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Erioschalcone B

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Chalcone
- Subclass: Dihydrochalcone

Canonical Smiles	CC(=CCc1c(O)ccc(c1O)C(=O)CCc1ccccc1)C
InChI	InChI=1S/C20H22O3/c1-14(2)8-10-16-19(22)13-11-17(20(16)23)18(21)12-9-15-6-4-3-5-7-15/h3-8,11,13,22-23H,9-10,12H2,1-2H3
InChIKey	ZNDLKFYDBGZDRM-UHFFFAOYSA-N
Formula	C₂₀H₂₂O₃
HBA	3
HBD	2
MW	310.39
Rotatable Bonds	6
TPSA	57.53
LogP	4.42
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	23
Formal Charge	0
Fraction CSP3	0.25
Exact Mass	310.16
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Eriosema glomerata	Leguminosae/Fabaceae	Plantae	109225

Showing of synonyms

Awouafack MD, Kouam SF, et al. (2008). Antimicrobial prenylated dihydrochalcones from Eriosema glomerata.. Planta medica,2008, 74(1), 50-54. [View] [PubMed]

Pubchem: 162965391

Zinc: ZINC000238782187

No compound-protein relationship available.

SMILES: c1ccccc1C(=O)CCc2ccccc2

Level: 1

Mol. Weight: 310.39 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 310.39 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.8
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.62
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.25

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.1
Plasma Protein Binding: 68.21
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 2.97
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.05
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 1.14
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.86
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 4.32
Rat (Acute): 1.86
Rat (Chronic Oral): 2.57
Fathead Minnow: 4.71
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 392.18
Hydration Free Energy: -10.15
Log(D) at pH=7.4: 4.17
Log(P): 5.31
Log S: -5.14
Log(Vapor Pressure): -7.69
Melting Point: 107.34
pKa Acid: 8.02
pKa Basic: 8.59

