5-hydroxy-7,8-dimethoxyflavanone - Compound Card

5-hydroxy-7,8-dimethoxyflavanone

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5-hydroxy-7,8-dimethoxyflavanone

Structure
Zoomed Structure
  • Family: Plantae - Lauraceae
  • Kingdom: Plantae
  • Class: Flavonoid
    • Subclass: Flavanone
Canonical Smiles COc1c(OC)cc(c2c1O[C@@H](CC2=O)c1ccccc1)O
InChI InChI=1S/C17H16O5/c1-20-14-9-12(19)15-11(18)8-13(10-6-4-3-5-7-10)22-17(15)16(14)21-2/h3-7,9,13,19H,8H2,1-2H3/t13-/m0/s1
InChIKey VPGMCCIECGDASG-ZDUSSCGKSA-N
Formula C17H16O5
HBA 5
HBD 1
MW 300.31
Rotatable Bonds 3
TPSA 64.99
LogP 3.12
Number Rings 3
Number Aromatic Rings 2
Heavy Atom Count 22
Formal Charge 0
Fraction CSP3 0.24
Exact Mass 300.1
Number of Lipinski Rule Violations 0
# Species Family Kingdom NCBI Taxonomy ID
1 Beilschmiedia zenkeri Lauraceae Plantae 88849

Showing of synonyms

  • Lenta BN, Tantangmo F, et al. (2009). Bioactive constituents of the stem bark of Beilschmiedia zenkeri.. Journal of natural products,2009, 72(12), 2130-2134. [View] [PubMed]
Pubchem: 13963771
Nmrshiftdb2: 60069177
CPRiL: 411202
Structure

SMILES: c1cccc(c12)OC(CC2=O)c3ccccc3

Level: 1

Mol. Weight: 300.31 g/mol

Structure

SMILES: c1cccc(c12)OCCC2=O

Level: 0

Mol. Weight: 300.31 g/mol

Structure

SMILES: c1ccccc1

Level: 0

Mol. Weight: 300.31 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.58
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.560
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Non-Substrate
Skin Permeability
-2.18

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.230
Plasma Protein Binding
77.96
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Non-Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Substrate
CYP 2C19 Inhibitor
Inhibitor
CYP 2C19 Substrate
Non-Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Substrate
CYP 2D6 Inhibitor
Inhibitor
CYP 2D6 Substrate
Non-Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
9.680
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.430
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
0.890
Liver Injury II
Toxic
hERG Blockers
Toxic
Daphnia Maga
6.190
Micronucleos
Toxic
NR-AhR
Toxic
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Safe
NR-PPAR-gamma
Safe
NR-TR
Safe
T. Pyriformis
2.280
Rat (Acute)
2.000
Rat (Chronic Oral)
2.180
Fathead Minnow
4.620
Respiratory Disease
Safe
Skin Sensitisation
Safe
SR-ARE
Toxic
SR-ATAD5
Toxic
SR-HSE
Safe
SR-MMP
Toxic
SR-p53
Safe

