1,6-dihydroxy-5-methoxyxanthone - Compound Card

1,6-dihydroxy-5-methoxyxanthone

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1,6-dihydroxy-5-methoxyxanthone

Structure
Zoomed Structure
  • Family: Guttiferae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1c(O)ccc2c1oc1cccc(c1c2=O)O
InChI InChI=1S/C14H10O5/c1-18-14-9(16)6-5-7-12(17)11-8(15)3-2-4-10(11)19-13(7)14/h2-6,15-16H,1H3
InChIKey VTZRTHPAURPVRE-UHFFFAOYSA-N
Formula C14H10O5
HBA 5
HBD 2
MW 258.23
Rotatable Bonds 1
TPSA 79.9
LogP 2.37
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 258.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Garcinia polyantha Guttiferae Plantae 469941

Showing of synonyms

  • Louh GN, Lannang AM, et al. (2008). Polyanxanthone A, B and C, three xanthones from the wood trunk of Garcinia polyantha Oliv.. Phytochemistry,2008, 69(4), 1013-1017. [View] [PubMed]
Pubchem: 5481840
Nmrshiftdb2: 60077595

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 196.21 g/mol

Anticholinesterase

Absorption

Caco-2 (logPapp)
-4.89
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.570
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.54

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.260
Plasma Protein Binding
73.37
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.060
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.010
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Safe
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.720
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.520
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.580
Rat (Acute)
2.160
Rat (Chronic Oral)
2.660
Fathead Minnow
4.550
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
408.420
Hydration Free Energy
-10.090
Log(D) at pH=7.4
2.400
Log(P)
3.08
Log S
-3.94
Log(Vapor Pressure)
-6.87
Melting Point
234.25
pKa Acid
8.12
pKa Basic
3.28
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9540
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9310
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9232
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9201
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9174
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.9062
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9054
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8981
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8974
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8946
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8913
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8913
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8873
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8834
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8788
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8757
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8747
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8736
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8734
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8689
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8652
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8638
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8598
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8564
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8562
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8555
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8524
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 4 0.8516
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8515
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8470
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8464
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8459
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8455
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8449
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8443
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8423
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8414
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8407
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8373
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8328
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8320
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.8300
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8287
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8279
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8265
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8259
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.8227
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.8208
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8164
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8150
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8139
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8139
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.8101
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8084
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8074
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8073
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8060
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8058
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8022
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8019
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.8017
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7984
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7974
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.7970
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7942
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7925
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7919
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7905
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7890
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7889
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7884
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7865
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7859
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7855
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7852
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7824
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7814
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7783
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7783
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7780
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7774
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7766
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7753
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7751
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7747
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7745
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7721
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7713
Androgen receptor P10275 ANDR_HUMAN Homo sapiens 3 0.7711
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7687
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7667
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7632
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7614
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7595
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7593
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7590
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7587
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7587
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7579
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7575
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7566
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7562
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7550
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 3 0.7546
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7543
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7539
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7539
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7535
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7535
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7530
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7529
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7528
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7519
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7506
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7502
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7499
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7499
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7493
Riboflavin kinase Q969G6 RIFK_HUMAN Homo sapiens 4 0.7492
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7482
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7479
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7462
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7439
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7433
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7431
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7423
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7411
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7407
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7399
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7397
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7390
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7390
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7377
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7359
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7355
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7351
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7345
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7342
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7338
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7337
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7332
mitogen-activated protein kinase kinase Q7YTF7 Q7YTF7_PLAF7 Plasmodium falciparum 4 0.7323
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7321
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7319
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7309
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7304
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7296
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7290
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial P08559 ODPA_HUMAN Homo sapiens 3 0.7283
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7281
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7280
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7276
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 4 0.7273
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7269
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7251
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7244
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7235
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7217
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7216
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7216
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 4 0.7215
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7213
Transthyretin P02766 TTHY_HUMAN Homo sapiens 3 0.7213
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7210
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7208
Hematopoietic prostaglandin D synthase O60760 HPGDS_HUMAN Homo sapiens 2 0.7196
Insulin receptor P06213 INSR_HUMAN Homo sapiens 4 0.7182
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7179
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7170
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7170
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7164
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7159
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7153
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7146
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7138
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7137
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7121
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7112
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7096
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7094
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7075
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7074
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7066
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7064
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7062
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7055
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 4 0.7046
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7042
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7032
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7032
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7030
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7024

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