Pipyahyine - Compound Card

Pipyahyine

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Pipyahyine

Structure
Zoomed Structure
  • Family: Lauraceae
  • Kingdom: Plantae
  • Class: Amide
Canonical Smiles CC(CNC(=O)/C=C/C=C/CCCCCC/C=C/c1ccc2c(c1)OCO2)C
InChI InChI=1S/C24H33NO3/c1-20(2)18-25-24(26)14-12-10-8-6-4-3-5-7-9-11-13-21-15-16-22-23(17-21)28-19-27-22/h8,10-17,20H,3-7,9,18-19H2,1-2H3,(H,25,26)/b10-8+,13-11+,14-12+
InChIKey FPMPOFBEYSSYDQ-AUVZEZIHSA-N
Formula C24H33NO3
HBA 3
HBD 1
MW 383.53
Rotatable Bonds 12
TPSA 47.56
LogP 5.65
Number Rings 2
Number Aromatic Rings 1
Heavy Atom Count 28
Formal Charge 0
Fraction CSP3 0.46
Exact Mass 383.25
Number of Lipinski Rule Violations 1
# Species Family Kingdom NCBI Taxonomy ID
1 Beilschmiedia zenkeri Lauraceae Plantae 88849

Showing of synonyms

  • Lenta BN, Tantangmo F, et al. (2009). Bioactive constituents of the stem bark of Beilschmiedia zenkeri.. Journal of natural products,2009, 72(12), 2130-2134. [View] [PubMed]
Pubchem: 6442405
Chebi: 181825
Nmrshiftdb2: 60064010
Bindingdb: 50479142
CPRiL: 211596
Structure

SMILES: O1COc(c12)cccc2

Level: 0

Mol. Weight: 122.12 g/mol

No bioactivities available.

Absorption

Caco-2 (logPapp)
-4.9
Human Oral Bioavailability 20%
Bioavailable
Human Intestinal Absorption
Absorbed
Madin-Darby Canine Kidney
-4.18
Human Oral Bioavailability 50%
Bioavailable
P-Glycoprotein Inhibitor
Inhibitor
P-Glycoprotein Substrate
Substrate
Skin Permeability
-3.16

Distribution

Blood-Brain Barrier (CNS)
-
Blood-Brain Barrier
Penetrable
Fraction Unbound (Human)
1.57
Plasma Protein Binding
76.55
Steady State Volume of Distribution
-

Metabolism

Breast Cancer Resistance Protein
Inhibitor
CYP 1A2 Inhibitor
Inhibitor
CYP 1A2 Substrate
Non-Substrate
CYP 2C19 Inhibitor
Non-Inhibitor
CYP 2C19 Substrate
Substrate
CYP 2C9 Inhibitor
Inhibitor
CYP 2C9 Substrate
Non-Substrate
CYP 2D6 Inhibitor
Non-Inhibitor
CYP 2D6 Substrate
Substrate
CYP 3A4 Inhibitor
Inhibitor
CYP 3A4 Substrate
Non-Substrate
OATP1B1
Non-Inhibitor
OATP1B3
Non-Inhibitor

Excretion

Clearance
5.0
Organic Cation Transporter 2
Non-Inhibitor
Half-Life of Drug
-

Toxicity

AMES Mutagenesis
Safe
Avian
Safe
Bee
Toxic
Bioconcentration Factor
1.6
Biodegradation
Safe
Carcinogenesis
Safe
Crustacean
Toxic
Liver Injury I (DILI)
Safe
Eye Corrosion
Safe
Eye Irritation
Safe
Maximum Tolerated Dose
-0.31
Liver Injury II
Safe
hERG Blockers
Toxic
Daphnia Maga
6.1
Micronucleos
Safe
NR-AhR
Safe
NR-AR
Safe
NR-AR-LBD
Safe
NR-Aromatase
Safe
NR-ER
Safe
NR-ER-LBD
Safe
NR-GR
Toxic
NR-PPAR-gamma
Safe
NR-TR
Toxic
T. Pyriformis
-5.36
Rat (Acute)
2.39
Rat (Chronic Oral)
2.12
Fathead Minnow
5.32
Respiratory Disease
Toxic
Skin Sensitisation
Toxic
SR-ARE
Toxic
SR-ATAD5
Safe
SR-HSE
Toxic
SR-MMP
Safe
SR-p53
Safe

