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Zanthomamide

Family: Plantae - Lauraceae
Kingdom: Plantae
Class: Amide

Canonical Smiles	O=C(/C=C/c1ccccc1)NCCc1ccc2c(c1)OCO2
InChI	InChI=1S/C18H17NO3/c20-18(9-7-14-4-2-1-3-5-14)19-11-10-15-6-8-16-17(12-15)22-13-21-16/h1-9,12H,10-11,13H2,(H,19,20)/b9-7+
InChIKey	VLYAGIXYMUMJMN-VQHVLOKHSA-N
Formula	C₁₈H₁₇NO₃
HBA	3
HBD	1
MW	295.34
Rotatable Bonds	5
TPSA	47.56
LogP	2.79
Number Rings	3
Number Aromatic Rings	2
Heavy Atom Count	22
Formal Charge	0
Fraction CSP3	0.17
Exact Mass	295.12
Number of Lipinski Rule Violations	0

#	Species	Family	Kingdom	NCBI Taxonomy ID
1	Beilschmiedia zenkeri	Lauraceae	Plantae	88849

Showing of synonyms

Lenta BN, Tantangmo F, et al. (2009). Bioactive constituents of the stem bark of Beilschmiedia zenkeri.. Journal of natural products,2009, 72(12), 2130-2134. [View] [PubMed]

Pubchem: 14237550

Zinc: ZINC000014887273

Nmrshiftdb2: 70097217

Chembl: CHEMBL1081790

No compound-protein relationship available.

SMILES: c1ccccc1C=CC(=O)NCCc(c2)ccc(c23)OCO3

Level: 1

Mol. Weight: 295.34 g/mol

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 295.34 g/mol

SMILES: c1ccccc1

Level: 0

Mol. Weight: 295.34 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp): -4.9
Human Oral Bioavailability 20%: Bioavailable
Human Intestinal Absorption: Absorbed
Madin-Darby Canine Kidney: -4.28
Human Oral Bioavailability 50%: Bioavailable
P-Glycoprotein Inhibitor: Inhibitor
P-Glycoprotein Substrate: Non-Substrate
Skin Permeability: -2.5

Distribution

Blood-Brain Barrier (CNS): -
Blood-Brain Barrier: Penetrable
Fraction Unbound (Human): 1.34
Plasma Protein Binding: 78.71
Steady State Volume of Distribution: -

Metabolism

Breast Cancer Resistance Protein: Inhibitor
CYP 1A2 Inhibitor: Inhibitor
CYP 1A2 Substrate: Substrate
CYP 2C19 Inhibitor: Inhibitor
CYP 2C19 Substrate: Non-Substrate
CYP 2C9 Inhibitor: Inhibitor
CYP 2C9 Substrate: Substrate
CYP 2D6 Inhibitor: Inhibitor
CYP 2D6 Substrate: Substrate
CYP 3A4 Inhibitor: Inhibitor
CYP 3A4 Substrate: Substrate
OATP1B1: Non-Inhibitor
OATP1B3: Non-Inhibitor

Excretion

Clearance: 10.26
Organic Cation Transporter 2: Non-Inhibitor
Half-Life of Drug: -

Toxicity

AMES Mutagenesis: Safe
Avian: Safe
Bee: Toxic
Bioconcentration Factor: 1.23
Biodegradation: Safe
Carcinogenesis: Toxic
Crustacean: Toxic
Liver Injury I (DILI): Toxic
Eye Corrosion: Safe
Eye Irritation: Safe
Maximum Tolerated Dose: 0.72
Liver Injury II: Toxic
hERG Blockers: Safe
Daphnia Maga: 5.91
Micronucleos: Toxic
NR-AhR: Toxic
NR-AR: Safe
NR-AR-LBD: Safe
NR-Aromatase: Safe
NR-ER: Safe
NR-ER-LBD: Safe
NR-GR: Safe
NR-PPAR-gamma: Safe
NR-TR: Safe
T. Pyriformis: 3.41
Rat (Acute): 1.99
Rat (Chronic Oral): 1.65
Fathead Minnow: 4.65
Respiratory Disease: Toxic
Skin Sensitisation: Toxic
SR-ARE: Toxic
SR-ATAD5: Toxic
SR-HSE: Safe
SR-MMP: Safe
SR-p53: Safe

General Properties

Boiling Point: 415.54
Hydration Free Energy: -10.85
Log(D) at pH=7.4: 3.79
Log(P): 3.25
Log S: -3.98
Log(Vapor Pressure): -8.66
Melting Point: 125.78
pKa Acid: 10.94
pKa Basic: 3.04

