3-geranyloxyemodin anthrone - Compound Card

3-geranyloxyemodin anthrone

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3-geranyloxyemodin anthrone

Structure
Zoomed Structure
  • Family: Plantae - Hypericaceae
  • Kingdom: Plantae
  • Class: Anthraquinone
Canonical Smiles C/C(=C\COc1cc(O)c2c(c1)Cc1c(C2=O)c(O)cc(c1)C)/CCC=C(C)C
InChI InChI=1S/C25H28O4/c1-15(2)6-5-7-16(3)8-9-29-20-13-19-12-18-10-17(4)11-21(26)23(18)25(28)24(19)22(27)14-20/h6,8,10-11,13-14,26-27H,5,7,9,12H2,1-4H3/b16-8+
InChIKey ZAHZJSNPMSTJBM-LZYBPNLTSA-N
Formula C25H28O4
HBA 4
HBD 2
MW 392.5
Rotatable Bonds 6
TPSA 66.76
LogP 5.61
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 29
Formal Charge 0
Fraction CSP3 0.32
Exact Mass 392.2
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Vismia laurentii Guttiferae Plantae 2704497
2 Psorospermum aurantiacum Hypericaceae Plantae 999533

Showing of synonyms

  • Tiani G, Ahmed I, et al. (2013). Kenganthranol F, a new Anthranol from Psorospermum aurantiacum.. Natural Product Communications, 2013, 8(1), 103-104. [View] [PubMed]
  • Wabo HK, Kouam SF, et al. (2007). Prenylated anthraquinones and other constituents from the seeds of Vismia laurentii.. Chemical & pharmaceutical bulletin,2007, 55(11), 1640-1642. [View] [PubMed]
Pubchem: 23661636
Nmrshiftdb2: 60076227

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)Cc3c(C2=O)cccc3

Level: 0

Mol. Weight: 392.5 g/mol

Algicidal

Absorption

Caco-2 (logPapp)
-4.81
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.66
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.95

