Variabilin - Compound Card

Variabilin

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Variabilin

Structure
Zoomed Structure
  • Family: Plantae - Leguminosae/Fabaceae
  • Kingdom: Plantae
  • Class: Terpenoid
    • Subclass: Sesquiterpene
Canonical Smiles C/C(=C\CC/C(=C/CCc1cocc1)/C)/CCCC(/C=C/1\OC(=O)C(=C1O)C)C
InChI InChI=1S/C25H34O4/c1-18(8-5-9-19(2)11-7-13-22-14-15-28-17-22)10-6-12-20(3)16-23-24(26)21(4)25(27)29-23/h8,11,14-17,20,26H,5-7,9-10,12-13H2,1-4H3/b18-8+,19-11+,23-16-
InChIKey HPVSJNGZYYDDMU-FECKPXKMSA-N
Formula C25H34O4
HBA 4
HBD 1
MW 398.54
Rotatable Bonds 11
TPSA 59.67
LogP 6.96
Number Rings 2
Number Aromatic Rings 1
Heavy Atom Count 29
Formal Charge 0
Fraction CSP3 0.48
Exact Mass 398.25
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Millettia macrophylla Leguminosae/Fabaceae Plantae 1712208

Showing of synonyms

  • Zingue S, Tchoumtchoua J, et al. (2016). Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms.. BMC complementary and alternative medicine,2016, 16(1), 421. [View] [PubMed]

No compound-protein relationship available.

Structure

SMILES: O=C(O1)C=CC1=CCCCCC=CCCC=CCCc2ccoc2

Level: 1

Mol. Weight: 398.54 g/mol

Structure

SMILES: C=C1C=CC(=O)O1

Level: 0

Mol. Weight: 398.54 g/mol

Structure

SMILES: c1ccoc1

Level: 0

Mol. Weight: 398.54 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.95
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.78
Human Oral Bioavailability 50%
Non-Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-3.48

