ANPDB

Select a section from the left sidebar

Peplidiforone C

Family: Plantae - Hypericaceae
Kingdom: Plantae
Class: Phenyl Polyketide
- Subclass: Polyketide Derivative

Canonical Smiles	c1(ccccc1)c1cc(c(o1)C(=O)C(C)(C=C)C)OC
InChI	InChI=1S/C17H18O3/c1-5-17(2,3)16(18)15-14(19-4)11-13(20-15)12-9-7-6-8-10-12/h5-11H,1H2,2-4H3
InChIKey	KTOBSTNTMBOQFC-UHFFFAOYSA-N
Formula	C₁₇H₁₈O₃
HBA	3
HBD	0
MW	270.33
Rotatable Bonds	5
TPSA	39.44
LogP	4.35
Number Rings	2
Number Aromatic Rings	2
Heavy Atom Count	20
Formal Charge	0
Fraction CSP3	0.24
Exact Mass	270.13
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Hypericum peplidifolium	Hypericaceae	Plantae	1321341

Showing of synonyms

Fobofou SA, Harmon CR, et al. (2016). Prenylated phenyl polyketides and acylphloroglucinols from Hypericum peplidifolium.. Phytochemistry,2016, 124, 108-113. [View] [PubMed]

No compound-protein relationship available.

SMILES: o1cccc1-c2ccccc2

Level: 1

Mol. Weight: 270.33 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 270.33 g/mol

SMILES: c1ccoc1

Level: 0

Mol. Weight: 270.33 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.37
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.38
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -1.7

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.41
Plasma Protein Binding: 51.99
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Non-Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Non-Substrate
CYP 2D6 Inhibitor: Non-Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Non-Inhibitor
CYP 3A4 Substrate: Non-Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 8.67
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Safe
Bioconcentration Factor: 2.09
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Safe
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.89
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 6.46
Micronucleos: Toxic
NR-AhR: Safe
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.73
Rat (Acute): 1.97
Rat (Chronic Oral): 1.98
Fathead Minnow: 4.76
Respiratory Disease: Safe
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Safe
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 339.03
Hydration Free Energy: -9.33
Log(D) at pH=7.4: 3.87
Log(P): 4.31
Log S: -4.88
Log(Vapor Pressure): -5.01
Melting Point: 43.49
pKa Acid: 8.84
pKa Basic: 3.03