General Properties

Boiling Point
447.04
Hydration Free Energy
-4.8
Log(D) at pH=7.4
4.8
Log(P)
6.89
Log S
-5.36
Log(Vapor Pressure)
-8.31
Melting Point
90.42
pKa Acid
11.27
pKa Basic
5.22
Protein Name UniProt ID Entry Name Species #Pharmacophore Points Probability (0.7 ≤ Tversky Score ≤ 1.0)
Camphor 5-monooxygenase P00183 CPXA_PSEPU Pseudomonas putida 3 0.9621
Peridinin-chlorophyll a protein, high-salt form O76183 O76183_AMPCA Amphidinium carterae 3 0.8742
Thymidylate synthase P0A884 TYSY_ECOLI Escherichia coli 2 0.8643
ADP-ribosylation factor 1 P84077 ARF1_HUMAN Homo sapiens 2 0.8562
2-aminohexano-6-lactam racemase Q7M181 ACLR_ACHOB Achromobacter obae 3 0.8504
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 3 0.8142
SKP1-like protein 1A Q39255 SKP1A_ARATH Arabidopsis thaliana 3 0.7888
Type IV / VI secretion system DotU domain-containing protein Q9KN50 Q9KN50_VIBCH Vibrio cholerae serotype O1 2 0.7880
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7833
LL-diaminopimelate aminotransferase, chloroplastic Q93ZN9 DAPAT_ARATH Arabidopsis thaliana 2 0.7790
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase O33877 FABA_PSEAE Pseudomonas aeruginosa 3 0.7788
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7786
Avd protein A7YYL1 A7YYL1_XENTR Xenopus tropicalis 3 0.7760
Carbonic anhydrase 2 P00918 CAH2_HUMAN Homo sapiens 2 0.7732
Sex hormone-binding globulin P04278 SHBG_HUMAN Homo sapiens 2 0.7649
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7624
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7621
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7611
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Q05603 COBT_SALTY Salmonella typhimurium 2 0.7606
Polyprotein Q80J95 Q80J95_9CALI Murine norovirus 1 2 0.7594
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7579
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7578
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 3 0.7576
Vitamin D-binding protein P02774 VTDB_HUMAN Homo sapiens 2 0.7553
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7545
Phenylalanine-4-hydroxylase P00439 PH4H_HUMAN Homo sapiens 2 0.7530
Avidin P02701 AVID_CHICK Gallus gallus 3 0.7522
ADP-ribosylation factor 1 P84080 ARF1_BOVIN Bos taurus 2 0.7519
Purine nucleoside phosphorylase DeoD-type O34925 DEOD_BACSU Bacillus subtilis 2 0.7501
LIM domain kinase 1 P53667 LIMK1_HUMAN Homo sapiens 2 0.7490
Photosynthetic reaction center cytochrome c subunit P07173 CYCR_BLAVI Blastochloris viridis 2 0.7488
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7488
Serine/threonine-protein kinase Chk2 O96017 CHK2_HUMAN Homo sapiens 2 0.7478
TamL D3Y1I2 D3Y1I2_9ACTN Streptomyces sp. 307-9 3 0.7478
Serine/threonine-protein kinase 24 Q9Y6E0 STK24_HUMAN Homo sapiens 2 0.7475
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7461
DNA gyrase subunit A P0AES5 GYRA_SHIFL Shigella flexneri 2 0.7456
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7451
Aromatic-amino-acid aminotransferase P95468 TYRB_PARDE Paracoccus denitrificans 2 0.7441
Tryptophan synthase beta chain 2 Q97TX6 TRPB2_SACS2 Saccharolobus solfataricus 2 0.7440
NADPH-dependent 7-cyano-7-deazaguanine reductase Q9KTK0 QUEF_VIBCH Vibrio cholerae serotype O1 2 0.7437
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7436
Liver carboxylesterase 1 P23141 EST1_HUMAN Homo sapiens 2 0.7436
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7435
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7434
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7421
Mitochondrial poly(A) polymerase F1NBW0 F1NBW0_CHICK Gallus gallus 2 0.7420
Chorismate mutase AroH P19080 AROH_BACSU Bacillus subtilis 2 0.7416
