1,5-dihydroxy-6-methoxyxanthone - Compound Card

1,5-dihydroxy-6-methoxyxanthone

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1,5-dihydroxy-6-methoxyxanthone

Structure
Zoomed Structure
  • Family: Hypericaceae
  • Kingdom: Plantae
  • Class: Xanthone
Canonical Smiles COc1ccc2c(c1O)oc1c(c2=O)c(O)ccc1
InChI InChI=1S/C14H10O5/c1-18-10-6-5-7-12(16)11-8(15)3-2-4-9(11)19-14(7)13(10)17/h2-6,15,17H,1H3
InChIKey DUTGTZKSYPRUPX-UHFFFAOYSA-N
Formula C14H10O5
HBA 5
HBD 2
MW 258.23
Rotatable Bonds 1
TPSA 79.9
LogP 2.37
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 19
Formal Charge 0
Fraction CSP3 0.07
Exact Mass 258.05
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Hypericum roeperianum Hypericaceae Plantae —

Showing of synonyms

  • Damen F, Demgne OMF, et al. (2021). A new polyketide from the bark of Hypericum roeperianum Schimp. (Hypericaceae).. Natural product research,2021, 35(14), 2381-2387. [View] [PubMed]
Pubchem: 15957491
Nmrshiftdb2: 60061110

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc3c(c2=O)cccc3

Level: 0

Mol. Weight: 196.21 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.8
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.640
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.23