Protein Name	UniProt ID	Entry Name	Species	#Pharmacophore Points	Probability (0.7 ≤ Tversky Score ≤ 1.0)
Peptidyl-prolyl cis-trans isomerase FKBP1A	P62942	FKB1A_HUMAN	Homo sapiens	3	0.9807
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.9596
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.9559
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.9555
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.9521
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.9510
Norsolorinic acid synthase	Q12053	AFLC_ASPPU	Aspergillus parasiticus	3	0.9502
Serine/threonine-protein kinase SKY1	Q03656	SKY1_YEAST	Saccharomyces cerevisiae	3	0.9461
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.9443
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.9434
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.9409
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.9378
3'-5' exoribonuclease Rv2179c	P9WJ73	EXRBN_MYCTU	Mycobacterium tuberculosis	3	0.9339
Serine/threonine-protein kinase 24	Q9Y6E0	STK24_HUMAN	Homo sapiens	3	0.9317
Methionine aminopeptidase 1	P53582	MAP11_HUMAN	Homo sapiens	3	0.9255
DNA gyrase subunit A	P0AES5	GYRA_SHIFL	Shigella flexneri	3	0.9223
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9209
ADP compounds hydrolase NudE	P45799	NUDE_ECOLI	Escherichia coli	3	0.9174
Serine/threonine-protein kinase toxin HipA	P23874	HIPA_ECOLI	Escherichia coli	3	0.9171
Serine/threonine-protein kinase Chk2	O96017	CHK2_HUMAN	Homo sapiens	3	0.9102
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9QYJ6	PDE10_RAT	Rattus norvegicus	3	0.9100
ATP-dependent molecular chaperone HSP82	P02829	HSP82_YEAST	Saccharomyces cerevisiae	3	0.9084
Neocarzinostatin	P0A3R9	NCZS_STRCZ	Streptomyces carzinostaticus	3	0.9079
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.9071
Capsid protein	Q9WBP8	Q9WBP8_9VIRU	Adeno-associated virus - 1	3	0.9071
Matrilysin	P09237	MMP7_HUMAN	Homo sapiens	4	0.9065
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.9059
Purine nucleoside phosphorylase	Q8I3X4	Q8I3X4_PLAF7	Plasmodium falciparum	3	0.8915
NAD-capped RNA hydrolase NudC	P32664	NUDC_ECOLI	Escherichia coli	3	0.8909
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.8900
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8866
Protein UshA	P07024	USHA_ECOLI	Escherichia coli	3	0.8837
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.8827
2-phospho-L-lactate transferase	Q8PVT6	COFD_METMA	Methanosarcina mazei	3	0.8809
Cyclin-dependent kinase 8	P49336	CDK8_HUMAN	Homo sapiens	3	0.8795
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.8759
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8759
Stromelysin-1	P08254	MMP3_HUMAN	Homo sapiens	3	0.8729
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8723
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.8687
Histone deacetylase 8	Q9BY41	HDAC8_HUMAN	Homo sapiens	3	0.8657
Aldo-keto reductase family 1 member B1	P15121	ALDR_HUMAN	Homo sapiens	3	0.8638
LIM domain kinase 1	P53667	LIMK1_HUMAN	Homo sapiens	3	0.8606
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.8573
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8570
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8559
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8532
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8512
Nitric oxide synthase 3	P29474	NOS3_HUMAN	Homo sapiens	3	0.8491
Ribosyldihydronicotinamide dehydrogenase [quinone]	P16083	NQO2_HUMAN	Homo sapiens	3	0.8481
Ephrin type-B receptor 2	P54763	EPHB2_MOUSE	Mus musculus	3	0.8480
Mitogen-activated protein kinase 1	P28482	MK01_HUMAN	Homo sapiens	3	0.8472
Calmodulin-like domain protein kinase isoenzyme gamma, related	F0V9W9	F0V9W9_NEOCL	Neospora caninum	3	0.8463
Abscisic acid receptor PYL2	O80992	PYL2_ARATH	Arabidopsis thaliana	3	0.8420
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.8410
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase	P0AF12	MTNN_ECOLI	Escherichia coli	3	0.8402
Methionine aminopeptidase	P0AE18	MAP1_ECOLI	Escherichia coli	3	0.8386
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8380
Lactoperoxidase	P80025	PERL_BOVIN	Bos taurus	3	0.8373
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.8326
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.8316
Thymidylate synthase	P00469	TYSY_LACCA	Lacticaseibacillus casei	3	0.8292
