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Isobonducellin

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Homoisoflavonoid

Canonical Smiles	COc1ccc(cc1)/C=C\1/COc2c(C1=O)ccc(c2)O
InChI	InChI=1S/C17H14O4/c1-20-14-5-2-11(3-6-14)8-12-10-21-16-9-13(18)4-7-15(16)17(12)19/h2-9,18H,10H2,1H3/b12-8-
InChIKey	DLQSYZMPSWHYMW-WQLSENKSSA-N
Formula	C₁₇H₁₄O₄
HBA	4
HBD	1
MW	282.29
Rotatable Bonds	2
TPSA	55.76
LogP	3.06
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.12
Exact Mass	282.09
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Caesalpinia welwitschiana	Leguminosae/Fabaceae	Plantae	1387604

Showing of synonyms

Essoung FRE, Mba'ning BM, et al. (2021). Antifeedant and ovicidal activities of a new cassane and other compounds from Caesalpinia welwitschiana Oliv. and Caesalpinia bonduc L. against Tuta absoluta (Lepidoptera: Gelechiidae).. Natural product research,2021, 35(24), 5681-5691. [View] [PubMed]

Pubchem: 10423880

Cas: 610778-85-3

Zinc: ZINC000038816510

Nmrshiftdb2: 70009238

Chembl: CHEMBL1253830

No compound-protein relationship available.

SMILES: c1ccccc1C=C(C2=O)COc(c23)cccc3

Level: 1

Mol. Weight: 282.29 g/mol

SMILES: O=C1C(=C)COc(c12)cccc2

Level: 0

Mol. Weight: 282.29 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 282.29 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.69
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.550
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.41

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.240
Plasma Protein Binding: 68.27
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.350
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.320
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.860
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.630
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Toxic
T. Pyriformis: 4.240
Rat (Acute): 1.980
Rat (Chronic Oral): 2.420
Fathead Minnow: 4.690
Respiratory Disease: Safe
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Safe

General Properties

Boiling Point: 409.460
Hydration Free Energy: -8.770
Log(D) at pH=7.4: 3.480
Log(P): 3.29
Log S: -5.57
Log(Vapor Pressure): -7.08
Melting Point: 176.1
pKa Acid: 7.82
pKa Basic: 4.73

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9761
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9500
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.9493
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9493
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.9390
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9386
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9380
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.9377
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9376
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9366
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9343
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9321
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.9313
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.9304
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9292
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.9245
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9222
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9140
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9102
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9080
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	3	0.9070
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8993
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.8990
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.8977
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8923
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8921
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8808
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8808
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.8775
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8758
Cyclic AMP receptor protein	Q5SID7	CRP_THET8	Thermus thermophilus	3	0.8753
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8711
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8704
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8637
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.8559
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8556
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8546
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8517
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.8482
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8471
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8451
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8429
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8407
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.8404
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8372
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8369
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	3	0.8364
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8364
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8359
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8334
DNA-binding transcriptional dual regulator CRP	P0ACJ8	CRP_ECOLI	Escherichia coli	3	0.8319
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8316
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8303
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8290
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8282
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8279
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.8262
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8250
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8232
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.8231
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.8158
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8154
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.8151
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8107
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8099
orotidine-5'-phosphate decarboxylase	Q8T6J6	Q8T6J6_PLAFA	Plasmodium falciparum	4	0.8094
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8092
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.8091
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8062
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.8030
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8005
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7973
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7921
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7912
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7891
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7889
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7860
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7848
Kinesin-like protein KIF11	P52732	KIF11_HUMAN	Homo sapiens	3	0.7845
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7801
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7782
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7762
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7754
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.7724
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7723
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7717
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7684
Histone-lysine N-methyltransferase SETD7	Q8WTS6	SETD7_HUMAN	Homo sapiens	3	0.7657
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7643
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7638
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7627
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7621
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7621
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.7615
Flavin-dependent thymidylate synthase	Q9WYT0	THYX_THEMA	Thermotoga maritima	3	0.7595
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.7593
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7583
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7579
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7568
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7559
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7525
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7517
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7514
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7507
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7506
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7504
Uridine phosphorylase	Q5XA29	Q5XA29_STRP6	Streptococcus pyogenes serotype M6	3	0.7502
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	3	0.7500
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7500
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.7497
WxcM-like protein	Q12KT8	Q12KT8_SHEDO	Shewanella denitrificans	3	0.7487
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7472
Serpin domain-containing protein	H0ZQY2	H0ZQY2_TAEGU	Taeniopygia guttata	3	0.7469
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7459
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.7454
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7449
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7440
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7440
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.7427
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7421
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7415
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7406
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7406
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7405
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7402
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7389
Putative FAD-dependent oxygenase EncM	Q9KHK2	Q9KHK2_9ACTN	Streptomyces maritimus	3	0.7389
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7378
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7375
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7373
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7364
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7354
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7344
Xanthine dehydrogenase/oxidase	P22985	XDH_RAT	Rattus norvegicus	3	0.7344
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7341
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7341
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7340
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7329
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7318
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7315
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7311
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	3	0.7309
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7308
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7307
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7301
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7290
3-hydroxyanthranilate 3,4-dioxygenase	Q1LCS4	3HAO_CUPMC	Cupriavidus metallidurans	2	0.7282
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7277
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7272
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	3	0.7270
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7260
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7256
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	4	0.7245
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7243
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7243
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7242
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7240
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7234
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7230
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7228
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.7227
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7222
Pyruvate kinase PKM	P14618	KPYM_HUMAN	Homo sapiens	3	0.7222
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7211
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7209
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	3	0.7208
Bifunctional dihydrofolate reductase-thymidylate synthase	Q07422	DRTS_TOXGO	Toxoplasma gondii	3	0.7205
Probable flavin-dependent thymidylate synthase	O41156	THYX_PBCV1	Paramecium bursaria Chlorella virus 1	3	0.7203
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7199
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7199
Acyl-homoserine-lactone synthase	Q4VSJ8	Q4VSJ8_BURGL	Burkholderia glumae	4	0.7196
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q8ZMF7	ISPF_SALTY	Salmonella typhimurium	3	0.7193
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7191
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7191
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7179
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	5	0.7177
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	2	0.7167
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7159
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7145
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7145
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7144
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7143
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7136
Dihydrofolate reductase	P0ABQ4	DYR_ECOLI	Escherichia coli	4	0.7126
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7125
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	2	0.7123
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.7113
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7110
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7105
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7101
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7094
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7093
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7088
Cytidylate kinase	Q5SL35	KCY_THET8	Thermus thermophilus	3	0.7086
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7078
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7075
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	3	0.7071
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7070
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7069
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7062
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7055
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7050
cytokinin dehydrogenase	E3T1W8	E3T1W8_MAIZE	Zea mays	2	0.7050
Uridine phosphorylase	Q9KT71	Q9KT71_VIBCH	Vibrio cholerae serotype O1	3	0.7049
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.7048
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7043
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7040
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7024
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	2	0.7020
Avidin	P02701	AVID_CHICK	Gallus gallus	2	0.7020
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	2	0.7019
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7005
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7004
Peroxisome proliferator-activated receptor alpha	Q07869	PPARA_HUMAN	Homo sapiens	2	0.7002
Aspartate carbamoyltransferase catalytic subunit	P0A786	PYRB_ECOLI	Escherichia coli	3	0.7001

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