5,6-dihydroxy-7,3′,4′-trimethoxyflavone - Compound Card

5,6-dihydroxy-7,3′,4′-trimethoxyflavone

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5,6-dihydroxy-7,3′,4′-trimethoxyflavone

Structure
Zoomed Structure
  • Family: Plantae - Lamiaceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavone
Canonical Smiles COc1cc(ccc1OC)c1cc(=O)c2c(o1)cc(c(c2O)O)OC
InChI InChI=1S/C18H16O7/c1-22-11-5-4-9(6-13(11)23-2)12-7-10(19)16-14(25-12)8-15(24-3)17(20)18(16)21/h4-8,20-21H,1-3H3
InChIKey QIEMGQKOGFTYLN-UHFFFAOYSA-N
Formula C18H16O7
HBA 7
HBD 2
MW 344.32
Rotatable Bonds 4
TPSA 98.36
LogP 2.9
Number Rings 3
Number Aromatic Rings 3
Heavy Atom Count 25
Formal Charge 0
Fraction CSP3 0.17
Exact Mass 344.09
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Plectranthus glandulosus Lamiaceae Plantae 2485351

Showing of synonyms

  • Nanmeni G, Tedonkeu AT, et al. (2021). An Efflux Pumps Inhibitor Significantly Improved the Antibacterial Activity of Botanicals from Plectranthus glandulosus towards MDR Phenotypes.. TheScientificWorldJournal,2021, 2021, 5597524. [View] [PubMed]
Pubchem: 10020367
Nmrshiftdb2: 60067451

No compound-protein relationship available.

Structure

SMILES: c1cccc(c12)oc(cc2=O)-c3ccccc3

Level: 1

Mol. Weight: 344.32 g/mol

Structure

SMILES: c1cccc(c12)occc2=O

Level: 0

Mol. Weight: 344.32 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 344.32 g/mol

Antibacterial

Absorption

Caco-2 (logPapp)
-4.71
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.860
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Non-Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-1.49

