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Orobol

Family: Plantae - Leguminosae/Fabaceae
Kingdom: Plantae
Class: Flavonoid
- Subclass: Flavone

Canonical Smiles	Oc1cc(O)c2c(c1)occ(c2=O)c1ccc(c(c1)O)O
InChI	InChI=1S/C15H10O6/c16-8-4-12(19)14-13(5-8)21-6-9(15(14)20)7-1-2-10(17)11(18)3-7/h1-6,16-19H
InChIKey	IOYHCQBYQJQBSK-UHFFFAOYSA-N
Formula	C₁₅H₁₀O₆
HBA	6
HBD	4
MW	286.24
Rotatable Bonds	1
TPSA	111.13
LogP	2.28
Number Rings	3
Number Aromatic Rings	3
Heavy Atom Count	21
Formal Charge	0
Fraction CSP3	0.0
Exact Mass	286.05
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Pseudarthria hookeri	Leguminosae/Fabaceae	Plantae	992776

Showing of synonyms

Tchamgoue J, Hafizur R, et al. (2016). Flavonoids and other constituents with insulin secretion activity from Pseudarthria hookeri. Phytochemistry Letters, 2016, 17, 181-186. [View]

Pubchem: 5281801

Cas: 480-23-9

Zinc: ZINC000006092209

Kegg Ligand: C10510

Chebi: 69437

Nmrshiftdb2: 60023809

Metabolights: MTBLC69437

Chembl: CHEMBL241609

Comptox: DTXSID20197380

Bindingdb: 50025463

CPRiL: 104792

SMILES: c1cccc(c12)occ(c2=O)-c3ccccc3

Level: 1

Mol. Weight: 286.24 g/mol

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 286.24 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 286.24 g/mol

Insulin secretory

Absorption

Caco-2 (logPapp): -5.16
Human Oral Bioavailability 20%: Non-Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -5.12
Human Oral Bioavailability 50%: Non-Bioavailable
P-Glycoprotein Inhibitor: Non-Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: 0.01

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Non-Penetrable
Fraction Unbound (Human): 0.81
Plasma Protein Binding: 87.07
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Non-Substrate
CYP 2C19 Inhibitor: Non-Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Non-Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Non-Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 6.87
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 0.95
Biodegradation: Safe
Carcinogenesis: Safe
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Toxic
Maximum Tolerated Dose: 1.59
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 4.99
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Toxic
NR-ER-LBD: Toxic
NR-GR: Toxic
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.96
Rat (Acute): 2.37
Rat (Chronic Oral): 3.17
Fathead Minnow: 4.27
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Safe
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Toxic
SR-p53: Toxic

General Properties

Boiling Point: 481.41
Hydration Free Energy: -12.91
Log(D) at pH=7.4: 2.45
Log(P): 2.74
Log S: -3.63
Log(Vapor Pressure): -8.93
Melting Point: 321.89
pKa Acid: 6.0
pKa Basic: 7.69