General Properties

Boiling Point
387.700
Hydration Free Energy
-8.180
Log(D) at pH=7.4
2.580
Log(P)
3.19
Log S
-4.64
Log(Vapor Pressure)
-6.86
Melting Point
117.58
pKa Acid
7.26
pKa Basic
2.94
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Chitinase A Q9AMP1 Q9AMP1_VIBHA Vibrio harveyi 3 0.9852
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9688
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.9605
Cytochrome P450 1A1 P04798 CP1A1_HUMAN Homo sapiens 3 0.9522
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9520
Serine/threonine-protein kinase 10 O94804 STK10_HUMAN Homo sapiens 3 0.9414
Heat shock protein HSP 90-beta P08238 HS90B_HUMAN Homo sapiens 3 0.9382
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9381
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9358
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9334
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9320
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9309
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9301
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9252
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9220
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 3 0.9204
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9195
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.9141
Cyclic dipeptide N-prenyltransferase D1D8L6 D1D8L6_ASPFM Neosartorya fumigata 3 0.9140
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9133
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.9129
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.9109
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 3 0.9084
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Q8DNV6 Q8DNV6_STRR6 Streptococcus pneumoniae 3 0.9028
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 4 0.9015
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.9012
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 3 0.9011
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8971
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8920
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.8866
APH(2'')-Id O68183 O68183_ENTCA Enterococcus casseliflavus 4 0.8863
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.8847
Caspase-6 P55212 CASP6_HUMAN Homo sapiens 3 0.8790
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.8781
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8756
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8721
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.8689
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8649
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.8627
Proto-oncogene tyrosine-protein kinase receptor Ret P07949 RET_HUMAN Homo sapiens 3 0.8612
Protein polybromo-1 Q86U86 PB1_HUMAN Homo sapiens 5 0.8590
Sulfide-quinone reductase B7JBP8 SQRD_ACIF2 Acidithiobacillus ferrooxidans) 3 0.8586
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.8576
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.8560
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.8506
ActVA 6 protein Q53908 Q53908_STRCH Streptomyces coelicolor 3 0.8506
Rhodopsin kinase GRK1 P28327 GRK1_BOVIN Bos taurus 3 0.8504
DNA topoisomerase 4 subunit B H7C794 PARE_ENTFA Enterococcus faecalis 3 0.8501
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Q15750 TAB1_HUMAN Homo sapiens 3 0.8483
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.8473
Thymidylate synthase P0A886 TYSY_ECO57 Escherichia coli O157:H7 3 0.8467
Aldo-keto reductase family 1 member B1 P15121 ALDR_HUMAN Homo sapiens 3 0.8441
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8428
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.8421
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 3 0.8364
Leucoanthocyanidin dioxygenase Q96323 LDOX_ARATH Arabidopsis thaliana 4 0.8360
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8319
Mitogen-activated protein kinase 10 P53779 MK10_HUMAN Homo sapiens 3 0.8276
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Q9Y233 PDE10_HUMAN Homo sapiens 3 0.8269
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.8251
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.8228
Peroxisome proliferator-activated receptor gamma P37231 PPARG_HUMAN Homo sapiens 3 0.8193
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 3 0.8181
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Q3JRA0 ISPF_BURP1 Burkholderia pseudomallei 4 0.8178
Tau-tubulin kinase 1 Q5TCY1 TTBK1_HUMAN Homo sapiens 3 0.8175
Chalcone synthase 2 P30074 CHS2_MEDSA Medicago sativa 4 0.8173
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.8168
Protoporphyrinogen oxidase P50336 PPOX_HUMAN Homo sapiens 3 0.8165
Nodulin-13 P93330 NOD13_MEDTR Medicago truncatula 3 0.8133
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 3 0.8105
Flavonoid 3-O-glucosyltransferase A6XNC6 UGFGT_MEDTR Medicago truncatula 3 0.8073
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8052
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 3 0.8037
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.8025
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 3 0.8024
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.8017
Proto-oncogene tyrosine-protein kinase Src P12931 SRC_HUMAN Homo sapiens 3 0.8006