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7416
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase Q9TQS6 DHDH_MACFA Macaca fascicularis 2 0.7411
Glycogen synthase kinase-3 beta P49841 GSK3B_HUMAN Homo sapiens 2 0.7410
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7407
Peroxidase C1A P00433 PER1A_ARMRU Armoracia rusticana 2 0.7396
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7393
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7392
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7391
tRNA-guanine(15) transglycosylase O58843 ATGT_PYRHO Pyrococcus horikoshii 2 0.7390
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 3 0.7388
Amine oxidase [flavin-containing] B P27338 AOFB_HUMAN Homo sapiens 2 0.7384
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7384
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 P04191 AT2A1_RABIT Oryctolagus cuniculus 2 0.7381
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7378
MAP kinase-activated protein kinase 2 P49137 MAPK2_HUMAN Homo sapiens 2 0.7375
Polymerase acidic protein C3W5S0 C3W5S0_I09A0 Influenza A virus 2 0.7370
prolyl oligopeptidase Q9X6R4 Q9X6R4_AERCA Aeromonas caviae 2 0.7369
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7367
Aminoglycoside N(3)-acetyltransferase A0A3P1UCA6 Q81P86_BACAN Bacillus anthracis 2 0.7367
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7365
Sodium-dependent dopamine transporter Q7K4Y6 DAT_DROME Drosophila melanogaster 2 0.7362
RIO-type serine/threonine-protein kinase Rio1 O28471 RIO1_ARCFU Archaeoglobus fulgidus 2 0.7362
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7360
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7359
Uncharacterized protein YML079W Q03629 YMH9_YEAST Saccharomyces cerevisiae 2 0.7358
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7351
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7349
Neutrophil gelatinase-associated lipocalin P80188 NGAL_HUMAN Homo sapiens 2 0.7348
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7347
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Q81LL4 MTNN_BACAN Bacillus anthracis 2 0.7338
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7331
Serine/threonine-protein kinase SKY1 Q03656 SKY1_YEAST Saccharomyces cerevisiae 2 0.7329
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7329
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7328
N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) Q91XE4 ACY3_MOUSE Mus musculus 2 0.7324
Prolyl tripeptidyl peptidase Q7MUW6 PTP_PORGI Porphyromonas gingivalis 2 0.7320
Toxoflavin degrading enzyme E3SET7 E3SET7_PAEPO Paenibacillus polymyxa 2 0.7319
Purine nucleoside phosphorylase P00491 PNPH_HUMAN Homo sapiens 2 0.7317
Thermolysin P00800 THER_BACTH Bacillus thermoproteolyticus 2 0.7316
Ephrin type-B receptor 2 P54763 EPHB2_MOUSE Mus musculus 2 0.7316
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7315
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7312
ADP compounds hydrolase NudE P45799 NUDE_ECOLI Escherichia coli 2 0.7311
L-lactate dehydrogenase A chain P04642 LDHA_RAT Rattus norvegicus 2 0.7310
RNA polymerase sigma factor SigA Q5SKW1 Q5SKW1_THET8 Thermus thermophilus 2 0.7307
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7301
Transcriptional activator, LuxR/UhpA family of regulators Q7NQP7 Q7NQP7_CHRVO Chromobacterium violaceum 2 0.7296
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7296
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7292
Albumin P02768 ALBU_HUMAN Homo sapiens 2 0.7291
Cysteine desulfurase IscS 2 O29689 ISCS2_ARCFU Archaeoglobus fulgidus 2 0.7290
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7284