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.9619
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.9588
IOMT 3	Q06YR3	Q06YR3_MEDTR	Medicago truncatula	4	0.9525
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9430
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.9374
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	3	0.9316
Biflaviolin synthase CYP158A1	Q9KZF5	C1581_STRCO	Streptomyces coelicolor / M145)	3	0.9269
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9246
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.9194
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	4	0.9119
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	4	0.9087
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.9050
Transthyretin	P02766	TTHY_HUMAN	Homo sapiens	4	0.9041
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.9009
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	3	0.8968
Dihydrofolate reductase	P22906	DYR_CANAX	Candida albicans	4	0.8967
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8951
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8951
Isoflavone-7-O-methyltransferase 8	O24529	7OMT8_MEDSA	Medicago sativa	5	0.8882
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8878
Dihydrofolate reductase	P00378	DYR_CHICK	Gallus gallus	3	0.8806
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8801
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	3	0.8786
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.8765
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8759
Steroid C26-monooxygenase	P9WPP1	CP125_MYCTU	Mycobacterium tuberculosis	3	0.8733
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8722
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8721
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.8714
Histone deacetylase 4	P56524	HDAC4_HUMAN	Homo sapiens	3	0.8696
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8690
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	3	0.8654
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8637
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8636
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	3	0.8634
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.8598
Tau-tubulin kinase 1	Q5TCY1	TTBK1_HUMAN	Homo sapiens	4	0.8594
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	3	0.8587
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	4	0.8580
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8571
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	3	0.8570
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	3	0.8562
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	Q33862	Q33862_ASCSU	Ascaris suum	3	0.8536
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.8517
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.8503
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.8501
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	4	0.8497
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8491
Pteridine reductase, putative	Q581W1	Q581W1_TRYB2	Trypanosoma brucei brucei	4	0.8479
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8469
DNA topoisomerase 4 subunit B	H7C794	PARE_ENTFA	Enterococcus faecalis	3	0.8468
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.8444
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.8428
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	4	0.8417
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8382
Sulfide-quinone reductase	B7JBP8	SQRD_ACIF2	Acidithiobacillus ferrooxidans)	3	0.8374
Nucleoside diphosphate kinase A 2	P52175	NDKA2_BOVIN	Bos taurus	4	0.8368
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8363
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8353
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.8346
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.8325
Fibroblast growth factor receptor 1	P11362	FGFR1_HUMAN	Homo sapiens	3	0.8314
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase	Q9TQS6	DHDH_MACFA	Macaca fascicularis	3	0.8310
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	3	0.8303
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8276
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.8260
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	3	0.8255
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.8234
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8228
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	4	0.8214
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	3	0.8209
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.8180
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.8174
Lactoperoxidase	A0A452E9Y6	PERL_CAPHI	Capra hircus	3	0.8154
Reaction center protein L chain	P0C0Y7	RCEH_RHOSH	Rhodobacter sphaeroides	3	0.8144
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	4	0.8135
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	3	0.8104
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	4	0.8091
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.8082
Cyclic dipeptide N-prenyltransferase	D1D8L6	D1D8L6_ASPFM	Neosartorya fumigata	3	0.8072
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8060
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	4	0.8052
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	4	0.8049
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	4	0.8041
Nodulin-13	P93330	NOD13_MEDTR	Medicago truncatula	3	0.8039
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.8036
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.8032
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	3	0.8018
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	3	0.7999
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7969
Pteridine reductase	O76290	O76290_TRYBB	Trypanosoma brucei brucei	3	0.7938
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.7936
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7927
Major strawberry allergen Fra a 1-3	D0E0C7	FRA13_FRAAN	Fragaria ananassa	4	0.7924
Cytohesin-2	Q99418	CYH2_HUMAN	Homo sapiens	3	0.7913
Beta-glucosidase 12	B8AVF0	BGL12_ORYSI	Oryza sativa subsp. indica	3	0.7887
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7865
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.7857
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7848
ADP-ribosylation factor 1	P84077	ARF1_HUMAN	Homo sapiens	2	0.7848
Major pollen allergen Bet v 1-A	P15494	BEV1A_BETPN	Betula pendula	3	0.7833
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase	O67060	ISPE_AQUAE	Aquifex aeolicus	3	0.7812
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.7809
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7806
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7803
Chalcone synthase 2	P30074	CHS2_MEDSA	Medicago sativa	4	0.7802
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7782
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7773
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	5	0.7771
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	3	0.7759
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7757
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	3	0.7741
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	4	0.7740
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7733