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.57
Plasma Protein Binding
53.76
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.36
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Safe
Bioconcentration Factor
0.83
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.8
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
7.11
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-11.58
Rat (Acute)
2.56
Rat (Chronic Oral)
2.22
Fathead Minnow
5.66
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
423.62
Hydration Free Energy
-4.5
Log(D) at pH=7.4
4.39
Log(P)
6.31
Log S
-6.46
Log(Vapor Pressure)
-8.05
Melting Point
37.44
pKa Acid
8.12
pKa Basic
6.3
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.9729
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 3 0.9719
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9654
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.9646
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.9601
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.9518
Cytochrome b6 P83791 CYB6_MASLA Mastigocladus laminosus 3 0.9432
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.9411
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.9400
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9381
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.9365
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.9360
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.9325
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9319
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.9317
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.9244
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9232
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9232
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 3 0.9156
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.9141
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.9064
Sterol 14alpha-demethylase P9WPP9 CP51_MYCTU Mycobacterium tuberculosis 3 0.9041
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.9022
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9007
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8916
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.8911
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8836
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8833
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8793
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 3 0.8788
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.8731
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8631
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8610
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8547
Cartilage oligomeric matrix protein P35444 COMP_RAT Rattus norvegicus 3 0.8540
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.8456
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8432
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.8405
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8388
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8384
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 3 0.8363
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.8357
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8355
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 3 0.8316
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 3 0.8313
Beta-elicitin cryptogein P15570 ELIB_PHYCR Phytophthora cryptogea 3 0.8300
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.8273
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 3 0.8231
Fatty acid-binding protein, adipocyte P15090 FABP4_HUMAN Homo sapiens 2 0.8216
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.8206
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8168
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.8164
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8161
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.8151
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.8128
Cellular retinol-binding protein type II Q8UVG6 Q8UVG6_DANRE Danio rerio 3 0.8111
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.8087
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8072
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8068
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8049
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.8044
Hemolymph juvenile hormone binding protein Q9U556 Q9U556_BOMMO Bombyx mori 3 0.8043
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.8020
17-beta-hydroxysteroid dehydrogenase 14 Q9BPX1 DHB14_HUMAN Homo sapiens 2 0.8012
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.8008
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.8000
Glycylpeptide N-tetradecanoyltransferase A5K1A2 A5K1A2_PLAVS Plasmodium vivax 3 0.7991
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7987
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7979
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7974
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7968
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7959
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7954
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7953
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7953
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7945
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7942
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 2 0.7938
Oxysterols receptor LXR-beta P55055 NR1H2_HUMAN Homo sapiens 3 0.7934
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7933
Nuclear receptor ROR-gamma P51449 RORG_HUMAN Homo sapiens 2 0.7928
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7927
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7925
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7923
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7923
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7922
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7918
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7912
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7906
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7904
Cytochrome P450 S6BVH1 S6BVH1_RHOER Rhodococcus erythropolis 3 0.7903
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7899
Peridinin-chlorophyll a protein, high-salt form O76183 O76183_AMPCA Amphidinium carterae 3 0.7898
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7898
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7894
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7891
Lanosterol 14-alpha-demethylase Q385E8 Q385E8_TRYB2 Trypanosoma brucei brucei 3 0.7890
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7890
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7881
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7878
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7877
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7876
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7871
Aromatase P11511 CP19A_HUMAN Homo sapiens 2 0.7870
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7867
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7861
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7860
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7858
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7856
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7846
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7845
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7844
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7843
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7836
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7835
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7834
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7830
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7830
Retinol-binding protein 2 P06768 RET2_RAT Rattus norvegicus 3 0.7829
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 2 0.7828
Chitinase Q54276 Q54276_SERMA Serratia marcescens 2 0.7826
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7825
Progesterone receptor P06401 PRGR_HUMAN Homo sapiens 2 0.7823
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7819
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 2 0.7817
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 2 0.7815