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.8285
Macrophage metalloelastase	P39900	MMP12_HUMAN	Homo sapiens	3	0.8282
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.8274
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.8257
Heat shock cognate 71 kDa protein	P11142	HSP7C_HUMAN	Homo sapiens	3	0.8257
Casein kinase II subunit alpha	P68400	CSK21_HUMAN	Homo sapiens	3	0.8230
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.8222
Decaprenylphosphoryl-beta-D-ribose oxidase	I6X8C4	I6X8C4_MYCTU	Mycobacterium tuberculosis	3	0.8216
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.8214
prolyl oligopeptidase	Q9X6R4	Q9X6R4_AERCA	Aeromonas caviae	3	0.8212
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.8207
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.8200
Purine nucleoside phosphorylase DeoD-type	Q5EEL8	DEOD_BACCE	Bacillus cereus	3	0.8187
Mitogen-activated protein kinase 10	P53779	MK10_HUMAN	Homo sapiens	3	0.8183
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	3	0.8144
Activin receptor type-1	Q04771	ACVR1_HUMAN	Homo sapiens	3	0.8129
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.8123
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.8088
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.8074
Pol protein	Q000H7	Q000H7_9HIV1	Human immunodeficiency virus 1	3	0.8073
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.8072
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.8062
Aldo-keto reductase family 1 member C3	P42330	AK1C3_HUMAN	Homo sapiens	2	0.8061
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.8058
Collagenase 3	P45452	MMP13_HUMAN	Homo sapiens	3	0.8055
Serine/threonine-protein kinase 10	O94804	STK10_HUMAN	Homo sapiens	3	0.8049
Proto-oncogene tyrosine-protein kinase Src	P12931	SRC_HUMAN	Homo sapiens	3	0.8021
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	Q8DNV6	Q8DNV6_STRR6	Streptococcus pneumoniae	3	0.8021
ActVA 6 protein	Q53908	Q53908_STRCH	Streptomyces coelicolor	3	0.8020
Pantothenate synthetase	P9WIL5	PANC_MYCTU	Mycobacterium tuberculosis	3	0.8010
Seminal ribonuclease	P00669	RNS_BOVIN	Bos taurus	3	0.8004
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7984
Carnitine O-palmitoyltransferase 2, mitochondrial	P18886	CPT2_RAT	Rattus norvegicus	3	0.7961
tRNA-guanine(15) transglycosylase	O58843	ATGT_PYRHO	Pyrococcus horikoshii	3	0.7953
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7930
Antitumor antibiotic C-1027 apoprotein	Q06110	CAGA_STRGL	Streptomyces globisporus	2	0.7916
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7908
Serine hydroxymethyltransferase	Q7SIB6	Q7SIB6_GEOSE	Geobacillus stearothermophilus	3	0.7906
Gag-Pol polyprotein	P03369	POL_HV1A2	Human immunodeficiency virus type 1 group M subtype B	3	0.7897
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7893
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7891
NAD-dependent protein deacetylase	Q9WYW0	NPD_THEMA	Thermotoga maritima	3	0.7884
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7869
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	3	0.7869
Protein kinase C iota type	Q62074	KPCI_MOUSE	Mus musculus	3	0.7867
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7851
Class B acid phosphatase	Q540U1	APHA_SALTM	Salmonella typhimurium	2	0.7848
Biotin carboxylase	P24182	ACCC_ECOLI	Escherichia coli	3	0.7837
NADPH dehydrogenase 1	Q02899	OYE1_SACPS	Saccharomyces pastorianus	3	0.7834
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7808
Purine nucleoside phosphorylase DeoD-type	P0ABP8	DEOD_ECOLI	Escherichia coli	3	0.7793
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7767
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7758
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	P48736	PK3CG_HUMAN	Homo sapiens	3	0.7749
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7748
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	3	0.7746
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7739
Peptidyl-prolyl cis-trans isomerase FKBP5	Q13451	FKBP5_HUMAN	Homo sapiens	3	0.7737
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7737
cGMP-dependent protein kinase 2	Q13237	KGP2_HUMAN	Homo sapiens	2	0.7736
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7730
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7728
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7727
