5-hydroxy-3-methoxyxanthone - Compound Card

5-hydroxy-3-methoxyxanthone

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5-hydroxy-3-methoxyxanthone

Structure
Zoomed Structure
  • Family: Plantae - Hypericaceae
  • Kingdom: Plantae
  • Class: Xanthone
    • Subclass: Xanthone Derivative
Canonical Smiles COc1ccc2c(c1)oc1c(c2=O)cccc1O
InChI InChI=1S/C14H10O4/c1-17-8-5-6-9-12(7-8)18-14-10(13(9)16)3-2-4-11(14)15/h2-7,15H,1H3
InChIKey IGEOTHJTYYISJW-UHFFFAOYSA-N
Formula C14H10O4
HBA 4
HBD 1
MW 242.23
Rotatable Bonds 1
TPSA 59.67
LogP 2.66
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 18
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 242.06
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hypericum riparium Hypericaceae Plantae 269018

Showing of synonyms

  • Tala MF, Talontsi FM, et al. (2015). Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.. Fitoterapia,2015, 102, 149-155. [View] [PubMed]
Pubchem: 57490839
Nmrshiftdb2: 60077584

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 242.23 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.72
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.220
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.71

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.360
Plasma Protein Binding
77.41
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
1.430
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.640
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.740
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.180
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Toxic
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.610
Rat (Acute)
1.930
Rat (Chronic Oral)
2.280
Fathead Minnow
4.750
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
389.600
Hydration Free Energy
-10.580
Log(D) at pH=7.4
2.550
Log(P)
3.2
Log S
-4.12
Log(Vapor Pressure)
-6.81
Melting Point
202.81
pKa Acid
6.29
pKa Basic
2.54
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.9784
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.9437
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9405
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.9399
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9356
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.9310
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9257
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.9192
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.9186
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9163
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.9133
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9118
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9092
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.9086
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9029
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9020
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8978
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8969
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8957
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8898
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8896
Ceramide transfer protein Q9Y5P4 CERT_HUMAN Homo sapiens 3 0.8816
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8804
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8759
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.8739
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8713
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8694
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.8621
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.8616
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8564
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.8544
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8527
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.8500
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.8396
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8380
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8332
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.8324
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8285
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8273
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.8242
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8219
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8205
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8203
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8190
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8164
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8157
Alpha-1-acid glycoprotein 2 P19652 A1AG2_HUMAN Homo sapiens 3 0.8156
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8154
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8148
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.8147
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.8143
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 3 0.8113
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8087
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8039
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.8030
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.8029
Aurora kinase B-A Q6DE08 AUKBA_XENLA Xenopus laevis 3 0.7991
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7985
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7982
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7968
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Q33862 Q33862_ASCSU Ascaris suum 3 0.7960
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7923
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7902
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7889
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 3 0.7870
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7860
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7859
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7858
3-ketosteroid dehydrogenase Q9RA02 Q9RA02_RHOER Rhodococcus erythropolis 3 0.7854
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7853
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7813
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7793
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7781
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7781
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7776
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7772
Steroid C26-monooxygenase P9WPP1 CP125_MYCTU Mycobacterium tuberculosis 3 0.7770
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7768
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7752
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.7736
Tyrosine-protein kinase HCK P08631 HCK_HUMAN Homo sapiens 3 0.7734
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7725
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7724
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.7713
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7689
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7686
cAMP-dependent protein kinase catalytic subunit alpha P17612 KAPCA_HUMAN Homo sapiens 3 0.7679
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7677
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7677
Acetylcholinesterase P21836 ACES_MOUSE Mus musculus 3 0.7676
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7673