Coagulation factor X P00742 FA10_HUMAN Homo sapiens 2 0.7282
Serine/threonine-protein kinase N1 Q16512 PKN1_HUMAN Homo sapiens 2 0.7282
Capsid protein Q9WBP8 Q9WBP8_9VIRU Adeno-associated virus - 1 2 0.7282
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7280
Ribosome-inactivating protein 3 P25891 RIP3_MAIZE Zea mays 2 0.7277
Beta-galactoside-specific lectin 4 Q6ITZ3 ML4_VISAL Viscum album 2 0.7272
Basic phospholipase A2 VRV-PL-VIIIa P59071 PA2B8_DABRR Daboia russelii 2 0.7270
Tyrosine-protein kinase JAK3 P52333 JAK3_HUMAN Homo sapiens 2 0.7269
Avidin P02701 AVID_CHICK Gallus gallus 2 0.7268
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7268
Sulfotransferase 1A1 P50225 ST1A1_HUMAN Homo sapiens 2 0.7266
Cytidine and deoxycytidylate deaminase zinc-binding region Q82Y41 Q82Y41_NITEU Nitrosomonas europaea 2 0.7265
Pentaerythritol tetranitrate reductase P71278 P71278_ENTCL Enterobacter cloacae 2 0.7264
HTH-type transcriptional repressor PurR P0ACP7 PURR_ECOLI Escherichia coli 2 0.7262
Aspartate aminotransferase P00509 AAT_ECOLI Escherichia coli 2 0.7261
Ribosomal small subunit pseudouridine synthase A P0AA43 RSUA_ECOLI Escherichia coli 2 0.7261
Beta-1 adrenergic receptor P07700 ADRB1_MELGA Meleagris gallopavo 2 0.7261
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7261
11-beta-hydroxysteroid dehydrogenase 1 P28845 DHI1_HUMAN Homo sapiens 2 0.7260
Prostaglandin F2a synthase Q8I6L9 Q8I6L9_TRYCR Trypanosoma cruzi 2 0.7252
Methylketone synthase I E0YCS2 E0YCS2_SOLHA Solanum habrochaites 2 0.7251
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7248
3-hydroxybenzoate 4-monooxygenase Q6SSJ6 MOBA_COMTE Comamonas testosteroni 2 0.7248
Deacetoxycephalosporin C synthase P18548 CEFE_STRCL Streptomyces clavuligerus 2 0.7245
Serine/threonine-protein kinase toxin HipA P23874 HIPA_ECOLI Escherichia coli 2 0.7245
Dual specificity mitogen-activated protein kinase kinase 1 Q02750 MP2K1_HUMAN Homo sapiens 2 0.7245
Biotin carboxylase P43873 ACCC_HAEIN Haemophilus influenzae 2 0.7244
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 PK3CG_HUMAN Homo sapiens 2 0.7243
Pancreatic alpha-amylase P04746 AMYP_HUMAN Homo sapiens 2 0.7239
Alpha/beta hydrolase fold protein D2J2T6 D2J2T6_9RHIZ Ochrobactrum sp. T63 2 0.7238
Reaction center protein L chain P0C0Y7 RCEH_RHOSH Rhodobacter sphaeroides 2 0.7238
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7235
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7233
Mitogen-activated protein kinase 1 P28482 MK01_HUMAN Homo sapiens 2 0.7224
Norsolorinic acid synthase Q12053 AFLC_ASPPU Aspergillus parasiticus 2 0.7220
5-aminolevulinate synthase P18079 HEM1_RHOCB Rhodobacter capsulatus 2 0.7219
Heat shock protein HSP 90-alpha P07900 HS90A_HUMAN Homo sapiens 2 0.7208
NAD(P)H-hydrate epimerase Q8K4Z3 NNRE_MOUSE Mus musculus 2 0.7207
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7205
Cytochrome P450 Q93H81 Q93H81_STRAX Streptomyces avermitilis 2 0.7204
Myosin heavy chain kinase A P42527 MHCKA_DICDI Dictyostelium discoideum 2 0.7203
Cyclin-dependent kinase 2 P24941 CDK2_HUMAN Homo sapiens 2 0.7202
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7200
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7199
Aspartate aminotransferase, mitochondrial P00508 AATM_CHICK Gallus gallus 2 0.7197
N-alpha-acetyltransferase 50 Q9GZZ1 NAA50_HUMAN Homo sapiens 3 0.7192
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7189
Nitric oxide synthase, inducible P29477 NOS2_MOUSE Mus musculus 2 0.7185
5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase P0AF12 MTNN_ECOLI Escherichia coli 2 0.7180
Serine/threonine-protein kinase Chk1 O14757 CHK1_HUMAN Homo sapiens 2 0.7169