Glutathione S-transferase F2	P46422	GSTF2_ARATH	Arabidopsis thaliana	3	0.7720
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7716
11-beta-hydroxysteroid dehydrogenase 1	P28845	DHI1_HUMAN	Homo sapiens	3	0.7713
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	3	0.7709
Streptavidin	P22629	SAV_STRAV	Streptomyces avidinii	3	0.7697
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7692
Cytochrome P450	S6BVH1	S6BVH1_RHOER	Rhodococcus erythropolis	3	0.7691
Polymerase acidic protein	P03433	PA_I34A1	Influenza A virus	2	0.7684
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7683
5-methylthioadenosine/S-adenosylhomocysteine deaminase	Q7NZ90	Q7NZ90_CHRVO	Chromobacterium violaceum	3	0.7676
Protease	O38896	O38896_9HIV1	Human immunodeficiency virus 1	2	0.7675
S-adenosylmethionine decarboxylase proenzyme	P17707	DCAM_HUMAN	Homo sapiens	3	0.7668
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7668
Interstitial collagenase	P03956	MMP1_HUMAN	Homo sapiens	3	0.7666
Annexin A5	P08758	ANXA5_HUMAN	Homo sapiens	2	0.7666
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7665
Neprilysin	P08473	NEP_HUMAN	Homo sapiens	4	0.7648
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7640
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7638
APH(2'')-Id	O68183	O68183_ENTCA	Enterococcus casseliflavus	3	0.7637
Adenylate cyclase 2	A0A2U2H3Y1	A0A384LKY8_YERPE	Yersinia pestis	3	0.7637
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7634
Ephrin type-B receptor 4	P54760	EPHB4_HUMAN	Homo sapiens	3	0.7632
Deoxycytidine kinase	P27707	DCK_HUMAN	Homo sapiens	3	0.7624
Photosynthetic reaction center cytochrome c subunit	P07173	CYCR_BLAVI	Blastochloris viridis	2	0.7624
Ephrin type-A receptor 3	P29320	EPHA3_HUMAN	Homo sapiens	3	0.7617
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	3	0.7617
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7616
Lipoyl synthase 2	Q8DLC2	LIPA2_THEEB	Thermosynechococcus vestitus	4	0.7614
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2	O88703	HCN2_MOUSE	Mus musculus	3	0.7610
Caffeic acid O-methyltransferase	Q9ZTU2	Q9ZTU2_LOLPR	Lolium perenne	3	0.7608
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7606
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Q15119	PDK2_HUMAN	Homo sapiens	3	0.7595
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7592
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7587
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	3	0.7586
Adenosine kinase	Q9TVW2	ADK_TOXGO	Toxoplasma gondii	3	0.7579
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7574
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7570
HTH-type transcriptional regulator TtgR	Q9AIU0	TTGR_PSEPT	Pseudomonas putida	2	0.7570
MAP kinase-activated protein kinase 2	P49137	MAPK2_HUMAN	Homo sapiens	3	0.7558
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7556
Prolyl endopeptidase	P23687	PPCE_PIG	Sus scrofa	2	0.7556
Polyprotein	Q80J95	Q80J95_9CALI	Murine norovirus 1	2	0.7556
Flavin reductase like domain-containing protein	Q4UKE8	Q4UKE8_RICFE	Rickettsia felis	3	0.7553
Cytochrome P450 1A1	P04798	CP1A1_HUMAN	Homo sapiens	3	0.7551
Catechol O-methyltransferase	P22734	COMT_RAT	Rattus norvegicus	3	0.7550
Anthocyanidin 3-O-glucosyltransferase UFGT	P51094	UFOG_VITVI	Vitis vinifera	3	0.7549
Urokinase-type plasminogen activator	P00749	UROK_HUMAN	Homo sapiens	2	0.7537
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	3	0.7532
NADPH-dependent oxidoreductase 2-alkenal reductase	Q39172	AER_ARATH	Arabidopsis thaliana	2	0.7530
Phenylalanine-4-hydroxylase	P00439	PH4H_HUMAN	Homo sapiens	2	0.7526
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7516
Steroid Delta-isomerase	P00947	SDIS_COMTE	Comamonas testosteroni	2	0.7516
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	2	0.7512
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7508
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7507
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	3	0.7506
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7503
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7502
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7501
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q08210	PYRD_PLAF7	Plasmodium falciparum	3	0.7501
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7498
Thymidylate synthase	P0A884	TYSY_ECOLI	Escherichia coli	2	0.7490