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7993
Epidermal growth factor receptor P00533 EGFR_HUMAN Homo sapiens 3 0.7967
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 3 0.7926
O-methyltransferase family 2 D5STZ7 D5STZ7_PLAL2 Planctopirus limnophila 4 0.7853
Glycogen synthase Q9V2J8 Q9V2J8_PYRAB Pyrococcus abyssi 3 0.7849
Mycocyclosin synthase P9WPP7 CP121_MYCTU Mycobacterium tuberculosis 3 0.7840
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7832
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7814
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7798
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7775
Riboflavin synthase P0AFU8 RISA_ECOLI Escherichia coli 4 0.7766
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 3 0.7766
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 3 0.7759
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7756
Glycogenin-1 P46976 GLYG_HUMAN Homo sapiens 3 0.7755
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7752
Nitric oxide synthase 3 P29474 NOS3_HUMAN Homo sapiens 3 0.7736
Activin receptor type-1 Q04771 ACVR1_HUMAN Homo sapiens 3 0.7731
Cyclin-dependent kinase 9 P50750 CDK9_HUMAN Homo sapiens 3 0.7730
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7727
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7724
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7724
Bromodomain-containing protein 2 P25440 BRD2_HUMAN Homo sapiens 3 0.7722
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7698
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7686
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 4 0.7679
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 3 0.7677
Chitinase Q54276 Q54276_SERMA Serratia marcescens 3 0.7664
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7655
Homoserine dehydrogenase P31116 DHOM_YEAST Saccharomyces cerevisiae 3 0.7654
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 3 0.7651
Histidine kinase 4 Q9C5U0 AHK4_ARATH Arabidopsis thaliana 3 0.7649
Heat shock protein 75 kDa, mitochondrial Q12931 TRAP1_HUMAN Homo sapiens 3 0.7645
Single-strand selective monofunctional uracil DNA glycosylase Q9YGN6 SMUG1_XENLA Xenopus laevis 4 0.7641
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7620
Lysozyme C II P11941 LYSC2_ONCMY Oncorhynchus mykiss 3 0.7617
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7608
tyrosine--tRNA ligase Q4QFJ7 Q4QFJ7_LEIMA Leishmania major 3 0.7606
Ephrin type-B receptor 4 P54760 EPHB4_HUMAN Homo sapiens 3 0.7583
Putative ketoacyl reductase P16544 ACT3_STRCO Streptomyces coelicolor / M145) 3 0.7579
Secoisolariciresinol dehydrogenase Q94KL8 SILD_PODPE Podophyllum peltatum 3 0.7567
Metallo-beta-lactamase type 2 P52699 BLAB_SERMA Serratia marcescens 3 0.7557
Gag-Pol polyprotein P04584 POL_HV2RO Human immunodeficiency virus type 2 subtype A 3 0.7536
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7513
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 3 0.7507
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7492
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7473
WxcM-like protein Q12KT8 Q12KT8_SHEDO Shewanella denitrificans 3 0.7458
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7457
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 3 0.7455
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 3 0.7455
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7447
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7439
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7432
Methionine aminopeptidase 1 P53582 MAP11_HUMAN Homo sapiens 2 0.7431
Polyribonucleotide nucleotidyltransferase A7ZS61 PNP_ECO24 Escherichia coli O139:H28 3 0.7424
Tyrosine-protein kinase Lck P06239 LCK_HUMAN Homo sapiens 3 0.7423
Enoyl-ACP reductase Q9BH77 Q9BH77_PLAFA Plasmodium falciparum 3 0.7423
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7412
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 3 0.7411
Gag-Pol polyprotein P03367 POL_HV1BR Human immunodeficiency virus type 1 group M subtype B 3 0.7408
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7405
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7405
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase P62617 ISPF_ECOLI Escherichia coli 3 0.7405
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 3 0.7400
Serine/threonine-protein kinase PLK1 P53350 PLK1_HUMAN Homo sapiens 3 0.7387
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 2 0.7386
L-lactate dehydrogenase A chain P13491 LDHA_RABIT Oryctolagus cuniculus 2 0.7376
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7374
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7366
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7365
Ribosomal protein S6 kinase alpha-3 P18654 KS6A3_MOUSE Mus musculus 5 0.7353
Death-associated protein kinase 1 P53355 DAPK1_HUMAN Homo sapiens 4 0.7349
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 3 0.7346
IOMT 3 Q06YR3 Q06YR3_MEDTR Medicago truncatula 3 0.7345
Carbonyl reductase [NADPH] 1 P16152 CBR1_HUMAN Homo sapiens 3 0.7335
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7325
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7304
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7304