Trichothecene 15-O-acetyltransferase TRI3 Q9C1B7 TRI3_FUSSP Fusarium sporotrichioides 2 0.7168
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7161
cAMP-dependent protein kinase catalytic subunit alpha P00517 KAPCA_BOVIN Bos taurus 2 0.7161
Tyrosine-protein kinase JAK1 P23458 JAK1_HUMAN Homo sapiens 2 0.7161
S-norcoclaurine synthase Q67A25 NCS_THLFG Thalictrum flavum subsp. glaucum 2 0.7157
Histone-lysine N-methyltransferase EHMT1 Q9H9B1 EHMT1_HUMAN Homo sapiens 2 0.7156
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.7155
Pantothenate synthetase P9WIL4 PANC_MYCTO Mycobacterium tuberculosis 2 0.7151
Casein kinase II subunit alpha P68400 CSK21_HUMAN Homo sapiens 2 0.7150
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase P12995 BIOA_ECOLI Escherichia coli 2 0.7149
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7146
Pantothenate synthetase P9WIL5 PANC_MYCTU Mycobacterium tuberculosis 2 0.7145
Tyrosine-protein kinase JAK2 O60674 JAK2_HUMAN Homo sapiens 2 0.7144
Tetracycline repressor protein class H P51561 TETR8_PASMD Pasteurella multocida 2 0.7143
Biotin carboxylase P24182 ACCC_ECOLI Escherichia coli 2 0.7141
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7141
Stromelysin-1 P08254 MMP3_HUMAN Homo sapiens 2 0.7133
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Q0QF01 SDHA_PIG Sus scrofa 2 0.7133
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7132
Xanthine dehydrogenase/oxidase P22985 XDH_RAT Rattus norvegicus 2 0.7128
rRNA N-glycosylase D9J2T9 D9J2T9_MOMBA Momordica balsamina 2 0.7125
Protein kinase C iota type Q62074 KPCI_MOUSE Mus musculus 2 0.7125
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7123
ATP-dependent molecular chaperone HSP82 P02829 HSP82_YEAST Saccharomyces cerevisiae 2 0.7120
Cell division control protein 42 homolog P60953 CDC42_HUMAN Homo sapiens 2 0.7119
Alpha-ketoglutarate-dependent dioxygenase FTO Q9C0B1 FTO_HUMAN Homo sapiens 2 0.7117
LysR-type regulatory protein Q7WT50 Q7WT50_9BURK Burkholderia sp. DNT 2 0.7111
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7109
Muconolactone Delta-isomerase Q8G9L0 Q8G9L0_RHOOP Rhodococcus opacus 2 0.7107
Phospholipase A2, major isoenzyme P00592 PA21B_PIG Sus scrofa 2 0.7106
Carminomycin 4-O-methyltransferase DnrK Q06528 DNRK_STRPE Streptomyces peucetius 2 0.7103
Focal adhesion kinase 1 Q05397 FAK1_HUMAN Homo sapiens 2 0.7103
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase P19992 HSD_STREX Streptomyces exfoliatus 2 0.7102
Protein mono-ADP-ribosyltransferase PARP3 Q9Y6F1 PARP3_HUMAN Homo sapiens 2 0.7100
Hypoxanthine phosphoribosyltransferase Q4DRC4 Q4DRC4_TRYCC Trypanosoma cruzi 2 0.7085
Putative FAD-dependent oxygenase EncM Q9KHK2 Q9KHK2_9ACTN Streptomyces maritimus 2 0.7082
7,8-dihydroneopterin aldolase J7VEZ6 J7VEZ6_BACCE Bacillus cereus BAG3X2-1 2 0.7074
Soluble cytochrome b562 P0ABE7 C562_ECOLX Escherichia coli 2 0.7071
Streptavidin P22629 SAV_STRAV Streptomyces avidinii 2 0.7059
Anthranilate phosphoribosyltransferase P9WFX5 TRPD_MYCTU Mycobacterium tuberculosis 2 0.7058
Fibroblast growth factor receptor 2 P21802 FGFR2_HUMAN Homo sapiens 2 0.7058
Poly [ADP-ribose] polymerase 1 P09874 PARP1_HUMAN Homo sapiens 2 0.7046
Queuine tRNA-ribosyltransferase P28720 TGT_ZYMMO Zymomonas mobilis subsp. mobilis 2 0.7043
Biflaviolin synthase CYP158A2 Q9FCA6 C1582_STRCO Streptomyces coelicolor / M145) 2 0.7026
Alanine aminotransferase Q9P9M8 Q9P9M8_9EURY Pyrococcus furiosus 2 0.7026
Uracil phosphoribosyltransferase Q26998 UPP_TOXGO Toxoplasma gondii 2 0.7020
Lactotransferrin P24627 TRFL_BOVIN Bos taurus 2 0.7014
Phosphoenolpyruvate carboxykinase [GTP] A5TYT6 PCKG_MYCTA Mycobacterium tuberculosis 3 0.7003

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