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Erioschalcone A

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Chalcone
- Subclass: Dihydrochalcone

Canonical Smiles	COc1ccc(cc1)CCC(=O)c1ccc(c(c1O)CC=C(C)C)O
InChI	InChI=1S/C21H24O4/c1-14(2)4-10-17-20(23)13-11-18(21(17)24)19(22)12-7-15-5-8-16(25-3)9-6-15/h4-6,8-9,11,13,23-24H,7,10,12H2,1-3H3
InChIKey	RFZRFNUWZTVCJK-UHFFFAOYSA-N
Formula	C₂₁H₂₄O₄
HBA	4
HBD	2
MW	340.42
Rotatable Bonds	7
TPSA	66.76
LogP	4.43
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	25
Formal Charge	0
Fraction CSP3	0.29
Exact Mass	340.17
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Eriosema glomerata	Leguminosae/Fabaceae	Plantae	109225

Showing of synonyms

Awouafack MD, Kouam SF, et al. (2008). Antimicrobial prenylated dihydrochalcones from Eriosema glomerata.. Planta medica,2008, 74(1), 50-54. [View] [PubMed]

Pubchem: 102393958

Zinc: ZINC000238737390

Nmrshiftdb2: 70016628

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)CCc2ccccc2

Level: 1

Mol. Weight: 340.42 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 340.42 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.67
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.660
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.46

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.230
Plasma Protein Binding: 63.53
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 4.630
Organic Cation Transporter 2: Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 0.880
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.890
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.880
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.230
Rat (Acute): 1.880
Rat (Chronic Oral): 2.810
Fathead Minnow: 4.860
Respiratory Disease: Toxic
Skin Sensitisation: Safe
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 412.790
Hydration Free Energy: -10.240
Log(D) at pH=7.4: 4.050
Log(P): 5.22
Log S: -6.21
Log(Vapor Pressure): -7.59
Melting Point: 106.73
pKa Acid: 8.21
pKa Basic: 7.9