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Non-Penetrable
Fraction Unbound (Human)
1.320
Plasma Protein Binding
89.04
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Non-Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Non-Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
8.030
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.370
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Toxic
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
1.210
Liver Injury II
Toxic
hERG Blockers
Safe
Daphnia Maga
6.000
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
1.650
Rat (Acute)
2.330
Rat (Chronic Oral)
2.660
Fathead Minnow
4.930
Respiratory Disease
Toxic
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
456.900
Hydration Free Energy
-10.200
Log(D) at pH=7.4
2.650
Log(P)
2.13
Log S
-5.35
Log(Vapor Pressure)
-7.73
Melting Point
196.34
pKa Acid
7.94
pKa Basic
2.61
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9766
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.9766
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 4 0.9670
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.9555
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.9515
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9511
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 3 0.9510
Bromodomain adjacent to zinc finger domain protein 2B Q9UIF8 BAZ2B_HUMAN Homo sapiens 3 0.9444
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.9439
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9339
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.9298
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.9292
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 4 0.9226
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9176
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9176
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 3 0.9073
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9034
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.8985
3'-5' exoribonuclease Rv2179c P9WJ73 EXRBN_MYCTU Mycobacterium tuberculosis 3 0.8956
Cathepsin S P25774 CATS_HUMAN Homo sapiens 3 0.8944
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8919
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8872
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 3 0.8862
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8831
Nuclear receptor subfamily 4immunitygroup A member 1 P22736 NR4A1_HUMAN Homo sapiens 3 0.8814
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.8808
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 3 0.8807
Tetracycline repressor protein class B from transposon Tn10 P04483 TETR2_ECOLX Escherichia coli 3 0.8792
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8777
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 3 0.8765
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.8765
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8754
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8753
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8707
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8678
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8677
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 4 0.8614
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8610
cGMP-specific 3',5'-cyclic phosphodiesterase O76074 PDE5A_HUMAN Homo sapiens 3 0.8599
Transthyretin P02766 TTHY_HUMAN Homo sapiens 4 0.8574
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8573
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 4 0.8551
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8533
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8529
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8517
Thymidine phosphorylase Q7CP66 TYPH_SALTY Salmonella typhimurium 3 0.8488
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.8478
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8431
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.8389
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 4 0.8373
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8332
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.8332
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 3 0.8323
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8297
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.8271
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8251
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8248
Catalase-peroxidase Q3JNW6 KATG_BURP1 Burkholderia pseudomallei 3 0.8227
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.8223
Mitogen-activated protein kinase kinase kinase 5 Q99683 M3K5_HUMAN Homo sapiens 3 0.8218
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8179
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8169
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 3 0.8149
Estrogen receptor P03372 ESR1_HUMAN Homo sapiens 4 0.8147
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.8137
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8131
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.8115
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 5 0.8105
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 4 0.8103
Genome polyprotein O92972 POLG_HCVJ4 Hepatitis C virus genotype 1b 3 0.8088
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.8077
Transthyretin P02767 TTHY_RAT Rattus norvegicus 3 0.8062
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 3 0.8061
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 4 0.8055
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8033
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.8032
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8005
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.8000
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7997
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.7983
Gag-Pol polyprotein O12158 POL_HV192 Human immunodeficiency virus type 1 group M subtype C 3 0.7979
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta P78356 PI42B_HUMAN Homo sapiens 4 0.7971
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7903
Caffeic acid O-methyltransferase Q9ZTU2 Q9ZTU2_LOLPR Lolium perenne 4 0.7899
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7897
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 5 0.7895
Acetylcholinesterase P22303 ACES_HUMAN Homo sapiens 3 0.7890
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7890
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7878
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7858
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7857
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7854
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7795
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 3 0.7778
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7771
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7769
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7765
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7746
Chalcone--flavanone isomerase 1 P28012 CFI1_MEDSA Medicago sativa 3 0.7733
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.7729
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7725
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7718
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.7713
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7707
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7706
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7679
histidine kinase O32393 O32393_ARTPT Arthrospira platensis 3 0.7676
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7669
Cell division cycle 7-related protein kinase O00311 CDC7_HUMAN Homo sapiens 4 0.7623
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 3 0.7608
Prothrombin P00734 THRB_HUMAN Homo sapiens 3 0.7607
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 3 0.7600
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 4 0.7595
Proto-oncogene tyrosine-protein kinase Src P00523 SRC_CHICK Gallus gallus 3 0.7595