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	3	0.7705
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.7703
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	4	0.7692
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7688
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.7673
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	3	0.7659
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7639
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7627
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.7624
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7621
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7620
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7618
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7617
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7612
Genome polyprotein	Q2YHF0	POLG_DEN4T	Dengue virus type 4	3	0.7608
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7600
CREB-binding protein	Q92793	CBP_HUMAN	Homo sapiens	3	0.7589
Ribonuclease J	H9CZL7	H9CZL7_DEIRD	Deinococcus radiodurans	3	0.7585
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	4	0.7575
Dihydroflavonol 4-reductase	P51110	DFRA_VITVI	Vitis vinifera	4	0.7556
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	3	0.7556
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7556
Ephrin type-A receptor 4	Q03137	EPHA4_MOUSE	Mus musculus	4	0.7549
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	3	0.7549
Succinate dehydrogenase flavoprotein subunit	P0AC41	SDHA_ECOLI	Escherichia coli	3	0.7532
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7524
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.7509
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.7503
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7491
Serine/threonine-protein kinase Nek2	P51955	NEK2_HUMAN	Homo sapiens	3	0.7486
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7484
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7482
3-ketosteroid dehydrogenase	Q9RA02	Q9RA02_RHOER	Rhodococcus erythropolis	3	0.7477
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	4	0.7471
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7470
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	4	0.7467
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic	Q43088	RBCMT_PEA	Pisum sativum	4	0.7463
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	4	0.7463
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7462
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7426
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7425
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7419
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7416
Tyrosine-protein kinase JAK1	P23458	JAK1_HUMAN	Homo sapiens	4	0.7412
DNA gyrase subunit B	Q839Z1	GYRB_ENTFA	Enterococcus faecalis	3	0.7411
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7406
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	3	0.7403
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7394
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7373
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	3	0.7345
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	4	0.7342
Phosphodiesterase	Q8WQX9	Q8WQX9_9TRYP	Trypanosoma brucei	3	0.7338
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.7338
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7331
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	3	0.7324
Bromodomain protein, putative	Q8I240	Q8I240_PLAF7	Plasmodium falciparum	4	0.7320
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	3	0.7319
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7306
Serine/threonine-protein kinase PLK1	P53350	PLK1_HUMAN	Homo sapiens	3	0.7304
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7297
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.7297
Multidrug efflux pump subunit AcrB	P31224	ACRB_ECOLI	Escherichia coli	4	0.7287
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.7281
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7280
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7276
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7276
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7274
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.7274
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7267
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7253
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	3	0.7251
Secoisolariciresinol dehydrogenase	Q94KL8	SILD_PODPE	Podophyllum peltatum	4	0.7250
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7250
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	4	0.7240
Beta-galactosidase	P00722	BGAL_ECOLI	Escherichia coli	3	0.7238
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7236
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7229
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7226
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	4	0.7205
NTPase P4	Q94M05	Q94M05_9VIRU	Pseudomonas phage phi12	3	0.7202
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7199
Tyrosine 3-monooxygenase	P04177	TY3H_RAT	Rattus norvegicus	3	0.7190
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7181
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	O88704	HCN1_MOUSE	Mus musculus	4	0.7177
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7166
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	4	0.7158
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7158
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7156
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Q9Y3Q4	HCN4_HUMAN	Homo sapiens	4	0.7154
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7148
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	4	0.7142
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7124
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.7113
Carbonyl reductase [NADPH] 1	P16152	CBR1_HUMAN	Homo sapiens	3	0.7104
Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic	P80030	FABI_BRANA	Brassica napus	4	0.7100
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7097
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.7097
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7092
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.7079
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7073
Leucoanthocyanidin dioxygenase	Q96323	LDOX_ARATH	Arabidopsis thaliana	4	0.7072
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7058
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	3	0.7054
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	4	0.7049
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7048
Protocatechuate 3,4-dioxygenase beta chain	P00437	PCXB_PSEPU	Pseudomonas putida	2	0.7039
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7037
tyrosine--tRNA ligase	Q4QFJ7	Q4QFJ7_LEIMA	Leishmania major	3	0.7034
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7020
Neuropilin-1	O14786	NRP1_HUMAN	Homo sapiens	3	0.7019
Dihydrofolate reductase	P00381	DYR_LACCA	Lacticaseibacillus casei	3	0.7016
Maltokinase	A1TH50	MAK_MYCVP	Mycolicibacterium vanbaalenii	3	0.7015
Estrogen receptor beta	Q92731	ESR2_HUMAN	Homo sapiens	3	0.7012
Histone-lysine N-methyltransferase EHMT1	Q9H9B1	EHMT1_HUMAN	Homo sapiens	3	0.7001

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