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7489
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	2	0.7489
GCN5-related N-acetyltransferase	B1YEL6	B1YEL6_EXIS2	Exiguobacterium sibiricum	3	0.7482
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7478
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	3	0.7478
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	P78356	PI42B_HUMAN	Homo sapiens	3	0.7476
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7474
Caffeoyl-CoA O-methyltransferase	Q40313	CAMT_MEDSA	Medicago sativa	3	0.7473
Vanillyl-alcohol oxidase	P56216	VAOX_PENSI	Penicillium simplicissimum	3	0.7472
Maltokinase	A1TH50	MAK_MYCVP	Mycolicibacterium vanbaalenii	3	0.7471
CCA-adding enzyme	O28126	CCA_ARCFU	Archaeoglobus fulgidus	2	0.7467
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7463
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7456
Plasma membrane ATPase	Q42932	Q42932_NICPL	Nicotiana plumbaginifolia	2	0.7455
cGMP-dependent 3',5'-cyclic phosphodiesterase	O00408	PDE2A_HUMAN	Homo sapiens	3	0.7452
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7451
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	3	0.7446
Avidin	P02701	AVID_CHICK	Gallus gallus	3	0.7446
NADPH-dependent 7-cyano-7-deazaguanine reductase	Q9KTK0	QUEF_VIBCH	Vibrio cholerae serotype O1	3	0.7446
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7445
16S rRNA (adenine(1408)-N(1))-methyltransferase	A8C927	NPMA_ECOLX	Escherichia coli	3	0.7439
Cyclin-dependent kinase 9	P50750	CDK9_HUMAN	Homo sapiens	3	0.7438
Peroxisome proliferator-activated receptor gamma	P37231	PPARG_HUMAN	Homo sapiens	2	0.7432
Lactoylglutathione lyase	Q9CPU0	LGUL_MOUSE	Mus musculus	2	0.7430
Agglutinin alpha chain	P18674	LECA_MACPO	Maclura pomifera	3	0.7422
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	2	0.7421
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7419
Indole-3-glycerol phosphate synthase	P9WFX7	TRPC_MYCTU	Mycobacterium tuberculosis	2	0.7417
Nucleoside diphosphate kinase	Q5UQL3	NDK_MIMIV	Acanthamoeba polyphaga mimivirus	2	0.7416
Purine nucleoside phosphorylase DeoD-type	O34925	DEOD_BACSU	Bacillus subtilis	3	0.7410
cytokinin dehydrogenase	E3T1W8	E3T1W8_MAIZE	Zea mays	3	0.7403
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7393
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7390
Sulfotransferase 1A1	P50225	ST1A1_HUMAN	Homo sapiens	3	0.7390
Vascular endothelial growth factor receptor 2	P35968	VGFR2_HUMAN	Homo sapiens	3	0.7389
DNA (cytosine-5)-methyltransferase 1	Q9AXT8	H32_ARATH	Zea mays	3	0.7389
Beta-secretase 2	Q9Y5Z0	BACE2_HUMAN	Homo sapiens	2	0.7389
Serine/threonine-protein kinase pim-1	P11309	PIM1_HUMAN	Homo sapiens	3	0.7381
17beta-hydroxysteroid dehydrogenase	O93874	O93874_COCLU	Cochliobolus lunatus	3	0.7381
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7380
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	3	0.7368
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7367
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7365
Genome polyprotein	A0EKU1	A0EKU1_9FLAV	Meaban virus	3	0.7363
Macrophage colony-stimulating factor 1 receptor	P07333	CSF1R_HUMAN	Homo sapiens	3	0.7361
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7355
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7353
Nicotinamide phosphoribosyltransferase	P43490	NAMPT_HUMAN	Homo sapiens	3	0.7348
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	2	0.7346
Proto-oncogene tyrosine-protein kinase Src	P00523	SRC_CHICK	Gallus gallus	3	0.7344
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7343
Uncharacterized protein YML079W	Q03629	YMH9_YEAST	Saccharomyces cerevisiae	2	0.7343
Dihydrofolate reductase	P0A017	DYR_STAAU	Staphylococcus aureus	3	0.7341
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7335
Purine phosphoribosyltransferase (GpT-1)	Q97W95	Q97W95_SACS2	Saccharolobus solfataricus	3	0.7329
Cyclic GMP-AMP synthase	Q8C6L5	CGAS_MOUSE	Mus musculus	3	0.7327
F420-dependent methylenetetrahydromethanopterin dehydrogenase	P94951	MTD_METKA	Methanopyrus kandleri	2	0.7327
Mitogen-activated protein kinase 8	P45983	MK08_HUMAN	Homo sapiens	3	0.7327
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7321
cGMP-dependent protein kinase 1	Q13976	KGP1_HUMAN	Homo sapiens	2	0.7320
Bifunctional epoxide hydrolase 2	P34913	HYES_HUMAN	Homo sapiens	3	0.7307
