3-hydroxy-2,4-dimethoxyxanthone - Compound Card

3-hydroxy-2,4-dimethoxyxanthone

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3-hydroxy-2,4-dimethoxyxanthone

Structure
Zoomed Structure
  • Family: Hypericaceae
  • Kingdom: Plantae
  • Class: Xanthone
    • Subclass: Xanthone Derivative
Canonical Smiles COc1c(O)c(OC)cc2c1oc1ccccc1c2=O
InChI InChI=1S/C15H12O5/c1-18-11-7-9-12(16)8-5-3-4-6-10(8)20-14(9)15(19-2)13(11)17/h3-7,17H,1-2H3
InChIKey DQAQTPIWHUEPAU-UHFFFAOYSA-N
Formula C15H12O5
HBA 5
HBD 1
MW 272.26
Rotatable Bonds 2
TPSA 68.9
LogP 2.67
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 20
Formal Charge 0
Fraction CSP3 0.13
Exact Mass 272.07
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hypericum riparium Hypericaceae Plantae 269018

Showing of synonyms

  • Tala MF, Talontsi FM, et al. (2015). Antimicrobial and cytotoxic constituents from native Cameroonian medicinal plant Hypericum riparium.. Fitoterapia,2015, 102, 149-155. [View] [PubMed]
Pubchem: 12214333
Nmrshiftdb2: 60026996

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 196.21 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.62
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.220
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.38

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.420
Plasma Protein Binding
75.37
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.250
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.840
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.140
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
5.200
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.270
Rat (Acute)
1.990
Rat (Chronic Oral)
2.410
Fathead Minnow
4.870
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Toxic

