3-hydroxy-5-methoxyxanthone - Compound Card

3-hydroxy-5-methoxyxanthone

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3-hydroxy-5-methoxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Hypericaceae
  • Kingdom: Plantae
  • Class: Xanthone
    • Subclass: Xanthone Derivative
Canonical Smiles COc1cccc2c1oc1cc(O)ccc1c2=O
InChI InChI=1S/C14H10O4/c1-17-11-4-2-3-10-13(16)9-6-5-8(15)7-12(9)18-14(10)11/h2-7,15H,1H3
InChIKey FBYCHEZAAUZQDB-UHFFFAOYSA-N
Formula C14H10O4
HBA 4
HBD 1
MW 242.23
Rotatable Bonds 1
TPSA 59.67
LogP 2.66
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 242.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hypericum riparium Hypericaceae Plantae 269018

Showing of synonyms

  • Tala MF, Talontsi FM, et al. (2015). Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.. Fitoterapia,2015, 102, 149-155. [View] [PubMed]
Pubchem: 44395951
Bindingdb: 50155423

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 242.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.74
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.210
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.86

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.360
Plasma Protein Binding
77.5
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
1.420
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.630
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Toxic
Maximum Tolerated Dose
0.740
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
3.890
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.650
Rat (Acute)
1.900
Rat (Chronic Oral)
2.170
Fathead Minnow
4.730
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
394.830
Hydration Free Energy
-10.700
Log(D) at pH=7.4
2.240
Log(P)
3.06
Log S
-3.94
Log(Vapor Pressure)
-6.77
Melting Point
233.57
pKa Acid
6.44
pKa Basic
2.66
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9367
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9274
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9257
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9217
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9215
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9197
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9197
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9153
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9083
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9072
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9052
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9020
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.8965
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8951
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8943
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8924
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8919
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.8825
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8813
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8790
DNA polymerase III subunit epsilon P03007 DPO3E_ECOLI Escherichia coli 3 0.8787
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8773
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8745
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8675
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8668
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8653
Ras-related protein Ral-B P11234 RALB_HUMAN Homo sapiens 3 0.8641
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8635
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.8618
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.8610
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8586
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8578
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8569
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8562
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.8508
D-aminoacyl-tRNA deacylase Q8IIS0 DTD_PLAF7 Plasmodium falciparum 3 0.8508
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8506
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8464
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8463
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 3 0.8443
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.8418
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.8357
Gastrotropin P51161 FABP6_HUMAN Homo sapiens 3 0.8350
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8306
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8278
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.8239
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8203
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8196
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.8164
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.8164
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.8147
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.8123
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8122
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8085
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 2 0.8024
Threonine synthase 1, chloroplastic Q9S7B5 THRC1_ARATH Arabidopsis thaliana 3 0.8004
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7991
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7964
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7942
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7918
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7917
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7912
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7904
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7899
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7896
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7893
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7891
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7871
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7858
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7856
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7844
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7838
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7836
Naphthalene 1,2-dioxygenase system, large oxygenase component P0A110 NDOB_PSEPU Pseudomonas putida 3 0.7815
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7810
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7804
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7803
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7783
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7757
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7752
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7730
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7715
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7708
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7706
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7699
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7685
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7674
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7665
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7663
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7656
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7652
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7646
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7642
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7634
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7633
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7622
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7621
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7600
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7587
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7582
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 4 0.7581
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7575
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7569
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7562
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7559
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7553
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7553
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7550
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7548
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7547
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7533
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7527
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7522
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7519
Dihydrofolate reductase O30463 O30463_MYCAV Mycobacterium avium 3 0.7509
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7504
Dihydrofolate reductase Q83AB2 Q83AB2_COXBU Coxiella burnetii 3 0.7491
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7489
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7484
Aldo-keto reductase family 1 member B1 P80276 ALDR_PIG Sus scrofa 4 0.7475
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7475
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7474
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7474
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7466
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7448
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 2 0.7446
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7443
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7442
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7437
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7434
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7433
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7431
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7430
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7427
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 3 0.7427
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7427
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7424
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7415
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7415
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7408
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7407
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7405
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7394
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 2 0.7387
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7384
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7383
Glutathione S-transferase A1 P08263 GSTA1_HUMAN Homo sapiens 2 0.7370
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7366
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7364
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7364
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 3 0.7363
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7350
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7348
Abscisic acid receptor PYL2 O80992 PYL2_ARATH Arabidopsis thaliana 2 0.7348
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7346
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 3 0.7345
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7341
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7331
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7326
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 2 0.7320
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7316
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7315
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 2 0.7311
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7306
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7304
Capsid protein VP1 O56137 O56137_9VIRU Adeno-associated virus - 6 3 0.7304
Bifunctional dihydrofolate reductase-thymidylate synthase D9N170 D9N170_PLAFA Plasmodium falciparum 3 0.7290
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7286
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7280
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7279
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7271
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7261
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7260
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7255
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7254
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7253
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7248
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7244
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7240
Sepiapterin reductase Q64105 SPRE_MOUSE Mus musculus 3 0.7238
Urokinase-type plasminogen activator P00749 UROK_HUMAN Homo sapiens 2 0.7237
Aldo-keto reductase family 1 member B10 O60218 AK1BA_HUMAN Homo sapiens 2 0.7234
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7228
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7226
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7225
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7224
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7223
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7217
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7200
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7194
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.7192
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7189
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 3 0.7188
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7186
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7184
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7184
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 2 0.7176
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7171
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7171
Prostaglandin G/H synthase 1 P05979 PGH1_SHEEP Ovis aries 3 0.7168
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7157
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7143
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7139
Pentalenic acid synthase Q825I8 CYP28_STRAW Streptomyces avermitilis 2 0.7135
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7134
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7128
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7127
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7116
Thymidylate synthase P45352 TYSY_RAT Rattus norvegicus 2 0.7115
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7114
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7112
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7111
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7107
Probable NDP-rhamnosyltransferase Q9ALM8 Q9ALM8_SACSN Saccharopolyspora spinosa 2 0.7102
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7096
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7094
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7085
NAD(P)H dehydrogenase [quinone] 1 P15559 NQO1_HUMAN Homo sapiens 3 0.7081
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7074
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7072
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7071
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 2 0.7071
Dihydroorotate dehydrogenase (quinone), mitochondrial Q02127 PYRD_HUMAN Homo sapiens 3 0.7065
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 3 0.7064
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7064
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7055
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7047
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7041
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7039
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7035
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7035
Glycylpeptide N-tetradecanoyltransferase Q4Q5S8 Q4Q5S8_LEIMA Leishmania major 3 0.7034
Flavoredoxin Q72HI0 Q72HI0_THET2 Thermus thermophilus 3 0.7033
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7029
AcsD Q93AT8 Q93AT8_DICCH Dickeya chrysanthemi 3 0.7018
Cytochrome P450 130 P9WPN5 CP130_MYCTU Mycobacterium tuberculosis 3 0.7012
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7010
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7009
Prenyltransferase Q4R2T2 Q4R2T2_STRC1 Streptomyces sp 3 0.7005
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7002
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7000
Achbp I6L8L2 I6L8L2_CAPTE Capitella teleta 3 0.7000

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