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Na(+):neurotransmitter symporter (Snf family)	O67854	O67854_AQUAE	Aquifex aeolicus	3	0.9781
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.9733
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9698
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9655
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.9616
cGMP-specific 3',5'-cyclic phosphodiesterase	O76074	PDE5A_HUMAN	Homo sapiens	3	0.9611
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9560
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.9472
Acetylcholine-binding protein	P58154	ACHP_LYMST	Lymnaea stagnalis	3	0.9412
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	3	0.9402
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.9381
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.9365
Glycogen phosphorylase, muscle form	P00489	PYGM_RABIT	Oryctolagus cuniculus	3	0.9345
Tubulin alpha chain	D0VWZ0	D0VWZ0_SHEEP	Ovis aries	3	0.9344
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.9265
Protoporphyrinogen oxidase	P50336	PPOX_HUMAN	Homo sapiens	3	0.9221
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	3	0.9209
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	3	0.9191
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.9172
Proliferating cell nuclear antigen	P12004	PCNA_HUMAN	Homo sapiens	3	0.9134
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9084
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	3	0.8969
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.8954
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.8927
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	3	0.8820
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.8814
Proto-oncogene tyrosine-protein kinase receptor Ret	P07949	RET_HUMAN	Homo sapiens	3	0.8711
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	3	0.8604
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	2	0.8593
Beta-2 adrenergic receptor	P07550	ADRB2_HUMAN	Homo sapiens	2	0.8559
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.8554
Matrix metalloproteinase-9	P14780	MMP9_HUMAN	Homo sapiens	3	0.8553
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	3	0.8534
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.8502
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.8479
Cell division cycle 7-related protein kinase	O00311	CDC7_HUMAN	Homo sapiens	3	0.8315
Riboflavin synthase	P0AFU8	RISA_ECOLI	Escherichia coli	4	0.8273
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.8253
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8217
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8203
NAD(P)H dehydrogenase [quinone] 1	P15559	NQO1_HUMAN	Homo sapiens	3	0.8186
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	3	0.8151
Putative ketoacyl reductase	P16544	ACT3_STRCO	Streptomyces coelicolor / M145)	2	0.8147
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.8125
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	Q46381	BPHB_COMTE	Comamonas testosteroni	3	0.8096
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.8056
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.8049
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.8046
Glucose-1-phosphate thymidylyltransferase	Q9HU22	Q9HU22_PSEAE	Pseudomonas aeruginosa	3	0.8030
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.8022
Gag-Pol polyprotein	P04585	POL_HV1H2	Human immunodeficiency virus type 1 group M subtype B	3	0.8012
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	3	0.8011
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.8009
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7986
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7984
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7965
Focal adhesion kinase 1	Q00944	FAK1_CHICK	Gallus gallus	3	0.7963
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7942
17-beta-hydroxysteroid dehydrogenase type 1	P14061	DHB1_HUMAN	Homo sapiens	2	0.7925
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7925
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7904
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	2	0.7904
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	2	0.7884
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	3	0.7883
Bifunctional dihydrofolate reductase-thymidylate synthase	O02604	DRTS_PLAVI	Plasmodium vivax	2	0.7864
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7863
Bromodomain adjacent to zinc finger domain protein 2B	Q9UIF8	BAZ2B_HUMAN	Homo sapiens	2	0.7839
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7833
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	2	0.7802
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7799
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7791
Angiopoietin-1 receptor	Q02763	TIE2_HUMAN	Homo sapiens	3	0.7786
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7780
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7759
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7755
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7753
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7752
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7749
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7740
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	3	0.7737
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7720
Renin	P00797	RENI_HUMAN	Homo sapiens	2	0.7715
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7712
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	2	0.7702
Acetylcholinesterase	P22303	ACES_HUMAN	Homo sapiens	2	0.7697
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7694
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	3	0.7692
Acyl-coenzyme A synthetase ACSM2A, mitochondrial	Q08AH3	ACS2A_HUMAN	Homo sapiens	2	0.7688
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7686
Glutamate receptor 2	P42262	GRIA2_HUMAN	Homo sapiens	2	0.7682
