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Variabilin

Family: Leguminosae/Fabaceae
Kingdom: Plantae
Class: Terpenoid
- Subclass: Sesquiterpene

Canonical Smiles	C/C(=C\CC/C(=C/CCc1cocc1)/C)/CCCC(/C=C/1\OC(=O)C(=C1O)C)C
InChI	InChI=1S/C25H34O4/c1-18(8-5-9-19(2)11-7-13-22-14-15-28-17-22)10-6-12-20(3)16-23-24(26)21(4)25(27)29-23/h8,11,14-17,20,26H,5-7,9-10,12-13H2,1-4H3/b18-8+,19-11+,23-16-
InChIKey	HPVSJNGZYYDDMU-FECKPXKMSA-N
Formula	C₂₅H₃₄O₄
HBA	4
HBD	1
MW	398.54
Rotatable Bonds	11
TPSA	59.67
LogP	6.96
Number Rings	2
Number Aromatic Rings	1
Heavy Atom Count	29
Formal Charge	0
Fraction CSP3	0.48
Exact Mass	398.25
Number of Lipinski Rule Violations	1

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Millettia macrophylla	Leguminosae/Fabaceae	Plantae	1712208

Showing of synonyms

Zingue S, Tchoumtchoua J, et al. (2016). Estrogenic and cytotoxic potentials of compounds isolated from Millettia macrophylla Benth (Fabaceae): towards a better understanding of its underlying mechanisms.. BMC complementary and alternative medicine,2016, 16(1), 421. [View] [PubMed]

Pubchem: 54678431

Cas: 51847-87-1

Gnps: CCMSLIB00006716187

Nmrshiftdb2: 60043745

Chembl: CHEMBL463244

No compound-protein relationship available.

SMILES: O=C(O1)C=CC1=CCCCCC=CCCC=CCCc2ccoc2

Level: 1

Mol. Weight: 326.44 g/mol

SMILES: C=C1C=CC(=O)O1

Level: 0

Mol. Weight: 96.08 g/mol

SMILES: c1ccoc1

Level: 0

Mol. Weight: 68.07 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.95
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.78
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -3.48

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.57
Plasma Protein Binding: 53.76
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 2.36
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.83
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: -0.8
Liver Injury II: Safe
hERG Blockers: Safe
Daphnia Maga: 7.11
Micronucleos: Safe
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: -11.58
Rat (Acute): 2.56
Rat (Chronic Oral): 2.22
Fathead Minnow: 5.66
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Toxic
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 423.62
Hydration Free Energy: -4.5
Log(D) at pH=7.4: 4.39
Log(P): 6.31
Log S: -6.46
Log(Vapor Pressure): -8.05
Melting Point: 37.44
pKa Acid: 8.12
pKa Basic: 6.3

