1-(4-(E-3,7-dimethylocta-2,6-dienyloxy)-2.6-dihydroxylphenyl)-2-methylpropan-1-one - Compound Card

1-(4-(E-3,7-dimethylocta-2,6-dienyloxy)-2.6-dihydroxylphenyl)-2-methylpropan-1-one

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1-(4-(E-3,7-dimethylocta-2,6-dienyloxy)-2.6-dihydroxylphenyl)-2-methylpropan-1-one

Structure
Zoomed Structure
  • Family: Plantae - Hypericaceae
  • Kingdom: Plantae
  • Class: Phenolic
Canonical Smiles C/C(=C\COc1cc(O)c(c(c1)O)C(=O)C(C)C)/CCC=C(C)C
InChI InChI=1S/C20H28O4/c1-13(2)7-6-8-15(5)9-10-24-16-11-17(21)19(18(22)12-16)20(23)14(3)4/h7,9,11-12,14,21-22H,6,8,10H2,1-5H3/b15-9+
InChIKey TUADKQOMMLPDOK-OQLLNIDSSA-N
Formula C20H28O4
HBA 4
HBD 2
MW 332.44
Rotatable Bonds 8
TPSA 66.76
LogP 5.01
Number Rings 1
Number Aromatic Rings 1
Heavy Atom Count 24
Formal Charge 0
Fraction CSP3 0.45
Exact Mass 332.2
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Hypericum peplidifolium Hypericaceae Plantae 1321341

Showing of synonyms

  • Fobofou SA, Harmon CR, et al. (2016). Prenylated phenyl polyketides and acylphloroglucinols from Hypericum peplidifolium.. Phytochemistry,2016, 124, 108-113. [View] [PubMed]
Pubchem: 14282611
Nmrshiftdb2: 60031315

No compound-protein relationship available.

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 332.44 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.53
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.63
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.31