DNA gyrase subunit B Q839Z1 GYRB_ENTFA Enterococcus faecalis 3 0.7303
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 4 0.7297
Beta-lactamase Q9L5C8 Q9L5C8_ECOLX Escherichia coli 3 0.7292
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7292
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 4 0.7285
Glucose-1-phosphate thymidylyltransferase Q9HU22 Q9HU22_PSEAE Pseudomonas aeruginosa 3 0.7285
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 3 0.7277
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 3 0.7270
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7251
BMP-2-inducible protein kinase Q9NSY1 BMP2K_HUMAN Homo sapiens 3 0.7250
Vascular endothelial growth factor receptor 2 P35968 VGFR2_HUMAN Homo sapiens 3 0.7240
Beta-secretase 1 P56817 BACE1_HUMAN Homo sapiens 3 0.7238
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 3 0.7237
Protein S100-A13 Q99584 S10AD_HUMAN Homo sapiens 3 0.7222
Angiopoietin-1 receptor Q02763 TIE2_HUMAN Homo sapiens 3 0.7219
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 3 0.7219
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 3 0.7219
cGMP-dependent protein kinase, putative A5K0N4 A5K0N4_PLAVS Plasmodium vivax 3 0.7217
cAMP-dependent protein kinase type I-alpha regulatory subunit P00514 KAP0_BOVIN Bos taurus 3 0.7206
Phytohormone-binding protein CSBP A0A1S3THR8 PHBP_VIGRR Vigna radiata var. radiata 2 0.7198
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7192
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 3 0.7191
N-acetyltransferase domain-containing protein Q9HV14 Q9HV14_PSEAE Pseudomonas aeruginosa 2 0.7180
Casein kinase II subunit alpha P28523 CSK2A_MAIZE Zea mays 3 0.7179
Anthocyanidin 3-O-glucosyltransferase UFGT P51094 UFOG_VITVI Vitis vinifera 3 0.7160
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7157
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7155
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7141
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 3 0.7140
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7137
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7134
CCA-adding enzyme O28126 CCA_ARCFU Archaeoglobus fulgidus 2 0.7131
Prothrombin P00734 THRB_HUMAN Homo sapiens 2 0.7125
Gag-Pol polyprotein P03369 POL_HV1A2 Human immunodeficiency virus type 1 group M subtype B 3 0.7121
3',5'-cyclic-AMP phosphodiesterase 4D Q08499 PDE4D_HUMAN Homo sapiens 2 0.7116
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7112
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7112
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 3 0.7106
Ribonuclease J H9CZL7 H9CZL7_DEIRD Deinococcus radiodurans 3 0.7105
Cytohesin-2 Q99418 CYH2_HUMAN Homo sapiens 3 0.7103
Tyrosine-protein kinase SYK P43405 KSYK_HUMAN Homo sapiens 3 0.7102
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform O02697 PK3CG_PIG Sus scrofa 4 0.7098
Histone deacetylase 8 Q9BY41 HDAC8_HUMAN Homo sapiens 2 0.7088
Soluble acetylcholine receptor Q8WSF8 Q8WSF8_APLCA Aplysia californica 2 0.7085
Cyclin-dependent kinase 6 Q00534 CDK6_HUMAN Homo sapiens 4 0.7084
Cyclic GMP-AMP phosphodiesterase SMPDL3A Q92484 ASM3A_HUMAN Homo sapiens 2 0.7084
17beta-hydroxysteroid dehydrogenase O93874 O93874_COCLU Cochliobolus lunatus 2 0.7076
Mitogen-activated protein kinase 8 P45983 MK08_HUMAN Homo sapiens 3 0.7074
Serine/threonine-protein kinase pim-1 P11309 PIM1_HUMAN Homo sapiens 3 0.7070
Diamine acetyltransferase 1 P21673 SAT1_HUMAN Homo sapiens 2 0.7070
Nitric oxide synthase oxygenase O34453 NOSO_BACSU Bacillus subtilis 3 0.7068
Phosphoribosylformylglycinamidine synthase subunit PurL Q9X0X3 PURL_THEMA Thermotoga maritima 3 0.7065
Gag-Pol polyprotein P12497 POL_HV1N5 Human immunodeficiency virus type 1 group M subtype B 2 0.7062
Dihydrofolate reductase P16184 DYR_PNECA Pneumocystis carinii 3 0.7060
Glutathione S-transferase F2 P46422 GSTF2_ARATH Arabidopsis thaliana 3 0.7059
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7054
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 3 0.7051
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 3 0.7051
Endothiapepsin P11838 CARP_CRYPA Cryphonectria parasitica 2 0.7050
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7050
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7040
Cytosolic IMP-GMP specific 5'-nucleotidase Q5ZZB6 Q5ZZB6_LEGPH Legionella pneumophila subsp. pneumophila 3 0.7039
Endoplasmin P41148 ENPL_CANLF Canis lupus familiaris 3 0.7030
Uridine phosphorylase Q5XA29 Q5XA29_STRP6 Streptococcus pyogenes serotype M6 3 0.7029
UDP-galactopyranose mutase Q48485 GLF1_KLEPN Klebsiella pneumoniae 3 0.7023
Thymidylate synthase P00469 TYSY_LACCA Lacticaseibacillus casei 2 0.7020
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7011
Protein mono-ADP-ribosyltransferase PARP15 Q460N3 PAR15_HUMAN Homo sapiens 3 0.7007
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7006
NAD(P) transhydrogenase subunit alpha part 1 Q2RSB2 PNTAA_RHORT Rhodospirillum rubrum 3 0.7005
Poly [ADP-ribose] polymerase tankyrase-2 Q9H2K2 TNKS2_HUMAN Homo sapiens 3 0.7003
Mitogen-activated protein kinase 14 Q16539 MK14_HUMAN Homo sapiens 3 0.7002
Sphingosine 1-phosphate receptor 1 P21453 S1PR1_HUMAN Homo sapiens 3 0.7000

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