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.9729
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.9719
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9654
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.9646
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.9601
Probable NDP-rhamnosyltransferase	Q9ALM8	Q9ALM8_SACSN	Saccharopolyspora spinosa	3	0.9518
Cytochrome b6	P83791	CYB6_MASLA	Mastigocladus laminosus	3	0.9432
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.9411
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	3	0.9400
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.9381
Integrin alpha-L	P20701	ITAL_HUMAN	Homo sapiens	3	0.9365
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.9360
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	3	0.9325
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9319
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	3	0.9317
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.9244
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.9232
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.9232
Aldo-keto reductase family 1 member C1	Q04828	AK1C1_HUMAN	Homo sapiens	3	0.9156
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.9141
Vitamin D(3) 25-hydroxylase	C4B644	CPVDH_PSEAH	Pseudonocardia autotrophica	3	0.9064
Sterol 14alpha-demethylase	P9WPP9	CP51_MYCTU	Mycobacterium tuberculosis	3	0.9041
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.9022
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	2	0.9007
Rhodopsin	P02699	OPSD_BOVIN	Bos taurus	3	0.8916
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.8911
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8836
Retinol dehydratase	Q26490	Q26490_SPOFR	Spodoptera frugiperda	3	0.8833
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	3	0.8793
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	3	0.8788
Retinol-binding protein 2	P50120	RET2_HUMAN	Homo sapiens	3	0.8731
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	3	0.8631
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.8610
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.8547
Cartilage oligomeric matrix protein	P35444	COMP_RAT	Rattus norvegicus	3	0.8540
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.8456
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.8432
Corticosteroid-binding globulin	P08185	CBG_HUMAN	Homo sapiens	3	0.8405
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	3	0.8404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	3	0.8388
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	3	0.8384
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	3	0.8363
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.8357
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.8355
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	3	0.8316
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	3	0.8313
Beta-elicitin cryptogein	P15570	ELIB_PHYCR	Phytophthora cryptogea	3	0.8300
Retinol-binding protein 1	P09455	RET1_HUMAN	Homo sapiens	3	0.8273
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	3	0.8231
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.8216
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.8206
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8168
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.8164
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.8161
Retinol-binding protein 1	P02696	RET1_RAT	Rattus norvegicus	3	0.8151
Nuclear receptor coactivator 2	Q15596	NCOA2_HUMAN	Homo sapiens	3	0.8128
Cellular retinol-binding protein type II	Q8UVG6	Q8UVG6_DANRE	Danio rerio	3	0.8111
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	2	0.8087
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8072
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.8068
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.8049
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	3	0.8044
Hemolymph juvenile hormone binding protein	Q9U556	Q9U556_BOMMO	Bombyx mori	3	0.8043
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.8020
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.8012
Gastrotropin	Q6IMW5	Q6IMW5_DANRE	Danio rerio	2	0.8008
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.8000
Glycylpeptide N-tetradecanoyltransferase	A5K1A2	A5K1A2_PLAVS	Plasmodium vivax	3	0.7991
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7987
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7979
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7974
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7968
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7959
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7954
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7953
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7953
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7945
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7942
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	2	0.7938
Oxysterols receptor LXR-beta	P55055	NR1H2_HUMAN	Homo sapiens	3	0.7934
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7933
Nuclear receptor ROR-gamma	P51449	RORG_HUMAN	Homo sapiens	2	0.7928
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7927
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7925
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7923
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7923
3-alpha-hydroxysteroid dehydrogenase	P23457	DIDH_RAT	Rattus norvegicus	2	0.7922
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7918
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7912
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7906
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7904
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7903
CmeR	Q7B8P6	Q7B8P6_CAMJU	Campylobacter jejuni	2	0.7899
Peridinin-chlorophyll a protein, high-salt form	O76183	O76183_AMPCA	Amphidinium carterae	3	0.7898
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7898
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7894
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7891
Lanosterol 14-alpha-demethylase	Q385E8	Q385E8_TRYB2	Trypanosoma brucei brucei	3	0.7890
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7890
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7881