General Properties

Boiling Point
398.970
Hydration Free Energy
-9.630
Log(D) at pH=7.4
1.680
Log(P)
2.7
Log S
-4.11
Log(Vapor Pressure)
-6.62
Melting Point
173.27
pKa Acid
5.77
pKa Basic
1.8
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9751
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9493
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.9477
Biflaviolin synthase CYP158A1 Q9KZF5 C1581_STRCO Streptomyces coelicolor / M145) 3 0.9463
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9249
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9173
Dodecin Q5SIE3 DODEC_THET8 Thermus thermophilus 5 0.9160
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9145
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.9138
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.9136
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9131
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.9125
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.9093
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9085
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.9049
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9041
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8946
Fatty acid-binding protein, intestinal P12104 FABPI_HUMAN Homo sapiens 3 0.8878
Proliferating cell nuclear antigen P12004 PCNA_HUMAN Homo sapiens 3 0.8863
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8858
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8824
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8802
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8781
Flavin reductase like domain-containing protein Q4UKE8 Q4UKE8_RICFE Rickettsia felis 4 0.8734
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8702
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.8694
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8685
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.8597
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 3 0.8580
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8554
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8540
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8507
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8507
cAMP-dependent protein kinase catalytic subunit alpha P05132 KAPCA_MOUSE Mus musculus 3 0.8504
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8481
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.8306
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8300
EbrA repressor Q79SH7 Q79SH7_STRLI Streptomyces lividans 3 0.8294
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8282
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8274
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 3 0.8257
IAG-nucleoside hydrolase Q9GPQ4 Q9GPQ4_TRYVI Trypanosoma vivax 4 0.8245
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8176
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8174
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.8155
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8145
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.8137
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8135
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.8109
Diphtheria toxin P00588 DTX_CORBE Corynephage beta 3 0.8102
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8080
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.8075
TetR family transcriptional regulator Q58L87 Q58L87_MYCSM Mycolicibacterium smegmatis 3 0.8073
Deoxyribodipyrimidine photo-lyase Q8PYK9 Q8PYK9_METMA Methanosarcina mazei 5 0.8061
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8029
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8028
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8024
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7994
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7989
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.7960
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7955
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7951
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7943
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.7916
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7908
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7897
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 3 0.7892
Nucleoside permease Q9KPL5 Q9KPL5_VIBCH Vibrio cholerae serotype O1 4 0.7881
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7876
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7874
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7854
Flavin-dependent monooxygenase Q93L51 TETX_BACT4 Bacteroides thetaiotaomicron 3 0.7849
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7829
Transcriptional regulator, PadR-like family A2RI36 A2RI36_LACLM Lactococcus lactis subsp. cremoris 2 0.7828
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 4 0.7827
NAD-dependent protein deacetylase Q9WYW0 NPD_THEMA Thermotoga maritima 3 0.7819
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7808
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7801
Glycogen phosphorylase, muscle form P00489 PYGM_RABIT Oryctolagus cuniculus 3 0.7794
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7777
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7773
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7762
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7758
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7753
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7750
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7744
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 3 0.7736
Dipeptidyl peptidase 4 P27487 DPP4_HUMAN Homo sapiens 3 0.7727
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.7717
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 3 0.7707
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7700
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7698
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7686
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7684
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7683
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7680
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.7680
Cytosolic purine 5'-nucleotidase P49902 5NTC_HUMAN Homo sapiens 2 0.7678
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7668
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7661
Albumin P02768 ALBU_HUMAN Homo sapiens 3 0.7651
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7644
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7641
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7638
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 3 0.7632
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 3 0.7630
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7616
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7615
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 4 0.7608
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.7595
Lactoperoxidase A0A452E9Y6 PERL_CAPHI Capra hircus 3 0.7590
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7589
AGAP003309-PA A0A1U7F4W2 A0A1U7F4W2_ANOGA Anopheles gambiae 3 0.7586
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.7585
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.7584
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7582
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7569
HTH-type transcriptional regulator QacR P0A0N4 QACR_STAAU Staphylococcus aureus 3 0.7567
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.7562
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7559
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7553