16S rRNA (guanine(1405)-N(7))-methyltransferase Q763K9 Q763K9_ECOLX Escherichia coli 3 0.7670
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7661
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7645
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7644
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7623
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7605
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7600
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7589
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7574
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7573
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7573
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7573
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7560
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7558
Nucleoside diphosphate kinase A 2 P52175 NDKA2_BOVIN Bos taurus 3 0.7556
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7552
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 3 0.7550
Type II methyltransferase M.TaqI P14385 MTTA_THEAQ Thermus aquaticus 3 0.7540
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 3 0.7533
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7511
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7499
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7481
Dihydrofolate reductase type 1 from Tn4003 P13955 DYRA_STAAU Staphylococcus aureus 3 0.7479
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7479
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7478
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7477
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7471
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7466
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7454
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7432
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7431
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7430
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7427
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7426
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7422
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7406
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7405
Ketimine reductase mu-crystallin O54983 CRYM_MOUSE Mus musculus 2 0.7400
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial Q8N5Z0 AADAT_HUMAN Homo sapiens 2 0.7388
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7385
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7385
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7384
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7375
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7372
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7368
Endoplasmin P14625 ENPL_HUMAN Homo sapiens 3 0.7359
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7351
Multidrug efflux pump subunit AcrB P31224 ACRB_ECOLI Escherichia coli 3 0.7348
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 2 0.7344
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 2 0.7338
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7311
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7304
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7290
DNA topoisomerase 1 P06612 TOP1_ECOLI Escherichia coli 3 0.7283
TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase Q6T1W8 FDTA_ANETH Aneurinibacillus thermoaerophilus 3 0.7277
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7268
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7256
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7254
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.7249
Exotoxin A P11439 TOXA_PSEAE Pseudomonas aeruginosa 3 0.7245
NADPH dehydrogenase 1 Q02899 OYE1_SACPS Saccharomyces pastorianus 3 0.7241
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7232
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7216
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7215
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 2 0.7211
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7210
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7208
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7203
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 2 0.7202
glutaryl-CoA dehydrogenase (ETF) Q3JP94 Q3JP94_BURP1 Burkholderia pseudomallei 3 0.7197
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7196
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7195
Methyltransferase O26771 O26771_METTH Methanothermobacter thermautotrophicus 3 0.7195
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7177
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7167
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7161
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7159
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7159
Bifunctional dihydrofolate reductase-thymidylate synthase A7UD81 A7UD81_PLAFA Plasmodium falciparum 3 0.7158
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7156
cGMP-dependent protein kinase 1 Q13976 KGP1_HUMAN Homo sapiens 2 0.7156
Pheromone-binding protein ASP1 Q9U9J6 Q9U9J6_APIME Apis mellifera 2 0.7153
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 2 0.7134
Aldo-keto reductase family 1 member C3 P42330 AK1C3_HUMAN Homo sapiens 2 0.7130
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7123
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7121
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7118
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7116
Gag-Pol polyprotein P03366 POL_HV1B1 Human immunodeficiency virus type 1 group M subtype B 3 0.7111
Bifunctional dihydrofolate reductase-thymidylate synthase P13922 DRTS_PLAFK Plasmodium falciparum 3 0.7110
L-methionine gamma-lyase Q84AR1 Q84AR1_CITFR Citrobacter freundii 3 0.7109
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7108
Dihydrofolate reductase P0A017 DYR_STAAU Staphylococcus aureus 3 0.7107
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7102
Protoporphyrinogen oxidase, mitochondrial O24164 PPOM_TOBAC Nicotiana tabacum 2 0.7095
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7091
Eukaryotic translation initiation factor 4E type 3 Q9DBB5 IF4E3_MOUSE Mus musculus 3 0.7086
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Q9Y3Z3 SAMH1_HUMAN Homo sapiens 3 0.7081
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7078
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7073
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7072
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7063
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7058
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7048
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 2 0.7041
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7038
Geranyl diphosphate 2-C-methyltransferase D3KYU3 GPPMT_STRLS Streptomyces lasalocidi 3 0.7037
Polyamine aminopropyltransferase Q5SK28 SPEE_THET8 Thermus thermophilus 3 0.7036
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7036
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7035
Gag-Pol polyprotein P04585 POL_HV1H2 Human immunodeficiency virus type 1 group M subtype B 3 0.7028
Putative cytochrome P450 Q70AS3 Q70AS3_STRPE Streptomyces peucetius 3 0.7018
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 3 0.7007
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7002

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