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7878
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7877
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7876
Cytochrome P450 monooxygenase	Q5YNS8	Q5YNS8_NOCFA	Nocardia farcinica	3	0.7871
Aromatase	P11511	CP19A_HUMAN	Homo sapiens	2	0.7870
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7867
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7861
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7860
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7858
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7856
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7846
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7845
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7844
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7843
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7836
11-beta-hydroxysteroid dehydrogenase 1	P50172	DHI1_MOUSE	Mus musculus	2	0.7835
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7834
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7830
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7830
Retinol-binding protein 2	P06768	RET2_RAT	Rattus norvegicus	3	0.7829
Lactoylglutathione lyase	Q04760	LGUL_HUMAN	Homo sapiens	2	0.7828
Chitinase	Q54276	Q54276_SERMA	Serratia marcescens	2	0.7826
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7825
Progesterone receptor	P06401	PRGR_HUMAN	Homo sapiens	2	0.7823
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.7819
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	2	0.7817
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	2	0.7815
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7809
Sulfotransferase 2A1	Q06520	ST2A1_HUMAN	Homo sapiens	3	0.7804
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7793
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7786
Nuclear receptor subfamily 1 group I member 3	O35627	NR1I3_MOUSE	Mus musculus	2	0.7785
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7785
Albumin	P14639	ALBU_SHEEP	Ovis aries	2	0.7783
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7782
Steroid 21-hydroxylase	P08686	CP21A_HUMAN	Homo sapiens	2	0.7781
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7781
Trichosurin	Q29147	TRIC_TRIVU	Trichosurus vulpecula	2	0.7781
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7780
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7771
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7771
Bifunctional dihydrofolate reductase-thymidylate synthase	P13922	DRTS_PLAFK	Plasmodium falciparum	2	0.7770
Nuclear receptor ROR-alpha	P35398	RORA_HUMAN	Homo sapiens	4	0.7769
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	2	0.7767
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7762
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7762
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7760
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7757
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7756
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7752
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7750
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	2	0.7750
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	2	0.7749
Methyl-branched lipid omega-hydroxylase	P9WPP3	CP124_MYCTU	Mycobacterium tuberculosis	3	0.7748
ADP-ribosylation factor 1	P84080	ARF1_BOVIN	Bos taurus	3	0.7748
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7747
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7746
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7745
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7744
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7744
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.7742
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7742
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7735
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7733
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	2	0.7723
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7723
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7722
Prostaglandin reductase 2	Q8N8N7	PTGR2_HUMAN	Homo sapiens	2	0.7721
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7720
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7717
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7706
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7705
Cartilage oligomeric matrix protein	Q9R0G6	COMP_MOUSE	Mus musculus	3	0.7701
Fatty acid-binding protein, liver	P80226	FABPL_CHICK	Gallus gallus	2	0.7699
Bacteriorhodopsin	P02945	BACR_HALSA	Halobacterium salinarum	3	0.7695
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.7694
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7692
DNA double-strand break repair protein Mre11	Q9X1X0	Q9X1X0_THEMA	Thermotoga maritima MSB8	3	0.7690
Retinaldehyde-binding protein 1	P12271	RLBP1_HUMAN	Homo sapiens	3	0.7688
Lanosterol synthase	P48449	ERG7_HUMAN	Homo sapiens	3	0.7688
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase	O33877	FABA_PSEAE	Pseudomonas aeruginosa	2	0.7687
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	2	0.7686
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	4	0.7685
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7684
Sodium-dependent dopamine transporter	Q7K4Y6	DAT_DROME	Drosophila melanogaster	2	0.7683
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7683
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	2	0.7682
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7679
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7679
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7673
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7668
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7665
Protein LlR18A	P52778	L18A_LUPLU	Lupinus luteus	2	0.7659
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7649
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7648
Calmodulin-1	P0DP29	CALM1_RAT	Rattus norvegicus	2	0.7638
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7635
Probable esterase KAI2	Q9SZU7	KAI2_ARATH	Arabidopsis thaliana	2	0.7635
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7631
Sulfotransferase 2B1	O00204	ST2B1_HUMAN	Homo sapiens	2	0.7626
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	2	0.7625
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7625
