [View] [PubMed]
Pubchem: 231920
Pdb Ligand: U8N

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)cc[nH]c2=O

Level: 0

Mol. Weight: 161.16 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.91
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.36
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.95

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.52
Plasma Protein Binding
40.39
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Non-Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.89
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.4
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.62
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
3.35
Micronucleos
Toxic
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.75
Rat (Acute)
1.95
Rat (Chronic Oral)
2.73
Fathead Minnow
3.89
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Safe
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
359.41
Hydration Free Energy
-11.67
Log(D) at pH=7.4
0.58
Log(P)
0.2
Log S
-3.1
Log(Vapor Pressure)
-6.49
Melting Point
267.83
pKa Acid
3.37
pKa Basic
9.21
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.9437
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9429
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.9366
Putative choline kinase Q5CUP2 Q5CUP2_CRYPI Cryptosporidium parvum 3 0.9328
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.9309
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.9294
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9286
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.9277
Acidic phospholipase A2 3 P60045 PA2A3_NAJSG Naja sagittifera 3 0.9275
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.9260
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.9189
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9167
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.9147
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.9130
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.9097
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 3 0.9097
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.9024
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.9009
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.8985
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8977
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8944
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8924
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8915
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8910
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8879
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.8870
Chloramphenicol 3-O phosphotransferase Q56148 CPT_STRVP Streptomyces venezuelae 3 0.8867
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.8864
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8848
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8842
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.8835
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8835
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8826
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8825
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8817
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8815
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8763
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8740
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8699
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 3 0.8686
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8668
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.8659
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8600
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8546
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8495
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.8470
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.8467
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8456
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8438
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8409
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 3 0.8390
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8344
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8344
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.8342
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8282
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8260
Anthranilate phosphoribosyltransferase P50384 TRPD_SACS2 Saccharolobus solfataricus 3 0.8226
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8213
Anthranilate phosphoribosyltransferase P00500 TRPD_ACIAD Acinetobacter baylyi 3 0.8207
3-hydroxyanthranilate 3,4-dioxygenase Q1LCS4 3HAO_CUPMC Cupriavidus metallidurans 3 0.8203
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.8181
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8161
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.8160
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.8149
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.8137
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8092
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8049
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8015
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7945
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7940
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.7923
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 3 0.7921
Purine nucleoside phosphorylase DeoD-type P0ABP8 DEOD_ECOLI Escherichia coli 3 0.7904
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7903
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7901
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.7871
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7868
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7867
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7852
Protein mono-ADP-ribosyltransferase PARP14 Q460N5 PAR14_HUMAN Homo sapiens 3 0.7842
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7837
4-substituted benzoates-glutamate ligase GH3.12 Q9LYU4 GH312_ARATH Arabidopsis thaliana 3 0.7837
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7813
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7795
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7786
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7776
Cytochrome P450 2E1 P05181 CP2E1_HUMAN Homo sapiens 3 0.7762
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.7758
Thymidylate synthase P04818 TYSY_HUMAN Homo sapiens 3 0.7756
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7734
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7715
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7710
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7669
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7653
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7634
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7621
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7620
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7618
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7613
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7603
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7594
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7573
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7550
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 3 0.7531
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Q9Y3Q4 HCN4_HUMAN Homo sapiens 3 0.7518
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 3 0.7512
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7511
Protein mono-ADP-ribosyltransferase PARP10 Q53GL7 PAR10_HUMAN Homo sapiens 3 0.7497
Anthranilate phosphoribosyltransferase P50384 TRPD_SACS2 Saccharolobus solfataricus 3 0.7479
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7454
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7450
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7440
Methionine aminopeptidase P0AE18 MAP1_ECOLI Escherichia coli 3 0.7430
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7423
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7421
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 2 0.7420
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7418
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7415
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7415
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.7413
Mandelate racemase P11444 MANR_PSEPU Pseudomonas putida 3 0.7404
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7402
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7395
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7377
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7377
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7375
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 3 0.7374
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7365
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 4 0.7353
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7351
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7341
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7338
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7332
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7330
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7319
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 2 0.7317
Ribosome biogenesis GTPase YqeH D0VWU7 D0VWU7_GEOSE Geobacillus stearothermophilus 3 0.7301
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7287
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 Q9CCZ4 Y2640_MYCLE Mycobacterium leprae 3 0.7273
Beta-1,4-galactosyltransferase 1 P08037 B4GT1_BOVIN Bos taurus 3 0.7268
3-oxoacyl-[acyl-carrier-protein] synthase 1 Q2YQQ9 Q2YQQ9_BRUA2 Brucella abortus 3 0.7268
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7256
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 2 0.7235
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7232
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 3 0.7231
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7225
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7220
D-alanyl-D-alanine carboxypeptidase P15555 DAC_STRSR Streptomyces sp 2 0.7219
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7218
Hypoxanthine-guanine phosphoribosyltransferase P00492 HPRT_HUMAN Homo sapiens 3 0.7216
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7201
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7188
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7187
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7187
Elongation factor 1-alpha O59153 EF1A_PYRHO Pyrococcus horikoshii 3 0.7186
3-oxoacyl-[acyl-carrier-protein] synthase 2 P0AAI5 FABF_ECOLI Escherichia coli 3 0.7180
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7179
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7172
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7171
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7168
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7164
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7162
Elongation factor 1-alpha P02994 EF1A_YEAST Saccharomyces cerevisiae 3 0.7160
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7146
Genome polyprotein A0EKU1 A0EKU1_9FLAV Meaban virus 3 0.7146
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7146
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7142
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7137
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7135
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7116
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7115
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7113
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7111
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7109
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7103
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7100
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7098
DNA-directed DNA polymerase Q38087 DPOL_BPR69 Escherichia phage RB69 3 0.7092
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7085
Uridine phosphorylase P0A1F6 UDP_SALTY Salmonella typhimurium 3 0.7084
Aspartokinase 1, chloroplastic Q9LYU8 AK1_ARATH Arabidopsis thaliana 3 0.7078
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7073
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7063
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7060
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7054
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7053
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 3 0.7044
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7025
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.7024
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7013
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7008

Download SDF