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.9625
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.9537
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.9394
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.9336
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9324
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	4	0.9298
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.9288
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9271
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9194
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.9161
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	3	0.9147
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.9142
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	3	0.9114
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.9098
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.9008
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.8993
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.8977
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.8974
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8972
Acetolactate synthase catalytic subunit, mitochondrial	P07342	ILVB_YEAST	Saccharomyces cerevisiae	3	0.8968
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.8961
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	3	0.8951
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8948
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8928
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	3	0.8914
Isoliquiritigenin 2'-O-methyltransferase	P93324	CHOMT_MEDSA	Medicago sativa	4	0.8880
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.8869
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.8855
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8816
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.8782
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.8770
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8739
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8731
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8724
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8719
Rhodopsin kinase GRK1	P28327	GRK1_BOVIN	Bos taurus	3	0.8695
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8689
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.8683
Flavoredoxin	Q72HI0	Q72HI0_THET2	Thermus thermophilus	3	0.8682
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8679
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8611
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8610
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8586
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8581
Acetolactate synthase, chloroplastic	P17597	ILVB_ARATH	Arabidopsis thaliana	3	0.8576
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8575
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8565
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8554
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.8541
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8507
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8480
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8472
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8447
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8425
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8393
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8390
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.8371
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8328
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8325
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8322
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.8317
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8308
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8307
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	3	0.8290
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8287
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8279
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8260
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8252
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.8237
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.8237
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8228
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8216
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8214
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8212
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.8207
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	3	0.8199
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8191
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8185
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8134
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.8115
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.8110
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8099
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8035
Inorganic pyrophosphatase	Q3JUV5	Q3JUV5_BURP1	Burkholderia pseudomallei	3	0.8032
Proton-gated ion channel	Q7NDN8	GLIC_GLOVI	Gloeobacter violaceus	3	0.8032
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.8031
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8028
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.8013
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8005
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.8000
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7993
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.7986
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.7984
Gag-Pol polyprotein	P04584	POL_HV2RO	Human immunodeficiency virus type 2 subtype A	3	0.7978
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7977
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7971
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7968
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7956
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7953
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7947
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	4	0.7913
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.7912
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7884
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	4	0.7850
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7836
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7821
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7808
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7807
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	3	0.7796
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	4	0.7775
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.7772
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	Q6NVY1	HIBCH_HUMAN	Homo sapiens	3	0.7746
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7745
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7745
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	3	0.7743
C-1-tetrahydrofolate synthase, cytoplasmic	P11586	C1TC_HUMAN	Homo sapiens	3	0.7742
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7741
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7727
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.7713
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7711
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7705
HTH-type transcriptional regulator QacR	P0A0N4	QACR_STAAU	Staphylococcus aureus	3	0.7704
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7701
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7692
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	3	0.7684
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7679
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7677
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7674
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.7670
HLA class I histocompatibility antigen, B alpha chain	P01889	HLAB_HUMAN	Homo sapiens	3	0.7668
Abscisic acid receptor PYL9	Q84MC7	PYL9_ARATH	Arabidopsis thaliana	3	0.7662
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7661
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	3	0.7655
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7653
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7648
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.7644
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7642
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7638
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7629
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7627
Subunit alpha of sarocosine oxidase	Q50LF0	Q50LF0_9CORY	Corynebacterium sp. U-96	3	0.7619
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7619
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	3	0.7615
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7610
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.7607
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7607
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7586
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7577
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7576
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7569
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7561
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.7561
Cellular tumor antigen p53	P04637	P53_HUMAN	Homo sapiens	3	0.7551
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7548
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7548
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.7546
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	3	0.7543
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.7543
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7527
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	3	0.7524
Lanosterol 14-alpha-demethylase	Q385E8	Q385E8_TRYB2	Trypanosoma brucei brucei	3	0.7520
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7518
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7514
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7511
Polyribonucleotide nucleotidyltransferase	A7ZS61	PNP_ECO24	Escherichia coli O139:H28	3	0.7509
histone deacetylase	A5H660	A5H660_SCHMA	Schistosoma mansoni	3	0.7502
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7497
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.7495
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.7491
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7483
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7482
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7480
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7480
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7479
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7477
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.7477
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7476
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7469
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7467
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7464
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	4	0.7450
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7449
Phospholipase A2, major isoenzyme	P00592	PA21B_PIG	Sus scrofa	3	0.7442
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.7439
Glycogen synthase	Q9V2J8	Q9V2J8_PYRAB	Pyrococcus abyssi	3	0.7436
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7433
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7424
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7417
Dihydrofolate reductase	P00374	DYR_HUMAN	Homo sapiens	3	0.7415
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.7411
Ephrin type-A receptor 3	P29320	EPHA3_HUMAN	Homo sapiens	3	0.7403
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	2	0.7401
D-aminoacyl-tRNA deacylase	Q8IIS0	DTD_PLAF7	Plasmodium falciparum	2	0.7400
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.7393
Lethal(3)malignant brain tumor-like protein 1	Q9Y468	LMBL1_HUMAN	Homo sapiens	3	0.7387
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7383
HTH-type transcriptional regulator QacR	P0A0N3	QACR_STAAM	Staphylococcus aureus	3	0.7376
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7376
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.7374
Pyridoxal kinase	P82197	PDXK_SHEEP	Ovis aries	3	0.7370
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7370
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7370
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	3	0.7369
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7357
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.7356
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7355
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7341
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7337
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7334
Retinol-binding protein 1	P09455	RET1_HUMAN	Homo sapiens	3	0.7330
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7328
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7322
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7322
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	3	0.7316
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7314
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7312
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	3	0.7306
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7304
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7303
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7300
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7300
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7297
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	2	0.7291
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7291
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7287
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7286
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7279
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	4	0.7275
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7264
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7258
Metallo-beta-lactamase type 2	C7C422	BLAN1_KLEPN	Klebsiella pneumoniae	2	0.7256
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7247
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7245
Tannase	B3Y018	B3Y018_LACPN	Lactiplantibacillus plantarum	3	0.7245
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	3	0.7234
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.7234
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7233
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7232
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7230
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7228
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7224
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7222
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	2	0.7220
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7220
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	3	0.7219
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7213
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7212
Casein kinase II subunit alpha	P28523	CSK2A_MAIZE	Zea mays	3	0.7212
Serine/threonine-protein kinase B-raf	P15056	BRAF_HUMAN	Homo sapiens	3	0.7211
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7211
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.7210
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7206
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	4	0.7205
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7205
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7203
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7200
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7196
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7194
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.7192
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.7192
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7184
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7183
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.7177
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.7172
GTPase KRas	P01116	RASK_HUMAN	Homo sapiens	3	0.7170
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7166
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R_HUMAN	Homo sapiens	3	0.7160
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7159
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7158
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7157
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7154
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7153
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7152
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7151
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	2	0.7144
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7142
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7133
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7132
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7123
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	3	0.7123
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.7120
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7119
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7114
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7113
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7110
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7109
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7104
Gag-Pol polyprotein	P03366	POL_HV1B1	Human immunodeficiency virus type 1 group M subtype B	4	0.7103
Calmodulin-domain protein kinase 1, putative	A3FQ16	A3FQ16_CRYPI	Cryptosporidium parvum	3	0.7103
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7097
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7097
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7094
Vitamin D3 dihydroxylase	P18326	CPXE_STRGO	Streptomyces griseolus	3	0.7093
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7093
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7088
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	2	0.7087
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	3	0.7086
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	3	0.7084
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7083
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7079
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7075
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	2	0.7075
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7073
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7063
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7062
D-alanyl-D-alanine carboxypeptidase	P15555	DAC_STRSR	Streptomyces sp	2	0.7060
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7056
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7055
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7055
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7054
Bacteriorhodopsin	P02945	BACR_HALSA	Halobacterium salinarum	3	0.7053
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7047
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7043
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7041
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7038
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7034
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	2	0.7027
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7026
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7024
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7023
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7022
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7021
Botulinum neurotoxin type A	P0DPI0	BXA1_CLOBO	Clostridium botulinum	2	0.7019
Unconventional myosin-Va	Q02440	MYO5A_CHICK	Gallus gallus	2	0.7018
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7017
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7015
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7013
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7009
RNA-dependent RNA polymerase	Q6A562	Q6A562_9VIRU	Thosea asigna virus	2	0.7008
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7005
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7003

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