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9733
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.9701
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9690
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9638
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9594
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.9539
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9488
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9328
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.9328
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9245
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	4	0.9228
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.9158
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.9152
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.9140
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.9126
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9125
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.9040
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.9037
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9033
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8985
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8971
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8967
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8963
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8946
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.8944
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8923
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.8917
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8912
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8911
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8880
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8853
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.8853
Isoliquiritigenin 2'-O-methyltransferase	P93324	CHOMT_MEDSA	Medicago sativa	4	0.8814
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8773
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.8749
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.8729
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8726
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8693
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8690
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8685
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8682
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8643
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8615
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8608
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8604
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.8602
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8595
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	4	0.8591
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8589
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.8589
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8581
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8540
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8537
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.8536
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8491
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8473
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.8453
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8424
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8420
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.8414
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.8384
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.8352
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8340
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8338
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8334
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8305
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8287
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8281
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8281
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.8225
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8221
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8220
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8213
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8209
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.8208
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.8204
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8203
Thymidylate synthase	P0A886	TYSY_ECO57	Escherichia coli O157:H7	3	0.8195
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	O02697	PK3CG_PIG	Sus scrofa	3	0.8193
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.8181
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8170
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8165
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	4	0.8152
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8142
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8104
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8100
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8079
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8059
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8057
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8055
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8045
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.8037
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8034
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7981
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7972
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7967
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7965
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7963
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	3	0.7950
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7931
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	4	0.7922
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7921
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7914
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.7909
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7902
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7897
Vitamin D(3) 25-hydroxylase	C4B644	CPVDH_PSEAH	Pseudonocardia autotrophica	3	0.7885
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7881
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7871
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7864
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7854
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7851
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7847
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7827
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7823
Inorganic pyrophosphatase	Q3JUV5	Q3JUV5_BURP1	Burkholderia pseudomallei	3	0.7807
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7803
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7800
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7791
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7791
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7787
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7786
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7784
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7783
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7768
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7767
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.7759
C-1-tetrahydrofolate synthase, cytoplasmic	P11586	C1TC_HUMAN	Homo sapiens	3	0.7756
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.7756
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7755
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7750
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7733
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7729
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7726
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7718
Caspase-3	P42574	CASP3_HUMAN	Homo sapiens	2	0.7716
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7711
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7708
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7707
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7704
cGMP-dependent protein kinase 1	P00516	KGP1_BOVIN	Bos taurus	3	0.7704
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7703
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.7702
Ephrin type-A receptor 2	P29317	EPHA2_HUMAN	Homo sapiens	3	0.7697
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7695
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7691
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7690
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7688
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7684
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7676
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7671
Trichothecene 15-O-acetyltransferase TRI3	Q9C1B7	TRI3_FUSSP	Fusarium sporotrichioides	3	0.7658
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7655
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	4	0.7651
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7622
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7622
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7618
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7594
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7594
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7591
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7589
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7586
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7580
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	2	0.7580
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7572
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7571
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7564
Protein RecA	Q59560	RECA_MYCS2	Mycolicibacterium smegmatis155)	3	0.7564
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7564
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7561
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.7559
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7553
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7548
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7544
Beta-lactamase	P00811	AMPC_ECOLI	Escherichia coli	3	0.7529
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	4	0.7527
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7520
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7518
Cellular tumor antigen p53	P04637	P53_HUMAN	Homo sapiens	3	0.7513
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7512
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7507
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7504
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7503
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7501
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7496
Pteridine reductase 1	Q01782	PTR1_LEIMA	Leishmania major	3	0.7490
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	3	0.7489
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7487
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7480
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7479
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.7478
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	4	0.7478
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7477
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7475
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7470
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7470
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7465
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7464
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7456
Reductase homolog	Q9ZGC1	Q9ZGC1_STRCY	Streptomyces cyanogenus	4	0.7454
DNA polymerase III subunit epsilon	P03007	DPO3E_ECOLI	Escherichia coli	3	0.7446
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7444
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7443
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7441
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7440
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7438
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7437
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7435
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7434
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7431
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7429
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7427
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7427
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7426
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7423
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7412
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7411
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7407
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7406
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7404
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7404
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7400
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7395
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7395
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7393
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7392
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7391
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7385
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7378
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7378
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7376
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7376
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7376
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7373
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7372
2-aminohexano-6-lactam racemase	Q7M181	ACLR_ACHOB	Achromobacter obae	2	0.7371
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7370
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7368
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7367
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7364
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7363
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7363
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7356
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7354
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7353
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7351
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7350
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7349
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7349
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7348
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7343
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7341
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7340
Nucleoprotein	P33469	NCAP_CVHOC	Human coronavirus OC43	3	0.7339
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7337
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7337
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7336
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7336
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7335
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.7331
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7329
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.7328
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.7325
Hypoxanthine phosphoribosyltransferase	Q4DRC4	Q4DRC4_TRYCC	Trypanosoma cruzi	2	0.7324
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.7322
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.7322
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7318
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7314
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7309
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7307
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7306
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7306
Cyclin-G-associated kinase	O14976	GAK_HUMAN	Homo sapiens	4	0.7303
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7298
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7298
Pantothenate synthetase	P9WIL4	PANC_MYCTO	Mycobacterium tuberculosis	2	0.7293
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	2	0.7292
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7290
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7289
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7282
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7280
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.7279
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7278
3',5'-cyclic-AMP phosphodiesterase 4A	P27815	PDE4A_HUMAN	Homo sapiens	3	0.7277
Gentisate 1,2-dioxygenase	Q67FT0	Q67FT0_PSESE	Pseudaminobacter salicylatoxidans	2	0.7276
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7272
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7272
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7271
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7271
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7270
Thymidylate synthase	P45352	TYSY_RAT	Rattus norvegicus	2	0.7268
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7268
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7266
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.7264
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	2	0.7262
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7256
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	2	0.7256
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7255
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7255
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7254
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7253
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7252
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7251
Rifampin ADP-ribosyl transferase	A0QRS5	A0QRS5_MYCS2	Mycolicibacterium smegmatis155)	3	0.7244
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7243
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7243
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7243
Polymerase basic protein 2	Q2LG68	Q2LG68_9INFA	Influenza A virus)	4	0.7240
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7240
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7239
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7237
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7237
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7233
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7233
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7230
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7227
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	4	0.7220
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	2	0.7220
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.7213
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7213
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7208
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7207
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7203
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7194
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7189
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	O35904	PK3CD_MOUSE	Mus musculus	3	0.7188
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7187
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7187
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	P33038	MURA_ENTCC	Enterobacter cloacae subsp. cloacae	2	0.7185
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7181
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7176
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7176
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7169
Dual specificity mitogen-activated protein kinase kinase 1	Q02750	MP2K1_HUMAN	Homo sapiens	2	0.7167
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7164
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7161
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7161
Ephrin type-A receptor 3	P29320	EPHA3_HUMAN	Homo sapiens	3	0.7156
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7156
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7156
Mitogen-activated protein kinase kinase kinase 7	O43318	M3K7_HUMAN	Homo sapiens	3	0.7149
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7146
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7144
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	4	0.7141
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7141
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7139
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7137
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7136
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7135
Beta-adrenergic receptor kinase 1	P25098	ARBK1_HUMAN	Homo sapiens	3	0.7134
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7133
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7133
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	2	0.7131
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7129
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7126
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	2	0.7125
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7124
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7121
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	2	0.7121
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	2	0.7119
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7108
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7108
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	2	0.7106
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7098
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7091
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.7086
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7086
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7085
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7083
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7083
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7083
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7078
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.7077
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7076
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7074
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7068
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.7067
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7062
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	4	0.7060
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7058
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.7058
UDP-galactopyranose mutase	Q48485	GLF1_KLEPN	Klebsiella pneumoniae	3	0.7055
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7054
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7052
Cytochrome P450 2C5	P00179	CP2C5_RABIT	Oryctolagus cuniculus	3	0.7051
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7044
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7044
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7044
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7037
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7036
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	2	0.7033
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7028
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7024
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7020
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7018
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7018
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7016
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	4	0.7015
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7011
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7009
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7007
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7007
Lanosterol 14-alpha-demethylase	Q385E8	Q385E8_TRYB2	Trypanosoma brucei brucei	3	0.7005
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	3	0.7005

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