Regulatory protein SdiA	P07026	SDIA_ECOLI	Escherichia coli	3	0.7623
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7622
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7618
Disks large homolog 1	Q12959	DLG1_HUMAN	Homo sapiens	3	0.7616
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	2	0.7613
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7609
Enoyl-[acyl-carrier-protein] reductase [NADH]	P9WGR1	INHA_MYCTU	Mycobacterium tuberculosis	2	0.7608
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7603
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7601
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7600
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7599
Aminoglycoside 3'-phosphotransferase	P0A3Y5	KKA3_ENTFL	Enterococcus faecalis	2	0.7598
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	2	0.7597
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7581
Alcohol dehydrogenase 1C	P00326	ADH1G_HUMAN	Homo sapiens	2	0.7580
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7578
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7576
Retinol-binding protein 4	P02753	RET4_HUMAN	Homo sapiens	3	0.7575
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7575
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7575
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7574
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7573
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7573
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7572
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	2	0.7571
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7570
Aldo-keto reductase family 1 member B1	P80276	ALDR_PIG	Sus scrofa	2	0.7568
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7564
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7562
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7559
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7553
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	2	0.7552
Steroid 17-alpha-hydroxylase/17,20 lyase	P05093	CP17A_HUMAN	Homo sapiens	2	0.7552
Beta-lactoglobulin	P02754	LACB_BOVIN	Bos taurus	2	0.7545
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	2	0.7545
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	2	0.7542
Retinol-binding protein 2	P50120	RET2_HUMAN	Homo sapiens	3	0.7536
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7528
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7525
Putative cytochrome P450 120	Q59990	CP120_SYNY3	Synechocystis sp	3	0.7520
NPC intracellular cholesterol transporter 1	O15118	NPC1_HUMAN	Homo sapiens	4	0.7520
Fatty acid-binding protein 10-A, liver basic	Q9I8L5	FA10A_DANRE	Danio rerio	2	0.7511
Trichodiene synthase	P13513	TRI5_FUSSP	Fusarium sporotrichioides	2	0.7510
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	Q08AH3	ACS2A_HUMAN	Homo sapiens	2	0.7509
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.7490
Casein kinase II subunit alpha'	P19784	CSK22_HUMAN	Homo sapiens	2	0.7484
Retinaldehyde-binding protein 1	P12271	RLBP1_HUMAN	Homo sapiens	3	0.7483
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7482
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7481
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7480
Glutathione S-transferase P	P09211	GSTP1_HUMAN	Homo sapiens	2	0.7479
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7478
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	2	0.7472
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7469
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7467
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	2	0.7466
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7464
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7463
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7462
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	2	0.7458
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.7456
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7455
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7444
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7442
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7441
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	3	0.7437
Aldo-keto reductase family 1 member B10	O60218	AK1BA_HUMAN	Homo sapiens	2	0.7436
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7431
Heat shock protein 83	P12861	HSP83_TRYBB	Trypanosoma brucei brucei	3	0.7430
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7427
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7426
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	2	0.7426
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	2	0.7421
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7415
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7415
Thyroid hormone receptor alpha	P04625	THA_CHICK	Gallus gallus	3	0.7412
Thymidine kinase	P0DTH5	KITH_HHV11	Human herpesvirus 1	2	0.7412
AGAP003309-PA	A0A1U7F4W2	A0A1U7F4W2_ANOGA	Anopheles gambiae	2	0.7408
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	2	0.7395
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7390
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7388
Kynurenine 3-monooxygenase	P38169	KMO_YEAST	Saccharomyces cerevisiae	2	0.7386
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7379
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7374
Retinol-binding protein 1	P09455	RET1_HUMAN	Homo sapiens	3	0.7368
Aromatic-amino-acid aminotransferase	P95468	TYRB_PARDE	Paracoccus denitrificans	2	0.7367
Nuclear receptor ROR-beta	P45446	RORB_RAT	Rattus norvegicus	2	0.7366
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7365
Vitamin D3 receptor	P13053	VDR_RAT	Rattus norvegicus	3	0.7363
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7351
NADH:flavin oxidoreductase Sye1	Q8EEC8	Q8EEC8_SHEON	Shewanella oneidensis	2	0.7350
D(3) dopamine receptor	P35462	DRD3_HUMAN	Homo sapiens	2	0.7349
Epoxide hydrolase	Q41415	Q41415_SOLTU	Solanum tuberosum	2	0.7338
Chloramphenicol acetyltransferase	P62577	CAT_ECOLX	Escherichia coli	3	0.7336
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7330
Aldo-keto reductase family 1 member D1	P51857	AK1D1_HUMAN	Homo sapiens	2	0.7329
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7325
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7324