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7305
Ribonuclease 4	P15468	RNAS4_PIG	Sus scrofa	2	0.7305
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7304
Chalcone--flavanone isomerase 1	P28012	CFI1_MEDSA	Medicago sativa	3	0.7301
cAMP-dependent protein kinase catalytic subunit alpha	P00517	KAPCA_BOVIN	Bos taurus	3	0.7297
Gag-Pol polyprotein	O12158	POL_HV192	Human immunodeficiency virus type 1 group M subtype C	3	0.7292
HTH-type transcriptional repressor PurR	P0ACP7	PURR_ECOLI	Escherichia coli	2	0.7289
Dihydroorotate dehydrogenase (quinone), mitochondrial	Q63707	PYRD_RAT	Rattus norvegicus	2	0.7288
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1	O50008	METE1_ARATH	Arabidopsis thaliana	2	0.7288
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	3	0.7286
Chitinase A	Q9AMP1	Q9AMP1_VIBHA	Vibrio harveyi	2	0.7286
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7285
Ras-related protein Ral-B	P11234	RALB_HUMAN	Homo sapiens	2	0.7283
ALK tyrosine kinase receptor	Q9UM73	ALK_HUMAN	Homo sapiens	3	0.7279
Purine nucleoside phosphorylase	P00491	PNPH_HUMAN	Homo sapiens	2	0.7279
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7279
Purine nucleoside phosphorylase DeoD-type	P0ABP9	DEOD_ECO57	Escherichia coli O157:H7	3	0.7276
Metallophosphoesterase MPPED2	B1WBP0	MPPD2_RAT	Rattus norvegicus	3	0.7276
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7275
Single-stranded-DNA-specific exonuclease RecJ	D0EM60	D0EM60_DEIRD	Deinococcus radiodurans	2	0.7274
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7273
Beta-secretase 1	P56817	BACE1_HUMAN	Homo sapiens	2	0.7273
NAD(P)H-hydrate epimerase	Q8K4Z3	NNRE_MOUSE	Mus musculus	2	0.7273
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7271
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	3	0.7271
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7269
Mycocyclosin synthase	P9WPP7	CP121_MYCTU	Mycobacterium tuberculosis	2	0.7268
Endoplasmic reticulum aminopeptidase 2	Q6P179	ERAP2_HUMAN	Homo sapiens	2	0.7267
FMN-dependent NAD(P)H:quinone oxidoreductase 1	Q9I5F3	AZOR1_PSEAE	Pseudomonas aeruginosa	2	0.7260
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	2	0.7258
Cytidine and deoxycytidylate deaminase zinc-binding region	Q82Y41	Q82Y41_NITEU	Nitrosomonas europaea	2	0.7256
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7253
Aurora kinase A	O14965	AURKA_HUMAN	Homo sapiens	3	0.7253
Nuclear receptor subfamily 1 group I member 2	O75469	NR1I2_HUMAN	Homo sapiens	3	0.7252
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	P62617	ISPF_ECOLI	Escherichia coli	3	0.7252
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7251
Type II methyltransferase M.HhaI	P05102	MTH1_HAEPH	Haemophilus parahaemolyticus	3	0.7248
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7245
Gag-Pol polyprotein	P03367	POL_HV1BR	Human immunodeficiency virus type 1 group M subtype B	3	0.7242
Beta-galactoside-specific lectin 4	Q6ITZ3	ML4_VISAL	Viscum album	2	0.7242
Beta-1 adrenergic receptor	P07700	ADRB1_MELGA	Meleagris gallopavo	2	0.7241
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7241
Precorrin-3 methylase	O68097	O68097_RHOCA	Rhodobacter capsulatus	3	0.7238
Coagulation factor X	P00742	FA10_HUMAN	Homo sapiens	3	0.7237
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7234
Prostatic acid phosphatase	P15309	PPAP_HUMAN	Homo sapiens	2	0.7233
Tubulin alpha-1B chain	P81947	TBA1B_BOVIN	Bos taurus	2	0.7233
Myosin heavy chain kinase A	P42527	MHCKA_DICDI	Dictyostelium discoideum	3	0.7227
Adenylate cyclase type 5	P30803	ADCY5_CANLF	Canis lupus familiaris	3	0.7224
Geranyl diphosphate 2-C-methyltransferase	D3KYU3	GPPMT_STRLS	Streptomyces lasalocidi	3	0.7224
Disintegrin and metalloproteinase domain-containing protein 17	P78536	ADA17_HUMAN	Homo sapiens	2	0.7224
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	3	0.7222
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7219
3-hydroxybenzoate 4-monooxygenase	Q6SSJ6	MOBA_COMTE	Comamonas testosteroni	2	0.7219
cAMP-dependent protein kinase type I-alpha regulatory subunit	P00514	KAP0_BOVIN	Bos taurus	2	0.7218
N-acetyltransferase domain-containing protein	Q9HV14	Q9HV14_PSEAE	Pseudomonas aeruginosa	2	0.7216
Toxoflavin degrading enzyme	E3SET7	E3SET7_PAEPO	Paenibacillus polymyxa	2	0.7215
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7214