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.330
Plasma Protein Binding
76.73
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
3.210
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Toxic
Avian
Safe
Bee
Safe
Bioconcentration Factor
1.550
Biodegradation
Safe
Carcinogenesis
Toxic
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.180
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
4.850
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
4.540
Rat (Acute)
2.160
Rat (Chronic Oral)
2.920
Fathead Minnow
4.570
Respiratory Disease
Safe
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
405.830
Hydration Free Energy
-10.730
Log(D) at pH=7.4
2.730
Log(P)
2.87
Log S
-4.6
Log(Vapor Pressure)
-6.92
Melting Point
202.63
pKa Acid
5.9
pKa Basic
3.94
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.9577
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9447
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9407
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9309
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 3 0.9295
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9266
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9265
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.9196
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.9084
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8982
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8952
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8950
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8943
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8910
2-phospho-L-lactate transferase Q8PVT6 COFD_METMA Methanosarcina mazei 3 0.8909
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8850
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8789
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8745
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.8719
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 3 0.8669
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.8634
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8603
Protein ppBat Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron VPI-5482 3 0.8601
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8504
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8477
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8475
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.8474
Mycinamicin III 3''-O-methyltransferase Q49492 MYCF_MICGR Micromonospora griseorubida 2 0.8460
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.8452
NAD-capped RNA hydrolase NudC P32664 NUDC_ECOLI Escherichia coli 3 0.8446
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.8444
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.8438
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.8422
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase F6MZ55 F6MZ55_9FIRM Sporomusa ovata 3 0.8399
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8383
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 3 0.8378
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.8360
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8360
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8323
Succinate dehydrogenase flavoprotein subunit P0AC41 SDHA_ECOLI Escherichia coli 3 0.8308
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 4 0.8304
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8299
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8294
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.8260
tRNA (adenine(9)-N1)-methyltransferase Q4J894 TRM10_SULAC Sulfolobus acidocaldarius 4 0.8252
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8249
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.8185
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.8176
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8146
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.8113
Steroid Delta-isomerase P07445 SDIS_PSEPU Pseudomonas putida 3 0.8110
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8104
Odorant-binding protein P81245 OBP_PIG Sus scrofa 3 0.8103
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.8102
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8095
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.8054
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8035
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7962
Genome polyprotein P26663 POLG_HCVBK Hepatitis C virus genotype 1b 4 0.7959
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 3 0.7957
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7930
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7920
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7911
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 3 0.7901
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7878
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 4 0.7853
Tubulin alpha chain D0VWZ0 D0VWZ0_SHEEP Ovis aries 3 0.7838
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 4 0.7832
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7823
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.7814
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7812
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 3 0.7792
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 3 0.7784
uroporphyrinogen-III C-methyltransferase P95417 P95417_PSEAI Pseudomonas aeruginosa 4 0.7781
Enoyl-ACP reductase Q9BJJ9 Q9BJJ9_PLAFA Plasmodium falciparum 3 0.7771
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7764
Bifunctional dihydrofolate reductase-thymidylate synthase O02604 DRTS_PLAVI Plasmodium vivax 3 0.7751
Beta-glucosidase Q8T0W7 Q8T0W7_9NEOP Neotermes koshunensis 3 0.7741
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 3 0.7717
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7694
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7687
Glutamate receptor 2 P19491 GRIA2_RAT Rattus norvegicus 3 0.7647
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.7613
Nitroreductase domain-containing protein Q8DW21 Q8DW21_STRMU Streptococcus mutans serotype c 3 0.7597
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 3 0.7591
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7580
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7573
Lactoperoxidase P80025 PERL_BOVIN Bos taurus 3 0.7562
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7553
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7552
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7533
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7531
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7527
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7502
Angiotensin-converting enzyme 2 Q9BYF1 ACE2_HUMAN Homo sapiens 2 0.7495
Casein kinase I isoform gamma-3 Q9Y6M4 KC1G3_HUMAN Homo sapiens 3 0.7494
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7487
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7481
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 3 0.7477
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7464
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7462
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7457
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7456
Thiosulfate reductase Q72LA4 Q72LA4_THET2 Thermus thermophilus 4 0.7449
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7426
GCN5-related N-acetyltransferase B1YEL6 B1YEL6_EXIS2 Exiguobacterium sibiricum 3 0.7425
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 3 0.7420
Focal adhesion kinase 1 Q00944 FAK1_CHICK Gallus gallus 3 0.7411
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7410
Deoxycytidine kinase P27707 DCK_HUMAN Homo sapiens 4 0.7409
Pyridoxal kinase P82197 PDXK_SHEEP Ovis aries 3 0.7409
Vitamin D3 dihydroxylase P18326 CPXE_STRGO Streptomyces griseolus 3 0.7389
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7388
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7375
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7365
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase O67060 ISPE_AQUAE Aquifex aeolicus 3 0.7364
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 2 0.7360
Gag-Pol polyprotein P05896 POL_SIVM1 Simian immunodeficiency virus 3 0.7358
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 4 0.7352
Orotidine 5'-phosphate decarboxylase O58462 PYRF_PYRHO Pyrococcus horikoshii 3 0.7352
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7350
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 3 0.7337
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7330
DNA mismatch repair protein Msh2 P43246 MSH2_HUMAN Homo sapiens 3 0.7310
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7306
Pteridine reductase, putative Q581W1 Q581W1_TRYB2 Trypanosoma brucei brucei 3 0.7302
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7302
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7295
CREB-binding protein Q92793 CBP_HUMAN Homo sapiens 3 0.7293
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7286
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7279
Peptidyl-prolyl cis-trans isomerase FKBP1A P62942 FKB1A_HUMAN Homo sapiens 3 0.7269
Beta-galactosidase P00722 BGAL_ECOLI Escherichia coli 3 0.7262
Insulin receptor P06213 INSR_HUMAN Homo sapiens 4 0.7252
Acetylcholinesterase P04058 ACES_TETCF Tetronarce californica 3 0.7251
Cobalt-precorrin-4 C(11)-methyltransferase O87696 CBIF_BACME Priestia megaterium 3 0.7244
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7241
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7240
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.7240
Aklavinone 12-hydroxylase RdmE Q54530 DNRF_STREF Streptomyces purpurascens 4 0.7235
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7232
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7226
Peripheral plasma membrane protein CASK O14936 CSKP_HUMAN Homo sapiens 3 0.7205
Pteridine reductase 1 Q01782 PTR1_LEIMA Leishmania major 3 0.7204
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7201
Tubulin alpha-1B chain P81947 TBA1B_BOVIN Bos taurus 3 0.7185
Fibroblast growth factor receptor 1 P11362 FGFR1_HUMAN Homo sapiens 3 0.7185
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7184
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7166
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7165
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7155
S-adenosylmethionine decarboxylase proenzyme P17707 DCAM_HUMAN Homo sapiens 3 0.7147
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 3 0.7142
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7137
uroporphyrinogen-III C-methyltransferase Q5SKH6 Q5SKH6_THET8 Thermus thermophilus 4 0.7133
Putative HMP/thiamine-binding protein YkoF O34911 YKOF_BACSU Bacillus subtilis 3 0.7131
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7118
Alcohol dehydrogenase E chain P00327 ADH1E_HORSE Equus caballus 4 0.7116
Biphenyl dioxygenase subunit alpha P37333 BPHA_PARXL Paraburkholderia xenovorans 3 0.7113
Dihydroorotate dehydrogenase (quinone), mitochondrial Q08210 PYRD_PLAF7 Plasmodium falciparum 3 0.7105
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7097
Dimethylglycine dehydrogenase, mitochondrial Q63342 M2GD_RAT Rattus norvegicus 4 0.7091
DNA mismatch repair protein MutS P23909 MUTS_ECOLI Escherichia coli 3 0.7086
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7085
Cholinesterase P06276 CHLE_HUMAN Homo sapiens 2 0.7084
Nuclear receptor subfamily 5 group A member 2 O00482 NR5A2_HUMAN Homo sapiens 3 0.7072
Hygromycin-B 4-O-kinase P00557 KHYB_ECOLX Escherichia coli 3 0.7059
Maltokinase A1TH50 MAK_MYCVP Mycolicibacterium vanbaalenii 3 0.7058
Dihydrofolate reductase P00374 DYR_HUMAN Homo sapiens 3 0.7054
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.7052
Catechol O-methyltransferase P22734 COMT_RAT Rattus norvegicus 3 0.7049
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7047
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7047
Nicotinamide riboside kinase 1 Q9NWW6 NRK1_HUMAN Homo sapiens 3 0.7028
Lethal(3)malignant brain tumor-like protein 1 Q9Y468 LMBL1_HUMAN Homo sapiens 3 0.7026
Bromodomain-containing protein 4 O60885 BRD4_HUMAN Homo sapiens 3 0.7018
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7017

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