Anthranilate phosphoribosyltransferase	P9WFX5	TRPD_MYCTU	Mycobacterium tuberculosis	2	0.7681
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7678
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7672
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7671
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7669
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	2	0.7667
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	2	0.7664
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7657
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q08210	PYRD_PLAF7	Plasmodium falciparum	3	0.7652
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7651
Pheromone-binding protein ASP1	Q9U9J6	Q9U9J6_APIME	Apis mellifera	2	0.7641
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7636
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	2	0.7631
Estrogen receptor	P03372	ESR1_HUMAN	Homo sapiens	3	0.7626
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7626
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7617
1-deoxy-D-xylulose 5-phosphate reductoisomerase	P45568	DXR_ECOLI	Escherichia coli	2	0.7614
Protoporphyrinogen oxidase, mitochondrial	O24164	PPOM_TOBAC	Nicotiana tabacum	2	0.7610
Putative protease I	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron	2	0.7610
Eugenol synthase 1	Q15GI4	EGS1_OCIBA	Ocimum basilicum	3	0.7603
Cathepsin S	P25774	CATS_HUMAN	Homo sapiens	2	0.7601
A disintegrin and metalloproteinase with thrombospondin motifs 5	Q9UNA0	ATS5_HUMAN	Homo sapiens	3	0.7599
Farnesyl pyrophosphate synthase	P14324	FPPS_HUMAN	Homo sapiens	2	0.7595
Bromodomain-containing protein 4	O60885	BRD4_HUMAN	Homo sapiens	3	0.7590
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.7588
17-beta-hydroxysteroid dehydrogenase 14	Q9BPX1	DHB14_HUMAN	Homo sapiens	2	0.7585
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7584
Catalase-peroxidase 2	O59651	KATG2_HALMA	Haloarcula marismortui	2	0.7579
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7579
cGMP-dependent protein kinase, putative	A5K0N4	A5K0N4_PLAVS	Plasmodium vivax	3	0.7573
Homoserine dehydrogenase	P31116	DHOM_YEAST	Saccharomyces cerevisiae	3	0.7570
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7562
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	2	0.7562
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7557
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7552
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7550
F420-dependent NADP reductase	O29370	FNO_ARCFU	Archaeoglobus fulgidus	3	0.7549
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7544
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	2	0.7540
Aminoglycoside 3'-phosphotransferase AphA1-IAB	B0VD92	B0VD92_ACIBY	Acinetobacter baumannii	3	0.7538
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7538
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7529
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7510
Glucan 1,3-beta-glucosidase	P29717	EXG1_CANAL	Candida albicans	2	0.7510
Prostaglandin G/H synthase 2	Q05769	PGH2_MOUSE	Mus musculus	2	0.7509
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	2	0.7506
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7505
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7504
Abscisic acid receptor PYL1	Q8VZS8	PYL1_ARATH	Arabidopsis thaliana	2	0.7500
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7497
Acetylcholinesterase	P04058	ACES_TETCF	Tetronarce californica	2	0.7495
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	2	0.7492
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	2	0.7492
Neutrophil collagenase	P22894	MMP8_HUMAN	Homo sapiens	2	0.7489
Protein ppBat	Q8A8A4	Q8A8A4_BACTN	Bacteroides thetaiotaomicron VPI-5482	2	0.7483
Nuclear receptor subfamily 4immunitygroup A member 1	P22736	NR4A1_HUMAN	Homo sapiens	2	0.7481
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7476
Putative cytochrome P450	Q70AS3	Q70AS3_STRPE	Streptomyces peucetius	3	0.7469
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7468
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7460
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7459
Albumin	P02768	ALBU_HUMAN	Homo sapiens	3	0.7455
Angiotensin-converting enzyme 2	Q9BYF1	ACE2_HUMAN	Homo sapiens	2	0.7453
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	2	0.7451
Lactoylglutathione lyase	Q04760	LGUL_HUMAN	Homo sapiens	2	0.7443
Sex hormone-binding globulin	P04278	SHBG_HUMAN	Homo sapiens	3	0.7441
Poly [ADP-ribose] polymerase 1	P09874	PARP1_HUMAN	Homo sapiens	3	0.7437
ATP synthase subunit alpha, mitochondrial	P19483	ATPA_BOVIN	Bos taurus	2	0.7437
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7432
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7427
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7421
Hematopoietic prostaglandin D synthase	O60760	HPGDS_HUMAN	Homo sapiens	2	0.7417
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7405
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7403
Nucleoside 2-deoxyribosyltransferase	Q8RLY5	Q8RLY5_LACHE	Lactobacillus helveticus	2	0.7402
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7401
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7401
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7399
Tetracycline repressor protein class D	P0ACT4	TETR4_ECOLX	Escherichia coli	2	0.7398
(RS)-norcoclaurine 6-O-methyltransferase	Q5C9L7	6OMT_THLFG	Thalictrum flavum subsp. glaucum	3	0.7397
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7396
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7391
Uracil phosphoribosyltransferase	Q26998	UPP_TOXGO	Toxoplasma gondii	2	0.7390
Beta-glucosidase 12	B8AVF0	BGL12_ORYSI	Oryza sativa subsp. indica	2	0.7388
Aldo-keto reductase family 1 member C2	P52895	AK1C2_HUMAN	Homo sapiens	2	0.7382
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	2	0.7379
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7378