Mitochondrial poly(A) polymerase	F1NBW0	F1NBW0_CHICK	Gallus gallus	2	0.7213
Adenine DNA glycosylase	P83847	MUTY_GEOSE	Geobacillus stearothermophilus	3	0.7212
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	2	0.7212
Endothiapepsin	P11838	CARP_CRYPA	Cryphonectria parasitica	2	0.7207
L-seryl-tRNA(Sec) kinase	Q58933	PSTK_METJA	Methanocaldococcus jannaschii	2	0.7207
Cytidine deaminase	P19079	CDD_BACSU	Bacillus subtilis	3	0.7205
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	3	0.7203
Amine oxidase [flavin-containing] B	P27338	AOFB_HUMAN	Homo sapiens	3	0.7202
Plasmid partition protein A	P07620	PARA_ECOLX	Escherichia coli	3	0.7201
Soluble cytochrome b562	P0ABE7	C562_ECOLX	Escherichia coli	2	0.7198
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	P04191	AT2A1_RABIT	Oryctolagus cuniculus	2	0.7195
Poly [ADP-ribose] polymerase tankyrase-2	Q9H2K2	TNKS2_HUMAN	Homo sapiens	3	0.7194
Fumarate reductase subunit D	P0A8Q3	FRDD_ECOLI	Escherichia coli	3	0.7192
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7191
Mismatch repair endonuclease PMS2	P54278	PMS2_HUMAN	Homo sapiens	3	0.7177
Basic phospholipase A2 VRV-PL-VIIIa	P59071	PA2B8_DABRR	Daboia russelii	2	0.7177
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Q9Y233	PDE10_HUMAN	Homo sapiens	2	0.7175
Tetracycline repressor protein class B from transposon Tn10	P04483	TETR2_ECOLX	Escherichia coli	2	0.7175
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7172
Mitogen-activated protein kinase 14	Q16539	MK14_HUMAN	Homo sapiens	3	0.7170
Beta-lactamase	Q9L5C8	Q9L5C8_ECOLX	Escherichia coli	3	0.7166
Cyclin-dependent kinase 2	P24941	CDK2_HUMAN	Homo sapiens	3	0.7162
Beta-galactoside-specific lectin 1	P81446	ML1_VISAL	Viscum album	2	0.7161
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	3	0.7159
Tyrosine-protein kinase Lck	P06239	LCK_HUMAN	Homo sapiens	3	0.7157
Multidrug transporter MdfA	P0AEY8	MDFA_ECOLI	Escherichia coli	3	0.7156
Hexokinase-4	P35557	HXK4_HUMAN	Homo sapiens	3	0.7155
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	3	0.7152
RAC-alpha serine/threonine-protein kinase	P31749	AKT1_HUMAN	Homo sapiens	2	0.7152
Carbonic anhydrase 4	Q64444	CAH4_MOUSE	Mus musculus	2	0.7152
DNA mismatch repair protein MutS	P23909	MUTS_ECOLI	Escherichia coli	3	0.7151
Gag-Pol polyprotein	P12497	POL_HV1N5	Human immunodeficiency virus type 1 group M subtype B	2	0.7147
Pentaerythritol tetranitrate reductase	P71278	P71278_ENTCL	Enterobacter cloacae	2	0.7147
Ribosome-inactivating protein 3	P25891	RIP3_MAIZE	Zea mays	2	0.7146
Nitric oxide synthase 1	P29476	NOS1_RAT	Rattus norvegicus	3	0.7140
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	2	0.7139
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7139
Ribosomal small subunit pseudouridine synthase A	P0AA43	RSUA_ECOLI	Escherichia coli	2	0.7138
uroporphyrinogen-III C-methyltransferase	P95417	P95417_PSEAI	Pseudomonas aeruginosa	3	0.7134
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7132
Karilysin	D0EM77	KLY_TANFA	Tannerella forsythia	2	0.7132
Serine/threonine-protein kinase Chk1	O14757	CHK1_HUMAN	Homo sapiens	3	0.7129
3',5'-cyclic-AMP phosphodiesterase 4D	Q08499	PDE4D_HUMAN	Homo sapiens	3	0.7129
Epidermal growth factor receptor	P00533	EGFR_HUMAN	Homo sapiens	3	0.7127
L-lactate dehydrogenase A chain	P13491	LDHA_RABIT	Oryctolagus cuniculus	2	0.7126
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7125
Pancreatic alpha-amylase	P04746	AMYP_HUMAN	Homo sapiens	2	0.7121
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7119
mRNA cleavage and polyadenylation factor CLP1	Q08685	CLP1_YEAST	Saccharomyces cerevisiae	2	0.7119
Heat shock protein HSP 90-beta	P08238	HS90B_HUMAN	Homo sapiens	2	0.7118
Cystathionine beta-lyase MetC	P06721	METC_ECOLI	Escherichia coli	3	0.7115
Aminopeptidase N	P15145	AMPN_PIG	Sus scrofa	2	0.7115
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	3	0.7115
Dihydropteroate synthase	Q81VW8	Q81VW8_BACAN	Bacillus anthracis	3	0.7114
Histone deacetylase-like amidohydrolase	Q70I53	HDAH_ALCSD	Alcaligenes sp.)	2	0.7113
RNA 2'-O ribose methyltransferase	Q5SLL8	Q5SLL8_THET8	Thermus thermophilus	3	0.7110
Nickel-binding periplasmic protein	P33590	NIKA_ECOLI	Escherichia coli	2	0.7110
Heat shock protein HSP 90-alpha	P07900	HS90A_HUMAN	Homo sapiens	3	0.7109
Ribosomal RNA large subunit methyltransferase H	P0C1V0	RLMH_STAAU	Staphylococcus aureus	3	0.7107