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.12
Plasma Protein Binding
70.6
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
2.82
Organic Cation Transporter 2
Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.33
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.68
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.73
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
-6.73
Rat (Acute)
1.94
Rat (Chronic Oral)
2.45
Fathead Minnow
5.49
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
466.71
Hydration Free Energy
-6.21
Log(D) at pH=7.4
4.75
Log(P)
7.66
Log S
-6.76
Log(Vapor Pressure)
-8.54
Melting Point
144.07
pKa Acid
8.95
pKa Basic
6.55
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Flavin reductase (NADPH) P30043 BLVRB_HUMAN Homo sapiens 3 0.9583
E3 ubiquitin-protein ligase Mdm2 P56273 MDM2_XENLA Xenopus laevis 3 0.9487
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9387
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.9326
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9275
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9252
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 3 0.9210
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 3 0.9114
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.9105
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.9063
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha Q04631 FNTA_RAT Rattus norvegicus 4 0.9061
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8900
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8898
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8894
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8894
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8857
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8853
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.8815
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8811
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.8743
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.8725
Prostaglandin E synthase 2 Q9N0A4 PGES2_MACFA Macaca fascicularis 3 0.8713
Caspase-7 P55210 CASP7_HUMAN Homo sapiens 3 0.8685
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.8673
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8544
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 4 0.8524
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8518
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.8504
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8499
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 4 0.8468
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8465
Fatty acid-binding protein, liver P80226 FABPL_CHICK Gallus gallus 3 0.8437
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.8409
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8402
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.8348
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8327
Cholesterol side-chain cleavage enzyme, mitochondrial P05108 CP11A_HUMAN Homo sapiens 3 0.8299
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8286
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8244
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8237
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.8188
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8176
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.8173
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.8149
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8115
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8111
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8107
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 3 0.8099
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.8093
Cytochrome b6 P83791 CYB6_MASLA Mastigocladus laminosus 3 0.8092
Retinol dehydratase Q26490 Q26490_SPOFR Spodoptera frugiperda 3 0.8079
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.8070
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.8053
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.8050
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8046
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8044
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8038
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.8034
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7986
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7980
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7980
Enoyl-[acyl-carrier-protein] reductase [NADH] P9WGR1 INHA_MYCTU Mycobacterium tuberculosis 3 0.7979
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7945
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7943
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 4 0.7941
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7941
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7938
Prostaglandin G/H synthase 2 Q05769 PGH2_MOUSE Mus musculus 3 0.7918
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7917
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 3 0.7911
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7908
Calmodulin P62157 CALM_BOVIN Bos taurus 3 0.7886
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7886
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7882
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7877
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7865
Protein S100-A4 P26447 S10A4_HUMAN Homo sapiens 3 0.7862
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7861
Methionine aminopeptidase 2 P50579 MAP2_HUMAN Homo sapiens 3 0.7830
Vitamin D(3) 25-hydroxylase C4B644 CPVDH_PSEAH Pseudonocardia autotrophica 3 0.7804
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7804
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7803
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7798
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7797
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7782
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7776
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7775
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7774
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7754
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7751
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7750
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7738
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7738
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.7725
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7723
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7701
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.7693
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7689
Thiamine-phosphate synthase P39594 THIE_BACSU Bacillus subtilis 2 0.7674
Casein kinase II subunit alpha' P19784 CSK22_HUMAN Homo sapiens 2 0.7671
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7663
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.7653
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7651
Retinol-binding protein 1 P02696 RET1_RAT Rattus norvegicus 3 0.7648
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7644
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7642
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7638
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7634
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7629
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7610
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7606
E3 ubiquitin-protein ligase Mdm2 Q00987 MDM2_HUMAN Homo sapiens 3 0.7593
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7585
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7570
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7570
2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase Q84HC8 NCSB1_STRCZ Streptomyces carzinostaticus 2 0.7556
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7541
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7540
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7520
Casein kinase I isoform delta P48730 KC1D_HUMAN Homo sapiens 3 0.7520
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7500
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7485
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7485
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7483
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7477
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Q9R1E6 ENPP2_MOUSE Mus musculus 4 0.7474
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 2 0.7469
Enoyl-acyl carrier reductase Q6UCJ9 Q6UCJ9_TOXGO Toxoplasma gondii 4 0.7465
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7458
Tyrosine-protein kinase Lyn P25911 LYN_MOUSE Mus musculus 3 0.7456
Retinol-binding protein 4 P18902 RET4_BOVIN Bos taurus 4 0.7454
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7454
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7453
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.7453
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7452
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7451
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7450
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7447
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.7437
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7431
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7429
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7427
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 3 0.7422
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7413
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7413
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7413
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7408
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7399
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7396
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7395
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 3 0.7391
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 3 0.7390
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7389
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7387
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7385
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7382
Death-associated protein kinase 3 O43293 DAPK3_HUMAN Homo sapiens 2 0.7377
Orotidine 5'-phosphate decarboxylase Q9KQT7 PYRF_VIBCH Vibrio cholerae serotype O1 4 0.7371
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 3 0.7368
Enoyl-[acyl-carrier-protein] reductase [NADH] Q5NGQ3 Q5NGQ3_FRATT Francisella tularensis subsp. tularensis 3 0.7361
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.7355
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7349
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7348
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7342
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7331
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7331
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7331
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7322
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7322
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7322
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 4 0.7315
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7300
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7297
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7296
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7294
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7282
Protein BRASSINOSTEROID INSENSITIVE 1 O22476 BRI1_ARATH Arabidopsis thaliana 3 0.7278
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 3 0.7277
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.7274
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7267
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7260
Repressor Q8KLP4 Q8KLP4_STEMA Stenotrophomonas maltophilia 4 0.7253
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7249
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 2 0.7247
Squalene--hopene cyclase P33247 SQHC_ALIAD Alicyclobacillus acidocaldarius subsp. acidocaldarius 4 0.7241
Cytochrome P450 2A6 P11509 CP2A6_HUMAN Homo sapiens 3 0.7239
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7238
Bcl-2-like protein 1 Q07817 B2CL1_HUMAN Homo sapiens 3 0.7228
Aldehyde dehydrogenase, dimeric NADP-preferring P30838 AL3A1_HUMAN Homo sapiens 3 0.7227
Sulfotransferase 1E1 P49888 ST1E1_HUMAN Homo sapiens 3 0.7226
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7221
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 4 0.7217
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7213
Bifunctional F420 biosynthesis protein FbiB P9WP79 FBIB_MYCTU Mycobacterium tuberculosis 5 0.7206
Troponin C, slow skeletal and cardiac muscles P63316 TNNC1_HUMAN Homo sapiens 3 0.7197
Squalene--hopene cyclase P33247 SQHC_ALIAD Alicyclobacillus acidocaldarius subsp. acidocaldarius 4 0.7195
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7194
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7190
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7187
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7178
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7176
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 4 0.7175
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7174
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7173
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7167
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7161
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7157
Calmodulin P62157 CALM_BOVIN Bos taurus 4 0.7155
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7153
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7151
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.7147
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7146
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7143
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7140
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7139
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7138
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7135
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7133
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7133
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7132
Fructose-1,6-bisphosphatase 1 P00636 F16P1_PIG Sus scrofa 3 0.7132
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 3 0.7126
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.7119
Histone deacetylase-like amidohydrolase Q70I53 HDAH_ALCSD Alcaligenes sp.) 2 0.7116
Thymidine phosphorylase P07650 TYPH_ECOLI Escherichia coli 4 0.7110
Squalene synthase P37268 FDFT_HUMAN Homo sapiens 3 0.7108
Nuclear receptor subfamily 1 group I member 3 O35627 NR1I3_MOUSE Mus musculus 3 0.7106
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 4 0.7102
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7099
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7098
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7093
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 4 0.7091
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7089
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7083
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7081
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7080
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7075
Glucan 1,3-beta-glucosidase P29717 EXG1_CANAL Candida albicans 2 0.7071
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 5 0.7068
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7067
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7065
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7064
NADPH-dependent oxidoreductase 2-alkenal reductase Q39172 AER_ARATH Arabidopsis thaliana 2 0.7064
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7054
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7051
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7051
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7049
Squalene--hopene cyclase P33247 SQHC_ALIAD Alicyclobacillus acidocaldarius subsp. acidocaldarius 5 0.7038
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7036
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7033
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7033
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7031
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7029
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7029
Prolyl endopeptidase P23687 PPCE_PIG Sus scrofa 3 0.7013
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7012
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7009
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7007
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7001

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