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7368
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7362
Soluble acetylcholine receptor	Q8WSF8	Q8WSF8_APLCA	Aplysia californica	2	0.7361
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7358
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component	Q6Q272	HPAH_ACIBA	Acinetobacter baumannii	4	0.7357
Fatty acid-binding protein, adipocyte	P15090	FABP4_HUMAN	Homo sapiens	2	0.7357
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7354
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	2	0.7353
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	Q0QF01	SDHA_PIG	Sus scrofa	2	0.7351
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7350
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7345
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	3	0.7343
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7341
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7341
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7337
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7337
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	2	0.7335
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7335
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7334
Lactotransferrin	P24627	TRFL_BOVIN	Bos taurus	2	0.7334
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7333
2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase	P47229	BPHD_PARXL	Paraburkholderia xenovorans	2	0.7332
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	Q3JRA0	ISPF_BURP1	Burkholderia pseudomallei	3	0.7330
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7326
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7324
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	2	0.7324
Protein S100-A13	Q99584	S10AD_HUMAN	Homo sapiens	2	0.7319
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	2	0.7310
Fatty acid-binding protein, adipocyte	P04117	FABP4_MOUSE	Mus musculus	2	0.7307
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	2	0.7307
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7305
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7303
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7300
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.7296
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	3	0.7296
Biphenyl-2,3-diol 1,2-dioxygenase	P47228	BPHC_PARXL	Paraburkholderia xenovorans	2	0.7293
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7288
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7286
Cytochrome P450 2C9	P11712	CP2C9_HUMAN	Homo sapiens	2	0.7284
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7282
4-hydroxyphenylacetate 3-monooxygenase	Q8YHT7	Q8YHT7_BRUME	Brucella melitensis biotype 1	2	0.7280
Ketimine reductase mu-crystallin	O54983	CRYM_MOUSE	Mus musculus	2	0.7277
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7276
Pentalenic acid synthase	Q825I8	CYP28_STRAW	Streptomyces avermitilis	2	0.7274
Protein UshA	P07024	USHA_ECOLI	Escherichia coli	2	0.7274
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7273
Beta sliding clamp	P0A988	DPO3B_ECOLI	Escherichia coli	2	0.7271
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7271
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	3	0.7269
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7266
Phytohormone-binding protein CSBP	A0A1S3THR8	PHBP_VIGRR	Vigna radiata var. radiata	2	0.7261
Dodecin	Q5SIE3	DODEC_THET8	Thermus thermophilus	4	0.7260
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7260
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	2	0.7260
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	2	0.7259
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	2	0.7257
Cyclin-dependent kinase 5	Q00535	CDK5_HUMAN	Homo sapiens	3	0.7255
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7254
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7254
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	2	0.7250
Biflaviolin synthase CYP158A2	Q9FCA6	C1582_STRCO	Streptomyces coelicolor / M145)	2	0.7249
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7247
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7245
Prostaglandin F2a synthase	Q8I6L9	Q8I6L9_TRYCR	Trypanosoma cruzi	2	0.7241
Cholinesterase	P06276	CHLE_HUMAN	Homo sapiens	2	0.7240
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7240
Alpha-1-acid glycoprotein 2	P19652	A1AG2_HUMAN	Homo sapiens	2	0.7239
Transcriptional regulator, PadR-like family	A2RI36	A2RI36_LACLM	Lactococcus lactis subsp. cremoris	2	0.7237
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	2	0.7237
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7236
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	2	0.7234
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	2	0.7234
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	2	0.7233
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	2	0.7232
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7232
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7231
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7226
L-lactate dehydrogenase A chain	P04642	LDHA_RAT	Rattus norvegicus	2	0.7226
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7225
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	2	0.7222
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7222
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	2	0.7220
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	2	0.7219
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7215
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7215
Abscisic acid receptor PYL3	Q9SSM7	PYL3_ARATH	Arabidopsis thaliana	2	0.7208
Interleukin-2	P60568	IL2_HUMAN	Homo sapiens	2	0.7207
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7206
Pyruvate:ferredoxin oxidoreductase	P94692	PFOR_DESAF	Desulfocurvibacter africanus	3	0.7205
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.7205