clade A/E 93TH057 HIV-1 gp120 core	A0A0M3KKW9	A0A0M3KKW9_9HIV1	Human immunodeficiency virus 1	2	0.7106
Hygromycin-B 4-O-kinase	P00557	KHYB_ECOLX	Escherichia coli	3	0.7101
Adenosine 5'-monophosphoramidase HINT1	P80912	HINT1_RABIT	Oryctolagus cuniculus	2	0.7100
Malate synthase G	P9WK17	MASZ_MYCTU	Mycobacterium tuberculosis	3	0.7099
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7099
Nitric oxide synthase oxygenase	O34453	NOSO_BACSU	Bacillus subtilis	3	0.7098
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7097
DNA adenine methylase	P04392	DMA_BPT4	Enterobacteria phage T4	4	0.7091
Focal adhesion kinase 1	Q05397	FAK1_HUMAN	Homo sapiens	3	0.7088
Tetracycline repressor protein class H	P51561	TETR8_PASMD	Pasteurella multocida	2	0.7085
Type II methyltransferase M.TaqI	P14385	MTTA_THEAQ	Thermus aquaticus	2	0.7084
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase	Q05603	COBT_SALTY	Salmonella typhimurium	3	0.7080
Methionine aminopeptidase 2	P9WK19	MAP12_MYCTU	Mycobacterium tuberculosis	3	0.7080
Dipeptidyl peptidase 4	P22411	DPP4_PIG	Sus scrofa	3	0.7076
GTP 3',8-cyclase	P69848	MOAA_STAA8	Staphylococcus aureus	3	0.7075
Dipeptidyl peptidase 4	P14740	DPP4_RAT	Rattus norvegicus	2	0.7075
Carbonic anhydrase 2	P00918	CAH2_HUMAN	Homo sapiens	2	0.7070
Type IV / VI secretion system DotU domain-containing protein	Q9KN50	Q9KN50_VIBCH	Vibrio cholerae serotype O1	2	0.7068
Formate--tetrahydrofolate ligase	Q2RM91	FTHS_MOOTA	Moorella thermoacetica	2	0.7067
Serine/threonine-protein kinase CtkA	Q9ZKJ5	CTKA_HELPJ	Helicobacter pylori	3	0.7066
Glutamate receptor 2	P19491	GRIA2_RAT	Rattus norvegicus	3	0.7065
Cellular tumor antigen p53	P04637	P53_HUMAN	Homo sapiens	3	0.7062
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7061
Endoplasmin	P41148	ENPL_CANLF	Canis lupus familiaris	2	0.7061
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7060
Bromodomain-containing protein 2	P25440	BRD2_HUMAN	Homo sapiens	2	0.7059
Tryptase alpha/beta-1	Q15661	TRYB1_HUMAN	Homo sapiens	3	0.7058
RNA polymerase sigma factor SigA	Q5SKW1	Q5SKW1_THET8	Thermus thermophilus	2	0.7057
N-alpha-acetyltransferase 50	Q9GZZ1	NAA50_HUMAN	Homo sapiens	3	0.7053
Archaeal actin homolog	Q9HKL4	ACTH_THEAC	Thermoplasma acidophilum	2	0.7052
Amino-acid acetyltransferase	Q5FAK7	Q5FAK7_NEIG1	Neisseria gonorrhoeae	2	0.7050
tRNA (adenine(9)-N1)-methyltransferase	Q4J894	TRM10_SULAC	Sulfolobus acidocaldarius	3	0.7047
Polymerase basic protein 2	P31345	PB2_I75A3	Influenza A virus	2	0.7047
2',3'-cyclic-nucleotide 3'-phosphodiesterase	P16330	CN37_MOUSE	Mus musculus	2	0.7046
Genome polyprotein	P26663	POLG_HCVBK	Hepatitis C virus genotype 1b	2	0.7045
Alpha-ketoglutarate-dependent dioxygenase FTO	Q9C0B1	FTO_HUMAN	Homo sapiens	2	0.7044
Protein mono-ADP-ribosyltransferase PARP3	Q9Y6F1	PARP3_HUMAN	Homo sapiens	2	0.7044
Gag-Pol polyprotein	P05896	POL_SIVM1	Simian immunodeficiency virus	3	0.7043
Aldehyde dehydrogenase, mitochondrial	P05091	ALDH2_HUMAN	Homo sapiens	3	0.7042
Biotin carboxylase	P43873	ACCC_HAEIN	Haemophilus influenzae	3	0.7040
Polymerase acidic protein	C3W5S0	C3W5S0_I09A0	Influenza A virus	2	0.7034
Thermolysin	P00800	THER_BACTH	Bacillus thermoproteolyticus	3	0.7032
Abscisic acid receptor PYR1	O49686	PYR1_ARATH	Arabidopsis thaliana	2	0.7030
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	3	0.7028
Tyrosine-protein kinase JAK2	O60674	JAK2_HUMAN	Homo sapiens	3	0.7026
Probable nicotinate-nucleotide adenylyltransferase	C3L5T6	NADD_BACAC	Bacillus anthracis	2	0.7026
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7025
Peripheral plasma membrane protein CASK	O14936	CSKP_HUMAN	Homo sapiens	3	0.7023
Fibroblast growth factor receptor 2	P21802	FGFR2_HUMAN	Homo sapiens	3	0.7021
Glycogen synthase kinase-3 beta	P49841	GSK3B_HUMAN	Homo sapiens	2	0.7020
Prothrombin	P00734	THRB_HUMAN	Homo sapiens	2	0.7020
rRNA N-glycosylase	D9J2T9	D9J2T9_MOMBA	Momordica balsamina	2	0.7017
Queuine tRNA-ribosyltransferase	P28720	TGT_ZYMMO	Zymomonas mobilis subsp. mobilis	2	0.7010
Nitric oxide synthase, inducible	P29477	NOS2_MOUSE	Mus musculus	2	0.7009
Dipeptidyl peptidase 4	P27487	DPP4_HUMAN	Homo sapiens	2	0.7008
Nucleoside diphosphate kinase	A5J299	A5J299_PENVA	Penaeus vannamei	2	0.7006
Liver carboxylesterase 1	P23141	EST1_HUMAN	Homo sapiens	2	0.7001

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