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 3 0.7591
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7557
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7554
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7547
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.7546
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7546
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7546
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 2 0.7526
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7523
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7512
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7512
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7506
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7495
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7494
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 4 0.7490
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 2 0.7484
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 3 0.7481
Phosphoenolpyruvate carboxykinase [GTP] P9WIH3 PCKG_MYCTU Mycobacterium tuberculosis 3 0.7477
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 2 0.7473
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 2 0.7467
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7462
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.7458
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7449
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.7426
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7411
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7398
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 3 0.7397
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7397
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7395
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7390
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 3 0.7384
4,4'-diapophytoene synthase A9JQL9 CRTM_STAAU Staphylococcus aureus 3 0.7374
Dihydroflavonol 4-reductase P51110 DFRA_VITVI Vitis vinifera 6 0.7371
Non-receptor tyrosine-protein kinase TYK2 P29597 TYK2_HUMAN Homo sapiens 3 0.7371
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 3 0.7371
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7344
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7342
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7341
Ribosyldihydronicotinamide dehydrogenase [quinone] P16083 NQO2_HUMAN Homo sapiens 3 0.7338
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7330
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7324
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7314
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 4 0.7312
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7311
Steroid Delta-isomerase P00947 SDIS_COMTE Comamonas testosteroni 3 0.7309
RNA-dependent RNA polymerase Q6A562 Q6A562_9VIRU Thosea asigna virus 2 0.7306
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7301
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 5 0.7296
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7291
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7291
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7291
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7287
3-phosphoinositide-dependent protein kinase 1 O15530 PDPK1_HUMAN Homo sapiens 4 0.7285
Glutamate receptor 2 P42262 GRIA2_HUMAN Homo sapiens 3 0.7284
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7282
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 3 0.7280
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7277
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7276
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7259
Glucose-1-phosphate thymidylyltransferase Q9AGY4 Q9AGY4_ANETH Aneurinibacillus thermoaerophilus 4 0.7246
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7244
17-beta-hydroxysteroid dehydrogenase type 1 P14061 DHB1_HUMAN Homo sapiens 2 0.7240
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7238
Uncharacterized protein Q3F0V8 Q3F0V8_BACTI Bacillus thuringiensis serovar israelensis ATCC 35646 3 0.7236
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7235
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7226
Serine/threonine-protein kinase MRCK beta Q9Y5S2 MRCKB_HUMAN Homo sapiens 4 0.7222
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7220
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7216
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 3 0.7208
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7206
Eukaryotic translation initiation factor 4E-1 P29557 IF4E1_WHEAT Triticum aestivum 4 0.7202
Ras-related C3 botulinum toxin substrate 3 P60763 RAC3_HUMAN Homo sapiens 4 0.7195
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7193
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 3 0.7191
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7189
Kinesin-like protein KIF11 P52732 KIF11_HUMAN Homo sapiens 3 0.7187
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7184
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7179
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.7177
Aminoglycoside 3'-phosphotransferase AphA1-IAB B0VD92 B0VD92_ACIBY Acinetobacter baumannii 3 0.7173
HTH-type transcriptional regulator TtgR Q9AIU0 TTGR_PSEPT Pseudomonas putida 4 0.7170
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7164
Kinesin heavy chain Q41460 Q41460_SOLTU Solanum tuberosum 3 0.7164
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase Q46381 BPHB_COMTE Comamonas testosteroni 3 0.7139
Estrogen receptor beta Q92731 ESR2_HUMAN Homo sapiens 3 0.7138
Phosphodiesterase Q8WQX9 Q8WQX9_9TRYP Trypanosoma brucei 3 0.7136
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7136
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7135
Beta-secretase 2 Q9Y5Z0 BACE2_HUMAN Homo sapiens 2 0.7133
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7126
4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic Q9FYS3 HGGL_SECCE Secale cereale 3 0.7123
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.7122
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7121
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7115
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.7111
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.7101
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7097
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7096
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7088
Caspase-3 P42574 CASP3_HUMAN Homo sapiens 2 0.7087
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7076
Putative protease I Q8A8A4 Q8A8A4_BACTN Bacteroides thetaiotaomicron 2 0.7066
FMN-dependent NAD(P)H:quinone oxidoreductase 1 Q9I5F3 AZOR1_PSEAE Pseudomonas aeruginosa 3 0.7063
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7062
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A O76083 PDE9A_HUMAN Homo sapiens 4 0.7060
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 3 0.7059
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7057
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 2 0.7055
ATP synthase subunit alpha, mitochondrial P19483 ATPA_BOVIN Bos taurus 3 0.7053
Neuropilin-1 O14786 NRP1_HUMAN Homo sapiens 3 0.7050
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7043
Tetracycline repressor protein class D P0ACT4 TETR4_ECOLX Escherichia coli 2 0.7037
Glutathione S-transferase P P09211 GSTP1_HUMAN Homo sapiens 2 0.7029
Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic Q43088 RBCMT_PEA Pisum sativum 3 0.7028
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7028
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7026
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 3 0.7024
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7023
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.7021
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7013
Histone-lysine N-methyltransferase SETD7 Q8WTS6 SETD7_HUMAN Homo sapiens 3 0.7012
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7012

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