TetR family transcriptional regulator	Q58L87	Q58L87_MYCSM	Mycolicibacterium smegmatis	2	0.7204
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7198
Steroid Delta-isomerase	P07445	SDIS_PSEPU	Pseudomonas putida	3	0.7196
Stimulator of interferon genes protein	Q86WV6	STING_HUMAN	Homo sapiens	2	0.7194
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	2	0.7194
mRNA cleavage and polyadenylation factor CLP1	Q08685	CLP1_YEAST	Saccharomyces cerevisiae	2	0.7193
Ephrin type-A receptor 3	P29320	EPHA3_HUMAN	Homo sapiens	3	0.7192
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7189
Death-associated protein kinase 1	P53355	DAPK1_HUMAN	Homo sapiens	2	0.7185
HTH-type transcriptional regulator EthR	P9WMC1	ETHR_MYCTU	Mycobacterium tuberculosis	2	0.7185
Terminal oxygenase component of carbazole	Q84II6	Q84II6_JANS3	Janthinobacterium sp	2	0.7181
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7179
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7174
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7174
Tyrosine-protein kinase SYK	P43405	KSYK_HUMAN	Homo sapiens	2	0.7172
Genome polyprotein	O92972	POLG_HCVJ4	Hepatitis C virus genotype 1b	2	0.7172
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7170
Prostaglandin G/H synthase 1	P05979	PGH1_SHEEP	Ovis aries	2	0.7166
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	2	0.7163
Thymidine phosphorylase	Q7CP66	TYPH_SALTY	Salmonella typhimurium	2	0.7158
N-terminal acetyltransferase A complex subunit NAT1	P12945	NAT1_YEAST	Saccharomyces cerevisiae	2	0.7156
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7154
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	2	0.7148
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	2	0.7140
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7135
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	2	0.7132
4,4'-diapophytoene synthase	A9JQL9	CRTM_STAAU	Staphylococcus aureus	2	0.7127
Squalene synthase	P37268	FDFT_HUMAN	Homo sapiens	2	0.7127
Proline iminopeptidase	O32449	PIP_SERMA	Serratia marcescens	2	0.7127
Non-receptor tyrosine-protein kinase TYK2	P29597	TYK2_HUMAN	Homo sapiens	2	0.7125
Cytosolic purine 5'-nucleotidase	P49902	5NTC_HUMAN	Homo sapiens	2	0.7124
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7120
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	2	0.7119
EbrA repressor	Q79SH7	Q79SH7_STRLI	Streptomyces lividans	2	0.7118
Calmodulin-1	P0DP29	CALM1_RAT	Rattus norvegicus	2	0.7118
Diamine acetyltransferase 1	P21673	SAT1_HUMAN	Homo sapiens	2	0.7117
Alpha/beta hydrolase fold protein	D2J2T6	D2J2T6_9RHIZ	Ochrobactrum sp. T63	2	0.7114
Nucleoside diphosphate kinase	A5J299	A5J299_PENVA	Penaeus vannamei	2	0.7104
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7103
Nitric oxide synthase, inducible	P35228	NOS2_HUMAN	Homo sapiens	2	0.7098
Cyclin-dependent kinase 6	Q00534	CDK6_HUMAN	Homo sapiens	2	0.7095
Transthyretin	P02767	TTHY_RAT	Rattus norvegicus	2	0.7094
Flavin-dependent monooxygenase	Q93L51	TETX_BACT4	Bacteroides thetaiotaomicron	2	0.7087
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7085
Pyridoxal kinase	O00764	PDXK_HUMAN	Homo sapiens	2	0.7084
Fatty acid-binding protein, intestinal	P12104	FABPI_HUMAN	Homo sapiens	2	0.7083
Enoyl-ACP reductase	Q9BH77	Q9BH77_PLAFA	Plasmodium falciparum	2	0.7081
Albumin	P14639	ALBU_SHEEP	Ovis aries	2	0.7077
NmrA-like family domain-containing protein 1	Q9HBL8	NMRL1_HUMAN	Homo sapiens	2	0.7075
Biphenyl-2,3-diol 1,2-dioxygenase	P17297	BPHC_PSES1	Pseudomonas sp	2	0.7075
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.7073
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7072
Thymidylate synthase	P45352	TYSY_RAT	Rattus norvegicus	2	0.7070
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7068
Serine/threonine-protein kinase MRCK beta	Q9Y5S2	MRCKB_HUMAN	Homo sapiens	3	0.7067
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7066
Valacyclovir hydrolase	Q86WA6	BPHL_HUMAN	Homo sapiens	2	0.7066
Odorant binding protein ASP1	Q8WRW5	Q8WRW5_APIME	Apis mellifera	2	0.7065
Enoyl-ACP reductase	Q9BJJ9	Q9BJJ9_PLAFA	Plasmodium falciparum	2	0.7057
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7056
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7056
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7055
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	O76083	PDE9A_HUMAN	Homo sapiens	2	0.7055
3-phosphoinositide-dependent protein kinase 1	O15530	PDPK1_HUMAN	Homo sapiens	3	0.7052
Protein S100-A4	P26447	S10A4_HUMAN	Homo sapiens	2	0.7052
Phenazine biosynthesis protein A/B	Q396C9	Q396C9_BURL3	Burkholderia lata	2	0.7052
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7049
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7047
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7045
Alpha/beta hydrolase fold	A5VAT9	A5VAT9_SPHWW	Sphingomonas wittichii	2	0.7044
Thiamine-phosphate synthase	P39594	THIE_BACSU	Bacillus subtilis	2	0.7041
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	2	0.7039
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	2	0.7038
Casein kinase I isoform gamma-3	Q9Y6M4	KC1G3_HUMAN	Homo sapiens	3	0.7035
Carbonic anhydrase 1	P00915	CAH1_HUMAN	Homo sapiens	2	0.7035
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	2	0.7034
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	2	0.7029
Albumin	P02768	ALBU_HUMAN	Homo sapiens	2	0.7026
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7024
Unconventional myosin-Va	Q02440	MYO5A_CHICK	Gallus gallus	2	0.7019
Chloramphenicol 3-O phosphotransferase	Q56148	CPT_STRVP	Streptomyces venezuelae	2	0.7017
Tyrosine-protein phosphatase non-receptor type 1	P18031	PTN1_HUMAN	Homo sapiens	3	0.7015
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7014
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	2	0.7007
S-methyl-5'-thioadenosine phosphorylase	Q97W94	MTAP_SACS2	Saccharolobus solfataricus	2	0.7002
Carbonic anhydrase 12	O43570	CAH12_HUMAN	Homo sapiens	2	0.7001

Download SDF