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7809
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7804
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7793
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7786
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 2 0.7785
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7785
Albumin P14639 ALBU_SHEEP Ovis aries 2 0.7783
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7782
Steroid 21-hydroxylase P08686 CP21A_HUMAN Homo sapiens 2 0.7781
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7781
Trichosurin Q29147 TRIC_TRIVU Trichosurus vulpecula 2 0.7781
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7780
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7771
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7771
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 2 0.7770
Nuclear receptor ROR-alpha P35398 RORA_HUMAN Homo sapiens 4 0.7769
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 2 0.7767
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7762
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7762
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7760
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7757
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7756
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7752
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7750
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 2 0.7750
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 2 0.7749
Methyl-branched lipid omega-hydroxylase P9WPP3 CP124_MYCTU Mycobacterium tuberculosis 3 0.7748
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 3 0.7748
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7747
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 2 0.7746
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7745
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7744
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7744
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7742
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7742
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7735
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 2 0.7733
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 2 0.7723
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7723
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7722
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7721
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7720
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7717
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7706
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7705
Cartilage oligomeric matrix protein Q9R0G6 COMP_MOUSE Mus musculus 3 0.7701
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 2 0.7699
Bacteriorhodopsin P02945 BACR_HALSA Halobacterium salinarum 3 0.7695
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7694
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7692
DNA double-strand break repair protein Mre11 Q9X1X0 Q9X1X0_THEMA Thermotoga maritima MSB8 3 0.7690
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7688
Lanosterol synthase P48449 ERG7_HUMAN Homo sapiens 3 0.7688
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 2 0.7687
HTH-type transcriptional regulator EthR P9WMC1 ETHR_MYCTU Mycobacterium tuberculosis 2 0.7686
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 4 0.7685
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7684
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7683
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7683
Odorant binding protein ASP1 Q8WRW5 Q8WRW5_APIME Apis mellifera 2 0.7682
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7679
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7679
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7673
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7668
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7665
Protein LlR18A P52778 L18A_LUPLU Lupinus luteus 2 0.7659
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7649
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7648
Calmodulin-1 P0DP29 CALM1_RAT Rattus norvegicus 2 0.7638
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7635
Probable esterase KAI2 Q9SZU7 KAI2_ARATH Arabidopsis thaliana 2 0.7635
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7631
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7626
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7625
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7625
Regulatory protein SdiA P07026 SDIA_ECOLI Escherichia coli 3 0.7623
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7622
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7618
Disks large homolog 1 Q12959 DLG1_HUMAN Homo sapiens 3 0.7616
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 2 0.7613
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7609
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 2 0.7608
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7603
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7601
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7600
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7599
Aminoglycoside 3'-phosphotransferase P0A3Y5 KKA3_ENTFL Enterococcus faecalis 2 0.7598
Eugenol synthase 1 Q15GI4 EGS1_OCIBA Ocimum basilicum 2 0.7597
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7581
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7580
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7578
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7576
Retinol-binding protein 4 P02753 RET4_HUMAN Homo sapiens 3 0.7575
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7575
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7575
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 2 0.7574
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7573
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7573
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7572
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7571
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7570
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 2 0.7568
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7564
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7562
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7559
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 2 0.7553
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 2 0.7552
Steroid 17-alpha-hydroxylase/17,20 lyase P05093 CP17A_HUMAN Homo sapiens 2 0.7552
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 2 0.7545
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 2 0.7545
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 2 0.7542
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7536
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7528
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 2 0.7525
Putative cytochrome P450 120 Q59990 CP120_SYNY3 Synechocystis sp 3 0.7520
NPC intracellular cholesterol transporter 1 O15118 NPC1_HUMAN Homo sapiens 4 0.7520
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 2 0.7511
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7510
Acyl-coenzyme A synthetase ACSM2A, mitochondrial Q08AH3 ACS2A_HUMAN Homo sapiens 2 0.7509
Beta-2 adrenergic receptor P07550 ADRB2_HUMAN Homo sapiens 2 0.7490
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7484
Retinaldehyde-binding protein 1 P12271 RLBP1_HUMAN Homo sapiens 3 0.7483
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7482
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7481
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7480
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7479
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 2 0.7478
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 2 0.7472
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7469
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 2 0.7467
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 2 0.7466
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7464
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7463
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7462
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 2 0.7458
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 3 0.7456
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7455