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
0.86
Plasma Protein Binding
45.97
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
7.58
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
0.53
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.42
Liver Injury II
Safe
hERG Blockers
Safe
Daphnia Maga
6.72
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
3.96
Rat (Acute)
2.0
Rat (Chronic Oral)
2.58
Fathead Minnow
4.95
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
366.69
Hydration Free Energy
-9.74
Log(D) at pH=7.4
3.83
Log(P)
6.25
Log S
-6.12
Log(Vapor Pressure)
-6.47
Melting Point
85.63
pKa Acid
9.01
pKa Basic
5.96
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Corticosteroid-binding globulin P08185 CBG_HUMAN Homo sapiens 3 0.9522
Neocarzinostatin P0A3R9 NCZS_STRCZ Streptomyces carzinostaticus 3 0.9398
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9335
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9302
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.9223
Fatty acid-binding protein 10-A, liver basic Q9I8L5 FA10A_DANRE Danio rerio 3 0.9219
Mexicain P84346 MEX1_JACME Jacaratia mexicana 3 0.9185
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.9166
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.9101
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9089
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 3 0.9017
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.9014
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8929
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 3 0.8925
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8905
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8856
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8789
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8780
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8746
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8709
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 3 0.8691
Rhodopsin P02699 OPSD_BOVIN Bos taurus 3 0.8640
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8562
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8557
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8544
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.8542
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 3 0.8534
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.8530
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8521
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.8506
Gentisate 1,2-dioxygenase Q67FT0 Q67FT0_PSESE Pseudaminobacter salicylatoxidans 3 0.8475
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.8463
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.8382
Integrin alpha-L P20701 ITAL_HUMAN Homo sapiens 3 0.8375
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.8375
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.8370
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.8318
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8310
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 3 0.8280
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.8269
Serpin domain-containing protein H0ZQY2 H0ZQY2_TAEGU Taeniopygia guttata 3 0.8255
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 3 0.8212
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8198
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8184
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8180
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 3 0.8166
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 3 0.8151
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8130
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8114
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 3 0.8098
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8092
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.8048
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 3 0.8025
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 3 0.8018
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 2 0.8011
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.8010
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 2 0.7997
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7988
Lactoylglutathione lyase Q9CPU0 LGUL_MOUSE Mus musculus 2 0.7971
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 3 0.7967
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7954
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7928
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial Q15119 PDK2_HUMAN Homo sapiens 3 0.7915
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7908
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7896
Aldo-keto reductase family 1 member C1 Q04828 AK1C1_HUMAN Homo sapiens 2 0.7889
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7880
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 3 0.7875
Proton-gated ion channel Q7NDN8 GLIC_GLOVI Gloeobacter violaceus 3 0.7859
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7852
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7850
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7836
Beta-lactoglobulin P02754 LACB_BOVIN Bos taurus 3 0.7831
11-beta-hydroxysteroid dehydrogenase 1 P50172 DHI1_MOUSE Mus musculus 2 0.7824
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7820
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7815
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7811
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7793
CmeR Q7B8P6 Q7B8P6_CAMJU Campylobacter jejuni 2 0.7788
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7786
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7775
Multidrug transporter MdfA P0AEY8 MDFA_ECOLI Escherichia coli 3 0.7772
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7761
DNA double-strand break repair protein Mre11 Q9X1X0 Q9X1X0_THEMA Thermotoga maritima MSB8 4 0.7754
Aldo-keto reductase family 1 member C2 P52895 AK1C2_HUMAN Homo sapiens 2 0.7748
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7746
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7737
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7721
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7713
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 3 0.7707
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7693
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7664
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7662
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7659
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7641
Tryptophan synthase alpha chain P00929 TRPA_SALTY Salmonella typhimurium 3 0.7628
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7628
Sulfotransferase 2A1 Q06520 ST2A1_HUMAN Homo sapiens 2 0.7623
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7620
3-alpha-hydroxysteroid dehydrogenase P23457 DIDH_RAT Rattus norvegicus 2 0.7619
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.7618
Class 10 plant pathogenesis-related protein 2B Q9LLQ2 P102B_LUPLU Lupinus luteus 2 0.7615
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7601
Thymidine phosphorylase P07650 TYPH_ECOLI Escherichia coli 4 0.7598
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 2 0.7587
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7585
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7570
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7570
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7566
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7562
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7552
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7539
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 3 0.7533
Predicted acetyltransferase Q97ML2 Q97ML2_CLOAB Clostridium acetobutylicum 3 0.7528
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7527
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7521
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 3 0.7519
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7516
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7514
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7508
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7500
Na(+):neurotransmitter symporter (Snf family) O67854 O67854_AQUAE Aquifex aeolicus 3 0.7494
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 2 0.7483
Abscisic acid receptor PYL3 Q9SSM7 PYL3_ARATH Arabidopsis thaliana 2 0.7480
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7479
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7476
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7471
chitinase B0Y2Y2 B0Y2Y2_ASPFC Aspergillus fumigatus 3 0.7466
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7460
Nuclear receptor ROR-beta P45446 RORB_RAT Rattus norvegicus 2 0.7448
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7445
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7440
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.7434
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7426
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7416
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7412
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7409
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7396
Phenazine biosynthesis protein A/B Q396C9 Q396C9_BURL3 Burkholderia lata 3 0.7394
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7386
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7374
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7373
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7372
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7369
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7368
Lactoylglutathione lyase Q04760 LGUL_HUMAN Homo sapiens 3 0.7365
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7363
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7362
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7359
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7343
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7341
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7334
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7331
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7330
Aldo-keto reductase family 1 member D1 P51857 AK1D1_HUMAN Homo sapiens 2 0.7327
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7325
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7323
Glutamate decarboxylase 1 Q99259 DCE1_HUMAN Homo sapiens 3 0.7319
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7311
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7308
Sulfotransferase 2B1 O00204 ST2B1_HUMAN Homo sapiens 2 0.7306
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.7301
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7297
Cytochrome P450 monooxygenase Q5YNS8 Q5YNS8_NOCFA Nocardia farcinica 2 0.7295
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7294
Gastrotropin Q6IMW5 Q6IMW5_DANRE Danio rerio 2 0.7292
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7292
Alcohol dehydrogenase 1C P00326 ADH1G_HUMAN Homo sapiens 2 0.7282
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7269
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 2 0.7266
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7261
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7259
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7257
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7252
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.7251
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7249
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7238
Prostaglandin reductase 2 Q8N8N7 PTGR2_HUMAN Homo sapiens 2 0.7228
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7228
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 2 0.7223
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A Q13946 PDE7A_HUMAN Homo sapiens 3 0.7221
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.7207
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7206
Nuclear receptor subfamily 1 group I member 2 O75469 NR1I2_HUMAN Homo sapiens 4 0.7204
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7200
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7199
Metallo-beta-lactamase type 2 P26918 BLAB_AERHY Aeromonas hydrophila 2 0.7190
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7190
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 4 0.7187
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B Q13370 PDE3B_HUMAN Homo sapiens 3 0.7187
Ferrochelatase, mitochondrial P22830 HEMH_HUMAN Homo sapiens 3 0.7184
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7168
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7161
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7153
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7144
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7143
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 3 0.7141
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7131
Dihydropteroate synthase Q81VW8 Q81VW8_BACAN Bacillus anthracis 3 0.7127
cGMP-dependent 3',5'-cyclic phosphodiesterase O00408 PDE2A_HUMAN Homo sapiens 3 0.7121
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 2 0.7120
orotidine-5'-phosphate decarboxylase Q8T6J6 Q8T6J6_PLAFA Plasmodium falciparum 4 0.7096
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 2 0.7096
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7086
Epoxide hydrolase Q41415 Q41415_SOLTU Solanum tuberosum 2 0.7086
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7081
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7079
Trichodiene synthase P13513 TRI5_FUSSP Fusarium sporotrichioides 2 0.7079
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7078
Acetolactate synthase, chloroplastic P17597 ILVB_ARATH Arabidopsis thaliana 2 0.7073
Retinoic acid receptor RXR-alpha P19793 RXRA_HUMAN Homo sapiens 3 0.7071
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.7069
EhpF Q8GPH0 Q8GPH0_ENTAG Enterobacter agglomerans 3 0.7068
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7068
histone deacetylase A5H660 A5H660_SCHMA Schistosoma mansoni 3 0.7062
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7052
Jasmonoyl--L-amino acid synthetase JAR1 Q9SKE2 JAR1_ARATH Arabidopsis thaliana 3 0.7036
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7035
Transcriptional activator protein LasR P25084 LASR_PSEAE Pseudomonas aeruginosa 4 0.7019
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7011
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7008

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