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.7323
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7313
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7307
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7303
Carminomycin 4-O-methyltransferase DnrK	Q06528	DNRK_STRPE	Streptomyces peucetius	2	0.7299
Dicamba O-demethylase, oxygenase component	Q5S3I3	DDMC_STEMA	Stenotrophomonas maltophilia	2	0.7299
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7297
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7295
Genome polyprotein	P03303	POLG_HRV14	Human rhinovirus 14	3	0.7284
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7279
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7275
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7268
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7254
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.7246
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7244
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7243
D-alanine--D-alanine ligase	Q5HEB7	DDL_STAAC	Staphylococcus aureus	2	0.7236
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7235
cAMP-dependent protein kinase catalytic subunit alpha	P17612	KAPCA_HUMAN	Homo sapiens	2	0.7235
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.7224
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7223
Muconolactone Delta-isomerase	Q8G9L0	Q8G9L0_RHOOP	Rhodococcus opacus	2	0.7212
Retinoic acid receptor gamma	P13631	RARG_HUMAN	Homo sapiens	3	0.7208
Cytochrome P450 2A6	P11509	CP2A6_HUMAN	Homo sapiens	2	0.7204
Lanosterol 14-alpha demethylase CYP51	P10614	CP51_YEAST	Saccharomyces cerevisiae	3	0.7203
Ferrochelatase, mitochondrial	P22830	HEMH_HUMAN	Homo sapiens	3	0.7203
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	3	0.7201
Acetylcholinesterase	P21836	ACES_MOUSE	Mus musculus	2	0.7198
Camphor 5-monooxygenase	P00183	CPXA_PSEPU	Pseudomonas putida	3	0.7195
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7186
Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily	Q9XZJ5	Q9XZJ5_STRER	Strongyloides stercoralis	3	0.7175
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	2	0.7172
Methionine aminopeptidase 2	P50579	MAP2_HUMAN	Homo sapiens	2	0.7171
Protein BRASSINOSTEROID INSENSITIVE 1	O22476	BRI1_ARATH	Arabidopsis thaliana	3	0.7170
Abscisic acid receptor PYL9	Q84MC7	PYL9_ARATH	Arabidopsis thaliana	2	0.7170
Achbp	I6L8L2	I6L8L2_CAPTE	Capitella teleta	2	0.7167
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	2	0.7161
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7159
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	3	0.7157
Corticosteroid-binding globulin	P31211	CBG_RAT	Rattus norvegicus	3	0.7155
Mycinamicin III 3''-O-methyltransferase	Q49492	MYCF_MICGR	Micromonospora griseorubida	3	0.7151
Gastrotropin	P51161	FABP6_HUMAN	Homo sapiens	2	0.7143
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	3	0.7142
Beta-elicitin cinnamomin	P15569	ELIB_PHYCI	Phytophthora cinnamomi	3	0.7131
Glutathione S-transferase A1	P08263	GSTA1_HUMAN	Homo sapiens	2	0.7127
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	4	0.7126
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	2	0.7125
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	P19992	HSD_STREX	Streptomyces exfoliatus	2	0.7124
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	P60472	UPPS_ECOLI	Escherichia coli	3	0.7121
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7116
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	2	0.7116
Quorum-sensing transcriptional activator	Q8XBD0	Q8XBD0_ECO57	Escherichia coli O157:H7	2	0.7110
Envelope glycoprotein gp160	Q0ED31	Q0ED31_9HIV1	Human immunodeficiency virus 1	2	0.7108
Retinoic acid receptor beta	P10826	RARB_HUMAN	Homo sapiens	3	0.7107
Methylketone synthase I	E0YCS2	E0YCS2_SOLHA	Solanum habrochaites	2	0.7105
C-C chemokine receptor type 5	P51681	CCR5_HUMAN	Homo sapiens	3	0.7102
Cytochrome P450	Q93H81	Q93H81_STRAX	Streptomyces avermitilis	2	0.7098
Retinol-binding protein 2	P50120	RET2_HUMAN	Homo sapiens	3	0.7096
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7096
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7094
Envelope glycoprotein gp160	C6G099	C6G099_9HIV1	Human immunodeficiency virus 1	2	0.7092
Nuclear receptor coactivator 2	Q15596	NCOA2_HUMAN	Homo sapiens	3	0.7091
Virginiamycin A acetyltransferase	P26839	VATA_STAAU	Staphylococcus aureus	3	0.7087
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7085
Metapyrocatechase	Q7WYF5	Q7WYF5_9PSED	Pseudomonas alkylphenolica	2	0.7083
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7080
Retinoic acid receptor RXR-alpha	P19793	RXRA_HUMAN	Homo sapiens	3	0.7076
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7071
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7065
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.7060
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	3	0.7059
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.7059
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7056
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7049
Aryl hydrocarbon receptor nuclear translocator	P53762	ARNT_MOUSE	Mus musculus	3	0.7046
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	2	0.7045
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	3	0.7039
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7039
Streptogramin A acetyltransferase	P50870	VATD_ENTFC	Enterococcus faecium	3	0.7038
Mineralocorticoid receptor	P08235	MCR_HUMAN	Homo sapiens	3	0.7038
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7035
Cellular retinoic acid-binding protein 2	P29373	RABP2_HUMAN	Homo sapiens	2	0.7027
ABC-type polar amino acid transport system, ATPase component	Q8RCC2	Q8RCC2_CALS4	Caldanaerobacter subterraneus subsp. tengcongensis	2	0.7022
Retinol-binding protein 4	P18902	RET4_BOVIN	Bos taurus	3	0.7021
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.7014
4-chlorobenzoyl CoA ligase	Q8GN86	Q8GN86_9BURK	Alcaligenes sp. AL3007	2	0.7012
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	2	0.7010
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.7007
Cholesterol 24-hydroxylase	Q9Y6A2	CP46A_HUMAN	Homo sapiens	2	0.7003
Fatty acid-binding protein, intestinal	P02693	FABPI_RAT	Rattus norvegicus	3	0.7002
Androgen receptor	P10275	ANDR_HUMAN	Homo sapiens	2	0.7000

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