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7444
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7442
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 2 0.7441
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 3 0.7437
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7436
Abscisic acid receptor PYR1 O49686 PYR1_ARATH Arabidopsis thaliana 2 0.7431
Heat shock protein 83 P12861 HSP83_TRYBB Trypanosoma brucei brucei 3 0.7430
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7427
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7426
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7426
Fumarate reductase subunit D P0A8Q3 FRDD_ECOLI Escherichia coli 2 0.7421
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7415
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7415
Thyroid hormone receptor alpha P04625 THA_CHICK Gallus gallus 3 0.7412
Thymidine kinase P0DTH5 KITH_HHV11 Human herpesvirus 1 2 0.7412
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 2 0.7408
Acetylcholine-binding protein P58154 ACHP_LYMST Lymnaea stagnalis 2 0.7395
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7390
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7388
Kynurenine 3-monooxygenase P38169 KMO_YEAST Saccharomyces cerevisiae 2 0.7386
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7379
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7374
Retinol-binding protein 1 P09455 RET1_HUMAN Homo sapiens 3 0.7368
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7367
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7366
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7365
Vitamin D3 receptor P13053 VDR_RAT Rattus norvegicus 3 0.7363
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7351
NADH:flavin oxidoreductase Sye1 Q8EEC8 Q8EEC8_SHEON Shewanella oneidensis 2 0.7350
D(3) dopamine receptor P35462 DRD3_HUMAN Homo sapiens 2 0.7349
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 2 0.7338
Chloramphenicol acetyltransferase P62577 CAT_ECOLX Escherichia coli 3 0.7336
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7330
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7329
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7325
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7324
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7323
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7313
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7307
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 2 0.7303
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7299
Dicamba O-demethylase, oxygenase component Q5S3I3 DDMC_STEMA Stenotrophomonas maltophilia 2 0.7299
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7297
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7295
Genome polyprotein P03303 POLG_HRV14 Human rhinovirus 14 3 0.7284
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7279
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7275
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7268
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7254
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7246
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7244
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7243
D-alanine--D-alanine ligase Q5HEB7 DDL_STAAC Staphylococcus aureus 2 0.7236
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7235
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 2 0.7235
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7224
N-terminal acetyltransferase A complex subunit NAT1 P12945 NAT1_YEAST Saccharomyces cerevisiae 2 0.7223
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7212
Retinoic acid receptor gamma P13631 RARG_HUMAN Homo sapiens 3 0.7208
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 2 0.7204
Lanosterol 14-alpha demethylase CYP51 P10614 CP51_YEAST Saccharomyces cerevisiae 3 0.7203
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7203
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7201
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.7198
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7195
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.7186
Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily Q9XZJ5 Q9XZJ5_STRER Strongyloides stercoralis 3 0.7175
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7172
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 2 0.7171
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7170
Abscisic acid receptor PYL9 Q84MC7 PYL9_ARATH Arabidopsis thaliana 2 0.7170
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 2 0.7167
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 2 0.7161
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7159
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 3 0.7157
Corticosteroid-binding globulin P31211 CBG_RAT Rattus norvegicus 3 0.7155
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 3 0.7151
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 2 0.7143
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 3 0.7142
Beta-elicitin cinnamomin P15569 ELIB_PHYCI Phytophthora cinnamomi 3 0.7131
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7127
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 4 0.7126
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7125
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7124
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) P60472 UPPS_ECOLI Escherichia coli 3 0.7121
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7116
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 2 0.7116
Quorum-sensing transcriptional activator Q8XBD0 Q8XBD0_ECO57 Escherichia coli O157:H7 2 0.7110
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 2 0.7108
Retinoic acid receptor beta P10826 RARB_HUMAN Homo sapiens 3 0.7107
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7105
C-C chemokine receptor type 5 P51681 CCR5_HUMAN Homo sapiens 3 0.7102
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7098
Retinol-binding protein 2 P50120 RET2_HUMAN Homo sapiens 3 0.7096
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7096
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7094
Envelope glycoprotein gp160 C6G099 C6G099_9HIV1 Human immunodeficiency virus 1 2 0.7092
Nuclear receptor coactivator 2 Q15596 NCOA2_HUMAN Homo sapiens 3 0.7091
Virginiamycin A acetyltransferase P26839 VATA_STAAU Staphylococcus aureus 3 0.7087
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7085
Metapyrocatechase Q7WYF5 Q7WYF5_9PSED Pseudomonas alkylphenolica 2 0.7083
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7080
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7076
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7071
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7065
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7060
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.7059
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7059
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7056
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7049
Aryl hydrocarbon receptor nuclear translocator P53762 ARNT_MOUSE Mus musculus 3 0.7046
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7045
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7039
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7039
Streptogramin A acetyltransferase P50870 VATD_ENTFC Enterococcus faecium 3 0.7038
Mineralocorticoid receptor P08235 MCR_HUMAN Homo sapiens 3 0.7038
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7035
Cellular retinoic acid-binding protein 2 P29373 RABP2_HUMAN Homo sapiens 2 0.7027
ABC-type polar amino acid transport system, ATPase component Q8RCC2 Q8RCC2_CALS4 Caldanaerobacter subterraneus subsp. tengcongensis 2 0.7022
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 3 0.7021
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 3 0.7014
4-chlorobenzoyl CoA ligase Q8GN86 Q8GN86_9BURK Alcaligenes sp. AL3007 2 0.7012
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 2 0.7010
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7007
Cholesterol 24-hydroxylase Q9Y6A2 CP46A_HUMAN Homo sapiens 2 0.7003
Fatty acid-binding protein, intestinal P02693 FABPI_RAT Rattus norvegicus 3 0.7002
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 2 0.7000

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