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7544
Riboflavin kinase Q969G6 RIFK_HUMAN Homo sapiens 4 0.7535
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7527
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7519
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.7515
4-hydroxyphenylacetate 3-monooxygenase Q8YHT7 Q8YHT7_BRUME Brucella melitensis biotype 1 2 0.7500
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7494
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7487
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7471
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7467
Chymotrypsinogen A P00766 CTRA_BOVIN Bos taurus 3 0.7460
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7453
Agglutinin alpha chain P18674 LECA_MACPO Maclura pomifera 3 0.7450
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7443
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7440
Deoxyribodipyrimidine photo-lyase P61497 PHR_THET8 Thermus thermophilus 4 0.7433
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7424
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7420
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7417
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7414
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7399
Phototropin Q8LPD9 PHOT_CHLRE Chlamydomonas reinhardtii 5 0.7391
p-hydroxyphenylacetate 3-hydroxylase, oxygenase component Q6Q272 HPAH_ACIBA Acinetobacter baumannii 4 0.7388
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7378
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7377
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7377
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7376
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7372
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7364
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7363
Flavin-dependent thymidylate synthase Q9WYT0 THYX_THEMA Thermotoga maritima 3 0.7359
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7355
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7352
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7338
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7335
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7333
Pteridine reductase O76290 O76290_TRYBB Trypanosoma brucei brucei 3 0.7317
Riboflavin biosynthesis protein Q9WZW1 Q9WZW1_THEMA Thermotoga maritima 4 0.7299
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7295
NAD(P)H dehydrogenase (quinone) Q9I509 NQOR_PSEAE Pseudomonas aeruginosa 5 0.7283
Thymidylate kinase Q9KQI2 KTHY_VIBCH Vibrio cholerae serotype O1 4 0.7255
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7255
Carbonic anhydrase 12 O43570 CAH12_HUMAN Homo sapiens 2 0.7248
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7239
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7234
cGMP-dependent protein kinase 2 Q13237 KGP2_HUMAN Homo sapiens 3 0.7231
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7223
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7219
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7219
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7217
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7213
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7212
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 3 0.7212
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 3 0.7209
F420-dependent NADP reductase O29370 FNO_ARCFU Archaeoglobus fulgidus 3 0.7207
Albumin P14639 ALBU_SHEEP Ovis aries 2 0.7189
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7188
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7188
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7183
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7180
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7173
Envelope glycoprotein gp160 Q0ED31 Q0ED31_9HIV1 Human immunodeficiency virus 1 3 0.7173
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7166
Diguanylate phosphodiesterase A6T8V8 A6T8V8_KLEP7 Klebsiella pneumoniae subsp. pneumoniae 4 0.7162
Peptidyl-prolyl cis-trans isomerase FKBP5 Q13451 FKBP5_HUMAN Homo sapiens 3 0.7161
Dihydrofolate reductase P00381 DYR_LACCA Lacticaseibacillus casei 3 0.7159
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7155
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7151
Nitroreductase NfnB A0R6D0 NFNB_MYCS2 Mycolicibacterium smegmatis155) 5 0.7150
Xylose isomerase P24300 XYLA_STRRU Streptomyces rubiginosus 3 0.7150
Deoxyribodipyrimidine photo-lyase P61497 PHR_THET8 Thermus thermophilus 5 0.7144
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.7142
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7133
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7130
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.7129
Dodecin A1WUH0 DODEC_HALHL Halorhodospira halophila) 5 0.7127
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 4 0.7127
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7126
Nitroreductase NfnB A0R6D0 NFNB_MYCS2 Mycolicibacterium smegmatis155) 5 0.7124
Tubulin alpha chain A0A0R4I993 A0A0R4I993_SUSBA Sus barbatus 3 0.7124
NAD-dependent protein deacetylase sirtuin-3, mitochondrial Q9NTG7 SIR3_HUMAN Homo sapiens 4 0.7105
dTDP-4-dehydrorhamnose 3,5-epimerase A0A6L7H6N0 A0A1S0QLH9_BACAN Bacillus anthracis 3 0.7103
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7102
Matrix metalloproteinase-9 P14780 MMP9_HUMAN Homo sapiens 3 0.7101
Biphenyl-2,3-diol 1,2-dioxygenase P17297 BPHC_PSES1 Pseudomonas sp 3 0.7099
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7095
Acetyl-CoA carboxylase Q00955 ACAC_YEAST Saccharomyces cerevisiae 3 0.7095
Bifunctional epoxide hydrolase 2 P34913 HYES_HUMAN Homo sapiens 2 0.7090
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7086
Transthyretin P02767 TTHY_RAT Rattus norvegicus 2 0.7081
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7077
Biphenyl-2,3-diol 1,2-dioxygenase P47228 BPHC_PARXL Paraburkholderia xenovorans 3 0.7076
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7070
Oxygen-insensitive NAD(P)H nitroreductase P38489 NFSB_ECOLI Escherichia coli 5 0.7063
2',3'-cyclic-nucleotide 3'-phosphodiesterase P16330 CN37_MOUSE Mus musculus 2 0.7056
A-type flavoprotein Q86QZ1 Q86QZ1_GIAIN Giardia intestinalis 4 0.7051
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7051
Nitroreductase Q5R179 Q5R179_IDILO Idiomarina loihiensis 5 0.7049
Uncharacterized protein O59088 O59088_PYRHO Pyrococcus horikoshii 5 0.7049
Catalase-peroxidase 2 O59651 KATG2_HALMA Haloarcula marismortui 3 0.7044
NmrA-like family domain-containing protein 1 Q9HBL8 NMRL1_HUMAN Homo sapiens 2 0.7039
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7037
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 4 0.7027
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7025
Single-stranded-DNA-specific exonuclease RecJ D0EM60 D0EM60_DEIRD Deinococcus radiodurans 2 0.7025
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7023
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7022
N-acetyl-S-alkylcysteine sulfoxide monooxygenase O34974 MOXC_BACSU Bacillus subtilis 5 0.7017
NADPH--cytochrome P450 reductase P16435 NCPR_HUMAN Homo sapiens 5 0.7016
Aurora kinase A O14965 AURKA_HUMAN Homo sapiens 4 0.7016
dTDP-4-dehydro-6-deoxyglucose 3-epimerase Q5SFD1 CHMJ_STRBI Streptomyces bikiniensis 3 0.7015
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7014
A disintegrin and metalloproteinase with thrombospondin motifs 5 Q9UNA0 ATS5_HUMAN Homo sapiens 3 0.7012
Oxygen-insensitive NAD(P)H nitroreductase Q01234 NFSB_ENTCL Enterobacter cloacae 5 0.7007
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7003

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